LOCUS       NM_001301298            5006 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus growth factor receptor bound protein 2-associated
            protein 1 (Gab1), transcript variant 1, mRNA.
ACCESSION   NM_001301298 XM_006530675
VERSION     NM_001301298.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5006)
  AUTHORS   Xu J, Li S, Jin W, Zhou H, Zhong T, Cheng X, Fu Y, Xiao P, Cheng H,
            Wang D, Ke Y, Jiang Z and Zhang X.
  TITLE     Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent
            intestinal inflammation
  JOURNAL   JCI Insight 8 (6), e162701 (2023)
   PUBMED   36795486
  REMARK    GeneRIF: Epithelial Gab1 calibrates RIPK3-dependent necroptosis to
            prevent intestinal inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5006)
  AUTHORS   Zhang Z, Shen C, Wu N, Wang J, Du W and Chen X.
  TITLE     Gab1 Overexpression Alleviates Doxorubicin-Induced Cardiac
            Oxidative Stress, Inflammation, and Apoptosis Through PI3K/Akt
            Signaling Pathway
  JOURNAL   J Cardiovasc Pharmacol 80 (6), 804-812 (2022)
   PUBMED   35856909
  REMARK    GeneRIF: Gab1 Overexpression Alleviates Doxorubicin-Induced Cardiac
            Oxidative Stress, Inflammation, and Apoptosis Through PI3K/Akt
            Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5006)
  AUTHORS   Song P, Xu H, He Y, Sun J, Xu Z, Huang P, Ge M, Zhang X, Ke Y and
            Cheng H.
  TITLE     GAB1 is upregulated to promote anaplastic thyroid cancer cell
            migration through AKT-MDR1
  JOURNAL   Biochem Biophys Res Commun 607, 36-43 (2022)
   PUBMED   35366541
  REMARK    GeneRIF: GAB1 is upregulated to promote anaplastic thyroid cancer
            cell migration through AKT-MDR1.
REFERENCE   4  (bases 1 to 5006)
  AUTHORS   Matoba S, Kozuka C, Miura K, Inoue K, Kumon M, Hayashi R, Ohhata T,
            Ogura A and Inoue A.
  TITLE     Noncanonical imprinting sustains embryonic development and
            restrains placental overgrowth
  JOURNAL   Genes Dev 36 (7-8), 483-494 (2022)
   PUBMED   35483741
REFERENCE   5  (bases 1 to 5006)
  AUTHORS   Sun L, Zhu H and Zhang K.
  TITLE     GAB1 alleviates septic lung injury by inhibiting the TLR4/
            NF-kappaB pathway
  JOURNAL   Clin Exp Pharmacol Physiol 49 (1), 94-103 (2022)
   PUBMED   34498273
  REMARK    GeneRIF: GAB1 alleviates septic lung injury by inhibiting the TLR4/
            NF-kappaB pathway.
REFERENCE   6  (bases 1 to 5006)
  AUTHORS   Yu CF, Roshan B, Liu ZX and Cantley LG.
  TITLE     ERK regulates the hepatocyte growth factor-mediated interaction of
            Gab1 and the phosphatidylinositol 3-kinase
  JOURNAL   J Biol Chem 276 (35), 32552-32558 (2001)
   PUBMED   11445578
REFERENCE   7  (bases 1 to 5006)
  AUTHORS   Sachs M, Brohmann H, Zechner D, Muller T, Hulsken J, Walther I,
            Schaeper U, Birchmeier C and Birchmeier W.
  TITLE     Essential role of Gab1 for signaling by the c-Met receptor in vivo
  JOURNAL   J Cell Biol 150 (6), 1375-1384 (2000)
   PUBMED   10995442
REFERENCE   8  (bases 1 to 5006)
  AUTHORS   Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B and Birchmeier
            W.
  TITLE     Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological
            responses
  JOURNAL   J Cell Biol 149 (7), 1419-1432 (2000)
   PUBMED   10871282
REFERENCE   9  (bases 1 to 5006)
  AUTHORS   Itoh M, Yoshida Y, Nishida K, Narimatsu M, Hibi M and Hirano T.
  TITLE     Role of Gab1 in heart, placenta, and skin development and growth
            factor- and cytokine-induced extracellular signal-regulated kinase
            mitogen-activated protein kinase activation
  JOURNAL   Mol Cell Biol 20 (10), 3695-3704 (2000)
   PUBMED   10779359
REFERENCE   10 (bases 1 to 5006)
  AUTHORS   Weidner KM, Di Cesare S, Sachs M, Brinkmann V, Behrens J and
            Birchmeier W.
  TITLE     Interaction between Gab1 and the c-Met receptor tyrosine kinase is
            responsible for epithelial morphogenesis
  JOURNAL   Nature 384 (6605), 173-176 (1996)
   PUBMED   8906793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132176.1 and BX523462.1.
            
            [WARNING] On Oct 12, 2023 this sequence was replaced by
            NM_001301298.2.
            
            On Aug 1, 2014 this sequence version replaced XM_006530675.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132176.1, SRR11927936.1716134.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4985              AK132176.1         2-4986
            4986-5006           BX523462.1         428-448
FEATURES             Location/Qualifiers
     source          1..5006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 38.47 cM"
     gene            1..5006
                     /gene="Gab1"
                     /note="growth factor receptor bound protein 2-associated
                     protein 1"
                     /db_xref="GeneID:14388"
                     /db_xref="MGI:MGI:108088"
     exon            1..988
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
     CDS             917..3094
                     /gene="Gab1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GRB2-associated-binding protein 1; GRB2-associated binder
                     1"
                     /codon_start=1
                     /product="GRB2-associated-binding protein 1 isoform 1"
                     /protein_id="NP_001288227.1"
                     /db_xref="CCDS:CCDS85569.1"
                     /db_xref="GeneID:14388"
                     /db_xref="MGI:MGI:108088"
                     /translation="MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDV
                     LEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEE
                     DMNKWVRCICDICGFNPTEEDPVKPLTGSSQAPVDSPFAISTAPASSQMEASSVALPP
                     PYQVISLPPHPDTLGLQDDPQDYLLLINCQSKKPEPNRTLFDSAKPTFSETDCNDNVP
                     SHQTPASSQSKHGMNGFFQQQMMYDCPPSRLTSVSGESSLYNLPRSYSHDVLPKESPS
                     STEADGELYTFNTPSGTAGVETQMRHVSISYDIPPTPGNTYQIPRTFPESTLGQSSKL
                     DTIPDIPPPRPPKPHPTHDRSPVETCGVPRTASDTDSSYCIPPPAGMTPSRSNTISTV
                     DLNKLRKDASSQDCYDIPRTFPSDRSSSLEGFHSQYKIKSVLTAGGVSGEELDENYVP
                     MNPNSPPRQHSGSFTEPIQEPNYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRR
                     PVPVADCEPPPVDRNLKPDRKGQSPKILRPKPHGLERTDSQTIGDFATRRKVKPAPLD
                     IKPLSEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMN
                     PNLSGEDPNLFASNSLDGGSSPMNKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSS
                     MADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPTKNVK"
     exon            989..1283
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1509
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2114
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2200
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2504
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2594
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2688
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2812
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2935
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..4992
                     /gene="Gab1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttttggctg gaagcgctcc ggaggagttt cagagaaagt ctgggctgaa gctagaggcg
       61 accgatcgtg ggaaggggag gcagaaaggc taggaggagg agggccgggg cccaggccgc
      121 gcctccccga acccgccgcg cgcccccggg gtgggggagg agcgcagggg acaggacaga
      181 ggggtccctc cccgaagcag agccgccctg cgcctcgtcc ctgtgctgat ccccgccctc
      241 atccgaggct ggagcgcaga cccaccctcc caccgcggac ccgcgacctc cccgacgccc
      301 ggcgacgccc tgaccctcgc tgctggtccg cgaactccct aggctgatca ggacctgccc
      361 ctgtgccggc tgccacccgg acgccgcacg ccttcccagg cgcccttttc cgagcagagg
      421 gaaagagaag atcgagcccc tctcagtgtg aatgcgccaa cgggcggagc ggagcggagc
      481 ggacaccgcg cgcgggcatt gtgtgtgcgc gtgcagcgtg gggtccgcag cggggagcac
      541 ccgcgggagg tcccgtttcc aaggggcgga gcgcagggct tccagttctg ggctccctgt
      601 ccggacagag tcccagcgga gcccgaccgc tgcctaggcg gcgggacggc gcgcctggcg
      661 gccaggaggg cgcactgaaa gaaggtcggc gagccctggt ccccgcggtt cccgatcgag
      721 ttcctcttca gtccgcgaat ctgcgggaga ggttcgatcg ccgacacagg gcgcggggag
      781 ccgggccgcc ccgtcggggg aatctgagac gtcctctggg ctgcgtttga ctgccgtgcc
      841 cgccgtgcac ggagcgcgtc cactgtgtcc accgacccct ttggtgtctg gtcctcgagt
      901 cctcacggcg tgcaccatga gcggcggcga agtggtttgc tcgggatggc tccgcaagtc
      961 gcccccggag aagaagttga agcgttatgc gtggaagaga aggtggtttg tgttgcgcag
     1021 tggccgtttg actggagacc cggatgtcct ggagtattac aaaaacgatc atgccaagaa
     1081 gcctattcgg attattgatt taaatttatg tcagcaagtt gatgctgggt tgacattcaa
     1141 caaaaaggag tttgaaaaca gctatatctt tgatatcaac accatcgacc ggattttcta
     1201 cttggtggca gatagtgagg aagacatgaa caagtgggtc cgttgtatct gtgacatctg
     1261 tggattcaat cccacagaag aagatcctgt gaagccgctg actggctcct cacaagcacc
     1321 cgtcgattca cctttcgcta taagtacagc accagcctcc agtcagatgg aagcttcttc
     1381 agtcgcgcta cctcctcctt accaggtcat cagccttccg ccacacccag acaccctcgg
     1441 cctccaggac gatccacaag actacctctt gctgatcaac tgtcaaagca agaagcctga
     1501 acctaacaga accctctttg actctgccaa gcccaccttt tctgagacag actgcaatga
     1561 caacgtccct tcccaccaga ctcctgcttc ctcccagagc aaacacggaa tgaatggctt
     1621 tttccagcaa caaatgatgt atgactgccc accgtcccgg ctgacatctg tctcgggaga
     1681 gtccagcctc tataacctgc ccaggagcta ttcccatgac gtgttgccaa aggaatcccc
     1741 atcaagcacg gaggccgacg gggagctgta cacctttaac accccatctg ggactgcagg
     1801 tgtagaaacg cagatgagac atgtatccat cagttacgac attccgccaa cacctggcaa
     1861 cacttaccag atcccacgga catttccaga aagcacactg ggacagtcat caaagctgga
     1921 caccattcct gatatccccc cacctcggcc accaaagcca catccaactc atgaccggtc
     1981 tcctgtggaa acgtgtggag tcccacgcac ggcctcggac actgacagca gttactgtat
     2041 ccctcctcca gcaggcatga cgccctcccg gagtaatacc atttccaccg tggatttgaa
     2101 caagttgcgg aaagatgcta gttctcaaga ttgctatgat attccacgga cctttccgag
     2161 cgatagatct agttccctgg aaggcttcca tagccagtat aaaatcaaaa gcgtgttgac
     2221 agcgggaggt gtctcgggtg aagagctgga tgagaactac gttcccatga accccaactc
     2281 gccacctcga caacattccg gcagctttac cgagccaatc caggagccaa actatgtgcc
     2341 aatgacccca gggacctttg acttttcttc ctttggaatg caagtccctc ctcctgctca
     2401 tatgggcttc aggtccagcc caaagacccc tcccaggagg ccagttcctg ttgctgactg
     2461 tgaaccaccc ccggtggata ggaacctcaa gccagacaga aaaggtcaga gtcctaaaat
     2521 tttaagaccc aaaccccatg gtttagagcg aactgattca caaaccatag gtgactttgc
     2581 tacaagaaga aaggtcaagc cggcaccttt agacataaaa cctctgtcag aatgggaaga
     2641 gctgcaagcc ccagtcagat ctcccatcac caggagcttc gctcgggact cctctaggtt
     2701 tcccatgtcc cctcggcctg attctgtgca cagtacgaca tcgagcagcg actctcatga
     2761 cagtgaagag aactatgtcc ccatgaatcc aaatctgtct ggcgaagacc cgaatctctt
     2821 tgccagcaac agccttgatg ggggaagcag cccgatgaat aaacccaaag gagacaaaca
     2881 agtcgaatac ctggatttag acctagattc tgggaagtcc acgccaccac ggaagcaaaa
     2941 gagcagtggt tctggcagca gcatggcaga cgagagggtg gattacgttg tggtggacca
     3001 acagaagact ctggccctga agagtaccag agaagcttgg acggatggga ggcagtccac
     3061 agagtccgag acacccacca agaatgtgaa gtgaagacat gccgtcgcct ctgccggcag
     3121 acgagatctg agtggaaaga gagatgccaa gtgaagatgt tcccactctc agtggagcct
     3181 cgagccagca ggggcagaga gaaggatctc tcacacatgt tcaagcaaat taggttgtga
     3241 atggtgctgt gtggtattgg atttataacg tgtaaataac ccggggaaat agtgttttta
     3301 gttcacagag aagcttctgt ccctaattaa cacacctgta gtattactat actgatgcac
     3361 ttttcattta aaaccttggt ttgggtcttc ccgatctacc ttaacagact ttccttggga
     3421 ggtcttttgg cctcctcaca ctactctata taacaatact aagtgaactg agctacttgt
     3481 aattctggaa attccagttg aagctacagg gctaacacca ttaaaacaag aagtaagttg
     3541 acacattcgc ttttctcttg aaggtggtag ccattagctt aagctgtaga acatagttgg
     3601 acttgtcctt cgttgttttc caaaaattcc ggggatattg tatatagcag gtcaagacct
     3661 agctctctga ctcatgtaca cttaggtttt aactgtagga ctttgttatt attatttttt
     3721 ttgttaatga cagtgttggg ttcatcgtgt gaaggttctg ctgggtagga tcttgcacct
     3781 ttcaaagact gcctcttagt tacactagta agcccccaaa tcatccacag catggactgc
     3841 tggcctgctc ttactcctgt ttatgtgtta aacattatct gcaaaaggca gattatacga
     3901 ctgaccaatc aggtacgtac aaggcactga tgtgctaata cagtgattgg gtcagacaaa
     3961 gtgcttcagt tagtgtgcgt tcgtcctaat cttggtttag aattaatgaa acagttggcg
     4021 ttcactgtca gcagcatagt gtgattttga atgaattagg caggaattca agattactac
     4081 tcttagctcg ctcgctctct ctctctctcc accgtagtgc tcttcctagg gttttctttc
     4141 ttctacttaa tatcttcttg gccttatatt taaatcccta tgcaattaat gttttatatc
     4201 tgcgttttta aaaaagaaat gtcattttaa gtgattcttg tatgtagcaa gcacctattg
     4261 cttttgtgag taaatgaatt aagacttttg tactgtgatt tgtactcact gccccagttc
     4321 cccaactgtt ggagccttgc tgctgtgaaa cgctgtagtc accatagttg tgtccaccac
     4381 ccagccgggt ctgtgagtct cacctgtcac gtgacatcgt ctggtgtgga tgttggctct
     4441 gaattagtgt cactgcagtt acacgtgtct gtctaggctt tgcaagatgc tgtagtcacc
     4501 atagtcgtga ccaccaccta gccaggtctg tgagtctcac ctgtcacgtg ccatcatctg
     4561 gtgtcactgc agttacacgt gtctgtctag gctttgccgc aaccttgaga agcagctagc
     4621 attttccgtt gttcacacag taaggacaat gtctctgcat tgatctgagg ctcactggtg
     4681 gcctggggaa gggacacaga gaacagaatg tctgcagctg aggcttgtct ctcttcgttc
     4741 agacctctta cctgttgcct gagtacacaa tgcaccccgc tttctggccc actggccacg
     4801 gtgctgtgcc taatctgagt tctcccctgg cttttccagt cagtttgaaa gctgtgttca
     4861 taactagatg aagtgtagaa tagtaatatt agatgctttt aaatgttcgc ttctttttaa
     4921 acaaaaacta aaacccagaa ctgaattttg aggtggattt ttaaataaaa aaagattgag
     4981 tttgctgtgt gaaaaaaaaa aaaaaa
//
