LOCUS       NM_021458              12742 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus frizzled class receptor 3 (Fzd3), mRNA.
ACCESSION   NM_021458
VERSION     NM_021458.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12742)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   2  (bases 1 to 12742)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   3  (bases 1 to 12742)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 12742)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12742)
  AUTHORS   Knapp,L., Sun,H., Wang,Y.M., Chen,B.J., Lin,X., Gao,N., Chen,P. and
            Ren,D.
  TITLE     Rab11a Is Essential for the Development and Integrity of the
            Stereocilia and Kinocilia in the Mammalian Organ of Corti
  JOURNAL   eNeuro 10 (6) (2023)
   PUBMED   37225424
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12742)
  AUTHORS   Sheldahl,L.C., Park,M., Malbon,C.C. and Moon,R.T.
  TITLE     Protein kinase C is differentially stimulated by Wnt and Frizzled
            homologs in a G-protein-dependent manner
  JOURNAL   Curr Biol 9 (13), 695-698 (1999)
   PUBMED   10395542
REFERENCE   7  (bases 1 to 12742)
  AUTHORS   Sarkar,L. and Sharpe,P.T.
  TITLE     Expression of Wnt signalling pathway genes during tooth development
  JOURNAL   Mech Dev 85 (1-2), 197-200 (1999)
   PUBMED   10415363
REFERENCE   8  (bases 1 to 12742)
  AUTHORS   Austin,T.W., Solar,G.P., Ziegler,F.C., Liem,L. and Matthews,W.
  TITLE     A role for the Wnt gene family in hematopoiesis: expansion of
            multilineage progenitor cells
  JOURNAL   Blood 89 (10), 3624-3635 (1997)
   PUBMED   9160667
REFERENCE   9  (bases 1 to 12742)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   10 (bases 1 to 12742)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB664692.1, BC050965.1, U43205.1, AC152169.2 and AC124489.2.
            
            On Apr 18, 2009 this sequence version replaced NM_021458.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050965.1, SRR7974084.24198.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BB664692.1         1-39
            40-1557             BC050965.1         1-1518
            1558-1558           U43205.1           1407-1407
            1559-2853           BC050965.1         1520-2814
            2854-11321          AC152169.2         135888-144355
            11322-12742         AC124489.2         1-1421
FEATURES             Location/Qualifiers
     source          1..12742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.09 cM"
     gene            1..12742
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /note="frizzled class receptor 3"
                     /db_xref="GeneID:14365"
                     /db_xref="MGI:MGI:108476"
     exon            1..132
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /inference="alignment:Splign:2.1.0"
     exon            133..652
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /inference="alignment:Splign:2.1.0"
     CDS             464..2464
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /note="frizzled-3; frizzled homolog 3"
                     /codon_start=1
                     /product="frizzled-3 precursor"
                     /protein_id="NP_067433.1"
                     /db_xref="CCDS:CCDS27212.1"
                     /db_xref="GeneID:14365"
                     /db_xref="MGI:MGI:108476"
                     /translation="MAVSWIVFDLWLLTVFLGQIGGHSLFSCEPITLRMCQDLPYNTT
                     FMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRL
                     CQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLNLVGDPTEGAPVAVQRD
                     YGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATL
                     FTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASSPAQYKAST
                     VTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAS
                     AWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLA
                     GIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWE
                     TTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSIFWVGSKKTCFEWA
                     SFFHGRRKKEIVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLA
                     MVDDQRSKAGSVHSKVSSYHGSLHRSRDGRYTPCSYRGMEERLPHGSMSRLTDHSRHS
                     SSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIEEDGTSA"
     exon            653..849
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1867
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2016
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2250
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..12742
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3508..3513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /note="hexamer: AATATA"
     polyA_site      3530
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
     regulatory      12714..12719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /note="hexamer: AATAAA"
     polyA_site      12742
                     /gene="Fzd3"
                     /gene_synonym="D930050A07Rik; fz-3; Fz3; mFz3"
                     /note="major polyA site"
ORIGIN      
        1 gggccgcgcg cctcgacgct cgcgaaggct cggcgcgcct gcggtcctcg gccgctcggg
       61 gaacctgagg gacgcgcggc tgcctgcggg gccagcggcg ctgcccggga gagcccggag
      121 gccggcggtg agctatttca acaagaaaga agccactctc ctcctaagat ggaatctgtg
      181 atttgggaat gcggttgatg gagttgctat gctggccaga tgtgcccaat gtaataaaat
      241 gaaaagaaga tacaagatga tgtcatcttc ccatattgtg aaaccaaaaa caaatgccct
      301 ttgtgagacc aggttaccag ttctttgaca gtacagggag tttttaaact gaggagccta
      361 acagataagg ggtactttca agctgagacc tgcaggcata tactgatcta aaacgcatct
      421 tgtgtagatc tgatcatccg agcctcattc tgatccagga agaatggctg tgagctggat
      481 tgtctttgat ctttggctct tgactgtgtt tctggggcag ataggtgggc acagtttgtt
      541 ttcttgtgaa cctataacct tgaggatgtg ccaagatttg ccttacaata ctaccttcat
      601 gcctaatctt ctgaaccatt atgaccaaca gactgcagct ttagcaatgg agcccttcca
      661 ccctatggtg aacctggatt gttctcggga ttttcggcca tttctttgtg cactctatgc
      721 ccctatttgt atggaatatg gacgtgtcac acttccctgc cgtaggctgt gtcagcgtgc
      781 ctatagcgag tgttcaaaac tcatggagat gtttggtgtc ccgtggcctg aagatatgga
      841 gtgcagtagg tttccagatt gtgatgagcc atatccccga cttgtggatt tgaatttagt
      901 tggagatcca actgaaggag ccccagttgc agtgcagagg gactatggtt tttggtgtcc
      961 cagagagtta aaaattgatc ctgatcttgg ctattccttt ctgcacgtgc gagattgttc
     1021 gccaccatgt cccaatatgt acttcaggag agaagaactg tcatttgctc gctatttcat
     1081 aggcctgatt tcaatcattt gcctctctgc cacattgttt acttttttaa cctttctaat
     1141 tgacgtcaca agattccgtt accctgaaag acctatcata ttttatgcag tctgctacat
     1201 gatggtgtca ttaattttct tcattgggtt tttgctggag gaccgagtag cctgcaatgc
     1261 atctagccct gcacagtata aggcttctac agtgacacaa ggatctcaca ataaggcctg
     1321 taccatgctc tttatggtac tatatttttt cactatggct ggcagtgtat ggtgggtaat
     1381 tcttaccatc acatggtttt tagcagctgt gccaaagtgg ggcagtgaag ctattgagaa
     1441 gaaagcattg ctgtttcatg ccagtgcctg gggcatcccc ggaactctaa ctatcatcct
     1501 tttagcgatg aataaaattg aaggtgacaa tattagtggc gtgtgttttg tcggcctcta
     1561 cgacgttgat gcattaagat atttcgttct cgctcccctc tgcctgtatg tggtagttgg
     1621 ggtttctctc cttttagccg gcattatatc cctaaacaga gttcggattg agatcccatt
     1681 agaaaaggaa aaccaagata agttagtgaa gttcatgatc cggattggtg ttttcagcat
     1741 tctctacctt gtgccactct tggttgtaat tggatgttac ttttatgagc aagcttaccg
     1801 cggcatctgg gagacaacat ggatccagga acgctgcaga gagtatcaca ttccatgtcc
     1861 gtaccaggtt actcagatga gtcgtccaga cctgattctc tttctgatga agtatctcat
     1921 ggctctcata gttgggattc cctctatatt ttgggttgga agcaaaaaga catgctttga
     1981 atgggccagt tttttccatg ggcgtaggaa aaaagagata gtgaatgaga gccggcaggt
     2041 gctccaggaa cctgactttg ctcagtcact cctgagggac ccaaatactc caattataag
     2101 aaaatcaaga ggaacttcca ctcaagggac atccacacat gcttcttcaa ctcagctggc
     2161 catggtggat gaccaaagaa gcaaagcagg gagtgtccac agcaaagtga gcagctacca
     2221 tggcagcctc cacaggtcac gggatggcag gtacactccc tgcagttacc gaggaatgga
     2281 ggagagacta cctcacggca gcatgtcacg gctgacggat cattccaggc acagtagttc
     2341 tcatcggctc aacgagcagt cccgacacag cagcatccga gacctcagta acaaccccat
     2401 gactcacatt acacatggca ccagcatgaa ccgtgttatt gaggaggatg gaaccagtgc
     2461 ttagtcttgt ctaaggtgaa atgtgtgctg ttgaaaagca ggttttagtt tttgccttcg
     2521 catggctggc tgctgtaact cactgtcgct ctgctttctt gggcagagtg tgcccactgg
     2581 gaaagtagat ctttgctctt tgtatcacat caaccctggg gtgtgaacac atcccaaacc
     2641 ctaaggatca tgtcatcaca aaagtaattc tttctaggct gtgaagagat gattgtctgg
     2701 tgagcatttt tataaacatg cttattttat atctagaaaa atcctctatg tgtggtgact
     2761 gctttgtagt gaattttcat ataatatgaa ctagttgtga aatgacattc tggtagctct
     2821 gttaataaaa caaagtttca gaattaaaga aaatttctat gcaaggttta tttctcagat
     2881 gaatactagg tctttgtagg tttatttcca cagagtgaaa aaaggaaccg tttttaaact
     2941 gtagaagact ttgataagcc agcaagagta ttttagctaa gataacagtg ccatggaaga
     3001 tctggttggc ctgtgggagg ttgtctcaaa gtctgtcagt cttcccccaa gatatgcagg
     3061 ctgtggatga gcactggagt agaggcagag atgagcattc ccctgtaatt ggattgggtt
     3121 ttgttttgta aatattactt ttatgggcta tgcttttata atatccatat gcatgataga
     3181 aacattttaa tttgtggcca tttttcccag gaaatagtag acaacttcat gttcatatat
     3241 gttctgtgga ggcatgcagt aaaataagca tcacacatta taaggggttt tagtggtaaa
     3301 aaaaaaagtt acaaatggca aaatattttc tgtgtattca ttgtcgtatt tttctacagt
     3361 gagatgtgat cttgccaaag ccattagacc ttggtaccca ggccctccta taatgagctg
     3421 attgtctgcc ccagattccc cagtagccag ttggctacag cttttgccca catccctatt
     3481 ttctgaatta ctctggttta cagctgaaat atatactctt aagtccaaaa tggtgatcga
     3541 cctgggttct tgaaaatcat tttaactaag tggagcatgg ttactctttc tgtgaatatc
     3601 gtttaatctt aaaaatatca agtaaaaacc tcttgacatt ttattttgta aagcttaaat
     3661 gatttaggtt atgaactgtg aactttattt gtatgaaatt gatcagaaag aaaaattctt
     3721 gaaaatgcta atatgtgatt cagaaaatat aagtgatcct cagccctgat tgcgggtaca
     3781 gatcactctg gaactctcag tagccaacat ctttctgtca ggtctgagtt gatgctttaa
     3841 aaacaaccag cttttcaggt gattgttagt gtagcccggc ttgaagctgt tcttttaagc
     3901 tcactttccc ctaaagatag gttgatggca tcagatttga ccacaggaag atggagccag
     3961 actcagtagt acacttacat tgtttcctga tatgcagttg cttcttactc tgctctaatc
     4021 cactataaaa tgcagaattc tcggctctcc tctctagaga gtcttactca ataaatcaaa
     4081 ggcagtagga tttcacaaat gtgtatttct aaaaatacca cagaagagtc ttagcaggtt
     4141 atccaagaat cacacccaga aaaaaaatat atatatatat accctagact ctggagaggt
     4201 ctggctttgc catatgctag ttttcaactt tgaacaagtc agcctccgtg agcctagctc
     4261 ctcttgttta aagatgaaga ttgaagatga atatctcctc tacctacctc acaaagttgt
     4321 caaattgaga tcaaatgaaa acaacagtct ggaagctctt tgaaactgaa gtgttgtgaa
     4381 atgtgcagga ttaagattct tgaggactaa agagctttat tggaggtcta ctgtagtaca
     4441 tttctagaca catgtttaat tcgtgtgtct gcttctctcg ccctttaaaa ctaggagtgc
     4501 ccacatgaca gaagagccag tttcctggta gccatgactt acttctgtca tgttgcttct
     4561 ccgaagtatg catcagtaga gattacccat tcttcataag acacatgtga gcatttggcc
     4621 ccacatgctt tctctttcct ctgtcttgcc agctttctcc ttggaactgg ggttaccact
     4681 tggagaggcc caaagtccct tataactgat aacttgtcta taaacagatc aataactcat
     4741 gaagcttctg tcagagaagc tccgggaaca gcatgagcaa accaaaacaa acatccacaa
     4801 accaaacagc agtgaagaga ggagaccagt gtgagctcaa agatgtcatc tgccaccatc
     4861 tgcatcactg cctattgcca agtgctagtt ggttgtcttt taaagtgggc caagtgtaga
     4921 cagtgaagag agcattgcca tgaaagtctc acctttgtgc ttccagagtt tgtgtgtgtt
     4981 gttgcatttc ctcttgcttt ggtagtggtg atgcgtatat ggataatgtt aaccttacag
     5041 tcaccttcac caagtaccat ccttcacttg ttctgtgcac tcagcacagt actgtttggt
     5101 ttaagtagct gttcaatttg ggccatgctc tttatcatgt tactgcgcca ggttttaaga
     5161 atcttttttt tttttttttt ttttgaagaa accattgaag aatgacagca gaacagttaa
     5221 ttccaaatct taacctgttt aacttgtctt gaacaagtct ggacagtttt cttaccatat
     5281 aggttacttt aatttctgtt gtgattggca tatgttaata cttagtgttt tctttgttca
     5341 attgacaacc aagaaaatga tagtgccctc taaaatgtta atattattaa aagggttttg
     5401 aaaagaactt tgattttagc aatatggttt tattcaataa ttaggcaaaa agatccaagg
     5461 cagtattaag ctcaaaacag taatttgttt cagagagcag ttgatgaata acaattagca
     5521 cagggcttag tacagagtaa gctttccagt aaatgtttag cgactagcta actacatggc
     5581 actcagacca tgagaattgt ttttatacac acacaccccc attgtgaatt tgttaaaaat
     5641 ctgtgtaaag taagaatctt ttcagtttca cacaaaaaag atgcaagaga taggaggttt
     5701 atagaaccta ggttcataag taaactcagg attcgtttaa gcttctttta tgcctttttg
     5761 tgacagctag gatgagaaaa gcttgggatt gcagaaacag gtcagtgggt aagtggacct
     5821 gctgctcttc caaaggaccc aagttcagtt cctccctccc ttgtgctcac agtgcctact
     5881 gtagctccag ctctggggat ctaacattcc cttctggcct cctgacacca acacacttgt
     5941 aacacacaca cataaataca aaatatgaaa aatgttcatt taattcaact atgtataatg
     6001 tatatacatt tacataaatt tgattactgt atatggaaat gcattggcat ttgtacatct
     6061 cttctggctt tccttccttt tcattttttg ttgttacagc cacatgagta ctgggacagg
     6121 cataggaaga gtaggcatgc ctccccatgc gctagactac aattgctttc tctaatctaa
     6181 ttctaatcct atttatcttt agtaattata ctgatacaga ataatgctta tctttcaaga
     6241 tccaaatctg agagagaaaa aacaatatta aaagtctgtt cagaccgcca ttttagtaga
     6301 cataggagtt tagttaactt atagtcagca catagtagta agtatgttta tccctgtgtt
     6361 ctctaactag gaagtctggc tttaaaggtt ttttaaagtt tcctctaata ttttgatcaa
     6421 aggtcgaggg agtacaaaat gcattaagtt caatatattt aactatgttg aatgataagt
     6481 tatatttacc tttttaccta aatagtcacc agaaacctat cttgcccttt tcggggattt
     6541 ttggggggat ggtagaattg tttataattg actctagttt tattagcacc acttcccata
     6601 gttaaaaatg ttttctactg tctaataatt caaaagttta aaatttgcca ggggtagtga
     6661 cacacatctt agcactccgg aggccgaggc aggagaatct cttgtgaggt catcctgatc
     6721 ttcatagtga gttccagggc agttaggact atatagaaga ccttgtctca aaaaagaaat
     6781 aaagattaag aaatcttaag gtaaagataa ttaaaaatta gtaattttta tttataaata
     6841 ttcagtgttc tattattcta ctcattacca ctatcgaatt agtacttttg actttttcga
     6901 gcttgttata tttcttaaag cagataagtg tattatttta ttagtagtat tatggcctta
     6961 agctttttgg tatataatcg ggcttgctca aatttgcaga cttttagatg attctttgtt
     7021 tttgctacct ggctttttaa aatttagaac tcaatggctt tgttttggca aggttttagt
     7081 taataactag taagaatgca ttgtgttatt ttaaaaaata tccaaggatt tttgagtcag
     7141 gaaagctgat atctagtttt gcctctcctt tcagtgagct ctgttaaccc gatagagcat
     7201 ttttgtttgc agttgaaagg aattcaggaa ttagattagg agtctcagat tccaccagac
     7261 tctaatttgt ttctcccttg accattttat agtcattgtt gagagctcac ttgtattgtc
     7321 ttcccataaa ctctgtttgc tcgatcagct tactcagcta aggcagctgc actctaggac
     7381 cccagtgtta gaaaagtatc ctgacagtgg gctccatttc cagccccctc acagactggc
     7441 tcaggctgat ctcagaggct taggtgtata tcccaggctg gctttgagct catggaactc
     7501 tcacccttgc caggcaagtg ctgggatttc agacatgcca ccatgttcta acttaagcga
     7561 tttttaaaag aggaaaatta tagataataa aagtaaaaga agttataaat accaggcatg
     7621 gcttttaatg ggaaaaattt agatgtcaac ataagttgat aaacaaaaga aatgacatga
     7681 tatttttgat atttgttctc ttaattatga atatagattt tctagtccag ccctcatacc
     7741 aaatgcattc tgtagagctg tagtgtagct cattgggaga gtacctccct agcatgtgtt
     7801 caaaataaaa tcagtgatga acagatcgct gacagcaccg gtccctttgc taattaaaag
     7861 gctgtcaggt ttttccagct ttcattagtg ttgtttttgc tgctgctgct gctgctactg
     7921 ctactactac tattactatt attttggttt ttcaagacaa tgtttctctg tgtagtcctg
     7981 gctgtcctgg aacttgctct gtagatcagg ctgaccttga actcagagat ctggttgcct
     8041 ctgcctccca cgtgagaggc ttaaagttat gtgccaccac tgcccagatt gattataaag
     8101 tctaaagaac ttagagaaat ggaatagaac tctttaactg cctcctcaac ttcattgaat
     8161 atgtgtagtt gcagattgcc acagaaaagc gatgaccgat tttaaaatat tagcaggatt
     8221 aggatttagc tcagcaatag acagggccat gggttcagtc ccagcattga aaataaaact
     8281 cataaaatat tgttagagat aaatgtgact tgttattgtt catttgtcct ggctttgcag
     8341 agaatattac cataaagttc ccttaattct cctggggcca gtgagatgac gtggcaggta
     8401 ctggcacttg ctgccgtgcc tgacagtgtt ggtttctagc ctagacactc atatgatggg
     8461 ggagagaaca gactcccaca agttgtcctt tgacctccac atgcgggttg tagtgcacat
     8521 gcacacacat aaacaaaata aattaataaa aaattgtaag tagtctttaa taaaacagat
     8581 tccaatagct tcatcctttc aatagaattc tcttgtaaat taatgacgct ttacatgaat
     8641 tggatcaagg aaatctcact tgctatcttc taatcttatg tgtttggatg ttctgcctgg
     8701 atctgtgtct gtgtaccatt tgaatgcctg gcactgaggg atcccctgaa ataaggctat
     8761 agagggttgt gtgccactat gtgggtgctg ggaatctaac cccagtcctg aaagatcttc
     8821 taaccactga gccattcctc cagcccaccc agttggaagg tgggtttctt agctctgact
     8881 gtctgcatcc cttcagacat cttgaatgcc ttggactgta gacatacagt gtacagttga
     8941 gactgaagtc tgatgagttc atagcattag gaagtaggta taggttgatg tactggtttc
     9001 tagtgggatt ttttttctaa ctatgtcagc tttgttgccc ctcccatccc ctttggttct
     9061 ggtgaacaag catgtgctag gcagccattc taccagtgag ctatatacac agcctcagcg
     9121 cctattagat ttccttagct acatttaatc ccttgtctta ggtctgtcac tggttctcag
     9181 aaattagatg ctcagtctct cagagagtcc tatggccata tgctgcataa tgatgcttta
     9241 gtcattttta gttaggaaac acatggcagc ctaaggcaag aggatcccaa ggttaagtcc
     9301 tgtttcagac accctgtcca tacagcagtg gtcccatagg gtcatatcac ttagtaacat
     9361 cataggcatg tgattcggtg agtgcatgct ctgacgttgc aaagtgaccc agttgcttag
     9421 caacatattc ctcggatgta ttctgccatt aaccataacc gttaacattt ttttaaattg
     9481 tctctaaaaa cagcacattt attttcagtt ttctggctct tacaagtcct tgttgttgca
     9541 tacattgact atgaagtcca gtttcaatga atattgggga ttgataatga gaagttctat
     9601 aagaaaaaaa agtaacccta gaggggtggt ttatagttat ccttcttttc tttttctgtt
     9661 tgtctagcca cccttccacc ctcagttttg aaaagctggc acatctcttc cctcagccct
     9721 gtctcaggtc attttcccag aactaatcgt gtcagcagaa gcacttacta tgaaatcatt
     9781 tttttaaaga aatctgcaca gtagattttt acattgagct gagatgaata tgccttgaaa
     9841 ataatataag tgtgaaattg tttaaatcat aaaatggatt ctctagcatg aaaatgtttg
     9901 tttaagctaa gtgtggggac tcacactgga atcccagtct cttgagaggc taagacagaa
     9961 gaattataca tttaaggcca tcttgtgctg catggtatat aattataggc caacctgagc
    10021 tacatagtaa gaccgtgtca aaaaccaagt agagggagaa ggggaaaggc attcagactc
    10081 tggaagctga ataaatgtgg attttgttat catttctctt tttatagtgc tccaacttcc
    10141 ccagaaccat ccagcttctc gtgttttatg tttgctttat tatttcccct gggactaggg
    10201 ccttgcctgc taccagagcc ttgcatatat tcggcaagtg ttccagctca ccagaccttg
    10261 gtcttttcta tcaggtatca aggccttgaa cttgctgtgt tgtgtagact agccttgaag
    10321 cttacattct tcccgcatgg cctcctgagt gccaaggttg cagtcgtgag cttctcatgt
    10381 acttaacatc agcttatatt tttccttcct tcctttcctt cctaattgtg tgtgtgtgtg
    10441 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtctgtc tgtgacgaat gtggaaccag
    10501 gcctttcttt tattatccac accttctgcc actgaaccat atctccagcc ctttaatacc
    10561 aactgcaaac agcttttctg cttttatttt cagtttctag attttgattt tgagtcttac
    10621 tttctcactg aagtttaaag ctttgtttcc tcgtggtaaa gtacacattg tcacctcccc
    10681 ctctcccccc gccagcttcc agagtacagt ttatagagcc tggagcatcg tgctggctta
    10741 tttcctttgt aggaactatt ataaaaatta attctcaaaa ttaaaatttt aaattaggaa
    10801 gtgttgtttt caagtccaac gtgatagata tatgtctata atcccagcat ttaggaggca
    10861 aggctaaatg aggccagagg attgccagga actgacggcc aggctgagct acataacaag
    10921 accctgtttt caaaaatgag aaaaaaaaat actctctaat attttaatct gataggttgg
    10981 aggagtattt atagaaacac gtatctatga taatagttat tcattgtctg taatacagaa
    11041 tatctaaatc ccatattaat gagctgtctc ttactttctt gtctcagtga acaactctgt
    11101 tgttgagtga tttctctgac acttgagctc aaggttctct cagtctgaat agttggaaat
    11161 actcttctaa gcatgtgaaa ttgctgtctt gggaggaagt aagcacatgt tagggactta
    11221 ggctgtttta gaagagatgt tagcttttca cctccactct tctcaggcta tcagaagaga
    11281 caactcttag gtcatctcaa aaactgctca gtcttgttgc tgaattcctg cttttaaaga
    11341 cactttatca acctgaagta aatacctttg agaacactta agatacataa gctcttcact
    11401 aagtctgtgt ttgattttca agcttttata agctgacata ctgtcacaat gtcaagggaa
    11461 tagtcgacaa ataccattta gaggtagact aatcccctgg tgtaataggt actcaatttt
    11521 tgccaactac agagttttat cctccaaaat aaatgaatgc catgctatac agccaacaca
    11581 tgttctgtaa gctttcatct aaagattttc tttatactta gctttctggt caggggaaca
    11641 aaggtataga aatataaaca cacagataag aatatgaaac tcctatccag gaaattctca
    11701 gttttatggt ccaaaaaggt ataaactagg ttgtttcaaa ctcagactaa attgccccat
    11761 attgttgtga gtaattcaaa tagttgcttg gagtcattac tcagtacccg ttgcactctt
    11821 ggagttattc tgggcgtctc agttctcgat gcattcttgt gttagacaaa ggtactttga
    11881 tttcagtaga gacttggtac acctcttcct cagtgatgcc cctcagtgag ccctaattta
    11941 gctgatctga tccccaaatg ctcagcctga aacctttcta gttcctactc gttccagtgg
    12001 ctctgatcag tctgtccaaa gtatgaccta cttcaagtgt taggaagaag caaattcaga
    12061 caattcatat taaattgtca gtgactataa tcttattatc ttgctgaaag agaaccaaac
    12121 acataaacat tgacagctct gctcaatgac aggaaattta caggtgaata ctgtccatgc
    12181 ttgctcaaaa aacactttcc ctgttttctg ttgacaagtt ttcaaggaat atggaggtgg
    12241 gaaaactact cctttttcat tattctgaaa cttattttta aataactggt acttagcaat
    12301 ttagttttta aaacactatt ccgaattaaa ttgctgaggt aactaaattc tagacctaac
    12361 cttgttttat catacagcca tctagttaga aagtgtttgt ggtgaagact tgtatcttgt
    12421 ggcactagtt cttcatgttt cttctccatg tgtcggctaa aacagatcat ttccagaaga
    12481 gtggaaagtt actgttgttg ggggtctgtg tagggcgggc acacccagtt agagcatggg
    12541 ctgtactgtc acggtagctg ggtgtgctct gcactctgct gttgtagatt tattttgttt
    12601 acagtagact gatgtcagtt ttgtaaatgt ttttcttagc actttaactg tgagtgtaaa
    12661 aactgatttt aaatgtagtg gttgtatatt ttggttataa attggaaatt tttaataaaa
    12721 ctaaataact tgttctcttg tc
//
