LOCUS       NM_008058               3346 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus frizzled class receptor 8 (Fzd8), mRNA.
ACCESSION   NM_008058
VERSION     NM_008058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3346)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3346)
  AUTHORS   Murphy,P., Armit,C., Hill,B., Venkataraman,S., Frankel,P.,
            Baldock,R.A. and Davidson,D.R.
  TITLE     Integrated analysis of Wnt signalling system component gene
            expression
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831952
REFERENCE   3  (bases 1 to 3346)
  AUTHORS   Xiao,Z., Liu,S., Li,Z., Cui,J., Wang,H., Wang,Z., Ren,Q., Xia,L.,
            Wang,Z. and Li,Y.
  TITLE     The Maternal Microbiome Programs the m6A Epitranscriptome of the
            Mouse Fetal Brain and Intestine
  JOURNAL   Front Cell Dev Biol 10, 882994 (2022)
   PUBMED   35874829
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3346)
  AUTHORS   Xu,W., Nelson-Maney,N.P., Balint,L., Kwon,H.B., Davis,R.B.,
            Dy,D.C.M., Dunleavey,J.M., St Croix,B. and Caron,K.M.
  TITLE     Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic
            Development
  JOURNAL   Int J Mol Sci 23 (10), 5712 (2022)
   PUBMED   35628521
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3346)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3346)
  AUTHORS   Tamai,K., Semenov,M., Kato,Y., Spokony,R., Liu,C., Katsuyama,Y.,
            Hess,F., Saint-Jeannet,J.P. and He,X.
  TITLE     LDL-receptor-related proteins in Wnt signal transduction
  JOURNAL   Nature 407 (6803), 530-535 (2000)
   PUBMED   11029007
REFERENCE   7  (bases 1 to 3346)
  AUTHORS   Borello,U., Buffa,V., Sonnino,C., Melchionna,R., Vivarelli,E. and
            Cossu,G.
  TITLE     Differential expression of the Wnt putative receptors Frizzled
            during mouse somitogenesis
  JOURNAL   Mech Dev 89 (1-2), 173-177 (1999)
   PUBMED   10559494
REFERENCE   8  (bases 1 to 3346)
  AUTHORS   Sheldahl,L.C., Park,M., Malbon,C.C. and Moon,R.T.
  TITLE     Protein kinase C is differentially stimulated by Wnt and Frizzled
            homologs in a G-protein-dependent manner
  JOURNAL   Curr Biol 9 (13), 695-698 (1999)
   PUBMED   10395542
REFERENCE   9  (bases 1 to 3346)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   10 (bases 1 to 3346)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132543.1 and AC108777.7.
            
            On Jun 30, 2009 this sequence version replaced NM_008058.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC138062.1, SRR11927936.3176269.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2155              BC132543.1         1-2155
            2156-3346           AC108777.7         113154-114344
FEATURES             Location/Qualifiers
     source          1..3346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.91 cM"
     gene            1..3346
                     /gene="Fzd8"
                     /gene_synonym="Fz8"
                     /note="frizzled class receptor 8"
                     /db_xref="GeneID:14370"
                     /db_xref="MGI:MGI:108460"
     exon            1..3346
                     /gene="Fzd8"
                     /gene_synonym="Fz8"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2122
                     /gene="Fzd8"
                     /gene_synonym="Fz8"
                     /note="frizzled-8; fz-8; frizzled homolog 8"
                     /codon_start=1
                     /product="frizzled-8 precursor"
                     /protein_id="NP_032084.2"
                     /db_xref="CCDS:CCDS29048.1"
                     /db_xref="GeneID:14370"
                     /db_xref="MGI:MGI:108460"
                     /translation="MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCK
                     GIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKK
                     PLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAA
                     PSPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGGKARPP
                     GGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVF
                     WIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEK
                     VACSGGAPGAGGAGGAGGAAAAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPA
                     LCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVK
                     SIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRI
                     RSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCP
                     CLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKG
                     AAVGAGAGGSGPGGSGPGPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPL
                     SQV"
     regulatory      2792..2797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzd8"
                     /gene_synonym="Fz8"
                     /note="hexamer: AATAAA"
     polyA_site      2815
                     /gene="Fzd8"
                     /gene_synonym="Fz8"
     regulatory      2959..2964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzd8"
                     /gene_synonym="Fz8"
                     /note="hexamer: AGTAAA"
     polyA_site      2983
                     /gene="Fzd8"
                     /gene_synonym="Fz8"
                     /note="major polyA site"
ORIGIN      
        1 cctcactgca gagccctcct gcgcgccgcc tagagaagga ggacttgggg tcccagcgcg
       61 cagcatggag tggggttacc tgttggaagt gacctcgctc ctagccgcct tggcggtgct
      121 acagcgctct agcggcgctg ccgcggcttc ggccaaggag ctggcgtgcc aagagatcac
      181 ggtgccgttg tgcaaaggca tcggttacaa ctacacttac atgcccaacc agttcaacca
      241 cgacacgcaa gatgaggcgg gcctagaggt gcaccagttt tggccgctgg tggagataca
      301 gtgctccccg gacctcaagt tctttctgtg tagcatgtac acgcccatct gcctggagga
      361 ctacaagaag cctctgccgc cttgtcgctc tgtgtgtgaa cgcgccaagg ccggctgcgc
      421 gccgctcatg cgccagtacg gctttgcttg gcctgaccgc atgcgctgcg atcggttgcc
      481 ggagcagggc aacccggaca ctctgtgcat ggactacaac cgcaccgacc tcaccacggc
      541 cgcgcccagc ccaccgcgcc gcctgcctcc gccgcctcct cccggcgagc agccgccctc
      601 tggcagcggc cacagccgcc cgccaggggc caggccccca catcgtggcg gcagcagtag
      661 gggcagcggg gacgcggcgg ctgcgccccc ttcgcgcggc gggaaggcga ggccccctgg
      721 tggcggcgct gctccctgcg agccggggtg ccagtgccgc gcgcccatgg tgagcgtgtc
      781 cagcgaacgc cacccgctct acaaccgcgt caagaccggc cagatcgcca actgtgcgct
      841 gccctgccac aaccccttct ttagccagga tgagcgcgcc ttcaccgtct tctggatcgg
      901 cctgtggtcg gtgctctgct tcgtctccac cttcgccact gtctctacct tcctcatcga
      961 tatggagcgc tttaagtacc cggaacggcc catcatattc ctctccgcct gttacctctt
     1021 cgtgtctgtc gggtacctgg tgcgcctggt ggcaggacat gagaaagtgg cctgcagcgg
     1081 cggcgctccg ggtgctggcg gagctggggg tgcgggcggc gcggcggcgg ctggcgcagg
     1141 ggcagcggga gcgggggcga gcagcccggg cgcgcgcggc gagtacgagg agctgggtgc
     1201 agtcgagcag catgttcgct atgaaaccac tggccccgcg ctgtgcacgg tggtctttct
     1261 ccttgtctac ttttttggca tggccagctc catctggtgg gtaatcctgt cgctcacgtg
     1321 gttcttggca gctggcatga agtggggtaa tgaggccata gcaggctact cgcagtactt
     1381 ccacctggcc gcgtggcttg tgcccagcgt caagtccatc gcggtgctgg cgctcagctc
     1441 cgtagacggc gacccggtgg cgggcatctg ctacgtgggc aaccagagcc ttgacaacct
     1501 acgcggcttt gtgctggcgc cactggttat ctacctcttc attgggacta tgtttctgtt
     1561 agctggcttc gtgtcgctgt tccgaatccg ttcagtcatc aagcagcaag gaggcccaac
     1621 taagacacac aagctagaaa aactcatgat ccgcttgggc ctcttcaccg tgctctacac
     1681 ggtgcccgct gccgtcgttg tcgcctgcct tttctatgag cagcacaacc gaccgcgctg
     1741 ggaggccacg cacaactgcc catgccttcg ggacctgcaa ccggaccagg ctcgcaggcc
     1801 cgattacgcg gtcttcatgc tcaagtactt catgtgccta gtagtgggca tcacatcggg
     1861 cgtgtgggtc tggtccggca agactctgga gtcctggcgc gcgttgtgca ctaggtgctg
     1921 ctgggccagc aagggcgctg cagtaggcgc gggcgctgga ggcagcggcc ctgggggcag
     1981 tggacccggg cccggcggag gtgggggaca cggcggaggc gggggatccc tctacagcga
     2041 cgtcagtacc ggcctgacgt ggcggtctgg cacggccagc tctgtatctt accctaagca
     2101 aatgccattg tcccaggtct gaaccctacg tggatgccca gaaggggcgg agaggagtgg
     2161 ggggatggag aacccgtggg cggcgaaggg accccagacc ggccagggtt cccacccctt
     2221 cccagtgttg actgctatta gcatgataat gaactcttaa tggtatccat tagcagcggg
     2281 gacttaaatg actcccttag aacaaagtac ctggcattga agcctcccag acttagcccc
     2341 tcctctctga tgccccagca cttaccccag acaatggttt cagtgggtta ggatagttgg
     2401 aaccctcctg gataccctgg atgagtcttg agggtacact acactacacc gcagacttca
     2461 tccaaggtcc tgcttcaccc tcgacttcat ctgcatcaat tcatgccctc atacacccta
     2521 gaggagggac aactgctacc ttgtgggact gcacagtttg ggtattctta atgaccaggc
     2581 agatgcctta aataaacaag aaatgtctta attatacacc ccaagtaaat acgggtttct
     2641 tacattaaag gatgtattta tataattatt tgttaggttg taaaaaaaaa gtgtaaaata
     2701 tgtatatatc caaagatata caatgtgtac attacttgta aaaagtttag aggctaccct
     2761 gtaagaacaa atataagtat tctattttgt caataaaaag acttttgata aatgatttaa
     2821 gtaccaccct gtcccccacc tctcctgaac tgttcccctt atgcttgctg aggacatgtg
     2881 aggaaatgga aattttctgg cttgccattt tgtactgaca gtagacctgt taacctctaa
     2941 ttcttaaact gttagcaaag taaatgtcat tgttgaaatg aaatcaaaat cgcgtttttg
     3001 cactttcccc aaaaatgatg tttttcatgg tctctccttg ctgacctatg ggttacagct
     3061 cttcatggtg tgtgtggatg gacagtttgc taaggtggcc attctacttg gcctgtttat
     3121 ttggctgata gaatgctaat gccacttaaa ttgcagccct atgtgaatga gtatcttcag
     3181 tctgtgattt tgaaagcact ggccttttac agagctggct gcactcagaa atgtggaggt
     3241 tagtatttaa ggccacaggt cacctctata ctgtaagtca cttgacaatc tggtgtagca
     3301 gagcaggtgc tggctaacag attaaacgaa tgggttaact tcttaa
//
