LOCUS       NM_008059                847 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus G0/G1 switch gene 2 (G0s2), mRNA.
ACCESSION   NM_008059
VERSION     NM_008059.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 847)
  AUTHORS   Corbet,A.K., Bikorimana,E., Boyd,R.I., Shokry,D., Kries,K.,
            Gupta,A., Paton,A., Sun,Z., Fazal,Z., Freemantle,S.J., Nelson,E.R.,
            Spinella,M.J. and Singh,R.
  TITLE     G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and
            ER- breast cancer cells
  JOURNAL   Transl Oncol 33, 101676 (2023)
   PUBMED   37086619
REFERENCE   2  (bases 1 to 847)
  AUTHORS   Wu,D., Zhang,Z., Sun,W., Yan,Y., Jing,M. and Ma,S.
  TITLE     The effect of G0S2 on insulin sensitivity: A proteomic analysis in
            a G0S2-overexpressed high-fat diet mouse model
  JOURNAL   Front Endocrinol (Lausanne) 14, 1130350 (2023)
   PUBMED   37033250
  REMARK    GeneRIF: The effect of G0S2 on insulin sensitivity: A proteomic
            analysis in a G0S2-overexpressed high-fat diet mouse model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 847)
  AUTHORS   Babochkina,T.I., Gerlinskaya,L.A., Anisimova,M.V., Kontsevaya,G.V.,
            Feofanova,N.A., Stanova,A.K., Moshkin,M.P. and Moshkin,Y.M.
  TITLE     Mother-Fetus Immune Cross-Talk Coordinates 'Extrinsic'/'Intrinsic'
            Embryo Gene Expression Noise and Growth Stability
  JOURNAL   Int J Mol Sci 23 (20), 12467 (2022)
   PUBMED   36293324
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 847)
  AUTHORS   Ma,Y., Zhang,M., Yu,H., Lu,J., Cheng,K.K.Y., Zhou,J., Chen,H. and
            Jia,W.
  TITLE     Activation of G0/G1 switch gene 2 by endoplasmic reticulum stress
            enhances hepatic steatosis
  JOURNAL   Metabolism 99, 32-44 (2019)
   PUBMED   31271806
  REMARK    GeneRIF: G0S2 is regulated by the PERK-eIF2alpha-ATF4 branch of the
            UPR and mediates ER stress-induced hepatic steatosis.
REFERENCE   5  (bases 1 to 847)
  AUTHORS   Zhang,X., Xie,X., Heckmann,B.L., Saarinen,A.M., Gu,H., Zechner,R.
            and Liu,J.
  TITLE     Identification of an intrinsic lysophosphatidic acid
            acyltransferase activity in the lipolytic inhibitor G0/G1 switch
            gene 2 (G0S2)
  JOURNAL   FASEB J 33 (5), 6655-6666 (2019)
   PUBMED   30802154
REFERENCE   6  (bases 1 to 847)
  AUTHORS   Wueest,S., Yang,X., Liu,J., Schoenle,E.J. and Konrad,D.
  TITLE     Inverse regulation of basal lipolysis in perigonadal and mesenteric
            fat depots in mice
  JOURNAL   Am J Physiol Endocrinol Metab 302 (1), E153-E160 (2012)
   PUBMED   21989031
  REMARK    GeneRIF: Lipolysis is differently regulated between perigonadal and
            mesenteric adipocytes, and these depot-specific differences might
            be explained by altered regulation of G0S2 and/or perilipin.
REFERENCE   7  (bases 1 to 847)
  AUTHORS   Yang,X., Lu,X., Lombes,M., Rha,G.B., Chi,Y.I., Guerin,T.M.,
            Smart,E.J. and Liu,J.
  TITLE     The G(0)/G(1) switch gene 2 regulates adipose lipolysis through
            association with adipose triglyceride lipase
  JOURNAL   Cell Metab 11 (3), 194-205 (2010)
   PUBMED   20197052
  REMARK    GeneRIF: overexpression of G0S2 diminishes the rate of lipolysis in
            both adipocytes and adipose tissue explants
REFERENCE   8  (bases 1 to 847)
  AUTHORS   Zandbergen,F., Mandard,S., Escher,P., Tan,N.S., Patsouris,D.,
            Jatkoe,T., Rojas-Caro,S., Madore,S., Wahli,W., Tafuri,S., Muller,M.
            and Kersten,S.
  TITLE     The G0/G1 switch gene 2 is a novel PPAR target gene
  JOURNAL   Biochem J 392 (Pt 2), 313-324 (2005)
   PUBMED   16086669
  REMARK    GeneRIF: A novel putative target gene of PPARalpha, G0S2 (G0/G1
            switch gene 2) was identified and characterized.
REFERENCE   9  (bases 1 to 847)
  AUTHORS   Chen,Y., Perry,D., Boackle,S.A., Sobel,E.S., Molina,H., Croker,B.P.
            and Morel,L.
  TITLE     Several genes contribute to the production of autoreactive B and T
            cells in the murine lupus susceptibility locus Sle1c
  JOURNAL   J Immunol 175 (2), 1080-1089 (2005)
   PUBMED   16002709
REFERENCE   10 (bases 1 to 847)
  AUTHORS   Bachner,D., Ahrens,M., Schroder,D., Hoffmann,A., Lauber,J.,
            Betat,N., Steinert,P., Flohe,L. and Gross,G.
  TITLE     Bmp-2 downstream targets in mesenchymal development identified by
            subtractive cloning from recombinant mesenchymal progenitors
            (C3H10T1/2)
  JOURNAL   Dev Dyn 213 (4), 398-411 (1998)
   PUBMED   9853961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY124107.1, AK003165.1 and BX639304.1.
            
            On Apr 10, 2008 this sequence version replaced NM_008059.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI250484.1, AK003165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BY124107.1         1-79
            80-841              AK003165.1         2-763
            842-847             BX639304.1         1-6                 c
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 97.69 cM"
     gene            1..847
                     /gene="G0s2"
                     /note="G0/G1 switch gene 2"
                     /db_xref="GeneID:14373"
                     /db_xref="MGI:MGI:1316737"
     exon            1..200
                     /gene="G0s2"
                     /inference="alignment:Splign:2.1.0"
     exon            201..843
                     /gene="G0s2"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..540
                     /gene="G0s2"
                     /note="putative lymphocyte G0/G1 switch protein 2;
                     G0S2-like protein"
                     /codon_start=1
                     /product="G0/G1 switch protein 2"
                     /protein_id="NP_032085.1"
                     /db_xref="CCDS:CCDS15636.1"
                     /db_xref="GeneID:14373"
                     /db_xref="MGI:MGI:1316737"
                     /translation="MESVQELIPLAKEMMAQKPRGKLVKLYVLGSVLALFGVVLGLVE
                     TVCSPFTAASRLRDQEAAVVELREACEQQSLHKQALLAGGKAQEATLCSRALSLRQHA
                     S"
     regulatory      822..827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="G0s2"
                     /note="hexamer: AATAAA"
     polyA_site      843
                     /gene="G0s2"
                     /note="major polyA site"
ORIGIN      
        1 tgcagtcagg gctcaggcca gtgagccagg aggcggatcc cggacaaaag atataaggac
       61 tctgttcaca gagcgctgca gctgcggagt gtccctccca aagagcagca gctgagggaa
      121 gaagaacgcc aaagccagtc tgacgcaagg acgcctgacc ttctccagca agtgctgcct
      181 ctcttcccac tgcaccctag gcccagccac ccacagccca gagctcagat ggaaagtgtg
      241 caggagctga tccctctggc caaggagatg atggcgcaga agccccgagg gaagctagtg
      301 aagctatacg tgctgggcag tgtgctggcg ctcttcggtg tggtgctcgg cctagttgag
      361 acggtgtgca gccctttcac agccgccagc cgtctgcgcg accaagaggc tgcagtggtg
      421 gagctgcggg aagcgtgtga acagcagtcc ctccacaagc aggccctgct ggcaggaggc
      481 aaggcacagg aggcgaccct gtgcagccgg gccctgtccc tccggcagca cgcctcttaa
      541 ggccggtgac tgacagagaa gggagacaca gatcatgacc caggtgggca acagagtcac
      601 atgctgtttc aaggtgccac cgaatccaga actgacccca cacagatcac ctaaggggtc
      661 tgggactgat ttgctgctgt gcagcacgca ctgtgatttg ccctaggctg tgcgagcaat
      721 caaggagcta tcactttgca ttagagaagg agacaggctt tttatacagt tatttttatt
      781 gttattatta ttattgcaat gactatcgtt ttgcattttg aaataaaaac cttttatact
      841 ctaaaaa
//
