LOCUS       NM_001015099            6634 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G2/M-phase specific E3 ubiquitin ligase (G2e3),
            transcript variant 1, mRNA.
ACCESSION   NM_001015099 XM_126912
VERSION     NM_001015099.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6634)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6634)
  AUTHORS   Powell,D.R., Doree,D.D., DaCosta,C.M., Platt,K.A., Hansen,G.M., van
            Sligtenhorst,I., Ding,Z.M., Revelli,J.P. and Brommage,R.
  TITLE     Obesity of G2e3 Knockout Mice Suggests That Obesity-Associated
            Variants Near Human G2E3 Decrease G2E3 Activity
  JOURNAL   Diabetes Metab Syndr Obes 13, 2641-2652 (2020)
   PUBMED   32801815
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6634)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   4  (bases 1 to 6634)
  AUTHORS   Brooks,W.S., Helton,E.S., Banerjee,S., Venable,M., Johnson,L.,
            Schoeb,T.R., Kesterson,R.A. and Crawford,D.F.
  TITLE     G2E3 is a dual function ubiquitin ligase required for early
            embryonic development
  JOURNAL   J Biol Chem 283 (32), 22304-22315 (2008)
   PUBMED   18511420
  REMARK    GeneRIF: G2E3 is a dual function ubiquitin ligase essential for
            prevention of apoptosis in early embryogenesis
REFERENCE   5  (bases 1 to 6634)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (bases 1 to 6634)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 6634)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY077085.1, AK129332.1, AK086526.1, AA231622.1 and CJ239277.1.
            
            On Nov 21, 2009 this sequence version replaced NM_001015099.1.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.163815.1, AK129332.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               BY077085.1         171-320
            151-5216            AK129332.1         54-5119
            5217-5962           AK086526.1         541-1286
            5963-6433           AA231622.1         47-517
            6434-6634           CJ239277.1         258-458
FEATURES             Location/Qualifiers
     source          1..6634
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 22.11 cM"
     gene            1..6634
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /note="G2/M-phase specific E3 ubiquitin ligase"
                     /db_xref="GeneID:217558"
                     /db_xref="MGI:MGI:2444298"
     exon            1..215
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            216..256
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..2370
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /EC_number="2.3.2.26"
                     /note="isoform 1 is encoded by transcript variant 1; G2/M
                     phase-specific E3 ubiquitin-protein ligase; G2/M
                     phase-specific HECT-type E3 ubiquitin transferase"
                     /codon_start=1
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform 1"
                     /protein_id="NP_001015099.2"
                     /db_xref="CCDS:CCDS25900.1"
                     /db_xref="GeneID:217558"
                     /db_xref="MGI:MGI:2444298"
                     /translation="MNENKPDNSQSLACVFCRKNDDCPNKYGEKKTYEKWNFSVHYYC
                     LLMSSGIWQRGKEEEGVYGFLIEDIRKEVQRASKLKCTVCKKNGASIGCVVPTCKRSY
                     HLPCGLQKECIFQFTDNFASFCWKHRPVQAITSNKYSSSLPCTICLEFVEPIPTYNIL
                     QSPCCKNAWFHRDCLQVQAINAGVFFFRCTLCNNTDIFQKEMLRMGIHIPEKDASWEL
                     EENAYQELLQSHDRCDIRRCHCKKGRDYNEPNSKWEVKRCQSCGSSGTHLACSSLQSW
                     EQNWECLDCRRITYTSDFQKAPKHPLANSTNVTVTDCLLEESSSKLPRQSTVAQHKEL
                     LRQGSKFRRDISTILIELGFQIKKKTKTLYINKANVWRSALEQFQSQKFNPSCSIDVV
                     YVNGNEVGSQHLGSKQEFLSHLMHHLENSSVFEGSLAKNLSLNSQAVKENLYYEVGKM
                     LAISLVHGGPSPGFFSETLFNCLAYGPENTLPTLDDVSDIDVAQIIIKIDSATDLNIL
                     NSVISQHYNYLEVSGCLRLTTSLSDKFMLVKDILFYHVINRVKAPFESFKQGLKTLGV
                     LEKIQTYPEAFYKILCHKPENLSAKNLSDLFTIHSVADVQTLRFWNSYLKAIEDGKSA
                     TTMEDILIFATGCSSVPPTGFKPSLSVECLHVDFPVADKYRNHLVLPATNTYEEFQEN
                     MDFTIRDTLRLEKEERSHILPRTLNVSSNEEMLI"
     exon            257..354
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            355..456
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            457..581
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            582..747
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            748..854
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            855..971
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1096
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1226
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1531
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1713
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1886
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2077
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..6634
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3000..3005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /note="hexamer: ATTAAA"
     polyA_site      3023
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
     regulatory      6612..6617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /note="hexamer: AATAAA"
     polyA_site      6631
                     /gene="G2e3"
                     /gene_synonym="6030408C04Rik; 9030416F18; D930034K21Rik;
                     mKIAA1333"
                     /note="major polyA site"
ORIGIN      
        1 ttccccgggg aggggccgag cagccgtggg ttccgggtcg caaacggaag tggacgacga
       61 atttgaattg tgcgagccgt tggatggggc tgagcgggtt gggcgtacgg cagcgctgcg
      121 gtcgacgtga gcggtaacgc ggcgagcctg ggacttgtgc cccgcgcctg gtgaagacgt
      181 gcccggggac agacggaggt gtcacgggcg gccggtaaaa tgaatgaaaa taaacctgat
      241 aattcacaaa gtcttgcttg tgttttctgc cgaaaaaatg atgactgtcc caataaatac
      301 ggagaaaaga aaacatatga aaaatggaat tttagtgtcc actactactg cttgttaatg
      361 tcaagtggaa tttggcagag aggtaaagaa gaagaaggag tttatggctt cctaatagaa
      421 gacatcagga aggaagtcca gagagcctcc aaactgaagt gtacagtttg caagaagaat
      481 ggtgcttcaa ttggatgtgt ggtacccacg tgtaaacgaa gttatcactt gccttgtgga
      541 cttcagaaag aatgtatttt ccagttcact gacaattttg cgtcattttg ctggaaacat
      601 cgacccgttc aagcaattac atctaataaa tatagtagtt ctttaccatg tactatctgt
      661 ttggaatttg tcgagcctat tcctacttat aacatactac aaagtccctg ttgtaagaat
      721 gcttggtttc atagagactg tttacaggtc caagcaataa atgcaggagt gtttttcttt
      781 agatgtacac tatgcaataa tacagacatc tttcagaagg agatgttgag aatgggaatt
      841 catattcctg aaaaagatgc atcctgggaa ttagaagaaa acgcgtatca agagctgctg
      901 cagagccacg accgctgtga tattcgaaga tgtcactgca aaaaaggccg agactacaac
      961 gaacctaaca gcaaatggga agtaaagcgg tgtcagagtt gtggttctag tggaacacac
     1021 ttagcctgtt cctcactaca gtcttgggaa caaaattggg agtgtttgga ctgtagaaga
     1081 attacctaca cttcagattt ccaaaaggcc cccaaacacc cattagccaa ctctactaat
     1141 gtgacagtta ctgactgctt gttggaagag tcatcatcta agctccccag acagtcaact
     1201 gtagcccagc ataaagaact actgaggcaa ggcagcaaat ttaggagaga catttcaaca
     1261 atattgatag agttaggatt ccaaattaaa aagaaaacta agacattata catcaacaaa
     1321 gccaatgtgt ggaggagtgc cttagagcag ttccagagcc agaagtttaa cccttcatgc
     1381 tccattgacg tagtgtatgt taatggcaat gaggttggaa gccagcatct tggatcaaag
     1441 caggaatttc tgagtcactt aatgcaccat cttgagaatt catcagtgtt tgaagggtcc
     1501 ttggcaaaga acttgtctct aaattctcaa gctgtgaaag agaatcttta ctatgaagtt
     1561 ggcaaaatgc ttgccatttc tttagttcat ggtggtcctt cgcctggttt cttttctgaa
     1621 accttgttta actgccttgc ttatggacca gaaaatactc taccaacttt ggatgatgta
     1681 tcagacattg atgttgcaca gattataatc aagatagatt ctgcaactga tttaaacatt
     1741 ttaaattcag taataagcca acactataac tacttagagg tcagtggatg tttaagactt
     1801 acgacatcat taagtgataa attcatgttg gtaaaagaca tccttttcta ccatgtaatt
     1861 aatagagtca aggcaccttt tgagagtttt aaacagggtc tgaaaacgct tggtgtttta
     1921 gagaaaattc aaacttaccc agaagcattt tataagatcc tatgtcataa acctgagaat
     1981 ctctctgcaa aaaacctcag tgacctcttc acaattcact cggtagcgga cgtacagact
     2041 ttgaggtttt ggaacagtta cttaaaggct atagaggatg gtaaatctgc aacaacgatg
     2101 gaagatattc ttatttttgc aactggctgt agttctgtcc caccaactgg atttaaaccc
     2161 tctctgtcag ttgaatgtct acatgtggat tttcctgttg cagacaaata tagaaaccat
     2221 ttagttctac cagccaccaa cacgtatgaa gagttccaag aaaatatgga tttcaccata
     2281 agagacactc taagattaga aaaggaagaa aggtctcaca tactacctcg gacattaaat
     2341 gtttcttcta atgaagaaat gcttatttaa aggctgctat tgatacctat ttttattaat
     2401 catcactttt gaacattctg gccagcttct tggcacaaca aaatttataa ctttctcata
     2461 aagggatggt ttggcttccg aaccactgaa ggtttggtta aggccttcta gtcatgtttg
     2521 gtgatagctt tctattactg tgttgccttc gtaacaccaa tatgaatatt ttctattact
     2581 gtgctttctt gataacttca tatattttta gaatggttgt acaaaccgtt caactgtaca
     2641 ggtgctcggc tatattagca tgacctatga aaaactgttt tctcgatttt ttttttttaa
     2701 attagaaata tttttttagg atgacactct ctagttttgt gcagctatca gatttgtttt
     2761 gttttgtttg ttctccttta ctgtttgtgg ttttttttgt ttgtttgttt tttgtttttt
     2821 tgtttgtttt tctctacata gtcctgattg tcttggaacc tgtctatgta gaacaagctg
     2881 tcaaattaaa gcaataaata gaaaagttgg ctaagtcatc tcataaatca gagatatttt
     2941 ttaatgtttt gcaattaagt gaccaatata tcaattaaat gactgattgt aaatagtcta
     3001 ttaaaagcaa ggctttacaa atatctctag aacctatgtg tcctccttaa gcttaaaatc
     3061 atggctgtgg ggttttcagg tgtgcttgaa aatcccttag aaagcacaga ctatttatgt
     3121 tctttagtag tcagaatgtc tcatgcttga aaccatctag gtgtctgaag agtctctgga
     3181 ccatcatggt ttcgcgccat aactgctatt tattattact aagattgttg tatgattggt
     3241 aagatctcac catagcattc tatagttacc ttcttttgct ttcaaaagat atacattgta
     3301 taatcaatga atgaattata atttaaaact acaagttaaa agaaatactc taattttgcc
     3361 acatagagat aaataatgta ttttgtatat tctttataaa ctatttattt ttcaattttt
     3421 attgtgttat gacagggtct ttctatagag ctcaactgtt ctaaatttgc aatcttcctg
     3481 ccttatagtc atttaggtgc tgggattatg acgtatatca atgtgcctag caatgtttat
     3541 tttttgatat gaatgctgta aaagagtaac aagaaaccac gtaataaaat caagatatgt
     3601 acagtctcat ctcaaggcac gacatcactc tcttgtaatc cgtgccccga gagactaagg
     3661 caagaggatc aggagtgata acgcaagttt aaaaccatcc tggcctacag gataccctgc
     3721 tcagtaaaga aagaaataag gacatgaccc actcatggta atgtcttcac acattaacac
     3781 aaagtatgtg ttatctgttg gtcatgtatt gtttactcct aagaaacaca agatttaaaa
     3841 gggacttaga tcccttaaac aacaggattg acttggtatt gacaatgccc ttcttaatgc
     3901 caaaggaaaa ctcagttgtc atcatagtgc cattttcttg gttgcatcag aaccttccaa
     3961 gttgtactta agaaaactaa tagtttctct ttatcttgag catttcttta tcttgtgtta
     4021 cattttgctg gatgtttcga aagtaatgaa gtgggccatc ataatttaaa tcttaaactc
     4081 aatagacacc ttttatttca agtgtgttga taagttggat ctttatgttt taacctgttt
     4141 aattccagct ggggagatgg ctcagtggtt aacagcactg tctgcccttc taaaggtcag
     4201 gagttcagtc ctgagctatg tgcaaaatgt ttaattccta cagagtttta aaggctgtta
     4261 aatccataca actcctaaat gctatttttt cagcttttag tttgaggggt ttttgtttgt
     4321 ttgttttttg ttttccccta agataaagcg aacacagcct tcataaaaca tagggtggga
     4381 ttatggagcc tgggactggc tggctacaag tgattttatt ccacttactc taggtaagac
     4441 aatggccttg ttggtgagat ggtctaaata ttaacaggat acttacttca agtgaaacat
     4501 cagatttcaa gatgtcttct ggttcaaacc tgttttgcat ggtttctaga tcagtctcta
     4561 tacacttgag gcttatcaga gaaactgcag tgttactgcg tcatgcttgt aatgttccca
     4621 ttctgtttta tagtatagtt ctcacattaa catacttagc ttcaaaatta tgaaggaaca
     4681 gttttatgtt tggttaagta aaaacccaga actagcgtgg tctctgttgt ctgcatttat
     4741 gcttccccct aattatattg gaagcttttg gaacttgcac attcagtgtt tataaagggg
     4801 tgtataatga gtttttccta tgactttgct ttagtgttta gtcataagaa agtggtaaga
     4861 actagactct gttgataaaa catggttact attgcatatt tgttatgctt caggtaatgc
     4921 agtgtaaatc attaaacaca tttaatgatg aattatttga atttatatta tctgtaactt
     4981 gggaaatttt gtagtcctta aaagagaccc agttttcaag ttctattttt gaccaccttc
     5041 aaatatactc cactacccac tgtatattag aatctgtgta gaagtagttt ataagtcggc
     5101 ctgtttaaaa tatatcaaaa caaatactgc tggggatttg gcctggtagt agaatggttt
     5161 gcctagctag tatgtggaag gccttgggtt taattttaaa gtatgaccaa aacattaaaa
     5221 aaaaaaaaaa gcatgaacat ttaacaataa catttctaag taaatgtttt tatgccacta
     5281 aaatgtgaag ttgtgaagtg ttcatataaa ctaaataaat gtgttgggaa tcttgagaca
     5341 gaaaggcaga atagcactgt tcctcaagga gggaagtcaa ggcaggagtc tgctggtggg
     5401 ggttgataca aagtgattgc tgcctactgc cttgctttcc atggcttgct catttgcttt
     5461 cttacagaag ccaaggccac tagtccaggg tggcactgca cacgggctgg gcccttccca
     5521 ttcgccacta attaagaaaa tgcctttcag ggttgcttac ttcctggttt catggagcca
     5581 ttttctcagt tgaagtgttc tctgcttgca tgtctctagc tgtgtcaggc atctaataag
     5641 gatggggtgg tcttttagtg cagatgtgtt tcttttcctt tttattagta tgtaattgtt
     5701 taaaacaggc tgtcacgaca catgcataca tgtgtgtaat gagctttggt catactcccc
     5761 ttcttgcctc atactgaacc ccttccctat ttccaggatt gtcttaaaca agtagtccat
     5821 ttacgaggct gatgttatta aagtgggtaa gatccaaaat ctttactctt cttgtctgag
     5881 agctccttga actcaagaaa caaactgttt ttagcaaatt ttctaagata aaactatccc
     5941 ttgatgttca attatttaaa ccaaaaaatc tggagttaaa cagctacaat aaatctaact
     6001 ctgaagtcat gatttttatt cttataatca acattaatat cattcttggt cgtagctttg
     6061 caggactgtt ctatatagtt actcttctaa tgaatatata tatctttatg tttactcccc
     6121 acattacacc attggacaga aacatgcaca ctgtataaat gtcttagtat tttatgataa
     6181 tgtgccttat agtcttggaa ggagttagta tggaacttaa atggtcaaat gacaaatttg
     6241 tacttaaaag tggggattct caggtgagta agattaaact cactggaagg tgggaaagcc
     6301 attctgctca agagtccatg gacaccagaa ttgagatact tcccctaggg cacaaactgg
     6361 tagttataga taacctgttg taactttata aaaataggta tctacatctg tcaaatgtgt
     6421 ttttattgta aaaaaaatgc aatcttgatt ttaaaaaata agataaatta tttgtataat
     6481 tttgaaagcc aaatttttga aagtatgatt tcatttcaga atctgactgc ctgagaatta
     6541 atccataatg cagtgtcatc ggtgggttca ttgattggta ataagttgtc attgtatata
     6601 tttttgacat taataaaatc tattatgaaa atgg
//
