LOCUS       NM_022721               6912 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus frizzled class receptor 5 (Fzd5), transcript variant
            1, mRNA.
ACCESSION   NM_022721
VERSION     NM_022721.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6912)
  AUTHORS   Mu,Q., Ha,A., Santos,A.J.M., Lo,Y.H., van Unen,V., Miao,Y.,
            Tomaske,M., Guzman,V.K., Alwahabi,S., Yuan,J.J., Deng,L., Li,L.,
            Garcia,K.C. and Kuo,C.J.
  TITLE     FZD5 controls intestinal crypt homeostasis and colonic Wnt
            surrogate agonist response
  JOURNAL   Dev Cell 60 (3), 342-351 (2025)
   PUBMED   39579768
REFERENCE   2  (bases 1 to 6912)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 6912)
  AUTHORS   Zhang,L., Liu,X., Li,W., Liu,K., Zhang,J., Liu,X. and Wang,J.
  TITLE     Integrative transcriptomic profiling of ncRNAs and mRNAs in
            developing mouse lens
  JOURNAL   Front Genet 15, 1405715 (2024)
   PUBMED   38933921
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6912)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 6912)
  AUTHORS   Peng,S., Guo,M., Wu,C., Liu,J., Zou,B., Chen,Y., Su,Y., Shi,L.,
            Zhu,S., Xu,S., Guo,D., Ju,R., Wei,L., Wei,Y. and Liu,C.
  TITLE     Age and light damage influence Fzd5 regulation of ocular
            growth-related genes
  JOURNAL   Exp Eye Res 239, 109769 (2024)
   PUBMED   38154732
  REMARK    GeneRIF: Age and light damage influence Fzd5 regulation of ocular
            growth-related genes.
REFERENCE   6  (bases 1 to 6912)
  AUTHORS   Ishikawa,T., Tamai,Y., Zorn,A.M., Yoshida,H., Seldin,M.F.,
            Nishikawa,S. and Taketo,M.M.
  TITLE     Mouse Wnt receptor gene Fzd5 is essential for yolk sac and
            placental angiogenesis
  JOURNAL   Development 128 (1), 25-33 (2001)
   PUBMED   11092808
REFERENCE   7  (bases 1 to 6912)
  AUTHORS   Borello,U., Buffa,V., Sonnino,C., Melchionna,R., Vivarelli,E. and
            Cossu,G.
  TITLE     Differential expression of the Wnt putative receptors Frizzled
            during mouse somitogenesis
  JOURNAL   Mech Dev 89 (1-2), 173-177 (1999)
   PUBMED   10559494
REFERENCE   8  (bases 1 to 6912)
  AUTHORS   Austin,T.W., Solar,G.P., Ziegler,F.C., Liem,L. and Matthews,W.
  TITLE     A role for the Wnt gene family in hematopoiesis: expansion of
            multilineage progenitor cells
  JOURNAL   Blood 89 (10), 3624-3635 (1997)
   PUBMED   9160667
REFERENCE   9  (bases 1 to 6912)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   10 (bases 1 to 6912)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101915.7.
            
            On Oct 18, 2022 this sequence version replaced NM_022721.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030111.1, SRR17784645.1182674.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-616               AC101915.7         61251-61866
            617-6912            AC101915.7         62146-68441
FEATURES             Location/Qualifiers
     source          1..6912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.74 cM"
     gene            1..6912
                     /gene="Fzd5"
                     /gene_synonym="5330434N09Rik; Fz-5; Fz5; mFz5"
                     /note="frizzled class receptor 5"
                     /db_xref="GeneID:14367"
                     /db_xref="MGI:MGI:108571"
     exon            1..616
                     /gene="Fzd5"
                     /gene_synonym="5330434N09Rik; Fz-5; Fz5; mFz5"
                     /inference="alignment:Splign:2.1.0"
     exon            617..6912
                     /gene="Fzd5"
                     /gene_synonym="5330434N09Rik; Fz-5; Fz5; mFz5"
                     /inference="alignment:Splign:2.1.0"
     CDS             870..2627
                     /gene="Fzd5"
                     /gene_synonym="5330434N09Rik; Fz-5; Fz5; mFz5"
                     /note="frizzled-5; frizzled homolog 5"
                     /codon_start=1
                     /product="frizzled-5 precursor"
                     /protein_id="NP_073558.2"
                     /db_xref="CCDS:CCDS15008.1"
                     /db_xref="GeneID:14367"
                     /db_xref="MGI:MGI:108571"
                     /translation="MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGI
                     GYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPL
                     PPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASP
                     KSFPAKPTLPGPPGAPSSGGECPSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNC
                     AVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSA
                     CYLCVSLGFLVRLVVGHASVACSREHSHIHYETTGPALCTVVFLLVYFFGMASSIWWV
                     ILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYV
                     GNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRI
                     GIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGPDAGQPRAKPEYWVLMLKYF
                     MCLVVGITSGVWIWSGKTLESWRRFTSRCCCSSRRGHKSGGAMAAGDYAEASAALTGR
                     TGPPGPTAAYHKQVSLSHV"
     regulatory      6886..6891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzd5"
                     /gene_synonym="5330434N09Rik; Fz-5; Fz5; mFz5"
                     /note="hexamer: ATTAAA"
     polyA_site      6912
                     /gene="Fzd5"
                     /gene_synonym="5330434N09Rik; Fz-5; Fz5; mFz5"
                     /note="major polyA site"
ORIGIN      
        1 agagggcagt cagcctgcgg ccgcgacttg tcctctgccg tcgcgcacag ctcggagctc
       61 cctggaggtg ggcgaaagag tgcgagagcg cgggggagga gccgagcggg gcgcgtcccg
      121 agagcgccgc caccgccccc cggagtctgc tggagcgcgg agccccctgc aggggaggcg
      181 gcgagcggct ggcgggacgc ggcggcgggt gcggactatg cagtccccgc ccgaccagcg
      241 ctggctgctc gctgtgctgt gaggtggcgg ggtcccctcc ggctgccgca cccctccgcg
      301 cagttcaagt gctgcccggc gcccttgccc ttcgtcccgg ccccgggacg ccggtggaag
      361 gcacggcctg cccctgcctt gctctgcccg aatcatgcag ggggccccga aggaagagaa
      421 ggcgagtgac cggcccgcgc cgcccatggt cgaggggcgc cctgctctct gaaacgccct
      481 ccacctgctg ccatgtgtcg ccgccacagg tacctagctt gtcgttaaac tttcccagct
      541 ctggcccgat tcggagtcgc gcgactgagg agcccggctg gtcgcagaca tctgccgccc
      601 agcaggatcc tccgagagtt ctgtccttgg agtcggagcc ctaatcatcc ctccagccct
      661 atctggtgtg gaactgagtg ctgccggcgg aggcagcgcc ttccagaaac agtttatctt
      721 tggacggatt tctttaagag aaaaagaaac caacaggttg ccagcccggg cgtcacactc
      781 aagactccgg agagggaagc cccggccgca gattcgtcgg ccaacgcaga ccctctcagg
      841 cagcgggagg caaagggaag aaggagacga tggctcgacc cgacccgtct gcgcctccct
      901 ctcttctgct gctgttgctg gcgcagctgg tgggccgggc agcggccgcc tccaaggccc
      961 cggtgtgcca ggaaatcacg gtgcccatgt gccgaggcat cggctacaac ctgacgcaca
     1021 tgcccaacca gttcaaccat gacacgcagg acgaagcagg cctggaggtg caccaattct
     1081 ggccgcttgt ggagatccac tgctcaccgg acctgcgctt cttcctgtgc tctatgtaca
     1141 cgcccatctg tttgcctgac taccacaagc cgctaccacc gtgccgttcc gtgtgcgagc
     1201 gcgccaaggc cggctgctcg ccgctcatgc gccagtacgg cttcgcctgg cccgagcgca
     1261 tgagctgcga ccgcctccct gtgctgggcg gcgacgccga ggttctgtgt atggattata
     1321 accgaagcga agccaccacc gcgtccccta agtccttccc ggccaaacct acactcccag
     1381 gaccaccagg ggcgccatct tccgggggcg agtgcccctc gggaggccca tccgtgtgca
     1441 cgtgccgcga gcccttcgtg cccatcctga aggagtcaca cccactctac aacaaggtgc
     1501 gcaccggcca agtgcccaac tgcgcggtgc cctgctacca gccgtccttc agcccggacg
     1561 agcgcacatt cgccaccttc tggattggcc tgtggtctgt gctgtgcttc atctccacgt
     1621 ccaccaccgt tgccaccttc ctcattgaca tggaacgatt ccgctaccct gagcgcccca
     1681 tcatcttctt gtctgcgtgc tacctgtgtg tgtcactggg attcttggtg cgcctggtag
     1741 tgggccatgc cagcgtcgct tgcagccgtg agcacagcca cattcactat gagactaccg
     1801 gccctgcgct gtgcacggtt gtcttcctct tagtctattt ctttggcatg gccagctcca
     1861 tctggtgggt catcctgtcg ctcacctggt tcttggcggc tggcatgaag tggggcaatg
     1921 aagccatcgc aggttatgca cagtacttcc accttgctgc ctggctcatc cccagtgtca
     1981 agtccattac ggcgctggca ctgagctcgg tggacgggga cccagtggct ggcatctgct
     2041 atgtgggcaa ccaaaacctg aactcactac gaggctttgt cttgggccca ctggtgctgt
     2101 acctgttggt gggcacgctc ttccttctgg caggcttcgt gtcactcttc cgcatccgga
     2161 gcgtcatcaa gcagggtggc actaagacgg acaagctaga gaagctcatg atccgcatcg
     2221 gcatcttcac cctgctctac acggtgccag ccagcatcgt ggtggcctgc tacctgtatg
     2281 agcagcacta ccgggagagc tgggaggcag ccctcacctg cgcgtgtccg ggaccggacg
     2341 ctggccagcc acgcgccaaa cccgagtact gggtgctcat gctcaagtac ttcatgtgcc
     2401 tggtggtggg catcacgtcg ggagtctgga tctggtccgg caagactctg gagtcttggc
     2461 ggcggttcac cagccgctgc tgctgcagct ctcggcgggg ccacaagagc ggtggcgcta
     2521 tggccgcagg agactatgcg gaggccagcg ccgcgctcac cggcaggacc gggccgcctg
     2581 gccccaccgc cgcataccac aagcaagtgt ccctgtcgca cgtataggaa ggcctggagg
     2641 ccgaggccca gggacagtgc tggaagttga agggggcagt tgtttcgctt ggtagctttg
     2701 tgaaggtcac ttccgtttac cttcttggtg ctgatgcccc ctcccagagt ggcttggaga
     2761 ggaaaagggg gcggtttcaa gagattacct gtccccagtc ttctacaggg ggctcggctc
     2821 gcagggcagt gggttaagtg tattctagtt tgcatttctt actgctttct ttagaagtac
     2881 cttgttttta atttatatgt attttaagtt ttaactttgt tgcattttgg caacaaaatt
     2941 tacctttgct ttgggggcta cataatcctc aaattggcat tgtaatgagg ttactgttgg
     3001 ttcaggtttt tttggactgt gtggtctaaa ttaggaaaat atatttccta tacgtgtctt
     3061 tttttttttt ttttataaat gtgaacagtg aaaggctgct gtgagtggga aggtgtggag
     3121 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg ttttaaggta gtttcttctt acagtgctta
     3181 aaatgtccag gacacttaga ggccagaggc catctgctct ttctgtgtct agccccctca
     3241 agtcctctgt gaaagtagac catgatgtgg ttaggaccat ccctcacatg ataaggttag
     3301 agttttgtga gcctccttaa ccttgctcag caagcgttgg gctcttggca gccgagctgc
     3361 catctttctc atccccgata gagccagccg cccttgtcgt gtcttgaata agttagagga
     3421 ggcattatag agcggaccta aacatttgcc ttggagcctg agggatgggg attggctgaa
     3481 tgtgaattct gaactagtga ggtggtgagc cttctgctgg agagggtggc tcttaagatg
     3541 ctccagagag ccccaccccc accccccacc cccgagcttt tgagaataaa aaattaggct
     3601 acaaatttca gtaaaaataa attcactccc tttttctgga agtagttagg actctttgct
     3661 aaagggggct ctcttttaga ttaaaggaca aaaaacggat atgcttccag taattaaagt
     3721 aaattcccat tgcttcgaat ctgcggctcc ggcccacctc ctttatcatg ttaaacagtc
     3781 ctccttgctt ttcttattcc tcctggtgga gagtggtgat tagaaaccac acccacccac
     3841 caatgaagtg ctcagactgg gggagggagg ttagttacct gggaacaaac cttggctcag
     3901 ggggaaaaca aatggccctg aactcaaggt ttaaagccag atagatatat tccccaaagc
     3961 agctacacca tgccctagta gcctgaaaac caacaagact cctaacttaa gctttgtaat
     4021 atgggggcta ctgtaagtgt aaagccactg ctggagagac caggtttctt tcccccccct
     4081 tttgagagag cctgtatagt gatggacacc cccttaccca gtttccctgc tattagaaga
     4141 gtctgtttgc tttcctaatc tatttaacta ttcattcact aagagtgtgg ggccattact
     4201 gggaaggaaa tggcagggcg taccagtgac caaggcagag cggggactga atttagggat
     4261 ctaaaatggc caagccactg aaatgtcacc aagctttcct agagaaacag ctggagtcta
     4321 ggcatcccga ttttcttttg cagcagctgg ggggtgggtt gggggtaggg agagttaagc
     4381 ctgagccagc tttatgcccc agggactgag tggaaaaaag cgtagttccc actgggaatg
     4441 taagcagtca gagggtgttc acatttgtaa aatactctgc cctcgctcac tggagtcaga
     4501 attagaattt cagtggcttc cacaagacct tgtacaccta gatgcaggac tctgtgaagg
     4561 tcttattccg atgccctttt ccttccggga acctcaacac actcactggc tatgcaccac
     4621 ttctgttttt caaatgaggt tcttttctta tcaccttgcc ctcttgcctt gtttagcatg
     4681 gtcttcccag aatctgctgc tccctcccca cccacccccc ctcagtctgc tgtgcatagt
     4741 tagggttgtt cctctctcac aaagaaaatc gagaattgga catacagtgt atctaaaagt
     4801 tgtggggtgg agcggatgaa agtgatttaa ttcatctttt ttagaatgat tatttttttc
     4861 catctaagca acatgccaaa gctgtaaaaa aaaagaatga ttaataatac cctttgaaca
     4921 atacagcagt tgaagtgggc gcaatgctag agctggaggc cgggaatgcc tttggatgga
     4981 gcttcagagg cctggagttt tctgtcctct gctcccctct cccttaccct tagagagaca
     5041 aagcgcacct gcttccctga agccaacagg agtttctagc cagccctagg ggagggaaga
     5101 gggaagctgc cttcggatga ctaccccctc ttcccaccct cttcccaccg cacgttttcc
     5161 tccactttgc atatctgtac tgataacaag aagcgaaatg aaaagccttg ggggagttca
     5221 gcaacttgtg caccgccagc cttgtgtagc tgagaggact agggttggtc tcagatccag
     5281 ggcgcgtgcc tttggccacc tcactcacct ctcaacccct gggatgcttc acagattaga
     5341 gagtgaggat ttaggtagtt taaagaaaga agcaggacct caatgactcc gatggccaga
     5401 tattaggaag gctttttgtt ttttaaattt atataatttc cctcctcaca ttttgaagtt
     5461 gtctgagttg gaagaaaatc ctttttcttg gtgccttatt ggtttcttct tgcaatcctt
     5521 tttgtcacag tttcctgtga tcattaccag tggccagggc cagtgtgtgt gcgcgcgcgc
     5581 gcacgcttgc cttgtgtgca cttgtgcgca tgtacaagct taaataatgt gcggatggca
     5641 ctggttctaa gttggtattc attaggctgt tccctcctgg gccagggcag cactaatctt
     5701 gacaccggct gccaggagaa aacatcatgg atcatacact gaaccttaat aacagcatca
     5761 gtgacctgca ccggcgagtg tggctgggaa ccccagagct aggaagcacg gttgtatatt
     5821 ttaatgaact gctgcccctg ctaaggaagc tgctttcact tttgtgctct atctacagaa
     5881 agacccaggg gggtaggagg gacaaagctt tgaataagtg cgttctaaca ctggcaaaca
     5941 ggactgagca catcacaaat ccaggcaggt gtgaggtaca gcggctaaga attgtctgct
     6001 gcctctctct gccctttctt gtcgccaaag tccaatcaag tgatcctggg aaagaaacag
     6061 cctggcttgg ggagtgcgct cagaagggaa acctaacaag acagtaaaga agggtaggga
     6121 agatgtagct aacctgcttc agactctcag agccttctgg tagtgtggtg acaatcgcag
     6181 gattgatttc atccaggata gtgtctgtct gtggtacata attttaaaag aatattaatt
     6241 catgttgtta caaactatgt atagtatgta tgttttgtgg gtgtgtatat acgtaatata
     6301 tattatatat atatatatat gagagagaga gatttagtga cttttgatac gggttggtgc
     6361 aggtgaattt attactgagc caaatgaggc acataccgag tcagcagttg gagtccaggg
     6421 cattcagtgc tgtgcatggt tggcatacat gtacagtgcc tatcccgtgc agtaagaatc
     6481 accaccggca tgccacatcc agtactcaga actcagagcc agcaatattt tatttgtaga
     6541 caatcagctt gaatctatag attttatgac tggcaaatga ttataatcct gaacccataa
     6601 cgctcgcaaa aggagaccca gagcgtcttg gagagacgtt tggtttggtt ttgtgcctgg
     6661 gagtcagtca gtacaacagc aactgtatgt gcttatgtta gtctcaagat ccttaacttg
     6721 ttgaccttat tattttggaa atttttttgt attatatttg tgggaaggta aaataatgat
     6781 tttaagattt ttatcaaata tggagattag ttatttatga aaaacaaaga aatgtctatt
     6841 tttgtttctt tgttcccaat taatgtagat aactttttaa aatgcattaa agcaatggtg
     6901 aagaaaatgt aa
//
