LOCUS       NM_008061               2274 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus glucose-6-phosphatase catalytic subunit 1 (G6pc1),
            mRNA.
ACCESSION   NM_008061
VERSION     NM_008061.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2274)
  AUTHORS   Chen,H., Luo,S., Deng,X., Li,S., Mao,Y., Yan,J., Cheng,Y., Liu,X.,
            Pan,J. and Huang,H.
  TITLE     Pre-eclamptic foetal programming predisposes offspring to hepatic
            steatosis via DNA methylation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167189 (2024)
   PUBMED   38648899
REFERENCE   2  (bases 1 to 2274)
  AUTHORS   Barahona,M.J., Ferrada,L., Vera,M. and Nualart,F.
  TITLE     Tanycytes release glucose using the glucose-6-phosphatase system
            during hypoglycemia to control hypothalamic energy balance
  JOURNAL   Mol Metab 84, 101940 (2024)
   PUBMED   38641253
  REMARK    GeneRIF: Tanycytes release glucose using the glucose-6-phosphatase
            system during hypoglycemia to control hypothalamic energy balance.
REFERENCE   3  (bases 1 to 2274)
  AUTHORS   Guo,C.G., Sun,R., Wang,X., Yuan,Y., Xu,Y., Li,S., Sun,X., Wang,J.,
            Hu,X., Guo,T., Chen,X.W., Xiao,R.P. and Zhang,X.
  TITLE     Intestinal SURF4 is essential for apolipoprotein transport and
            lipoprotein secretion
  JOURNAL   Mol Metab 79, 101847 (2024)
   PUBMED   38042368
REFERENCE   4  (bases 1 to 2274)
  AUTHORS   Oelkrug,R., Harder,L., Pedaran,M., Hoffmann,A., Kolms,B.,
            Inderhees,J., Gachkar,S., Resch,J., Johann,K., Johren,O., Krause,K.
            and Mittag,J.
  TITLE     Maternal thyroid hormone receptor beta activation in mice sparks
            brown fat thermogenesis in the offspring
  JOURNAL   Nat Commun 14 (1), 6742 (2023)
   PUBMED   37875497
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2274)
  AUTHORS   Wulfridge,P., Davidovich,A., Salvador,A.C., Manno,G.C.,
            Tryggvadottir,R., Idrizi,A., Huda,M.N., Bennett,B.J., Adams,L.G.,
            Hansen,K.D., Threadgill,D.W. and Feinberg,A.P.
  TITLE     Precision pharmacological reversal of strain-specific diet-induced
            metabolic syndrome in mice informed by epigenetic and
            transcriptional regulation
  JOURNAL   PLoS Genet 19 (10), e1010997 (2023)
   PUBMED   37871105
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2274)
  AUTHORS   Streeper,R.S., Svitek,C.A., Chapman,S., Greenbaum,L.E., Taub,R. and
            O'Brien,R.M.
  TITLE     A multicomponent insulin response sequence mediates a strong
            repression of mouse glucose-6-phosphatase gene transcription by
            insulin
  JOURNAL   J Biol Chem 272 (18), 11698-11701 (1997)
   PUBMED   9115220
REFERENCE   7  (bases 1 to 2274)
  AUTHORS   Lei,K.J., Chen,H., Pan,C.J., Ward,J.M., Mosinger,B. Jr., Lee,E.J.,
            Westphal,H., Mansfield,B.C. and Chou,J.Y.
  TITLE     Glucose-6-phosphatase dependent substrate transport in the glycogen
            storage disease type-1a mouse
  JOURNAL   Nat Genet 13 (2), 203-209 (1996)
   PUBMED   8640227
REFERENCE   8  (bases 1 to 2274)
  AUTHORS   Cole,T.J., Blendy,J.A., Monaghan,A.P., Krieglstein,K., Schmid,W.,
            Aguzzi,A., Fantuzzi,G., Hummler,E., Unsicker,K. and Schutz,G.
  TITLE     Targeted disruption of the glucocorticoid receptor gene blocks
            adrenergic chromaffin cell development and severely retards lung
            maturation
  JOURNAL   Genes Dev 9 (13), 1608-1621 (1995)
   PUBMED   7628695
REFERENCE   9  (bases 1 to 2274)
  AUTHORS   Shelly,L.L., Lei,K.J., Pan,C.J., Sakata,S.F., Ruppert,S., Schutz,G.
            and Chou,J.Y.
  TITLE     Isolation of the gene for murine glucose-6-phosphatase, the enzyme
            deficient in glycogen storage disease type 1A
  JOURNAL   J Biol Chem 268 (29), 21482-21485 (1993)
   PUBMED   8407995
REFERENCE   10 (bases 1 to 2274)
  AUTHORS   Hanigan,M.H., Winkler,M.L. and Drinkwater,N.R.
  TITLE     Induction of three histochemically distinct populations of hepatic
            foci in C57BL/6J mice
  JOURNAL   Carcinogenesis 14 (5), 1035-1040 (1993)
   PUBMED   8099313
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK050279.1 and AA238078.1.
            
            On Sep 15, 2015 this sequence version replaced NM_008061.3.
            
            Summary: The enzyme encoded by this gene is a multisubunit integral
            membrane protein of the endoplasmic reticulum that is composed of a
            catalytic subunit and transporters for glucose-6-phosphate,
            inorganic phosphate, and glucose. This gene is one of three
            glucose-6-phosphatase catalytic-subunit-encoding genes in mouse.
            Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose
            6-phosphate to D-glucose and orthophosphate and is a key enzyme in
            glucose homeostasis, functioning in gluconeogenesis and
            glycogenolysis. Mutations in this gene cause glycogen storage
            disease type I (GSD1). [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013448.1, AK050279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1692              AK050279.1         2-1693
            1693-2274           AA238078.1         1-582
FEATURES             Location/Qualifiers
     source          1..2274
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.83 cM"
     gene            1..2274
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; G6pt; Glc-6-Pase"
                     /note="glucose-6-phosphatase catalytic subunit 1"
                     /db_xref="GeneID:14377"
                     /db_xref="MGI:MGI:95607"
     exon            1..311
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; G6pt; Glc-6-Pase"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1155
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; G6pt; Glc-6-Pase"
                     /EC_number="3.1.3.9"
                     /note="Glc-6-Pase-alpha; glucose-6-phosphatase, catalytic"
                     /codon_start=1
                     /product="glucose-6-phosphatase catalytic subunit 1"
                     /protein_id="NP_032087.2"
                     /db_xref="CCDS:CCDS25466.1"
                     /db_xref="GeneID:14377"
                     /db_xref="MGI:MGI:95607"
                     /translation="MEEGMNILHDFGIQSTRYLQVNYQDSQDWFILVSVIADLRNAFY
                     VLFPIWFHLKETVGINLLWVAVVGDWFNLVFKWILFGQRPYWWVLDTDYYSNSSVPII
                     KQFPVTCETGPGSPSGHAMGAAGVYYVMVTSTLAIFRGKKKPTYGFRCLNVILWLGFW
                     AVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIRGIYNASLRKYCLITIFLFG
                     FALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALN
                     SSMYRKSCKGELSKLLPFRFACIVASLVLLHLFDSLKPPSQVELIFYILSFCKSATVP
                     FASVSLIPYCLARILGQTHKKSL"
     exon            312..421
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; G6pt; Glc-6-Pase"
                     /inference="alignment:Splign:2.1.0"
     exon            422..527
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; G6pt; Glc-6-Pase"
                     /inference="alignment:Splign:2.1.0"
     exon            528..643
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; G6pt; Glc-6-Pase"
                     /inference="alignment:Splign:2.1.0"
     exon            644..2259
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; G6pt; Glc-6-Pase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2238..2243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; G6pt; Glc-6-Pase"
                     /note="hexamer: ATTAAA"
     polyA_site      2259
                     /gene="G6pc1"
                     /gene_synonym="G6Pase; G6pc; G6pt; Glc-6-Pase"
                     /note="major polyA site"
ORIGIN      
        1 agcagaggga tcaaggccaa ccgggctgga ctcactgcac gggctctgct ggcagcttcc
       61 tgaggtacca agggaggaag gatggaggaa ggaatgaaca ttctccatga ctttgggatc
      121 cagtcgactc gctatctcca agtgaattac caagactccc aggactggtt catccttgtg
      181 tctgtgattg ctgacctgag gaacgccttc tatgtcctct ttcccatctg gttccatctt
      241 aaagagactg tgggcatcaa tctcctctgg gtggcagtgg tcggagactg gttcaacctc
      301 gtcttcaagt ggattctgtt tggacaacgc ccgtattggt gggtcctgga caccgactac
      361 tacagcaaca gctccgtgcc tataataaag cagttccctg tcacctgtga gaccggacca
      421 ggaagtccct ctggccatgc catgggcgca gcaggtgtat actatgttat ggtcacttct
      481 actcttgcta tctttcgagg aaagaaaaag ccaacgtatg gattccggtg tttgaacgtc
      541 atcttgtggt tgggattctg ggctgtgcag ctgaacgtct gtctgtcccg gatctacctt
      601 gctgctcact ttccccacca ggtcgtggct ggagtcttgt caggcattgc tgtggctgaa
      661 actttcagcc acatccgggg catctacaat gccagcctcc ggaagtattg tctcatcacc
      721 atcttcttgt ttggtttcgc gcttggattc tacctgctac taaaagggct aggggtggac
      781 ctcctgtgga ctttggagaa agctaagaga tggtgtgagc ggccagaatg ggtccacctt
      841 gacactacac cctttgccag cctcttcaaa aacctgggaa ccctcttggg gttggggctg
      901 gccctcaact ccagcatgta ccggaagagc tgcaagggag aactcagcaa gttgctccca
      961 ttccgcttcg cctgcattgt ggcttccttg gtcctcctgc atctctttga ctctctgaag
     1021 cccccatccc aggttgagtt gatcttctac atcttgtctt tctgcaagag cgcaacagtt
     1081 ccctttgcat ctgtcagtct tatcccatac tgcctagccc ggatcctggg acagacacac
     1141 aagaagtctt tgtaaggcat gcagagtctt tggtatttaa agtcaaccgc catgcaaagg
     1201 actaggaaca actaaagcct ctgaaaccca ttgtgaggcc agaggtgttg acatcggccc
     1261 tggtagccct gtctttcttt gctatcttaa ccaaaaggtg aatttttaca aagcttacag
     1321 ggctgtttga ggaaagtgtg aatgctggaa actgagtcat tctggatggt tccctgaaga
     1381 ttcgcttacc agcctcctgt cggatacaga agagcaagcc caggctagag atcccaactg
     1441 agaatgctct tgcggtgcag aatcttccgg ctgggaaaag gaaaagagca ccatgcattt
     1501 gccaggaaga gaaagaagga tcaggaggag ggagagtgtt ttatgtatcg agcaaaccag
     1561 atgcaatcta tgtctaaccg gcttcagttg tgtctgtgtt tttagatacg acacactcaa
     1621 taataataat agaccaacta gtgtaatgag tagccagtta aaggcgatta attctgcttc
     1681 cagatagtct ccactgtaca taaaaatcac actgtgtgct tgcattcctg tatggtagtg
     1741 gtgactgtct ctcacaccac cttctctatc acgtcacagt tttctcctcc tcagcctatg
     1801 tctgcattcc ccagaattct ccacttgttc cctggccctg ctgctggacc ctgctgtgtc
     1861 tggtaggcaa ctgtttgttg gtgcttttgt agggttaagt taaactctga gatcttgggc
     1921 aaaatggcaa ggagacccag gattcttctc tccaaaggtc actccgatgt tatttttgat
     1981 tcctggggca gaaatatgac tcctttccct agcccaagcc atccaagagc tctcattctt
     2041 agaagaaaag gcagcccctt ggtgactgtc ctcctgcctc ggctgatttg cagagtactt
     2101 cttcaaaaag aaaaaaatgg taaagctatt tattaaaaat tctttgtttt ttgctacaaa
     2161 tgatgcatat attttcaccc acaccaagca ctttgtttct aatatctttg ataagaaaac
     2221 tacatgtgca gtattttatt aaagcaacat tttatttaaa aaaaaaaaaa aaaa
//
