LOCUS       NM_008057               4840 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus frizzled class receptor 7 (Fzd7), mRNA.
ACCESSION   NM_008057
VERSION     NM_008057.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4840)
  AUTHORS   Long,H., Zhang,H., Ran,L., Xiang,L., Xie,P., Zou,L., Yi,L.,
            Tang,X., Chen,L., Li,Q. and Zhao,H.
  TITLE     Bioinformatics analysis and experimental validation reveal the
            anti-ferroptosis effect of FZD7 in acute kidney injury
  JOURNAL   Biochem Biophys Res Commun 692, 149359 (2024)
   PUBMED   38071893
  REMARK    GeneRIF: Bioinformatics analysis and experimental validation reveal
            the anti-ferroptosis effect of FZD7 in acute kidney injury.
REFERENCE   2  (bases 1 to 4840)
  AUTHORS   Zhu,X., Xu,M., Leu,N.A., Morrisey,E.E. and Millar,S.E.
  TITLE     FZD2 regulates limb development by mediating beta-catenin-dependent
            and -independent Wnt signaling pathways
  JOURNAL   Dis Model Mech 16 (3) (2023)
   PUBMED   36867021
REFERENCE   3  (bases 1 to 4840)
  AUTHORS   Gu,N.X., Guo,Y.R., Lin,S.E., Wang,Y.H., Lin,I.H., Chen,Y.F. and
            Yen,Y.
  TITLE     Frizzled 7 modulates goblet and Paneth cell fate, and maintains
            homeostasis in mouse intestine
  JOURNAL   Development 150 (4) (2023)
   PUBMED   36691900
  REMARK    GeneRIF: Frizzled 7 modulates goblet and Paneth cell fate, and
            maintains homeostasis in mouse intestine.
REFERENCE   4  (bases 1 to 4840)
  AUTHORS   Murphy,P., Armit,C., Hill,B., Venkataraman,S., Frankel,P.,
            Baldock,R.A. and Davidson,D.R.
  TITLE     Integrated analysis of Wnt signalling system component gene
            expression
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831952
REFERENCE   5  (bases 1 to 4840)
  AUTHORS   Do,M., Wu,C.C.N., Sonavane,P.R., Juarez,E.F., Adams,S.R., Ross,J.,
            Rodriguez Y Baena,A., Patel,C., Mesirov,J.P., Carson,D.A.,
            Advani,S.J. and Willert,K.
  TITLE     A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor
            Regression in Preclinical Models
  JOURNAL   Mol Cancer Ther 21 (1), 113-124 (2022)
   PUBMED   34667113
  REMARK    GeneRIF: A FZD7-specific Antibody-Drug Conjugate Induces Ovarian
            Tumor Regression in Preclinical Models.
REFERENCE   6  (bases 1 to 4840)
  AUTHORS   Borello,U., Buffa,V., Sonnino,C., Melchionna,R., Vivarelli,E. and
            Cossu,G.
  TITLE     Differential expression of the Wnt putative receptors Frizzled
            during mouse somitogenesis
  JOURNAL   Mech Dev 89 (1-2), 173-177 (1999)
   PUBMED   10559494
REFERENCE   7  (bases 1 to 4840)
  AUTHORS   Sheldahl,L.C., Park,M., Malbon,C.C. and Moon,R.T.
  TITLE     Protein kinase C is differentially stimulated by Wnt and Frizzled
            homologs in a G-protein-dependent manner
  JOURNAL   Curr Biol 9 (13), 695-698 (1999)
   PUBMED   10395542
REFERENCE   8  (bases 1 to 4840)
  AUTHORS   Austin,T.W., Solar,G.P., Ziegler,F.C., Liem,L. and Matthews,W.
  TITLE     A role for the Wnt gene family in hematopoiesis: expansion of
            multilineage progenitor cells
  JOURNAL   Blood 89 (10), 3624-3635 (1997)
   PUBMED   9160667
REFERENCE   9  (bases 1 to 4840)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   10 (bases 1 to 4840)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY233527.1, BC049781.1 and AK010239.2.
            
            On Oct 25, 2007 this sequence version replaced NM_008057.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               BY233527.1         46-322
            278-3450            BC049781.1         1-3173
            3451-4801           AK010239.2         1032-2382
            4802-4840           BC049781.1         4521-4559
FEATURES             Location/Qualifiers
     source          1..4840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 30.08 cM"
     gene            1..4840
                     /gene="Fzd7"
                     /gene_synonym="Fz7"
                     /note="frizzled class receptor 7"
                     /db_xref="GeneID:14369"
                     /db_xref="MGI:MGI:108570"
     exon            1..4809
                     /gene="Fzd7"
                     /gene_synonym="Fz7"
                     /inference="alignment:Splign:2.1.0"
     CDS             814..2532
                     /gene="Fzd7"
                     /gene_synonym="Fz7"
                     /note="frizzled-7; fz-7; mFz7; frizzled homolog 7"
                     /codon_start=1
                     /product="frizzled-7 precursor"
                     /protein_id="NP_032083.3"
                     /db_xref="CCDS:CCDS14985.1"
                     /db_xref="GeneID:14369"
                     /db_xref="MGI:MGI:108570"
                     /translation="MRGPGTAASHSPLGLCALVLALLGALPTDTRAQPYHGEKGISVP
                     DHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFL
                     CSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEIC
                     VGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTAMSPSDGRGRLSFPFSCPRQLKVPPYL
                     GYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVD
                     MRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGC
                     TILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTI
                     TILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRT
                     IMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKS
                     YAVPCPPGHFSPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSS
                     KGETAV"
     regulatory      4790..4795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzd7"
                     /gene_synonym="Fz7"
                     /note="hexamer: AATAAA"
     polyA_site      4809
                     /gene="Fzd7"
                     /gene_synonym="Fz7"
                     /note="major polyA site"
ORIGIN      
        1 ggctcccagg cgttactccg cgctccttcc ctggcgggcg gtgctggacg cggagagtcg
       61 cgggctggga ctgcgcgggg caggagaggc cgggtgcagg caggccgcgg gtgcaggggc
      121 ctcggcgctt cggattccgt gcaactccgt ttccaaaacc agcttgtcca gctcttacct
      181 cccgagcacc gatcagactc aaagcgagaa cgagccattt gacttgaaac ttggggccga
      241 ccttcctagg actgaaggag gctccagaat cagaagaggc ggctgcagtg gcccgcgggg
      301 cctcaaggag agaaggcgga gcagcaccac cgaggcgacg gccggggcga gcaggcaggg
      361 acgcagggcg ctggcctggc ggaggcctgg ctcggtttag gggacgtgcg tatcggcgtg
      421 cgcccggggc tcgagaaact tgggcaaact ttgaagggta accggagaag cttgttgctc
      481 gtcgccgcag agaaagccgc accgttacgt ctcggcgggg agggtaaggc gacacccctt
      541 ccctcgatcc cccactccag gcccaggagt ttgaacctcc ggcggctgcg tgagtgccac
      601 gcggaggcgg ctgcggcgcc ccctcggctg gcggcctcgc ccccgctgtg caggcaccct
      661 agcaccctcg gctccgcgcc gcccacggcc cggccccggc gccgggagga ctctcatgcg
      721 ccgggcgcgg cggcgcctcc ctgtatccaa gcctctcccc agcgcctcgt ctttttcctc
      781 cagctgagaa cgccgctgca ctcgcgaccg gcgatgcggg gccccggcac ggcggcgtcg
      841 cactcgcccc tgggcctctg cgccctggtg cttgctcttc tgggcgcgct gcccacggac
      901 acccgggctc agccatatca cggcgagaaa ggcatctcgg taccggacca cggcttctgc
      961 cagcccatct ccatcccgtt gtgcacggat atcgcctaca accagaccat cctgcccaac
     1021 ctgctgggcc acacgaacca agaggacgcg ggcctcgagg tgcaccagtt ctaccctctg
     1081 gtaaaggtgc agtgttctcc tgagctacgc ttcttcttat gctctatgta cgcacccgtg
     1141 tgcaccgtgc tcgaccaagc cattcctccg tgccgttcct tgtgcgagcg cgcccgacag
     1201 ggctgcgagg cgctcatgaa caagttcggc ttccagtggc cagagcggtt gcgctgcgag
     1261 aacttcccag tgcacggtgc cggcgagatc tgcgtggggc agaacacgtc cgacggctcc
     1321 gggggcgcgg gcggcagtcc caccgcctac cctactgctc cctacctgcc agacccacct
     1381 ttcactgcga tgtccccctc agatggcaga ggccgcttgt ctttcccctt ctcgtgtccg
     1441 cgccagctca aggtgccccc ctacctgggc taccgcttcc taggtgagcg tgactgcggt
     1501 gccccgtgtg agccgggccg tgctaacggc ctcatgtact ttaaagaaga ggagagacgg
     1561 ttcgcccgcc tctgggtggg tgtgtggtca gtgctgtgct gcgcctcgac gctcttcacg
     1621 gtgctcacct acctagtgga catgcgtcgc ttcagctatc cagagcgacc catcatcttc
     1681 ctgtcgggtt gctacttcat ggtggcagtg gcgcacgtgg caggcttcct gctagaggac
     1741 cgtgccgtgt gcgtggagcg cttctcggac gatggctacc gcacggtggc gcagggcacc
     1801 aagaaggagg gctgcaccat cctcttcatg gtgctttact tcttcggtat ggccagctcc
     1861 atctggtggg tcattctgtc cctcacttgg ttcctggcag ctggcatgaa gtggggccac
     1921 gaggccatcg aggccaactc gcagtacttt catctggccg cgtgggctgt gccagcggtc
     1981 aagacaatca ccattttggc catgggccag gtggatggtg acctactcag tggagtgtgc
     2041 tacgtgggcc tgtctagtgt ggatgcattg cggggcttcg tgctggcgcc cttgttcgtc
     2101 tacctcttca tcgggacgtc cttcctgttg gccggctttg tgtctctctt tcgcatccgc
     2161 accatcatga agcacgacgg caccaagaca gagaagctgg agaagctgat ggtgcgcatc
     2221 ggcgtcttca gcgtgctcta cacggtgccg gccaccatcg tgttggcctg ctacttttat
     2281 gagcaggcct tccgagagca ctgggaacgc acctggctcc tgcagacttg caagagctac
     2341 gctgtgccct gccctccggg ccacttctct cccatgagcc ccgactttac agtcttcatg
     2401 atcaagtacc tgatgaccat gatcgtgggc atcactacgg gcttctggat ctggtcgggc
     2461 aagaccctgc agtcatggcg tcgcttctac cacagactca gccacagcag caagggggaa
     2521 actgcggtat gagccccggt ccttacccac ccttgcctct tctacccttt tacaggagga
     2581 gaggcatggt agggagagaa ctgctgggtg ggggcttgtt tccgtaagct acctgccccc
     2641 tccactgagc tttaacctgg aagtgagaag ttatttggag gtgagaagag atttggggcg
     2701 agagatggtt ttgagaggag gcccagatga aaaaaggcaa aggcagtggc cgaaaagact
     2761 tctggctaag acttgcagga cgatgctaac tgtgaaagat atggaccggc tagggcctaa
     2821 gggaaaggtt gagaccagca gagagagaga ctggtgaggt tttcaggcgc cagagatgag
     2881 ccagggctgt gagtccaatc ccctgctgca aggcaagtgg ttgttctcac tctagtgaag
     2941 gggggctggg aggggagggt gataccgctc tgtctgtagc ctaggctttg tggccaagat
     3001 gggggggacc tcctgcggtg cccttgtcaa gtggtggtca aaccataatc tcttttcact
     3061 ggggccaaac tggagcccag atgggttaat ttccagggtc agaccttaca gtcctcctcc
     3121 cgggccccct cccgcctgct tttccttccc tactcctttc aagtctagta aaataagcat
     3181 ttggaaggcc gggccctgcc tgctagagtc ctagcgtgaa gttggttttc aagaggaggc
     3241 caagaaggcg agtgggagat acagtctgct actttttaat ttgttgctac tttttcattt
     3301 tctagggaag gcagagagaa aaagaatgtt ttatttggtt tcataccctg aaaaaaagtc
     3361 atgacttgtt gcttttcaaa acaggaacgc attcacacac acacacaccc catcccaccc
     3421 cccttgtctt tgttgtaaga gacaaagcgg gaaacaaaag tgtctccctg aggaaaggcc
     3481 taactgtgaa gccagcagct tttacaggca aagccacaga aatccgaggt tttcctttgg
     3541 ttgttaattt ggttgagata aacattcctt tttaaggaag agtgaagagc agctttcata
     3601 cccattcagg cacacgttct gacttggata aaggaaatgc taggagtttt gttatttgtt
     3661 ttaaacagat ttaattcaga acacatgatc taatagactc gtttgcttaa tgaaatctcc
     3721 tcccattcta cgcccccata acccaaattt tgatttttct gcccccttcc ttccgtccaa
     3781 tttgggattt ttgctgtttt tgttttgttg tgttttgttt ttcctccaga cagggtatct
     3841 ctgtgtagcc ctgactatcc aggaactggc tctgtagagc aggctggctt tgaactcaca
     3901 gacatccacc tgcctctgcc tctcaattgc tgggattaaa ggcatggtcc accaggcctg
     3961 gctccccttc ctaatttgta tctttcaaga cataacgctc acattagtaa agataaaaga
     4021 caaaaatttt aacttaaagg tttaaaagca ttttgccctc attttcttgt tctagagatg
     4081 taaacatcta tctatcagac acatgagctg accctttctc tctctggttg catgaggcga
     4141 gggcaagagg aatgatagcg aaggaagagg agagtttgag tcaggtttca agaaagtcat
     4201 taagggaagg tgaacttcaa agtgattctg gagttctttg aaatgtgcta gaagacttac
     4261 atttattaat cttaaatcgt gtacttctct ttttttccct gcaatagaag tctggttctt
     4321 tggcataatg taaagctgag cagagcatca tgggagttga cctttaccct acctttgaca
     4381 ctgactgtcc tccaattttg caatgttctt cagtttctca gagcagtttt taatgccagc
     4441 caggggggga ttgtcgggag gacagattac ttcatatgtg tcctgttcag ttgaatggag
     4501 ctgcttttac aattaaagtg atcttgtatt ttttaaactt tcaaagtgat ctcacctgtc
     4561 agaatttttt taagctgcca ctacacaggt ttggcatctt ttgtgtttta tctctttaag
     4621 tgcatgtgaa atttgtaaaa tagagacagt gcagtatgta tattttgtaa atctcccatt
     4681 tttgtaagaa aatatatatt gtatttatac atttttactt tggatttttg ttttgtttac
     4741 ctttaaagat ctacaatgaa gccccacttt atcacatgta cagatcacga ataaattttt
     4801 taaaaaataa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
