LOCUS       NM_019757               2258 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus fizzy and cell division cycle 20 related 1 (Fzr1),
            mRNA.
ACCESSION   NM_019757
VERSION     NM_019757.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2258)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2258)
  AUTHORS   Ledvin,L., Gassaway,B.M., Tawil,J., Urso,O., Pizzo,D., Welsh,K.A.,
            Bolhuis,D.L., Fisher,D., Bonni,A., Gygi,S.P., Brown,N.G. and
            Ferguson,C.J.
  TITLE     The anaphase-promoting complex controls a
            ubiquitination-phosphoprotein axis in chromatin during
            neurodevelopment
  JOURNAL   Dev Cell 58 (23), 2666-2683 (2023)
   PUBMED   37875116
REFERENCE   3  (bases 1 to 2258)
  AUTHORS   Zhang,S., You,X., Zheng,Y., Shen,Y., Xiong,X. and Sun,Y.
  TITLE     The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor
            cascade in lung cancer cells
  JOURNAL   J Clin Invest 133 (4), e162434 (2023)
   PUBMED   36548081
  REMARK    GeneRIF: The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor
            suppressor cascade in lung cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2258)
  AUTHORS   Cuadrado,M., Garzon,J., Moreno,S. and Garcia-Higuera,I.
  TITLE     Efficient terminal erythroid differentiation requires the APC/C
            cofactor Cdh1 to limit replicative stress in erythroblasts
  JOURNAL   Sci Rep 12 (1), 10489 (2022)
   PUBMED   35729193
  REMARK    GeneRIF: Efficient terminal erythroid differentiation requires the
            APC/C cofactor Cdh1 to limit replicative stress in erythroblasts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2258)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
REFERENCE   6  (bases 1 to 2258)
  AUTHORS   Zhou,Y., Ching,Y.P., Ng,R.W. and Jin,D.Y.
  TITLE     Differential expression, localization and activity of two
            alternatively spliced isoforms of human APC regulator CDH1
  JOURNAL   Biochem J 374 (Pt 2), 349-358 (2003)
   PUBMED   12797865
REFERENCE   7  (bases 1 to 2258)
  AUTHORS   Chabes,A.L., Pfleger,C.M., Kirschner,M.W. and Thelander,L.
  TITLE     Mouse ribonucleotide reductase R2 protein: a new target for
            anaphase-promoting complex-Cdh1-mediated proteolysis
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 3925-3929 (2003)
   PUBMED   12655059
REFERENCE   8  (bases 1 to 2258)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2258)
  AUTHORS   Wang,C.X., Fisk,B.C., Wadehra,M., Su,H. and Braun,J.
  TITLE     Overexpression of murine fizzy-related (fzr) increases natural
            killer cell-mediated cell death and suppresses tumor growth
  JOURNAL   Blood 96 (1), 259-263 (2000)
   PUBMED   10891459
REFERENCE   10 (bases 1 to 2258)
  AUTHORS   Inbal,N., Listovsky,T. and Brandeis,M.
  TITLE     The mammalian Fizzy and Fizzy-related genes are regulated at the
            transcriptional and post-transcriptional levels
  JOURNAL   FEBS Lett 463 (3), 350-354 (1999)
   PUBMED   10606752
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF083809.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF083809.1, AK083686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2258
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2258
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /note="fizzy and cell division cycle 20 related 1"
                     /db_xref="GeneID:56371"
                     /db_xref="MGI:MGI:1926790"
     exon            1..101
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..211
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1624
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /function="cell cycle regulator"
                     /note="cell division cycle 20 related 1; cdh1/Hct1
                     homolog; fizzy/cell division cycle 20 related 1"
                     /codon_start=1
                     /product="fizzy-related protein homolog"
                     /protein_id="NP_062731.1"
                     /db_xref="CCDS:CCDS24057.1"
                     /db_xref="GeneID:56371"
                     /db_xref="MGI:MGI:1926790"
                     /translation="MDQDYERRLLRQIIIQNENTVPCVSEMRRTLTPANSPVSSPSKH
                     GDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGA
                     GIEKVQDPQTEDRRLQPSTPEHKGLFTYSLSSKRSSPDDGNDVSPYSLSPVSNKSQKL
                     LRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQ
                     VTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGA
                     LAWNADQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGND
                     NKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQP
                     LQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLA
                     MSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR"
     exon            212..337
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..401
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..529
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..612
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..796
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..862
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..965
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1150
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1384
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1489
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1582
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..2254
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1746..1751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /note="hexamer: ATTAAA"
     polyA_site      1764
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
                     /note="major polyA site"
     polyA_site      2036
                     /gene="Fzr1"
                     /gene_synonym="Cdh1; Fyr; FZR; FZR2; HCDH; HCDH1"
ORIGIN      
        1 gcggcggggc ctgtcgcaac ggcggggcct cgaacaggcg cggcgtgttc ctgggaccgg
       61 cgggaaccgg cgggtgccgg ctggcgaccg gagcgaggca ggctaccctc ggctgcgggc
      121 cttgcccgcc tgcccactcg ccatggacca ggactatgag cgaaggctcc tgcggcagat
      181 catcatccag aatgagaaca cagtgccctg tgtttcagag atgcggagaa ccctgacacc
      241 agccaactcc ccagtgtctt cacccagcaa gcatggtgac cgcttcatcc cctcgcgggc
      301 cggggccaac tggagcgtga acttccacag gatcaatgaa aatgagaagt cccccagcca
      361 gaaccgcaaa gccaaggacg ccacctcgga caatggcaaa gacggcctgg cctactccgc
      421 actgctgaag aatgagctgc tgggtgccgg catcgagaag gttcaggacc cacagacgga
      481 ggaccggcgg ctgcagccgt ccacaccaga gcacaagggg ctctttacgt attccctcag
      541 cagcaagcgc tcgagtccag atgatggcaa tgacgtgtcc ccatactctc tgtcccccgt
      601 tagcaacaaa agtcagaagc tgctgcggtc accacggaag cccacacgca agatctctaa
      661 gattcccttc aaggtgctgg acgcgccaga gcttcaggac gacttctacc tcaacttggt
      721 ggactggtcc tccctcaacg tgctcagcgt ggggctgggc acctgcgtgt acctgtggag
      781 tgcatgcacc agccaggtga cccggctctg tgacctctct gtagaagggg actcagtgac
      841 ttccgttggc tggtctgagc gggggaactt ggtcgcagta ggtacacaca agggcttcgt
      901 gcagatctgg gacgctgctg ctgggaagaa gctgtccatg ctggagggcc acacagcacg
      961 agtgggggcg ctggcctgga atgctgacca gttgtcatct ggtagccgtg accgcatgat
     1021 cctacagcgg gatatccgca caccacccct gcagtcagag cggcggctgc agggccaccg
     1081 gcaggaagtg tgtggcctaa agtggtccac agaccaccag ctgcttgcct cggggggcaa
     1141 tgacaacaag ctgctcgtgt ggaaccactc tagtctaagc cctgtgcagc agtatacgga
     1201 gcacctggca gccgtgaagg ctattgcctg gtccccacac cagcatggac tgctggcatc
     1261 tggtggtggc acggctgacc gctgcatccg attctggaac actctgacag gtcagccact
     1321 gcagtgcatt gacacaggct cacaagtgtg caacctggcc tggtccaagc acgccaatga
     1381 gctggtgagc acacatggct actcacagaa ccagatcctc gtgtggaagt acccgtccct
     1441 tacgcaggtg gccaagctca ctggccactc atatcgtgtc ctctacctgg ccatgtcccc
     1501 tgatggggag gccatagtca ccggagctgg agatgagacc ctgaggttct ggaatgtctt
     1561 cagcaaaaca cgctctacaa aggaatctgt gtctgtgctc aacctcttca cccggatccg
     1621 atagaccccg caggcgggat gtgaagccca caggcagaga tggagcagcc agcatgcata
     1681 ggccttgctg tgcccgcctt ccccagaagc atctggcggg cgggagccgg agaccccaga
     1741 gtctcattaa atgcctcatt gtgagctgtg gagccagtgt ctgggacggg gacatgggga
     1801 ccctcagcca gatggacact tgccacctgt taccactgcc caagccatat tggacacagc
     1861 tgagcaggag gctgagatcc catgaaatcc ccaaacccag tgtcacctgg ggacctgagc
     1921 cgttgtgccc ctctctgctg ccactccaaa ccagaagacc ctgggaggca ctggcaggga
     1981 cctgggcctc tcaccctgtg acactcttaa ctgcgttgac tctgattgca ttgccaccct
     2041 ttgtctgtgt gtgcgccttc tgtaacccct ccccgtgggt gtcagctcac cctgtcccta
     2101 gccagctgcc ttgtctgcct cttcctggct gcctctaagc ttcctgggcc tccctgtctt
     2161 cataccccat ctccactgcc ccttgcctgg ggattcccag tgtggtggct gtggcctatg
     2221 gtgtgtgcac gtgtgtatat atgtatttgt gacaaaaa
//
