LOCUS       NM_008062               2354 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus glucose-6-phosphate dehydrogenase X-linked (G6pdx),
            mRNA.
ACCESSION   NM_008062
VERSION     NM_008062.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2354)
  AUTHORS   Cao,S., Guo,J., Zhu,D., Sun,Z., Liu,L., Zhang,Y., Maratbek,S.,
            Wang,Z., Zhang,J., Li,W., Ding,J., Deng,X. and Zhang,H.
  TITLE     Brucella induced upregulation of NO promote macrophages glycolysis
            through the NF-kappaB/G6PD pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113038 (2024)
   PUBMED   39276450
  REMARK    GeneRIF: Brucella induced upregulation of NO promote macrophages
            glycolysis through the NF-kappaB/G6PD pathway.
REFERENCE   2  (bases 1 to 2354)
  AUTHORS   Lu,J., Ling,X., Sun,Y., Liu,L., Liu,L., Wang,X., Lu,C., Ren,C.,
            Han,X. and Yu,Z.
  TITLE     FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated
            redox homeostasis
  JOURNAL   Apoptosis 28 (7-8), 1128-1140 (2023)
   PUBMED   37119432
  REMARK    GeneRIF: FDX1 enhances endometriosis cell cuproptosis via
            G6PD-mediated redox homeostasis.
REFERENCE   3  (bases 1 to 2354)
  AUTHORS   Serna,E., Mauricio,M.D., San-Miguel,T., Guerra-Ojeda,S., Verdu,D.,
            Valls,A., Arc-Chagnaud,C., De la Rosa,A. and Vina,J.
  TITLE     Glucose 6-P Dehydrogenase Overexpression Improves Aging-Induced
            Endothelial Dysfunction in Aorta from Mice: Role of Arginase II
  JOURNAL   Int J Mol Sci 24 (4), 3622 (2023)
   PUBMED   36835034
  REMARK    GeneRIF: Glucose 6-P Dehydrogenase Overexpression Improves
            Aging-Induced Endothelial Dysfunction in Aorta from Mice: Role of
            Arginase II.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2354)
  AUTHORS   Jiang,A., Guo,H., Jiang,X., Tao,J., Wu,W. and Liu,H.
  TITLE     G6PD Deficiency Is Crucial for Insulin Signaling Activation in
            Skeletal Muscle
  JOURNAL   Int J Mol Sci 23 (13), 7425 (2022)
   PUBMED   35806430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2354)
  AUTHORS   Hashimoto,R. and Gupte,S.A.
  TITLE     G6PD is a critical enabler of hypoxia-induced accumulation of
            macrophages and platelets in mice lungs and contributor to lung
            inflammation
  JOURNAL   Vascul Pharmacol 144, 106976 (2022)
   PUBMED   35272030
  REMARK    GeneRIF: G6PD is a critical enabler of hypoxia-induced accumulation
            of macrophages and platelets in mice lungs and contributor to lung
            inflammation.
REFERENCE   6  (bases 1 to 2354)
  AUTHORS   Bergsagel,P.L., Timblin,C.R., Eckhardt,L., Laskov,R. and Kuehl,W.M.
  TITLE     Sequence and expression of a murine cDNA encoding PC326, a novel
            gene expressed in plasmacytomas but not normal plasma cells
  JOURNAL   Oncogene 7 (10), 2059-2064 (1992)
   PUBMED   1408147
REFERENCE   7  (bases 1 to 2354)
  AUTHORS   Toniolo,D., Filippi,M., Dono,R., Lettieri,T. and Martini,G.
  TITLE     The CpG island in the 5' region of the G6PD gene of man and mouse
  JOURNAL   Gene 102 (2), 197-203 (1991)
   PUBMED   1874446
REFERENCE   8  (bases 1 to 2354)
  AUTHORS   Neifer,S., Jung,A. and Bienzle,U.
  TITLE     Characterization of erythrocytic glucose-6-phosphate dehydrogenase
            in a mouse strain with reduced G6PD activity
  JOURNAL   Biomed Biochim Acta 50 (3), 233-238 (1991)
   PUBMED   1953691
REFERENCE   9  (bases 1 to 2354)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   10 (bases 1 to 2354)
  AUTHORS   Chapman,V.M. and Shows,T.B.
  TITLE     Somatic cell genetic evidence for X-chromosome linkage of three
            enzymes in the mouse
  JOURNAL   Nature 259 (5545), 665-667 (1976)
   PUBMED   943046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC075663.1 and AW489257.1.
            
            On Jul 25, 2018 this sequence version replaced NM_008062.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4937402.1,
                                           SRR7345562.3312506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2335              BC075663.1         282-2616
            2336-2354           AW489257.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.0 cM"
     gene            1..2354
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /note="glucose-6-phosphate dehydrogenase X-linked"
                     /db_xref="GeneID:14381"
                     /db_xref="MGI:MGI:105979"
     exon            1..58
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            59..186
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1614
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /EC_number="1.1.1.49"
                     /codon_start=1
                     /product="glucose-6-phosphate 1-dehydrogenase X"
                     /protein_id="NP_032088.1"
                     /db_xref="CCDS:CCDS30232.1"
                     /db_xref="GeneID:14381"
                     /db_xref="MGI:MGI:105979"
                     /translation="MAEQVALSRTQVCGILREELYQGDAFHQADTHIFIIMGASGDLA
                     KKKIYPTIWWLFRDGLLPEDTFIVGYARSRLTVDDIRKQSEPFFKATPEERPKLEEFF
                     ARNSYVAGQYDDAASYKHLNSHMNALHQGMQANRLFYLALPPTVYEAVTKNIQETCMS
                     QTGWNRIIVEKPFGRDLQSSNQLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFAN
                     RIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKP
                     ATTGSDDVRDEKVKVLKCISEVETDNVVLGQYVGNPNGEGEAANGYLDDPTVPHGSTT
                     ATFAAAVLYVENERWDGVPFILRCGKALNERKAEVRLQFRDVAGDIFHQQCKRNELVI
                     RVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQM
                     HFVRSDELREAWRIFTPLLHKIDREKPQPIPYVYGSRGPTEADELMKRVGFQYEGTYK
                     WVNPHKL"
     exon            187..224
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            225..333
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            334..551
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            552..710
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            711..836
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            837..930
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1117
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1353
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1430
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1523
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..2338
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2316..2321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /note="hexamer: ATTAAA"
     polyA_site      2335
                     /gene="G6pdx"
                     /gene_synonym="G28A; G6pd; Gpdx"
                     /note="major polyA site"
ORIGIN      
        1 gaaactggct gtgcgctaca gatctgtgaa cgtgtttggc agcggcaact aaactcagaa
       61 aacatcatgg cagagcaggt ggccctgagc cggacccagg tgtgtgggat cctgagggaa
      121 gagttgtacc agggtgatgc cttccaccaa gctgatacac acatatttat catcatgggt
      181 gcatcgggtg acctggccaa gaagaagatc tatcctacca tctggtggct gttccgggat
      241 ggccttctac ctgaagatac cttcattgtg ggctatgccc gctcacgact cacagtggac
      301 gacatccgaa agcagagtga gcccttcttt aaagccactc cagaagaaag acctaagctg
      361 gaggagttct ttgcccgtaa ttcctatgta gctggccagt atgatgatgc agcctcctat
      421 aagcacctca acagccacat gaatgccctg caccagggga tgcaggccaa ccgtctattc
      481 tacctggcct tgccccccac agtctatgaa gcagtcacca agaacattca agagacctgc
      541 atgagtcaga caggctggaa ccgcatcatc gtggagaagc ccttcgggag agacctacag
      601 agctccaatc aactgtcgaa ccacatctcc tctcttttcc gtgaggacca gatctaccgc
      661 attgaccact acctgggcaa agagatggtc cagaatctca tggtgctgag gtttgccaac
      721 aggatctttg gccccatctg gaatcgagac aacattgctt gtgtgatcct cacatttaaa
      781 gagccctttg gtactgaggg tcgtgggggc tattttgatg aatttgggat catcagggat
      841 gttatgcaga accacctcct gcagatgttg tgtctggtgg ccatggaaaa gcctgccact
      901 acaggttcag atgatgtccg tgatgagaag gtcaaagtgt tgaagtgtat ctcagaggtg
      961 gaaactgaca acgtggtcct tggccaatat gtggggaacc ccaatggaga aggagaagct
     1021 gccaatggat acttagatga ccccacagta ccccatgggt ccaccactgc cacttttgca
     1081 gcagctgtcc tctatgtgga gaatgaacgg tgggacgggg tacccttcat cctgcgctgt
     1141 ggcaaagccc tgaatgaacg caaagctgaa gtgagactgc agttccgaga cgtggcaggt
     1201 gacatcttcc accaacagtg caagcgtaat gagctggtca tccgtgtgca gcccaatgag
     1261 gcagtataca ccaagatgat gaccaagaag cctggcatgt tctttaaccc tgaggagtcg
     1321 gagctggatc taacttatgg caacagatac aagaatgtga agctccctga tgcctatgaa
     1381 cgcctcatcc tggatgtctt ctgtgggagc cagatgcact ttgtccggag tgatgaactc
     1441 agggaagcct ggcgtatctt cacaccactg ctgcacaaga ttgatcgaga aaagccccag
     1501 cccatcccct atgtatatgg cagccgcggc cccacagagg cagatgagct gatgaagaga
     1561 gtgggcttcc agtacgaggg tacctacaag tgggtgaacc ctcacaagct ctgagccctg
     1621 gaagttacac catctatact ctgcctcttc tggccaccct ttctgcatct tcccttttca
     1681 ccatctaacc ctatattagg actattgacc ccatattgga aggactttgg gaccataggc
     1741 cttagataca cattctagtt cctgggcttg gaccgccatt ttgtcctatg ctgctgccac
     1801 tgccaccacc agtaaaccca gctacattcc tcaaatacca ggcatttaaa actcattgta
     1861 gggtttcagg gccaccactg gccctatctg agccacccat ctttccacaa gacctgaatc
     1921 acctcccttc cagccgctgc agaaagaatg cctatcagtc tgcccctgga ctccttaagg
     1981 agttaggaac aatggggagg agccttaggc ctcaaaggga caatgaccaa accagacttc
     2041 ccagaggcta tgggcaagct cctcaaaact tgaaggaagt ggtcaaggac acctatgtga
     2101 gaggacctgc ccatggccac actagcctca gtgctactag acattcctcc tcaccagatg
     2161 gaagagacct catgctgcct agcaatattt tgggggctct agatgtcccc tgaccaattc
     2221 catactccat ggtcaacctc atcccaccta tgggcagcct ccttaccaaa ggaaggcaag
     2281 cacagcagct agaattttcc tatcccaacc ctgccattaa atcctcaaaa cagttttaaa
     2341 aaaaaaaaaa aaaa
//
