LOCUS       NM_001080795            4226 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus G3BP stress granule assembly factor 2 (G3bp2),
            transcript variant 3, mRNA.
ACCESSION   NM_001080795
VERSION     NM_001080795.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4226)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4226)
  AUTHORS   Yun,D., Zhou,L., Shi,J., Li,X., Wu,X. and Sun,F.
  TITLE     G3BP2, a stress granule assembly factor, is dispensable for
            spermatogenesis in mice
  JOURNAL   PeerJ 10, e13532 (2022)
   PUBMED   35782098
  REMARK    GeneRIF: G3BP2, a stress granule assembly factor, is dispensable
            for spermatogenesis in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4226)
  AUTHORS   Wang,J.J., Ge,W., Zhai,Q.Y., Liu,J.C., Sun,X.W., Liu,W.X., Li,L.,
            Lei,C.Z., Dyce,P.W., De Felici,M. and Shen,W.
  TITLE     Single-cell transcriptome landscape of ovarian cells during
            primordial follicle assembly in mice
  JOURNAL   PLoS Biol 18 (12), e3001025 (2020)
   PUBMED   33351795
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4226)
  AUTHORS   Kato,Y., Iwamori,T., Ninomiya,Y., Kohda,T., Miyashita,J., Sato,M.
            and Saga,Y.
  TITLE     ELAVL2-directed RNA regulatory network drives the formation of
            quiescent primordial follicles
  JOURNAL   EMBO Rep 20 (12), e48251 (2019)
   PUBMED   31657143
REFERENCE   5  (bases 1 to 4226)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4226)
  AUTHORS   Kedersha,N., Panas,M.D., Achorn,C.A., Lyons,S., Tisdale,S.,
            Hickman,T., Thomas,M., Lieberman,J., McInerney,G.M., Ivanov,P. and
            Anderson,P.
  TITLE     G3BP-Caprin1-USP10 complexes mediate stress granule condensation
            and associate with 40S subunits
  JOURNAL   J Cell Biol 212 (7), 845-860 (2016)
   PUBMED   27022092
  REMARK    Erratum:[J Cell Biol. 2020 Jan 6;219(1):e20150802809202019c. doi:
            10.1083/jcb.20150802809202019c.. PMID: 31851327]
REFERENCE   7  (bases 1 to 4226)
  AUTHORS   Bikkavilli,R.K. and Malbon,C.C.
  TITLE     Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine
            methylation of G3BP2
  JOURNAL   J Cell Sci 125 (Pt 10), 2446-2456 (2012)
   PUBMED   22357953
  REMARK    GeneRIF: Wnt3a-stimulated LRP6 phosphorylation is dependent upon
            arginine methylation of G3BP2.
REFERENCE   8  (bases 1 to 4226)
  AUTHORS   Shiina,N., Yamaguchi,K. and Tokunaga,M.
  TITLE     RNG105 deficiency impairs the dendritic localization of mRNAs for
            Na+/K+ ATPase subunit isoforms and leads to the degeneration of
            neuronal networks
  JOURNAL   J Neurosci 30 (38), 12816-12830 (2010)
   PUBMED   20861386
REFERENCE   9  (bases 1 to 4226)
  AUTHORS   Kennedy,D., Wood,S.A., Ramsdale,T., Tam,P.P., Steiner,K.A. and
            Mattick,J.S.
  TITLE     Identification of a mouse orthologue of the human
            ras-GAP-SH3-domain binding protein and structural confirmation that
            these proteins contain an RNA recognition motif
  JOURNAL   Biomed Pept Proteins Nucleic Acids 2 (3), 93-99 (1996)
   PUBMED   9575347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY272229.1, AK076117.1, AK169571.1 and BY578810.1.
            
            On Oct 22, 2014 this sequence version replaced NM_001080795.1.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (b) has the same
            N- and C-termini but is shorter compared to isoform a. Variants 3,
            4, and 8 all encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167186.1, BC048176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY272229.1         2-27
            27-1857             AK076117.1         1-1831
            1858-4210           AK169571.1         391-2743
            4211-4226           BY578810.1         381-396
FEATURES             Location/Qualifiers
     source          1..4226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 45.84 cM"
     gene            1..4226
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /note="G3BP stress granule assembly factor 2"
                     /db_xref="GeneID:23881"
                     /db_xref="MGI:MGI:2442040"
     exon            1..216
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     exon            217..335
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1590
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /note="isoform b is encoded by transcript variant 3;
                     Ras-GTPase-activating protein (GAP120) SH3-domain binding
                     protein 2; ras GTPase-activating protein-binding protein
                     2; GTPase activating protein (SH3 domain) binding protein
                     2"
                     /codon_start=1
                     /product="ras GTPase-activating protein-binding protein 2
                     isoform b"
                     /protein_id="NP_001074264.1"
                     /db_xref="CCDS:CCDS39149.1"
                     /db_xref="GeneID:23881"
                     /db_xref="MGI:MGI:2442040"
                     /translation="MVMEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGG
                     VDASGKPQEAVYGQNDIHHKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSG
                     QPERKFMQTFVLAPEGSVPNKFYVHNDMFRYEDEVFGDSEPELDEESEDEVEEEQEDR
                     QPSPEPVQENANSAYYDAHPVTNGIEEPLEESSHEPEPEPESETKTEELKPQVEEKHL
                     EELEEKSATPPPAEPASLPQEPPKPRVDAKPEVQSQPPRVREQRPRERPGFPPRGPRP
                     GRGDMEQNDSDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELRINTKGV
                     GGKLPNFGFVVFDDSEPVQRILIAKPIMFRGEVRLNVEEKKTRAARERETRGGGDDRR
                     DIRRNDRGPGGPRGIVGGGMMRDRDGRGPPPRGGMTQKLGSGRGTGQMEGRFTGQRR"
     exon            336..417
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     exon            418..591
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     exon            592..682
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     exon            683..785
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     exon            786..966
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1069
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1198
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1317
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..4226
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4188..4193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /note="hexamer: AATAAA"
     polyA_site      4211
                     /gene="G3bp2"
                     /gene_synonym="E430034L04Rik; G3BP; mKIAA0660"
                     /note="major polyA site"
ORIGIN      
        1 aagagggggc ggcggcaaag ggggcgggac gtccgtgttc ttggagctcg ttgcagctct
       61 aggctctcgg gaagaggtgg ctgtgagggg ccccgagctc gcggctctcc ggattccgaa
      121 gcctcgggtt gcttcgaggg aggagaatct gctgcggccg atcccgcgac actactgacc
      181 tccgcgcgac gtgcccgccg ccgctgttgg ttggagcatt tgacattgtg cagcaaagaa
      241 atggttatgg agaagcccag tccgctgctt gtggggcggg agtttgtgag gcaatattat
      301 actttgctga ataaagctcc cgagtatttg cacaggttct atggcaggaa ttcctcctat
      361 gttcatggtg gagtggatgc cagtggaaag ccccaggaag cagtttatgg ccaaaatgat
      421 atacaccaca aagtgttatc tctgaacttc agtgaatgtc ataccaaaat tcgtcatgtg
      481 gatgctcatg caaccttgag tgatggtgta gtggtacagg tcatgggctt gctgtctaac
      541 agtggacagc ctgagaggaa gtttatgcaa acctttgttc tggctccaga aggatctgtt
      601 ccaaataaat tttatgttca caatgatatg tttcgttatg aagatgaagt gtttggtgat
      661 tctgaaccag aacttgatga agagtcagaa gatgaagtgg aagaggagca agaagacagg
      721 cagccgtctc ctgaacctgt gcaagagaat gctaacagcg cttactatga cgcacacccc
      781 gtgactaatg gcatagagga gcctttagaa gaatcctctc atgaacctga gcctgagcca
      841 gaatctgaaa caaagactga agagctgaaa ccacaagtgg aggagaaaca cttggaagag
      901 ctggaggaga agtcggccac tcctcctcct gctgagcctg cttctctgcc tcaggaaccg
      961 ccaaagccga gggttgatgc taagccagaa gttcagtctc agccaccgcg tgtacgggaa
     1021 cagcgacctc gagagcggcc tggtttccct cctcgaggac caaggccagg cagaggagat
     1081 atggaacaga atgactctga caaccggaga ataattcgct atccggacag tcatcagctt
     1141 ttcgttggta acttgcctca tgatattgat gaaaatgaac tgaaagaatt ctttatgagt
     1201 tttggaaacg ttgtggaact tcgcatcaat accaagggtg ttgggggaaa acttccaaat
     1261 tttggttttg tggtttttga tgactctgaa ccagttcaga gaatcttaat tgcaaaacca
     1321 attatgtttc gaggagaagt acgtttaaat gtggaagaga aaaaaacaag agctgccaga
     1381 gagcgagaaa ccagaggtgg tggcgatgac cgcagggata tcaggcgcaa tgatcggggt
     1441 cctggtggtc cacgtggaat tgtgggtggt ggaatgatgc gtgatcgtga cggaagaggg
     1501 ccacctccac gaggtggcat gacacagaaa cttggttctg gaagaggaac cgggcaaatg
     1561 gaaggtcgct tcacaggaca gcgtcgttga agtcccactg ttggcagttt tggcagtggt
     1621 acctaactca tcgtgtttgc attcttgtta agtttttttg gctttggaat gtgacacagc
     1681 ctttttgatc atttctttga tgtgaaaagc atcttttggt tatcagttaa attgaggtgg
     1741 acattatttc cccaatttca caacaggatt catattgtta atttataaag ctagacttgg
     1801 agaattaagg actgagaaat gaccatatct taaactgtct acaacaaaat gaactttaaa
     1861 aaaaaaaaaa aggacatgcc cactgagttc aggtcatttg agttaaaaca aaaaaaaaaa
     1921 tcctctgctg cacattttgt ttaagtgtta actgtttctg ctattaatgt tggaaacaca
     1981 aatagtgcaa tttgtgcaat tggagaatct tgcctttttt cttgtctccc tcccaccccc
     2041 caacacaaac aaacagaagc ttgtacgtat tcattagaat gcactatcgg gtactctgaa
     2101 gtcattaaca ttgaaatctg caccaggagg caacagggga aaaaaaagtt tgatcttctt
     2161 ttccagtaga gaatagtttg tgaaatgata agggcattct atctgcttgc tgtgaccagc
     2221 gtgtgcacac aaaccttaac aagactgcaa atactccaga aggaagtcat ttagttatga
     2281 acgaaataag aaaagtgaga acttcaaaag ctgtggtctt aaatactaga ccaggtttag
     2341 tagctctgtt ttgtcagttt tctatttgcc ctcttgagta cagggatgga tggatggctg
     2401 ctcaacacac tcctcccctc tctcctttaa gctgtgtcca gtgaaagctg tccttcctgt
     2461 attctgttct ctggtaatgt aataagcatg atggtgcctt ctattacatc attccagtct
     2521 tgctggtgat cctgtacggt gtggtctatg aattgctgca ctgcaaagcc acacagctgc
     2581 aaaacgttga agaaaatcat tgatgtataa aaattgcagt atctttcaaa tcagtaaaat
     2641 ggatgcttat tatttatctt gttcttcagt taacatctgt gttctgtggg ggagggaggg
     2701 agtcatgtgt gtttgaaggg agaagtccat tgagtctcta attgactttt ctttcagctc
     2761 cagtgtgaac tataaaacca taatcactca gttcttggaa aagtcaaaca acgtggtgga
     2821 cattttgtca cattttagaa gcagtcagat tcccccaaac ggcacgtgaa cctgagtgcg
     2881 gatactgcaa ttttcagagg gaagaatggc agctcttatg ggtgggggac gggaactgtc
     2941 actcattttg cacaactctt gaactgatgt cagcacccaa atggctcctg aatttaagtc
     3001 tgggaggaca tctttttatt tttacatgaa tctttaaaca attctgtgag cagagtttct
     3061 agctgctgga ttgttgtctg tctttatagc aggtcccagt gaaccacaag aatggcgagg
     3121 gttatctggt tacagttgga tcaatcagta tatatcagat ttctggtgtt tcaagcaaga
     3181 agcgggcgga gtaaacgcgt gtgaccactt aaagctgctt gttaacatgg aagacttctc
     3241 cactctccct tagtgagaac aaatacacac ttgacatggg agcaaactgg ttctgaactt
     3301 tgtgactgtt tgctagtgac gcaactattg gttttttgtc aactgggcaa tatgggtaaa
     3361 atttcctttt ttccctaaga atgaggtctt ccatgtttga ggaaatgtct tgcactattg
     3421 catatatttt gtggacacag atttttgtag tttccatttt ggaaggctaa agtgttttgt
     3481 ttgtttgaaa cagttttaca ctttctaatg tacagtactt gaagttcgta ctagagaatt
     3541 cctttgtagt tttgaagctt ttatccaaac tactttgaaa taggtggctt tcttgtcagt
     3601 ggtttgcccc ccaggtgtaa tttttctttt gttattattc ctcctcctat tgtgtatagg
     3661 tgtgtatatg tgtgtaaata tttcacacaa caacatctgt acaagcatat atatttcaaa
     3721 tccaagatct tgccctgtaa cccatatcta ctgttctggc gacaaaagac agatgttaag
     3781 tgtaacagat aattggagct acgagccatt cagcttcagc ctttccagac cacacacgag
     3841 acattaacca tcccatggag aagtttacat ggtgactgtt cacctgcagt actgtggact
     3901 ttgaacattt tgtccccttt ccagtgaaaa actaaaaagt agtcatctgc cattactgtt
     3961 atttgctgat tttattttat tttgatggta atattctatc cttatgacac tattgcaacc
     4021 aaattggctt taccatcttg gctttagtag gtatagaaga aagtggatta ccatctttat
     4081 tttgtaatgt gttaaataag cattatatgc tggtagaatc tagtttaatt gtttcaggta
     4141 gaaagtattc ttttgagttt ccattttgaa tgtgtttgga ctaaaacaat aaactactga
     4201 tgtctgcagc atttatctat gtccct
//
