LOCUS       NM_001162494            4086 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus frizzled class receptor 6 (Fzd6), transcript variant
            2, mRNA.
ACCESSION   NM_001162494
VERSION     NM_001162494.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4086)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   2  (bases 1 to 4086)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4086)
  AUTHORS   Paramore,S.V., Goodwin,K., Fowler,E.W., Devenport,D. and
            Nelson,C.M.
  TITLE     Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and
            widening independently of the planar cell polarity complex
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39225402
REFERENCE   4  (bases 1 to 4086)
  AUTHORS   Paramore,S.V., Trenado-Yuste,C., Sharan,R., Nelson,C.M. and
            Devenport,D.
  TITLE     Vangl-dependent mesenchymal thinning shapes the distal lung during
            murine sacculation
  JOURNAL   Dev Cell 59 (10), 1302-1316 (2024)
   PUBMED   38569553
REFERENCE   5  (bases 1 to 4086)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4086)
  AUTHORS   Sheldahl,L.C., Park,M., Malbon,C.C. and Moon,R.T.
  TITLE     Protein kinase C is differentially stimulated by Wnt and Frizzled
            homologs in a G-protein-dependent manner
  JOURNAL   Curr Biol 9 (13), 695-698 (1999)
   PUBMED   10395542
REFERENCE   7  (bases 1 to 4086)
  AUTHORS   Sarkar,L. and Sharpe,P.T.
  TITLE     Expression of Wnt signalling pathway genes during tooth development
  JOURNAL   Mech Dev 85 (1-2), 197-200 (1999)
   PUBMED   10415363
REFERENCE   8  (bases 1 to 4086)
  AUTHORS   Austin,T.W., Solar,G.P., Ziegler,F.C., Liem,L. and Matthews,W.
  TITLE     A role for the Wnt gene family in hematopoiesis: expansion of
            multilineage progenitor cells
  JOURNAL   Blood 89 (10), 3624-3635 (1997)
   PUBMED   9160667
REFERENCE   9  (bases 1 to 4086)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   10 (bases 1 to 4086)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB613669.1, CD348842.1, AC164883.5, AK138964.1 and BE648857.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088399.1, SRR7345562.932698.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BB613669.1         1-30
            31-718              CD348842.1         1-688
            719-1284            AC164883.5         148394-148959
            1285-3962           AK138964.1         2-2679
            3963-4086           BE648857.1         1-124               c
FEATURES             Location/Qualifiers
     source          1..4086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15"
     gene            1..4086
                     /gene="Fzd6"
                     /gene_synonym="Fz6; rst"
                     /note="frizzled class receptor 6"
                     /db_xref="GeneID:14368"
                     /db_xref="MGI:MGI:108474"
     exon            1..153
                     /gene="Fzd6"
                     /gene_synonym="Fz6; rst"
                     /inference="alignment:Splign:2.1.0"
     exon            154..492
                     /gene="Fzd6"
                     /gene_synonym="Fz6; rst"
                     /inference="alignment:Splign:2.1.0"
     exon            493..689
                     /gene="Fzd6"
                     /gene_synonym="Fz6; rst"
                     /inference="alignment:Splign:2.1.0"
     exon            690..1707
                     /gene="Fzd6"
                     /gene_synonym="Fz6; rst"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1856
                     /gene="Fzd6"
                     /gene_synonym="Fz6; rst"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2276
                     /gene="Fzd6"
                     /gene_synonym="Fz6; rst"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..4083
                     /gene="Fzd6"
                     /gene_synonym="Fz6; rst"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4061..4066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzd6"
                     /gene_synonym="Fz6; rst"
                     /note="hexamer: AATAAA"
     polyA_site      4083
                     /gene="Fzd6"
                     /gene_synonym="Fz6; rst"
                     /note="major polyA site"
ORIGIN      
        1 agtctcgcgg gatcgcccag ctctcgctcc ccgttgcggc cccggaggcg gtcgaggccc
       61 ggacgctgcc ccccaccgaa agctcgcccc ggctgtctgg ggtggcgggg ccgcgcgacg
      121 ccgagggaca gccaccttcc tctgccgccc gagcagttgc cccagaattc attttcagga
      181 aacagcttct atcaaaatgg tacaaagaat gcaatgagga atttgtacat tttatctctg
      241 atttgagaat ctttttgatg cggaaaggag cataagaata atccaagcca tgtggtaaaa
      301 tcggagtctg gcaagatgga aaggtccccg tttctgttgg cgtgcattct tctgcccctc
      361 gtaagaggac acagcctttt cacctgtgag ccaatcaccg ttcccagatg tatgaaaatg
      421 acttacaaca tgacgttctt ccctaacctg atgggtcatt atgaccaggg gatcgctgct
      481 gtggaaatgg ggcactttct gcatcttgca aatctagaat gttcaccaaa cattgaaatg
      541 ttcctttgcc aagcttttat accaacctgc acagagcaaa ttcatgtagt tctaccctgt
      601 cggaaattgt gtgagaaaat agtttctgat tgcaaaaaac taatggacac ttttggcatc
      661 cgatggcctg aagaacttga atgtaacaga ttgccacact gtgatgacac tgttcctgta
      721 acttctcatc cacacacaga gctttctggg ccacagaaga aatcagatca agtcccaaga
      781 gacattggat tttggtgtcc aaagcacctt aggacttccg gggaccaagg ctataggttt
      841 ctgggaattg aacagtgtgc ccctccgtgc cccaatatgt attttaaaag tgatgaacta
      901 gactttgcca aaagtttcat aggaatagtt tcaatatttt gtctttgtgc aactctgttc
      961 acgttcctta catttttaat tgacgttaga cgattcagat acccagagag accaattatc
     1021 tattactctg tctgctacag cattgtctct ctcatgtact tcgtggggtt tttgctgggc
     1081 aatagcacgg cttgtaataa ggcagacgag aagctggagc tcggggacac cgttgtccta
     1141 gggtcaaaga ataaggcttg cagtgtggta tttatgtttc tgtatttttt tacaatggct
     1201 ggcaccgtgt ggtgggtgat tctcaccatt acgtggttct tagctgccgg gagaaaatgg
     1261 agttgcgaag ctattgaaca aaaagcagtg tggttccatg ccgttgcctg gggggcgccc
     1321 gggttcctga ccgtcatgct gctcgctatg aataaggttg aaggagacaa cattagcggc
     1381 gtttgcttcg ttggcctgta tgacctggac gcctctcgct acttcgtcct tctgcctctg
     1441 tgcctctgcg tatttgttgg gctgtctctc ctcttagccg gcatcatctc cttgaatcat
     1501 gtccgacaag tcatacagca tgatggccgg aaccaagaga agctaaagaa attcatgatt
     1561 cgcatcggag tcttcagtgg cctgtatctt gtgcccttag tgacacttct cggttgctat
     1621 gtctatgagc tagtgaacag gatcacctgg gagatgacat ggttctctga tcattgtcac
     1681 cagtaccgca tcccgtgccc ttaccaggca aatccaaaag ctcgaccaga attggcttta
     1741 tttatgataa aatatctgat gacattaatt gttggtatct ctgcggtctt ctgggttgga
     1801 agcaaaaaga cgtgcacaga atgggccggg ttctttaagc gaaaccgcaa gcgagacccc
     1861 atcagtgaga gccgccgagt gctgcaagag tcctgtgagt tcttcctgaa gcacaactct
     1921 aaagtgaagc acaagaagaa gcatggcgca ccagggcctc ataggctgaa ggtcatttcc
     1981 aagtccatgg gaactagcac aggagcgacc acaaatcatg gcacctctgc catggcaatc
     2041 gctgaccatg attacttagg gcaagaaact tcaacagaag tccacacctc cccagaagca
     2101 tccgtcaaag agggacgagc agaccgagca aacactccca gcgccaaaga tcgggactgt
     2161 ggggaatctg cagggcccag ttccaagctc tctgggaacc ggaacggcag ggaaagccga
     2221 gcgggcggcc tgaaggagag aagcaatgga tcagaggggg ctccaagtga aggaagggta
     2281 agtccaaaga gcagcgttcc tgagactggc ctgatagact gcagcacttc acaggccgcc
     2341 agttctccag aaccaaccag cctcaagggc tccacatctc tgcctgttca ctcagcttcc
     2401 agagctagga aagagcaggg tgctggcagc cattccgacg cttgaagaaa actgtctcgt
     2461 tcccccagaa gcacatgtat gttacactgg agatgaccaa ctgatttgtc ttataaaggc
     2521 cactgttgag ctgggagagt agcccagtgg tacagcgccc acctggaata cttgaggacc
     2581 tggggttgtc tcccagcact gcaaaaggaa aattcactgt tacagtcttc cttgcactta
     2641 aaccagcttt gtctattgtt tttttggttt ggcttttatt tttgttgctg ttatttttgt
     2701 tgttgtttgt ttgttttttt gtttgtttgt ttgagacagg gtttctttgc tagccctgac
     2761 tgtcctgaaa ctccctctgt agaccaggct ggcctcaaac ttacagagat ctgcctgcct
     2821 cagcctcccg agtgctggga ataatggtgt ggtcaccact gcccagcctt ttgtctgttt
     2881 ttaaacttga aagaaacaac agcccagatt tcaaaaataa tataatgcat ttatacctaa
     2941 aaaaccaacc aggagtgccc agttaataac actttttaaa tgtggggatg ggaagggcat
     3001 tagaggagtc ttccttctat tgaagattca ttaaagtatt ttaagatatg ctctttcact
     3061 ctttatataa atccaagatt tttctttgct gaagtattta aaacttttgt acctttatat
     3121 gtagatatga atttgaaaat atgcttatgt gtatttgaac ttttgaaaat cctagagaat
     3181 tgaatcaaat atttttatga tgtttttcta ctattttagc tactttgcga ctgtgatagc
     3241 tgttacactg gatttttaaa aaacttgtac agcagcctct ttacagtaaa aagagtgggt
     3301 gtcacactga aaggtctgta agaagtggtc acagccaccc ctaccttccc caaaaggagg
     3361 aacttggtgg caggtccctc cctgattgga ctgtcccttt ctttctgcat gttataaatc
     3421 agcaggtaag atggtaggtt tttacaagtt aggccgagct gtcgattccc cttttaagtg
     3481 ttgaattagg attgaattat ggccatttgt agttgctcgt gcctgtcttt attttagtat
     3541 tttatttccc gagacaggaa ctcactgtgt ggtgctcctt ggctgtctgg tgttcagtct
     3601 gtcccaggca ggtcacagag atctccccct ctgcagccca ctcatctctc ccaagccacc
     3661 acactcagct tttatctgtt ttaaaaattt aaacttaaaa aaatgttttt ggaatagtac
     3721 aaacacattg tgttgtaaat ttctttgatg ctatgcaaaa ttcctatctg catctaagcc
     3781 tgcaaaagaa aatgtgcgaa gggcagagtc agagttgggc aggaagagtg tagtgcagca
     3841 gatgcagcgt gaagacactg aaggtgctaa gacagcgtct cagtgctggt cctccttaag
     3901 gattatctcg ccagcgaggt tttcttagat actttgatcc cattggagct ctgttaaagt
     3961 ttaaaatgaa aattatcatg tactgtatgg gaaatgtaaa tactaacttt tccacatatg
     4021 taaacttcag acacaaattt ttttgtgtgt tcttttcatc aataaaattt tctttgtata
     4081 aaaaaa
//
