LOCUS       NM_021331               2066 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus glucose-6-phosphatase, catalytic, 2 (G6pc2),
            transcript variant 1, mRNA.
ACCESSION   NM_021331
VERSION     NM_021331.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2066)
  AUTHORS   Martin,C.C., Oeser,J.K., Wangmo,T., Flemming,B.P., Attie,A.D.,
            Keller,M.P. and O'Brien,R.M.
  TITLE     Multiple promoter and enhancer differences likely contribute to
            augmented G6PC2 expression in human versus mouse pancreatic islet
            alpha cells
  JOURNAL   J Mol Endocrinol 73 (3), e240051 (2024)
   PUBMED   39121091
  REMARK    GeneRIF: Multiple promoter and enhancer differences likely
            contribute to augmented G6PC2 expression in human versus mouse
            pancreatic islet alpha cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2066)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
REFERENCE   3  (bases 1 to 2066)
  AUTHORS   Kang,S., Bae,M.J., Kang,M.K., Kim,H., Kang,Y.R., Jo,W.S., Lee,C.G.,
            Jung,B., Lee,J., Moon,C., Son,Y., Lee,H.J. and Kim,J.S.
  TITLE     Possible association of G6PC2 and MUC6 induced by low-dose-rate
            irradiation in mouse intestine with inflammatory bowel disease
  JOURNAL   Mol Med Rep 30 (1) (2024)
   PUBMED   38785154
  REMARK    GeneRIF: Possible association of G6PC2 and MUC6 induced by
            low-dose-rate irradiation in mouse intestine with inflammatory
            bowel disease.
REFERENCE   4  (bases 1 to 2066)
  AUTHORS   Hawes,E.M., Boortz,K.A., Oeser,J.K., O'Rourke,M.L. and O'Brien,R.M.
  TITLE     G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity
  JOURNAL   J Mol Endocrinol 71 (4), e230070 (2023)
   PUBMED   37855366
  REMARK    GeneRIF: G6PC1 and G6PC2 influence G6P flux but not HSD11B1
            activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2066)
  AUTHORS   Frigeri,C., Martin,C.C., Svitek,C.A., Oeser,J.K., Hutton,J.C.,
            Gannon,M. and O'Brien,R.M.
  TITLE     The proximal islet-specific glucose-6-phosphatase catalytic
            subunit-related protein autoantigen promoter is sufficient to
            initiate but not maintain transgene expression in mouse islets in
            vivo
  JOURNAL   Diabetes 53 (7), 1754-1764 (2004)
   PUBMED   15220199
  REMARK    GeneRIF: Cis-acting elements elsewhere in IGRP gene may be required
            for determining appropriate IGRP tissue-specific expression and for
            maintenance of IGRP gene expression in adult mice.
REFERENCE   6  (bases 1 to 2066)
  AUTHORS   Petrolonis,A.J., Yang,Q., Tummino,P.J., Fish,S.M., Prack,A.E.,
            Jain,S., Parsons,T.F., Li,P., Dales,N.A., Ge,L., Langston,S.P.,
            Schuller,A.G., An,W.F., Tartaglia,L.A., Chen,H. and Hong,S.B.
  TITLE     Enzymatic characterization of the pancreatic islet-specific
            glucose-6-phosphatase-related protein (IGRP)
  JOURNAL   J Biol Chem 279 (14), 13976-13983 (2004)
   PUBMED   14722102
  REMARK    GeneRIF: IGRP is likely the authentic islet-specific
            glucose-6-phosphatase catalytic subunit, and selective inhibitors
            to this molecule can be obtained.
REFERENCE   7  (bases 1 to 2066)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   8  (bases 1 to 2066)
  AUTHORS   Martin,C.C., Bischof,L.J., Bergman,B., Hornbuckle,L.A.,
            Hilliker,C., Frigeri,C., Wahl,D., Svitek,C.A., Wong,R.,
            Goldman,J.K., Oeser,J.K., Lepretre,F., Froguel,P., O'Brien,R.M. and
            Hutton,J.C.
  TITLE     Cloning and characterization of the human and rat islet-specific
            glucose-6-phosphatase catalytic subunit-related protein (IGRP)
            genes
  JOURNAL   J Biol Chem 276 (27), 25197-25207 (2001)
   PUBMED   11297555
REFERENCE   9  (bases 1 to 2066)
  AUTHORS   Ebert,D.H., Bischof,L.J., Streeper,R.S., Chapman,S.C., Svitek,C.A.,
            Goldman,J.K., Mathews,C.E., Leiter,E.H., Hutton,J.C. and
            O'Brien,R.M.
  TITLE     Structure and promoter activity of an islet-specific
            glucose-6-phosphatase catalytic subunit-related gene
  JOURNAL   Diabetes 48 (3), 543-551 (1999)
   PUBMED   10078554
REFERENCE   10 (bases 1 to 2066)
  AUTHORS   Arden,S.D., Zahn,T., Steegers,S., Webb,S., Bergman,B., O'Brien,R.M.
            and Hutton,J.C.
  TITLE     Molecular cloning of a pancreatic islet-specific
            glucose-6-phosphatase catalytic subunit-related protein
  JOURNAL   Diabetes 48 (3), 531-542 (1999)
   PUBMED   10078553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK148450.1, AK148465.1 and
            BP758187.1.
            
            On Feb 4, 2014 this sequence version replaced NM_021331.3.
            
            Summary: This gene encodes an enzyme that belongs to the
            glucose-6-phosphatase catalytic subunit family. Members of this
            family catalyze the hydrolysis of glucose-6-phosphate, the terminal
            step in gluconeogenic and glycogenolytic pathways, to release
            glucose into the bloodstream. The family member encoded by this
            gene is found specifically in pancreatic islets but has not been
            shown to have phosphotransferase or phosphatase activity exhibited
            by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a
            model for human type 1 diabetes, an autoimmune disease in which T
            lymphocytes attack and destroy insulin-producing pancreatic beta
            cells. In NOD mice, the protein encoded by this gene is a major
            target of cell-mediated autoimmunity. Variations in the human and
            mouse genes are associated with lower fasting plasma glucose
            levels. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148465.1, Z47787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AK148450.1         2-50
            50-2061             AK148465.1         2-2013
            2062-2066           BP758187.1         21-25               c
FEATURES             Location/Qualifiers
     source          1..2066
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 39.66 cM"
     gene            1..2066
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
                     /note="glucose-6-phosphatase, catalytic, 2"
                     /db_xref="GeneID:14378"
                     /db_xref="MGI:MGI:1277193"
     exon            1..302
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1152
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
                     /EC_number="3.1.3.9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glucose-6-phosphatase, catalytic, related sequence;
                     islet-specific glucose-6-phosphatase catalytic
                     subunit-related protein; G-6-Pase 2"
                     /codon_start=1
                     /product="glucose-6-phosphatase 2 isoform 1"
                     /protein_id="NP_067306.1"
                     /db_xref="CCDS:CCDS16089.1"
                     /db_xref="GeneID:14378"
                     /db_xref="MGI:MGI:1277193"
                     /translation="MDFLHRSGVLIIHHLQEDYRTYYGFLNFMSNVGDPRNIFSIYFP
                     LWFQLNQNVGTKMIWVAVIGDWFNLIFKWILFGHRPYWWIQETEIYPNHSSPCLEQFP
                     TTCETGPGSPSGHAMGSSCVWYVMVTAALSYTISRMEESSVTLHRLTWSFLWSVFWLI
                     QISVCISRVFIATHFPHQVILGVIGGMLVAEAFEHTPGVHMASLSVYLKTNVFLFLFA
                     LGFYLLLRLFGIDLLWSVPIAKKWCANPDWIHIDSTPFAGLVRNLGVLFGLGFAINSE
                     MFLRSCQGENGTKPSFRLLCALTSLTTMQLYRFIKIPTHAEPLFYLLSFCKSASIPLM
                     VVALIPYCVHMLMRPGDKKTK"
     exon            303..412
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            413..524
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            525..640
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            641..2066
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1896..1901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
                     /note="hexamer: AATAAA"
     polyA_site      1916
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
     regulatory      2042..2047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
                     /note="hexamer: ATTAAA"
     polyA_site      2062
                     /gene="G6pc2"
                     /gene_synonym="G6pc-rs; IGRP"
                     /note="major polyA site"
ORIGIN      
        1 agtgcatcac aagggtacca tatagagaca gtgggacaca gggccctgca gttccacctg
       61 cttcatgctt agacctgcat caagatggat ttccttcata ggagtggagt gcttattatt
      121 catcatctgc aggaggacta ccggacttac tatggttttc taaattttat gtccaatgtt
      181 ggagaccccc gaaatatctt ttctatttac ttcccacttt ggtttcagtt gaatcagaat
      241 gttggaacca agatgatctg ggtagcggtc ataggggact ggttcaatct catatttaaa
      301 tggatattgt ttggccatcg tccttactgg tggatacaag aaactgagat ttatccaaat
      361 cattcaagcc catgtcttga gcagtttcct actacgtgtg aaacaggccc aggaagtcca
      421 tctggccacg caatgggctc atcgtgcgtc tggtatgtca tggtaacagc tgccctaagc
      481 tacaccatca gccggatgga ggagtcctct gtcactctgc acagactgac ctggtccttt
      541 ctgtggagtg ttttctggtt gattcaaatc agcgtctgca tctcaagagt attcatagcc
      601 acacatttcc cccatcaggt cattcttgga gtgattggtg ggatgctagt agccgaggcc
      661 tttgaacaca ctccaggagt ccacatggcc agcttgagtg tgtacctgaa gaccaacgtc
      721 ttcctcttcc tgtttgccct cggcttttac ctgcttctcc gactgttcgg tattgacctg
      781 ctgtggtccg tgcccatcgc caaaaagtgg tgtgccaacc cagactggat ccacattgac
      841 agcacgcctt ttgctggact cgtgagaaac ctcggggtcc tctttggctt gggtttcgcc
      901 atcaactcag aaatgttcct tcggagctgc cagggagaaa atggcaccaa gccgagcttc
      961 cgcttgctct gtgctctgac ctcactgacc acaatgcaac tttatcgctt catcaagatc
     1021 ccgactcacg cggaaccttt attttacctg ttgtctttct gtaaaagtgc gtccatcccc
     1081 ctgatggtgg tggctctaat tccctactgt gtacatatgt taatgagacc cggtgacaag
     1141 aagactaaat agagctgcag tgccctgtgg tctgaggatc acctactttc tgttttcctc
     1201 aatagagcca cagcacagag actgggagcg tctctacaga ggtcacacca tgatgaccaa
     1261 aggtcctgct ccacccacag acatgtttag tctgctttcc aagtggcatt taaaaaataa
     1321 cagtatttaa ccagaaagtc catattttct tgacaaaact gacaatacgg taacatatga
     1381 gagatggtat aacccatgta aagacagttg acaggggctg gatgcttaca ttccagttag
     1441 cagaaagact ccttctaatc atagtattta gcagtcaaca aaacccccag gagctgatgt
     1501 ttctatcatc ttaaagtctg gctacttcag gctcctgtgg accacttaga agtgaccacg
     1561 gtctactttt acttttagga gtcaattctt tcaaaattct catgtatcag ataaggaaat
     1621 agaggtttgt tcagatcaag taacttgact gtaatagtgc agggttgaaa ccagagttgg
     1681 aacacaaggc ttctgataca tatatctcta taagaatgct ttctttcttt ctttttaggg
     1741 agttaaaaaa aaagagcaaa tgcatgtatt taaaatctat gtttgccatc taaaacaccc
     1801 atgttttcag aaatggcatt ggaatgctac attctgcttg acttatgctc agagtacagt
     1861 gtcttttcca ggctagcaat ggctgtatat atttcaataa acgctgctga aaacaaccca
     1921 ctggattact gttcaccaga aaagcctcat ctcttcactg gggcatcccc atgttttact
     1981 tctaagagtc aagtctgtca aaaatgagga taatcaaatt cttctacctc agaaaaaaat
     2041 gattaaatac tagtgcatcg gactaa
//
