LOCUS       NM_020510               3628 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus frizzled class receptor 2 (Fzd2), mRNA.
ACCESSION   NM_020510
VERSION     NM_020510.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3628)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3628)
  AUTHORS   Zhu,X., Xu,M., Leu,N.A., Morrisey,E.E. and Millar,S.E.
  TITLE     FZD2 regulates limb development by mediating beta-catenin-dependent
            and -independent Wnt signaling pathways
  JOURNAL   Dis Model Mech 16 (3) (2023)
   PUBMED   36867021
REFERENCE   3  (bases 1 to 3628)
  AUTHORS   Mitsiadis,T.A., Pagella,P., Gomes Rodrigues,H., Tsouknidas,A.,
            Ramenzoni,L.L., Radtke,F., Mehl,A. and Viriot,L.
  TITLE     Notch Signaling Pathway in Tooth Shape Variations throughout
            Evolution
  JOURNAL   Cells 12 (5), 761 (2023)
   PUBMED   36899896
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3628)
  AUTHORS   Liegel,R.P., Michalski,M.N., Vaidya,S., Bittermann,E., Finnerty,E.,
            Menke,C.A., Diegel,C.R., Zhong,Z.A., Williams,B.O. and
            Stottmann,R.W.
  TITLE     Successful therapeutic intervention in new mouse models of frizzled
            2-associated congenital malformations
  JOURNAL   Development 150 (3) (2023)
   PUBMED   36789910
REFERENCE   5  (bases 1 to 3628)
  AUTHORS   Xie,Z. and Bankaitis,V.A.
  TITLE     Phosphatidylinositol transfer protein/planar cell polarity axis
            regulates neocortical morphogenesis by supporting interkinetic
            nuclear migration
  JOURNAL   Cell Rep 39 (9), 110869 (2022)
   PUBMED   35649377
REFERENCE   6  (bases 1 to 3628)
  AUTHORS   van Gijn,M.E., Blankesteijn,W.M., Smits,J.F., Hierck,B. and
            Gittenberger-de Groot,A.C.
  TITLE     Frizzled 2 is transiently expressed in neural crest-containing
            areas during development of the heart and great arteries in the
            mouse
  JOURNAL   Anat Embryol (Berl) 203 (3), 185-192 (2001)
   PUBMED   11303904
REFERENCE   7  (bases 1 to 3628)
  AUTHORS   Malik,T.H. and Shivdasani,R.A.
  TITLE     Structure and expression of a novel frizzled gene isolated from the
            developing mouse gut
  JOURNAL   Biochem J 349 Pt 3 (Pt 3), 829-834 (2000)
   PUBMED   10903145
REFERENCE   8  (bases 1 to 3628)
  AUTHORS   Toyofuku,T., Hong,Z., Kuzuya,T., Tada,M. and Hori,M.
  TITLE     Wnt/frizzled-2 signaling induces aggregation and adhesion among
            cardiac myocytes by increased cadherin-beta-catenin complex
  JOURNAL   J Cell Biol 150 (1), 225-241 (2000)
   PUBMED   10893270
REFERENCE   9  (bases 1 to 3628)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   10 (bases 1 to 3628)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB527017.1, BC055727.1 and AL672269.15.
            
            On Feb 10, 2007 this sequence version replaced NM_020510.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK048420.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CB527017.1         36-56
            22-2152             BC055727.1         1-2131
            2153-3628           AL672269.15        31391-32866
FEATURES             Location/Qualifiers
     source          1..3628
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.45 cM"
     gene            1..3628
                     /gene="Fzd2"
                     /gene_synonym="Fz10; Fzd10; Mfz10; Mfz10a"
                     /note="frizzled class receptor 2"
                     /db_xref="GeneID:57265"
                     /db_xref="MGI:MGI:1888513"
     exon            1..3628
                     /gene="Fzd2"
                     /gene_synonym="Fz10; Fzd10; Mfz10; Mfz10a"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..2014
                     /gene="Fzd2"
                     /gene_synonym="Fz10; Fzd10; Mfz10; Mfz10a"
                     /note="frizzled-2; fz-2; mFz2; fz-10; frizzled-10;
                     frizzled homolog 2"
                     /codon_start=1
                     /product="frizzled-2 precursor"
                     /protein_id="NP_065256.1"
                     /db_xref="CCDS:CCDS25501.1"
                     /db_xref="GeneID:57265"
                     /db_xref="MGI:MGI:1888513"
                     /translation="MRARSALPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFC
                     QPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYA
                     PVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNH
                     SEDGAPALLTTAPPSGLQPGAGGTPGGPGGGGSPPRYATLEHPFHCPRVLKVPSYLSY
                     KFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQ
                     RFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTI
                     LFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITI
                     LAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIM
                     KHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLA
                     IPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHG
                     ETTV"
     regulatory      3604..3609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzd2"
                     /gene_synonym="Fz10; Fzd10; Mfz10; Mfz10a"
                     /note="hexamer: AATAAA"
     polyA_site      3628
                     /gene="Fzd2"
                     /gene_synonym="Fz10; Fzd10; Mfz10; Mfz10a"
                     /note="major polyA site"
ORIGIN      
        1 gagtcgctgg gtagaggagg gtggggagag gggaagccca gaggctagag gaggaagagg
       61 agctagggca gcggtgcgcc gcgtctccga ccctcagtcc gaccgcggcg agccagcagg
      121 cgggtgcgcc gccccctccc ccgccgccca atctccccaa ctctgcggcc gcgagcaaag
      181 tttgcaagga gacgcgggag gcggccgggc agctaggcgg cagcggggaa ggcgcgcggt
      241 ctctgggttg ggggcggggg ctggggggcg cccaggagcc gagtgggggg cggcggccag
      301 catgcgggcc cgcagcgccc tgccccgcag cgccctgccc cgcctgctgc tgccactgct
      361 gctgctgccg gccgccggac cggcccagtt ccacggggag aagggcatct ccatcccgga
      421 ccacggcttc tgccagccca tctccatccc gctgtgcacg gacatcgcct acaaccagac
      481 catcatgccc aaccttcttg gccacacgaa ccaggaagac gcgggcctgg aggtgcatca
      541 gttctacccg ctggtgaagg tgcagtgctc gcccgagctg cgcttcttcc tgtgctccat
      601 gtacgcgccg gtgtgcacag tgctggagca ggccatcccg ccgtgccgct ccatctgcga
      661 gcgcgcgcgc caaggctgcg aggcgctcat gaacaagttc ggcttccaat ggcccgagcg
      721 cctccgctgc gagcatttcc cgcgtcacgg cgcggagcag atctgcgtgg gccagaacca
      781 ctcggaggac ggagctcctg cgctactcac caccgcgcca ccttctgggc tgcagcccgg
      841 cgcgggtggc accccgggcg gccctggcgg tggtggctcg ccaccgcgtt acgccactct
      901 ggagcaccct ttccactgtc cccgcgtcct caaggtgccg tcctatctca gctataagtt
      961 tctgggtgag cgcgattgtg ccgcgccctg cgagcccgca cggcccgacg gctctatgtt
     1021 cttctcgcaa gaggagactc gttttgcccg tctctggatc ctcacatggt cggtgttgtg
     1081 ctgcgcttcc actttcttca cggtcaccac ctatttagtg gacatgcagc gatttcgcta
     1141 cccagagcgg cccatcatct ttctgtccgg ctgctacacc atggtgtcag tggcctacat
     1201 tgcgggcttc gttctccagg agcgcgtggt atgcaatgag cgcttctcag aggacggtta
     1261 tcgcacggtg gtgcagggca ctaagaaaga aggctgcact atactcttca tgatgctcta
     1321 cttcttcagc atggccagct ccatctggtg ggtgattctg tccctcacct ggttcctggc
     1381 agccggaatg aagtggggcc acgaggccat cgaggccaat tcgcagtact tccacctggc
     1441 cgcctgggcc gtgccggccg tcaaaaccat caccatcttg gccatgggcc agatcgacgg
     1501 cgacctgctg agcggcgtgt gcttcgtggg cctcaatagc ctggacccgc tgcggggctt
     1561 cgtgctggcg ccgctcttcg tatacctgtt catcggtaca tccttcctgc tggccggctt
     1621 cgtgtcactc ttccgcatcc gcaccatcat gaagcacgac ggcaccaaga cggagaagct
     1681 ggagaggctc atggtgcgca ttggcgtctt ctcggtgctc tacacggtac cggccaccat
     1741 cgtcatcgcc tgctacttct atgagcaggc cttccgcgag cactgggagc gctcctgggt
     1801 aagccagcac tgcaagagcc tagccatccc ctgcccggcc cactacacgc cccgcatgtc
     1861 gcccgacttc acagtctaca tgatcaaata cctcatgacg ctcatcgtgg gcatcacgtc
     1921 gggcttctgg atctggtccg gcaagacact gcactcgtgg aggaagttct acactcgtct
     1981 caccaacagc cggcatggcg agaccactgt gtgaagcggt ctcgcctgcc tgccgggctt
     2041 tcccctctcc caggtccgga ctgcaccgtg ccctccttca ctcaggaggg gggagggtgc
     2101 accctacgga ctcctatttt atttttttaa ataaagaacg gtaaaaaaaa aaccatttta
     2161 tttttaggtc gctttttaaa aagaactctg cccaacaccc ccctaccagg tttgtaatta
     2221 aaactgtaaa tagtctttgt aaatttaatt atatattttc tatttaaaag aaaaaagaaa
     2281 aaaaaatcga agacaccagg gctgaagagt ggtgtggggg tgggggagga ggtctcgact
     2341 tttctaagtg cccttttaaa agctgccctg tgctctggtt cgaatttttt tttagtgatt
     2401 tggcagggct gggcctgctg ggagaggcac ctagcctgct cgctattttt gttggcttaa
     2461 aggagttggg agttagttcc actcaacttc tataaaagct aaatttgcaa gcctcctcac
     2521 cgacgagggg cctgtggaag ctgttggata ttttttttaa caagacttgg attcgttttt
     2581 gttttatttc cctttctcct cgctccacac cccccatccc cctctttctc cctcctcatt
     2641 tgttctgtct cccccgctcg ctcagtatct ggaaacctcc caatccagat gtagacgtgg
     2701 aaaaaaacat agcgctttta gggagagggc ggagatgtgg ggaggaatgg cctccacccc
     2761 ccaccacccc cccagcccac tccccgtggg cacggagatc cttctgtggt ttcagctctg
     2821 gcccacgcgc agagaatggg caacaaaacg ctttgtgtag tgtgtcttga catccccccc
     2881 agtgcacaca ccactttaag aatgacctcc tttccctggg ttttgggggt accgctagcc
     2941 tctgtgttgg caaaccctgg gatctttggc gcttccgttc ccttctctcc cggtaggctg
     3001 ctcttccgcg gtgggatcca ggttagctgt ttgtaggatt gggttgtgtg ttatgtgtgg
     3061 gtttttgttc gggttgtttt tcttttccaa aagcagtaaa aataggttgg gttggaggga
     3121 gggaatggat gggctggtgg gatttttagt tttcttttga caaaagactg gccttaaaaa
     3181 aaacaaaaaa caaaagcaaa aagttgttca gggaaacaac aaaaactaat gggtaagttt
     3241 gctttagaag gtctctctgg gcaggctctt tgtggcggtg ggggtggggt tgagtgttta
     3301 cgtgacattc tatatcataa gatattgata agaatgtttc taacatgttt cttccccgcc
     3361 cctgcacaca aataaaagta aggattttgc taagttagcg gcctgagaga tgttctataa
     3421 agtatctttg ttagtgtgag aatcccagtt tccagcaggc atgggttccc tcgagcctgg
     3481 agtactttac agcttgcatg ctaaagaagc gatctgaaga ccagtgtgcc agagctccgc
     3541 tctcaaccgt ctctcctgtt tcttgataat aaatagtgca aattaaaacc taataatcat
     3601 cataataaag tgcatttaat tatcttca
//
