LOCUS       NP_780493                582 aa            linear   ROD 25-FEB-2025
DEFINITION  frizzled-10 precursor [Mus musculus].
ACCESSION   NP_780493 XP_979164
VERSION     NP_780493.1
DBSOURCE    REFSEQ: accession NM_175284.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 582)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (residues 1 to 582)
  AUTHORS   Zhan,Y., Wen,Y., Zheng,F., Du,L.J., Chen,T.Y., Shen,X.L., Wu,R. and
            Tang,X.G.
  TITLE     MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10
            to Inhibit GSK3beta/beta-Catenin Signaling and Induce Enteric Glial
            Cell Apoptosis
  JOURNAL   Mol Neurobiol 61 (3), 1543-1561 (2024)
   PUBMED   37728849
  REMARK    GeneRIF: MiR-26b-3p Promotes Intestinal Motility Disorder by
            Targeting FZD10 to Inhibit GSK3beta/beta-Catenin Signaling and
            Induce Enteric Glial Cell Apoptosis.
REFERENCE   3  (residues 1 to 582)
  AUTHORS   Weiss,A.C., Blank,E., Bohnenpoll,T., Kleppa,M.J., Rivera-Reyes,R.,
            Taketo,M.M., Trowe,M.O. and Kispert,A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   4  (residues 1 to 582)
  AUTHORS   Murphy,P., Armit,C., Hill,B., Venkataraman,S., Frankel,P.,
            Baldock,R.A. and Davidson,D.R.
  TITLE     Integrated analysis of Wnt signalling system component gene
            expression
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831952
REFERENCE   5  (residues 1 to 582)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (residues 1 to 582)
  AUTHORS   Muzio,L., Soria,J.M., Pannese,M., Piccolo,S. and Mallamaci,A.
  TITLE     A mutually stimulating loop involving emx2 and canonical wnt
            signalling specifically promotes expansion of occipital cortex and
            hippocampus
  JOURNAL   Cereb Cortex 15 (12), 2021-2028 (2005)
   PUBMED   15800025
REFERENCE   7  (residues 1 to 582)
  AUTHORS   Wang,Z., Shu,W., Lu,M.M. and Morrisey,E.E.
  TITLE     Wnt7b activates canonical signaling in epithelial and vascular
            smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5
  JOURNAL   Mol Cell Biol 25 (12), 5022-5030 (2005)
   PUBMED   15923619
  REMARK    GeneRIF: Data demonstrate that Wnt7b signals through Fzd1 and -10
            and LRP5 and implicate these Wnt coreceptors in the regulation of
            lung airway and vascular development.
REFERENCE   8  (residues 1 to 582)
  AUTHORS   Reddy,S.T., Andl,T., Lu,M.M., Morrisey,E.E. and Millar,S.E.
  TITLE     Expression of Frizzled genes in developing and postnatal hair
            follicles
  JOURNAL   J Invest Dermatol 123 (2), 275-282 (2004)
   PUBMED   15245425
REFERENCE   9  (residues 1 to 582)
  AUTHORS   Nunnally,A.P. and Parr,B.A.
  TITLE     Analysis of Fz10 expression in mouse embryos
  JOURNAL   Dev Genes Evol 214 (3), 144-148 (2004)
   PUBMED   14758554
REFERENCE   10 (residues 1 to 582)
  AUTHORS   Kim,A.S., Lowenstein,D.H. and Pleasure,S.J.
  TITLE     Wnt receptors and Wnt inhibitors are expressed in gradients in the
            developing telencephalon
  JOURNAL   Mech Dev 103 (1-2), 167-172 (2001)
   PUBMED   11335128
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY509002.1.
            
            On May 4, 2006 this sequence version replaced XP_979164.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY509002.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Mus musculus"
                     /strain="CD-1"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 67.67 cM"
     Protein         1..582
                     /product="frizzled-10 precursor"
                     /note="frizzled-10; frizzled homolog 10"
                     /calculated_mol_wt=62999
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2338
     mat_peptide     22..582
                     /product="Frizzled-10. /id=PRO_0000013006"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
                     /calculated_mol_wt=62999
     Region          31..157
                     /region_name="CRD_FZ"
                     /note="CRD_domain cysteine-rich domain, also known as Fz
                     (frizzled) domain; cl02447"
                     /db_xref="CDD:470581"
     Site            order(42,44..45,48..50)
                     /site_type="other"
                     /note="putative Wnt binding site [polypeptide binding]"
                     /db_xref="CDD:143549"
     Site            49
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Region          153..189
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Site            154
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Region          218..537
                     /region_name="7tmF_FZD10"
                     /note="class F frizzled subfamily 10, member of
                     7-transmembrane G protein-coupled receptors; cd15037"
                     /db_xref="CDD:320165"
     Site            order(219,228,278,297,379,384,386,389..390,395,470,
                     473..474,500,505,508..509)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:320165"
     Region          227..252
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320165"
     Site            227..247
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Region          261..282
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320165"
     Site            264..284
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Region          311..337
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320165"
     Site            313..333
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Site            353..373
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Region          354..370
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320165"
     Region          392..421
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320165"
     Site            395..415
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Region          441..468
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320165"
     Site            445..465
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Site            486
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Region          498..523
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320165"
     Site            504..524
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Region          527..532
                     /region_name="Lys-Thr-X-X-X-Trp motif, mediates
                     interaction with the PDZ domain of Dvl family members.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Region          561..582
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     Region          580..582
                     /region_name="PDZ-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKG4.1)"
     CDS             1..582
                     /gene="Fzd10"
                     /gene_synonym="Fz-10"
                     /coded_by="NM_175284.3:113..1861"
                     /db_xref="CCDS:CCDS51652.1"
                     /db_xref="GeneID:93897"
                     /db_xref="MGI:MGI:2136761"
ORIGIN      
        1 mqhpgprlwl vlqvmigsct aissmdlerp gdgkcqpvei pmckdigynt trmpnlmghe
       61 nqreaaiqlh efaplveygc hshlrfflcs lyapmcteqv stpipacrvm ceqarlkcsp
      121 imeqfkfrwp dsldcsklpn kndpnylcme apnngsdeps rgsgmfpplf rpqrphsaqe
      181 hplkdggpgr agcdnpgkfh hveksescap lctpgvdvyw srddkrfavv wlaiwsvlcf
      241 fssaftvltf lidpsrfryp erpiiflsmc ycvysvgyii rlfagaesia cdrdsgqlyv
      301 iqeglestgc tlvflvlyyf gmasslwwvv ltltwflaag kkwgheaiea nssyfhlaaw
      361 aipavktili lvmrrvagde ltgvcyvgsm dvnaltgfvl vplacylvig tsfilsgfva
      421 lfhirrvmkt ggentdklek lmvrigvfsl lytvpatcvi acyfyerlnm dywkmlatqh
      481 kckmnnqtkt pdclmttsip avevfmvkvs mllvvgitsg vwvwtsktlq swqhvcsrgl
      541 krksrrkpas vvtsagiykk aqhpqkphlg kyelpaqpsa cv
//
