LOCUS       NM_175935               1612 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus glucose 6 phosphatase, catalytic, 3 (G6pc3), mRNA.
ACCESSION   NM_175935
VERSION     NM_175935.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1612)
  AUTHORS   Roberts,G.A.G. and Tunster,S.J.
  TITLE     Characterising the dynamics of placental glycogen stores in the
            mouse
  JOURNAL   Placenta 99, 131-140 (2020)
   PUBMED   32798765
REFERENCE   2  (bases 1 to 1612)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1612)
  AUTHORS   Lim,G.E., Albrecht,T., Piske,M., Sarai,K., Lee,J.T.C.,
            Ramshaw,H.S., Sinha,S., Guthridge,M.A., Acker-Palmer,A.,
            Lopez,A.F., Clee,S.M., Nislow,C. and Johnson,J.D.
  TITLE     14-3-3zeta coordinates adipogenesis of visceral fat
  JOURNAL   Nat Commun 6, 7671 (2015)
   PUBMED   26220403
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1612)
  AUTHORS   Gautam,S., Kirschnek,S., Gentle,I.E., Kopiniok,C., Henneke,P.,
            Hacker,H., Malleret,L., Belaaouaj,A. and Hacker,G.
  TITLE     Survival and differentiation defects contribute to neutropenia in
            glucose-6-phosphatase-beta (G6PC3) deficiency in a model of mouse
            neutrophil granulocyte differentiation
  JOURNAL   Cell Death Differ 20 (8), 1068-1079 (2013)
   PUBMED   23686134
  REMARK    GeneRIF: Survival and differentiation defects contribute to
            neutropenia in glucose-6-phosphatase-beta (G6PC3) deficiency in a
            model of mouse neutrophil granulocyte differentiation.
REFERENCE   5  (bases 1 to 1612)
  AUTHORS   Jun,H.S., Cheung,Y.Y., Lee,Y.M., Mansfield,B.C. and Chou,J.Y.
  TITLE     Glucose-6-phosphatase-beta, implicated in a congenital neutropenia
            syndrome, is essential for macrophage energy homeostasis and
            functionality
  JOURNAL   Blood 119 (17), 4047-4055 (2012)
   PUBMED   22246029
REFERENCE   6  (bases 1 to 1612)
  AUTHORS   Cheung,Y.Y., Kim,S.Y., Yiu,W.H., Pan,C.J., Jun,H.S., Ruef,R.A.,
            Lee,E.J., Westphal,H., Mansfield,B.C. and Chou,J.Y.
  TITLE     Impaired neutrophil activity and increased susceptibility to
            bacterial infection in mice lacking glucose-6-phosphatase-beta
  JOURNAL   J Clin Invest 117 (3), 784-793 (2007)
   PUBMED   17318259
  REMARK    GeneRIF: The absence of G6Pase-beta led to neutropenia
REFERENCE   7  (bases 1 to 1612)
  AUTHORS   Wang,Y., Oeser,J.K., Yang,C., Sarkar,S., Hackl,S.I., Hasty,A.H.,
            McGuinness,O.P., Paradee,W., Hutton,J.C., Powell,D.R. and
            O'Brien,R.M.
  TITLE     Deletion of the gene encoding the ubiquitously expressed
            glucose-6-phosphatase catalytic subunit-related protein
            (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in
            lowered plasma cholesterol and elevated glucagon
  JOURNAL   J Biol Chem 281 (52), 39982-39989 (2006)
   PUBMED   17023421
  REMARK    GeneRIF: UGRP/G6Pase is the major glucose-6-phosphatase of
            physiological importance for glucose homeostasis in vivo.
REFERENCE   8  (bases 1 to 1612)
  AUTHORS   Ghosh,A., Cheung,Y.Y., Mansfield,B.C. and Chou,J.Y.
  TITLE     Brain contains a functional glucose-6-phosphatase complex capable
            of endogenous glucose production
  JOURNAL   J Biol Chem 280 (12), 11114-11119 (2005)
   PUBMED   15661744
REFERENCE   9  (bases 1 to 1612)
  AUTHORS   Boustead,J.N., Martin,C.C., Oeser,J.K., Svitek,C.A., Hunter,S.I.,
            Hutton,J.C. and O'Brien,R.M.
  TITLE     Identification and characterization of a cDNA and the gene encoding
            the mouse ubiquitously expressed glucose-6-phosphatase catalytic
            subunit-related protein
  JOURNAL   J Mol Endocrinol 32 (1), 33-53 (2004)
   PUBMED   14765991
REFERENCE   10 (bases 1 to 1612)
  AUTHORS   Garver,W.S., Heidenreich,R.A., Erickson,R.P., Thomas,M.A. and
            Wilson,J.M.
  TITLE     Localization of the murine Niemann-Pick C1 protein to two distinct
            intracellular compartments
  JOURNAL   J Lipid Res 41 (5), 673-687 (2000)
   PUBMED   10787428
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC069959.1.
            
            On May 16, 2004 this sequence version replaced NM_175935.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069959.1, AK165395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1612
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.79 cM"
     gene            1..1612
                     /gene="G6pc3"
                     /gene_synonym="0710001K01Rik; UGRP"
                     /note="glucose 6 phosphatase, catalytic, 3"
                     /db_xref="GeneID:68401"
                     /db_xref="MGI:MGI:1915651"
     exon            1..445
                     /gene="G6pc3"
                     /gene_synonym="0710001K01Rik; UGRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1268
                     /gene="G6pc3"
                     /gene_synonym="0710001K01Rik; UGRP"
                     /EC_number="3.1.3.9"
                     /note="glucose-6-phosphatase catalytic subunit-related;
                     G6Pase 3; G-6-Pase 3; ubiquitous glucose-6-phosphatase
                     catalytic subunit-related protein; glc-6-Pase-beta;
                     glucose-6-phosphatase-beta"
                     /codon_start=1
                     /product="glucose-6-phosphatase 3"
                     /protein_id="NP_787949.2"
                     /db_xref="CCDS:CCDS25491.1"
                     /db_xref="GeneID:68401"
                     /db_xref="MGI:MGI:1915651"
                     /translation="MESTLSAGIIMAEALQNRLPGLENMWLWVTFLGDPKNLFQFCFP
                     AAYYASRRLGISVLWITFIAEWLNLVFKWFLFGDRPFWWVHESGYSTQTPIQIHQFPS
                     SCETGPGSPSGHCMITGAALWPVMTAISSQVASRSRSPWVRVIPGLAYCTFLLAVGLS
                     RVFLLAHFPHQVLGGLIVGAALGWLMSPRVPMERELSFYGLTALALMLGASLMYWTLF
                     TLGLDLSWSINLASKWCERPEWVHMDSRPFASLSRDSGSALGLGIALHTPCYAQIRRA
                     HLGNGQKIACFVLAMGLLVFLEWLGYPPQISLFYIFNFLKYTLWPCLVLALVPWVVHT
                     LSDQEAPPIRSS"
     exon            446..552
                     /gene="G6pc3"
                     /gene_synonym="0710001K01Rik; UGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            553..643
                     /gene="G6pc3"
                     /gene_synonym="0710001K01Rik; UGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            644..762
                     /gene="G6pc3"
                     /gene_synonym="0710001K01Rik; UGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            763..904
                     /gene="G6pc3"
                     /gene_synonym="0710001K01Rik; UGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1543
                     /gene="G6pc3"
                     /gene_synonym="0710001K01Rik; UGRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1520..1525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G6pc3"
                     /gene_synonym="0710001K01Rik; UGRP"
                     /note="hexamer: AATAAA"
     polyA_site      1543
                     /gene="G6pc3"
                     /gene_synonym="0710001K01Rik; UGRP"
                     /note="major polyA site"
ORIGIN      
        1 gccggaggaa acagtaccag ctacggctcc aactcgcgcg tgtcagggac tgcgggggcg
       61 gggcggggcg ggggtggggc ttggtttaga cccccggcgg gtagggcggg gccgggggct
      121 agaaagggtg ggctctagag ggccagcagg tagccgcttc atttctgcta aggttcctcg
      181 acttgcaccc tacaacgggc tccaggctag aggactcctg attcaccatg gagtccacgc
      241 tgagcgcggg catcataatg gctgaagcac tacagaaccg gcttcccggg ctagagaata
      301 tgtggctctg ggtcaccttt ctgggcgatc ctaagaatct ttttcagttc tgcttccccg
      361 cggcctacta cgcctcccgc cgcctgggca tctccgtgct ctggatcacc ttcattgctg
      421 agtggctcaa ccttgtcttc aagtggtttc tgtttggaga caggcccttt tggtgggtgc
      481 atgaatccgg gtactccacc cagactccaa tccagattca ccagttccct tcttcttgtg
      541 agactggtcc aggcagcccc tccggccact gcatgatcac aggcgcagct ctttggcctg
      601 taatgacggc catttcttct caggtggctt ctcggtcccg cagcccctgg gtgagggtga
      661 ttcctggcct ggcttattgt accttcctat tggcagtcgg cctatctcgg gtcttcctct
      721 tagcacattt ccctcaccaa gtgttgggcg gccttattgt tggtgctgcc cttggctggc
      781 taatgagccc ccgggtaccc atggagcggg agcttagctt ttatgggttg actgctctgg
      841 ccctcatgct gggtgccagc ctcatgtatt ggactctctt tacactgggc ctagatcttt
      901 cctggtccat caacctggct tccaagtggt gtgaacggcc cgagtgggtg cacatggaca
      961 gtcggccttt tgcctcactg agccgtgact caggatctgc cctgggtctg ggcattgccc
     1021 tccacactcc ctgctatgcc cagatacggc gggcgcacct agggaatggc cagaaaatag
     1081 cttgctttgt gctggccatg gggctgctgg tcttcctgga atggctgggc tacccacctc
     1141 agatcagcct cttctacatc ttcaacttcc tcaagtatac cctctggccg tgcctggtct
     1201 tggcccttgt gccctgggtg gtgcacacat tgagtgacca ggaagcaccg cccattcgct
     1261 cctcttgatg tgttttgcct cccttgcccc aaagacaaca ctcctcgacc aaccaccaca
     1321 ctctaagaga cagccctttt cctgggctcc ggagcaggcc cgctcacctt gaacttcatt
     1381 tctgtctcat gctttgcagt cttagctccc ttttaaagaa ggacctctgt ttccaggagg
     1441 ctaagccatc ccccaggtcc ccacaaagca aaagcaacag gaggcctggt ggggaggggg
     1501 agctgctcag gaagacccca ataaagccct tggaacttgt gaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
