LOCUS       NM_013716               2751 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus G3BP stress granule assembly factor 1 (G3bp1),
            transcript variant 1, mRNA.
ACCESSION   NM_013716 XM_985138
VERSION     NM_013716.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2751)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2751)
  AUTHORS   Li,Y., Bie,J., Song,C., Li,Y., Zhang,T., Li,H., Zhao,L., You,F. and
            Luo,J.
  TITLE     SIRT2 negatively regulates the cGAS-STING pathway by deacetylating
            G3BP1
  JOURNAL   EMBO Rep 24 (12), e57500 (2023)
   PUBMED   37870259
  REMARK    GeneRIF: SIRT2 negatively regulates the cGAS-STING pathway by
            deacetylating G3BP1.
REFERENCE   3  (bases 1 to 2751)
  AUTHORS   Koppenol,R., Conceicao,A., Afonso,I.T., Afonso-Reis,R., Costa,R.G.,
            Tome,S., Teixeira,D., da Silva,J.P., Codesso,J.M., Brito,D.V.C.,
            Mendonca,L., Marcelo,A., Pereira de Almeida,L., Matos,C.A. and
            Nobrega,C.
  TITLE     The stress granule protein G3BP1 alleviates spinocerebellar
            ataxia-associated deficits
  JOURNAL   Brain 146 (6), 2346-2363 (2023)
   PUBMED   36511898
  REMARK    GeneRIF: The stress granule protein G3BP1 alleviates
            spinocerebellar ataxia-associated deficits.
REFERENCE   4  (bases 1 to 2751)
  AUTHORS   Cui,Q., Bi,H., Lv,Z., Wu,Q., Hua,J., Gu,B., Huo,C., Tang,M.,
            Chen,Y., Chen,C., Chen,S., Zhang,X., Wu,Z., Lao,Z., Sheng,N.,
            Shen,C., Zhang,Y., Wu,Z.Y., Jin,Z., Yang,P., Liu,H., Li,J. and
            Bai,G.
  TITLE     Diverse CMT2 neuropathies are linked to aberrant G3BP interactions
            in stress granules
  JOURNAL   Cell 186 (4), 803-820 (2023)
   PUBMED   36738734
  REMARK    GeneRIF: Diverse CMT2 neuropathies are linked to aberrant G3BP
            interactions in stress granules.
REFERENCE   5  (bases 1 to 2751)
  AUTHORS   Liu,H., Bai,Y., Zhang,X., Gao,T., Liu,Y., Li,E., Wang,X., Cao,Z.,
            Zhu,L., Dong,Q., Hu,Y., Wang,G., Song,C., Niu,X., Zheng,T.,
            Wang,D., Liu,Z., Jin,Y., Li,P., Bian,X., Cao,C. and Liu,X.
  TITLE     SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN
            Production by Interacting with G3BPs to Facilitate Viral
            Replication
  JOURNAL   J Virol 96 (12), e0041222 (2022)
   PUBMED   35652658
REFERENCE   6  (bases 1 to 2751)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   7  (bases 1 to 2751)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2751)
  AUTHORS   Tourriere,H., Gallouzi,I.E., Chebli,K., Capony,J.P., Mouaikel,J.,
            van der Geer,P. and Tazi,J.
  TITLE     RasGAP-associated endoribonuclease G3Bp: selective RNA degradation
            and phosphorylation-dependent localization
  JOURNAL   Mol Cell Biol 21 (22), 7747-7760 (2001)
   PUBMED   11604510
REFERENCE   9  (bases 1 to 2751)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 2751)
  AUTHORS   Parker,F., Maurier,F., Delumeau,I., Duchesne,M., Faucher,D.,
            Debussche,L., Dugue,A., Schweighoffer,F. and Tocque,B.
  TITLE     A Ras-GTPase-activating protein SH3-domain-binding protein
  JOURNAL   Mol Cell Biol 16 (6), 2561-2569 (1996)
   PUBMED   8649363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596207.10.
            
            On Mar 6, 2023 this sequence version replaced NM_013716.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB001927.1, AK220230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AL596207.10        63647-63753
            108-220             AL596207.10        79578-79690
            221-302             AL596207.10        81431-81512
            303-476             AL596207.10        82971-83144
            477-567             AL596207.10        85916-86006
            568-661             AL596207.10        87400-87493
            662-860             AL596207.10        89205-89403
            861-962             AL596207.10        90096-90197
            963-1074            AL596207.10        91603-91714
            1075-1203           AL596207.10        91865-91993
            1204-1313           AL596207.10        92510-92619
            1314-2751           AL596207.10        93411-94848
FEATURES             Location/Qualifiers
     source          1..2751
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 33.09 cM"
     gene            1..2751
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /note="G3BP stress granule assembly factor 1"
                     /db_xref="GeneID:27041"
                     /db_xref="MGI:MGI:1351465"
     exon            1..107
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     exon            108..220
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1523
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /EC_number="3.6.4.13"
                     /EC_number="3.6.4.12"
                     /note="isoform 1 is encoded by transcript variant 1; ras
                     GTPase-activating protein-binding protein 1; GTPase
                     activating protein (SH3 domain) binding protein 1; G3BP-1;
                     HDH-VIII; ATP-dependent DNA helicase VIII; GAP SH3
                     domain-binding protein 1; GAP SH3 binding protein;
                     Ras-GTPase-activating protein SH3-domain binding protein
                     1"
                     /codon_start=1
                     /product="ras GTPase-activating protein-binding protein 1
                     isoform 1"
                     /protein_id="NP_038744.1"
                     /db_xref="CCDS:CCDS24714.1"
                     /db_xref="GeneID:27041"
                     /db_xref="MGI:MGI:1351465"
                     /translation="MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYAHGG
                     LDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNN
                     QALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQ
                     QTPEVVPDDSGTFYDQTVSNDLEEHLEEPVVEPEPEPEPEPEPEPVSDIQEDKPEAAL
                     EEAAPDDVQKSTSPAPADVAPAQEDLRTFSWASVTSKNLPPSGAVPVTGTPPHVVKVP
                     ASQPRPESKPDSQIPPQRPQRDQRVREQRINIPPQRGPRPIREAGEPGDVEPRRMVRH
                     PDSHQLFIGNLPHEVDKSELKDFFQNFGNVVELRINSGGKLPNFGFVVFDDSEPVQKV
                     LSNRPIMFRGAVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGPSGGMRGPPRGGMVQ
                     KPGFGVGRGITTPRQ"
     exon            221..302
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     exon            303..476
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     exon            477..567
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     exon            568..661
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     exon            662..860
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     exon            861..962
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1074
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1203
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1313
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..2751
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2337..2342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /note="hexamer: AATAAA"
     polyA_site      2372
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /note="major polyA site"
     regulatory      2716..2721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /note="hexamer: ATTAAA"
     regulatory      2732..2737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /note="hexamer: AAGAAA"
     polyA_site      2738
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
                     /note="major polyA site"
     polyA_site      2751
                     /gene="G3bp1"
                     /gene_synonym="B430204O07; G3bp; mKIAA4115"
ORIGIN      
        1 gagcgcggct atatagcggg cggcgggcac gcgtgccgcg gcatcgcgcg agggacgccg
       61 ccacctcctc ccacgtagca gccctgtcct cccgctcagc cgcgcaggtt gaacccacca
      121 aagcgatggt tatggagaag cctagtcccc tgctggtcgg gcgggagttt gtgcgacagt
      181 actacactct gctgaaccag gccccggaca tgttgcacag attttatgga aagaactctt
      241 cctatgccca cgggggcttg gattccaacg ggaagccagc agatgcagtc tacgggcaga
      301 aggaaatcca caggaaagtg atgtcacaaa acttcaccaa ctgccacacc aagatccgcc
      361 acgtggatgc tcacgcaact ctgaatgacg gggtggtggt ccaagtgatg gggctactgt
      421 ccaacaacaa ccaggctctg cggaggttca tgcagacctt tgtccttgct cctgagggct
      481 ctgttgccaa caaattctat gttcacaacg acatcttcag gtaccaagat gaggtcttcg
      541 gtggctttgt cacagagcct caagaggaat ccgaggaaga agtagaagaa cctgaagaaa
      601 gacagcagac accagaggtg gtgcctgatg attctggaac tttctatgat cagactgtca
      661 gcaatgactt ggaggagcat ttagaggagc ctgtagtgga accagaaccg gagccagagc
      721 cggagccgga gccggaacct gtgtccgaca ttcaagagga caagcctgag gctgcattgg
      781 aagaagctgc tcccgacgat gtgcagaaga gcacttcccc ggccccggct gatgtggccc
      841 cggcacagga ggacttgagg acgttttctt gggcatctgt gacgagtaag aaccttcctc
      901 ccagtggggc tgttccagtg acggggacac cacctcatgt ggtcaaagtg ccagcgtcac
      961 agccccgtcc agaatctaaa cctgactctc agatcccacc acaaaggcct cagagagatc
     1021 agagagttcg agagcagcga atcaatatcc ctcctcagag aggaccccga ccaatccgtg
     1081 aggctggtga accaggagat gtggaacctc gaaggatggt gaggcaccct gacagtcacc
     1141 agctcttcat tgggaacctg ccacatgagg ttgacaagtc ggaactgaag gattttttcc
     1201 aaaattttgg caatgtggtg gagctgcgca tcaacagtgg tgggaagtta cccaatttcg
     1261 gttttgttgt gtttgatgat tctgaacctg ttcagaaggt ccttagtaat aggcccatca
     1321 tgttccgagg cgcggtccgc ctgaatgtgg aagagaagaa gactcgagct gccagagaag
     1381 gcgaccgcag ggataaccgc cttcggggac ctggaggccc ccgtggtggg ccgagtggtg
     1441 ggatgagagg ccctccccgc ggaggcatgg tgcagaaacc aggctttggc gtgggcaggg
     1501 ggattacaac tccaaggcag tgaattgctt ggctctgatc tccacacagc acacagcccc
     1561 ggctcctgca gaatggtgaa ttcctttaac cagcgtttgg tgtctcggaa tagtctatta
     1621 taaactgctt gagtttgtac aattttcatt tcgcttgtgt tcatggtgtg tgctcccaac
     1681 cccctttcct cccctgaccc cttagtcctt cattcccagt tttccggaat gatactttag
     1741 gaggaataga ttgtaaagag ggaagactga ccttcctgct cacgctgcgt atacagactg
     1801 gactttcacg gccattcccc agaggagcgc gtctcggctt cactgacagc ggaggtttcg
     1861 ttattgggag acacaggatt tgataaacat tttggaagca ggaaaaatca agtcacgact
     1921 cctttctggt gtggaaaaat tgccttttgg cacctggcgc tgggtccctg ctggtgtggc
     1981 taactgaata aaaggtggtt gcagaccttt gttcttttga catgtgatta ccaaacaact
     2041 ctaagcctcc atttttacca ttggatttta aattgtgatg tagcctgtca atgtctagaa
     2101 cacagctaag gacttttgtt gacctgttag aaattttttt ttttttgagg tagagttttt
     2161 catgttttat ttgtatttgt aaaaaaaaga aaaagaaaaa aaaagaaaaa agaaaaaagg
     2221 acaaaaaatt cccacaagaa aacaaacccc caaatctgat aacaaaaacc aagcaaaact
     2281 gtgccttcta tttatctttg attccggtcg gtcctggcaa ttgtttaaag aaaagtaata
     2341 aagattctag atttgttttc agattcaaag tatgtggggg aactgtagaa tttttttgat
     2401 cacgtgtatg tgtcgtgtta acattgttct gccttatcct aaaatcacgc cccagactgg
     2461 gatgctgctg aggaaggtgc ttctgtgagg ccggtgacct cagtggctct gtgcgccacg
     2521 ctctgctctg ctgtctgtca gggttcctgc tgggccagaa gagaaatttg gttgagtatc
     2581 ggacttggct aacgtgctct agggtctgca tttttttctt taaatcatag ccatatggta
     2641 aattttctat tttgttacgg ttctctttta ctgatggaca cgcagtgggt gtttcttgga
     2701 aaaaggccaa tttttattaa aatatttctg gaagaaaact tcatctggca a
//
