LOCUS       NM_008055               3685 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus frizzled class receptor 4 (Fzd4), mRNA.
ACCESSION   NM_008055
VERSION     NM_008055.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3685)
  AUTHORS   Oh,S.A., Jeon,J., Je,S.Y., Kim,S., Jung,J. and Ko,H.W.
  TITLE     TMEM132A regulates Wnt/beta-catenin signaling through stabilizing
            LRP6 during mouse embryonic development
  JOURNAL   Cell Commun Signal 22 (1), 482 (2024)
   PUBMED   39385148
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3685)
  AUTHORS   Luo,X., Zhang,D., Zheng,J., Liu,H., Sun,L., Guo,H., Wang,L. and
            Cui,S.
  TITLE     Casein kinase 1alpha mediates estradiol secretion via CYP19A1
            expression in mouse ovarian granulosa cells
  JOURNAL   BMC Biol 22 (1), 176 (2024)
   PUBMED   39183304
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3685)
  AUTHORS   Bian,F., Goda,C., Wang,G., Lan,Y.W., Deng,Z., Gao,W., Acharya,A.,
            Reza,A.A., Gomez-Arroyo,J., Merjaneh,N., Ren,X., Goveia,J.,
            Carmeliet,P., Kalinichenko,V.V. and Kalin,T.V.
  TITLE     FOXF1 promotes tumor vessel normalization and prevents lung cancer
            progression through FZD4
  JOURNAL   EMBO Mol Med 16 (5), 1063-1090 (2024)
   PUBMED   38589650
  REMARK    GeneRIF: FOXF1 promotes tumor vessel normalization and prevents
            lung cancer progression through FZD4.
REFERENCE   4  (bases 1 to 3685)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3685)
  AUTHORS   Pokrajac,N.T., Tokarew,N.J.A., Gurdita,A., Ortin-Martinez,A. and
            Wallace,V.A.
  TITLE     Meningeal macrophages inhibit chemokine signaling in pre-tumor
            cells to suppress mouse medulloblastoma initiation
  JOURNAL   Dev Cell 58 (20), 2015-2031 (2023)
   PUBMED   37774709
REFERENCE   6  (bases 1 to 3685)
  AUTHORS   Sheldahl,L.C., Park,M., Malbon,C.C. and Moon,R.T.
  TITLE     Protein kinase C is differentially stimulated by Wnt and Frizzled
            homologs in a G-protein-dependent manner
  JOURNAL   Curr Biol 9 (13), 695-698 (1999)
   PUBMED   10395542
REFERENCE   7  (bases 1 to 3685)
  AUTHORS   Sarkar,L. and Sharpe,P.T.
  TITLE     Expression of Wnt signalling pathway genes during tooth development
  JOURNAL   Mech Dev 85 (1-2), 197-200 (1999)
   PUBMED   10415363
REFERENCE   8  (bases 1 to 3685)
  AUTHORS   Austin,T.W., Solar,G.P., Ziegler,F.C., Liem,L. and Matthews,W.
  TITLE     A role for the Wnt gene family in hematopoiesis: expansion of
            multilineage progenitor cells
  JOURNAL   Blood 89 (10), 3624-3635 (1997)
   PUBMED   9160667
REFERENCE   9  (bases 1 to 3685)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   10 (bases 1 to 3685)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ171654.1, AK044794.1 and AK049945.1.
            
            On May 14, 2008 this sequence version replaced NM_008055.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049945.1, SRR1660819.153889.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CJ171654.1         11-21
            12-1020             AK044794.1         2-1010
            1021-2649           AK049945.1         936-2564
            2650-2759           AK044794.1         2640-2749
            2760-2767           AK049945.1         2674-2681
            2768-3414           AK044794.1         2758-3404
            3415-3685           AK049945.1         3329-3599
FEATURES             Location/Qualifiers
     source          1..3685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 49.32 cM"
     gene            1..3685
                     /gene="Fzd4"
                     /gene_synonym="Fz4"
                     /note="frizzled class receptor 4"
                     /db_xref="GeneID:14366"
                     /db_xref="MGI:MGI:108520"
     exon            1..606
                     /gene="Fzd4"
                     /gene_synonym="Fz4"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1935
                     /gene="Fzd4"
                     /gene_synonym="Fz4"
                     /note="frizzled-4; fz-4; mFz4; frizzled homolog 4"
                     /codon_start=1
                     /product="frizzled-4 precursor"
                     /protein_id="NP_032081.3"
                     /db_xref="CCDS:CCDS21441.1"
                     /db_xref="GeneID:14366"
                     /db_xref="MGI:MGI:108520"
                     /translation="MAWPGTGPSSRGAPGGVGLRLGLLLQFLLLLRPTLGFGDEEERR
                     CDPIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVY
                     VPMCTEKINIPIGPCGGMCLSVKRRCEPVLREFGFAWPDTLNCSKFPPQNDHNHMCME
                     GPGDEEVPLPHKTPIQPGEECHSVGSNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEF
                     TDIWMAVWASLCFISTTFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVG
                     RERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLK
                     WGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVV
                     APLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATC
                     VIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCS
                     NRLVNSGKVKREKRGNGWVKPGKGNETVV"
     exon            607..3685
                     /gene="Fzd4"
                     /gene_synonym="Fz4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzd4"
                     /gene_synonym="Fz4"
                     /note="hexamer: ATTAAA"
     polyA_site      2978
                     /gene="Fzd4"
                     /gene_synonym="Fz4"
                     /note="major polyA site"
ORIGIN      
        1 agcgctgggg cggtgagaac agcgcggcgt agagtgcagg cgggcttcgc cgaaaagccg
       61 gactcggccg gcgccgagtt ctgggatcgc cgcctgcagc catgacccta gcagtccatc
      121 cctcggcccg ggctccggac gtctgatatc ccgcacattc tcgtacaact gctggagagg
      181 cgactgctgc ccccttgtcg cccttggcgc cttaccgcat tccctatccg gagttgggag
      241 cagcgcggcc accggcgccc ctgtgcaaac tgggggtgtc tgctagatca gcctctgccg
      301 ctgctgcccg cagctctggc catggcctgg ccgggcacag ggccgagcag ccggggggcg
      361 cctggaggcg tcgggctcag gctggggctg ctgctgcagt tcctcctgct cctgcggccg
      421 acactggggt tcggggacga ggaggagcgg cgctgcgacc ccatccgcat cgccatgtgc
      481 cagaacctcg gctacaacgt gaccaagatg cccaacttag tgggacacga gctgcagaca
      541 gacgccgagc tgcagctgac aactttcacg ccgctcatcc agtacggctg ctccagccag
      601 ctgcagttct tcctttgttc ggtttatgtg ccaatgtgca cagagaagat caacatcccc
      661 atcggcccgt gcggtggcat gtgcctttca gtcaagagac gctgtgaacc agtcctgaga
      721 gaatttgggt ttgcctggcc cgacaccctg aactgcagca agttcccgcc ccagaacgac
      781 cacaaccaca tgtgcatgga aggaccaggt gatgaagagg ttcccttgcc ccacaagact
      841 cccatccagc ccggggaaga gtgccactcc gtgggaagca attctgatca gtacatctgg
      901 gtgaagagga gcctgaactg tgttctcaag tgtggctacg atgctggctt gtacagccgc
      961 tcagctaagg agttcacgga tatttggatg gctgtgtggg ccagcctctg cttcatctcc
     1021 accaccttca ccgtgctgac cttcctgatt gattcatcca ggttttctta ccctgagcgc
     1081 cccatcatat ttctcagtat gtgctataat atttatagca ttgcttatat tgttcggctg
     1141 actgtaggcc gggaaaggat atcctgtgat tttgaagagg cggcagagcc cgttctcatc
     1201 caagaaggac ttaagaacac aggatgtgca ataattttct tgctgatgta cttttttgga
     1261 atggccagct ccatttggtg ggttattctg acactcactt ggtttttggc agccggactc
     1321 aagtggggtc atgaagccat tgaaatgcac agttcttatt tccacatcgc agcctgggct
     1381 attcccgcag tgaaaaccat tgtcatcttg attatgagac tagtggatgc cgatgaactg
     1441 actggcttgt gctatgttgg gaaccaaaat ctagatgccc tcactggctt tgtggtggct
     1501 cctctcttta cgtatttggt gattggaacg ctgttcattg cggcgggttt ggtggcctta
     1561 ttcaaaatcc ggtccaatct tcaaaaagac gggacaaaga cagacaagtt ggaaaggcta
     1621 atggtcaaga tcggggtctt ctcagtactg tacacggttc ctgcaacctg tgtgattgcc
     1681 tgttatttct atgaaatctc aaactgggca ctctttcgat attctgcaga tgactcaaac
     1741 atggcagttg aaatgttgaa aatttttatg tctttgctcg tgggcatcac ttcaggcatg
     1801 tggatttggt ctgccaaaac tcttcacacg tggcaaaagt gttctaaccg attggtgaat
     1861 tctgggaagg taaagagaga gaagaggggg aatggttggg tgaagccagg aaaaggcaac
     1921 gagactgtgg tataagacta gccggcttcc tcgttcctca ttgtgaagga agtgatgcag
     1981 ggaatctcag tttgaacaaa cttagaaaca cttcagccca cacacaccca cgtcagccca
     2041 ccaccactca cccaactcag catcagaaga ccaatggctt cactgcagac tttggaatgg
     2101 tccaaaatgg aaaagccagt tagaggtttt caaagctgtg aaaaatcaaa atgttgatca
     2161 ctttagcagg tcacagcttg gagtccgtgg aggtcccgcc tagattcctg aagcccaggg
     2221 tgatagtgtt tgctcctact gggtgggatt tcaactgtga gttgataaca tgcaaggaga
     2281 aagattaatt tttaaaaccc ttttaaattt taaatagtaa ctaggtcttg cagatagcaa
     2341 agtgatctat aaacactgga aatgctgggt tgggagacgt gttgcagagt tttatagttt
     2401 ggctggtcta acataaacat cttctggcct acactgtctg ctgtttagaa ctctgtagcg
     2461 cactcccaag aggtggtgtc aaaatccttc agtgcctttg tcgtaaaaca gaattgtttg
     2521 agcaaacaaa agtactgtac taacacacgt aaggtatcca gtggatttct ctctcctgaa
     2581 atttcaacat ccctaattct aggcagcccc tgttttcttc actttaaact aatgactcaa
     2641 aaaaaaaaaa ggttattttt ataggatttt ttttttttgc actgcagcat gcctaatgag
     2701 aggaaaaggg aaggtgattc actttctgac aatcacttaa ttcagagaaa aatgagattt
     2761 gctaagttga cttaccttac cgaccctaga gacctattgc attaagcaat gttaagcaat
     2821 tgggacttaa aatattttag tttgtgtgat tgcatctagg cagacgccag tctggaagaa
     2881 ctgaaatgtt aaatttcttg gcaactttgc attcacacag attaactgtg taatttgtgt
     2941 gtgtcaatta caattaaaag cacattcttg gaccatgaca tagtatactc aattgacttt
     3001 aaaactgtgg tcaacttgca ttcttagtgt gatagtgcct ttcccccctg tagcataaga
     3061 atgttatcgg agtttggtct acttgccaca atggagactt attcagcttt gcaaaggcaa
     3121 ctaaggacag cagatccaaa tacgtggtgc ataattgttc cttagtaatg gacaaaggtt
     3181 cttataagat ttcactggag gcagtgtggc ctggagtatt tatatgatgc ctaatgaacc
     3241 tccagaatgc tggccagagg ctggattggt tagcagggga tatggtgtag acggagtgaa
     3301 atgagctgca aagtctaaca gcacgagtct taattgcctt tgctggggta tccaaagcct
     3361 ttaaaattta tgctttaagt ccctcacaag gggggtaccc gctagcaacc tatcaaaagt
     3421 tgaagttctt ttaaaattgt gactggcctt tttcttaacc tgccttaggc cttttaatca
     3481 ccagatctct gggacaaaac attgtacatg tcacaggttg ctctccttgt atttcatgcc
     3541 tgtctgcttc agcaacttca gttatttatt gattcatgct tttagtaaga gagcccttaa
     3601 tgttttgtcc aatcctactt tgtggagaaa catttcatgg attccaaatc ccaaataggc
     3661 aaataggtgt tcaaattctg gaaat
//
