LOCUS       NM_021457               4395 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus frizzled class receptor 1 (Fzd1), mRNA.
ACCESSION   NM_021457
VERSION     NM_021457.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4395)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4395)
  AUTHORS   Gessner,N.R., Peiravi,M., Zhang,F., Yimam,S., Springer,D. and
            Harbison,S.T.
  TITLE     A conserved role for frizzled in sleep architecture
  JOURNAL   Sleep Adv 4 (1), zpad045 (2023)
   PUBMED   38033424
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4395)
  AUTHORS   Zhu,X., Xu,M., Leu,N.A., Morrisey,E.E. and Millar,S.E.
  TITLE     FZD2 regulates limb development by mediating beta-catenin-dependent
            and -independent Wnt signaling pathways
  JOURNAL   Dis Model Mech 16 (3) (2023)
   PUBMED   36867021
REFERENCE   4  (bases 1 to 4395)
  AUTHORS   Parichha,A., Datta,D., Suresh,V., Chatterjee,M., Holtzman,M.J. and
            Tole,S.
  TITLE     Dentate gyrus morphogenesis is regulated by beta-catenin function
            in hem-derived fimbrial glia
  JOURNAL   Development 149 (21) (2022)
   PUBMED   36196585
REFERENCE   5  (bases 1 to 4395)
  AUTHORS   Murphy,P., Armit,C., Hill,B., Venkataraman,S., Frankel,P.,
            Baldock,R.A. and Davidson,D.R.
  TITLE     Integrated analysis of Wnt signalling system component gene
            expression
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831952
REFERENCE   6  (bases 1 to 4395)
  AUTHORS   Hsieh,M., Johnson,M.A., Greenberg,N.M. and Richards,J.S.
  TITLE     Regulated expression of Wnts and Frizzleds at specific stages of
            follicular development in the rodent ovary
  JOURNAL   Endocrinology 143 (3), 898-908 (2002)
   PUBMED   11861511
  REMARK    GeneRIF: Fz-1 is expressed at distinct stages of follicular
            development.
REFERENCE   7  (bases 1 to 4395)
  AUTHORS   Bleul,C.C. and Boehm,T.
  TITLE     Laser capture microdissection-based expression profiling identifies
            PD1-ligand as a target of the nude locus gene product
  JOURNAL   Eur J Immunol 31 (8), 2497-2503 (2001)
   PUBMED   11500834
REFERENCE   8  (bases 1 to 4395)
  AUTHORS   Xu,L., Tan,L., Goldring,M.B., Olsen,B.R. and Li,Y.
  TITLE     Expression of frizzled genes in mouse costochondral chondrocytes
  JOURNAL   Matrix Biol 20 (2), 147-151 (2001)
   PUBMED   11334716
REFERENCE   9  (bases 1 to 4395)
  AUTHORS   Borello,U., Buffa,V., Sonnino,C., Melchionna,R., Vivarelli,E. and
            Cossu,G.
  TITLE     Differential expression of the Wnt putative receptors Frizzled
            during mouse somitogenesis
  JOURNAL   Mech Dev 89 (1-2), 173-177 (1999)
   PUBMED   10559494
REFERENCE   10 (bases 1 to 4395)
  AUTHORS   Cygan,J.A., Johnson,R.L. and McMahon,A.P.
  TITLE     Novel regulatory interactions revealed by studies of murine limb
            pattern in Wnt-7a and En-1 mutants
  JOURNAL   Development 124 (24), 5021-5032 (1997)
   PUBMED   9362463
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE948559.1, AK143101.1 and BC053010.1.
            
            On Nov 27, 2007 this sequence version replaced NM_021457.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               BE948559.1         343-523             c
            182-4344            AK143101.1         2-4164
            4345-4395           BC053010.1         4100-4150
FEATURES             Location/Qualifiers
     source          1..4395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 2.61 cM"
     gene            1..4395
                     /gene="Fzd1"
                     /gene_synonym="FZ-1; Fz1"
                     /note="frizzled class receptor 1"
                     /db_xref="GeneID:14362"
                     /db_xref="MGI:MGI:1196625"
     exon            1..4378
                     /gene="Fzd1"
                     /gene_synonym="FZ-1; Fz1"
                     /inference="alignment:Splign:2.1.0"
     CDS             637..2565
                     /gene="Fzd1"
                     /gene_synonym="FZ-1; Fz1"
                     /note="frizzled-1; mFz1; frizzled homolog 1"
                     /codon_start=1
                     /product="frizzled-1 precursor"
                     /protein_id="NP_067432.2"
                     /db_xref="CCDS:CCDS19072.1"
                     /db_xref="GeneID:14362"
                     /db_xref="MGI:MGI:1196625"
                     /translation="MAEEAAPSESRAAGRLSLELCAEALPGRREEVGHEDTASHRRPR
                     ADPRRWASGLLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQSGQQYNGERG
                     ISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAEL
                     KFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGA
                     GELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGYRGGYPGGAGTVERGKFSCPRALR
                     VPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVL
                     TYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGT
                     KKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVP
                     AIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSL
                     FRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVA
                     QSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNS
                     WRKFYTRLTNSKQGETTV"
     regulatory      4354..4359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fzd1"
                     /gene_synonym="FZ-1; Fz1"
                     /note="hexamer: AATGAA"
     polyA_site      4373
                     /gene="Fzd1"
                     /gene_synonym="FZ-1; Fz1"
                     /note="major polyA site"
ORIGIN      
        1 tacttcctcc acctcctccg gtctgctgcg ggctccagtc cgggctcgga gggaaagggc
       61 tccctttgcg ctgtgaagcg ggtgctgcga ttgggcgacg gtccctgagc cgccagctcc
      121 gcgtcggttt caaggctcct ccctcccggt gaaagacaga ctggggggcg cctagaaacc
      181 cgttggaggg cgcgcgaggg agagcagagg ctgcgagttg agggattgac acaaatggtc
      241 aggcggcggc ggagaaggag gaggcggagg cgcagggggg acccagggcg gctaggctgc
      301 cgagagttgg gcgctcctct gcccggctgc gaccactaac gcggcgccgc ctgacaagag
      361 ccacagcctg ccgcgggcca gggaagaggg acgcgacccc ggcgcgcctg gaccactctt
      421 gctctcctcg ccgcccgcgc ttcatgaacc gcaagtttcc gcggcggcgg cggcggctgc
      481 gggacgcgga gcagaatccc ggggagcggg cagagagcgg ccgcaccccg acggagggca
      541 cgggcgacca gctctcccgg atcacagtgg gagccaccac ccgccgcgcc gctgcccgtc
      601 ccagtcaatc cgcgccgagg agggagccga aaaagtatgg ctgaggaggc ggcgcctagc
      661 gagtcccggg ccgccggccg gctgagcttg gaactttgtg ccgaagcact cccgggccgg
      721 cgggaggagg tggggcacga ggacacggcc agccaccgcc gcccccgggc tgatccccgg
      781 cgttgggcta gcgggctgct gctgctgctt tggttgctgg aggctcctct gcttttgggg
      841 gtccgagcgc aggcggcggg ccaggtatcc gggccgggcc agcaagcccc gccgccgccc
      901 cagccccagc agagcgggca gcagtacaac ggcgaacggg gcatctccat cccggaccac
      961 ggctactgcc agcccatctc catcccgctg tgcacggaca tcgcgtacaa ccagaccatc
     1021 atgcccaacc tgctgggcca cacgaatcag gaggacgccg gtctggaggt gcaccagttc
     1081 taccctctgg tgaaggtgca gtgctccgcc gagctcaagt tcttcctgtg ctccatgtac
     1141 gcgcctgtgt gcaccgtact ggagcaggcg ctaccgccct gccgctccct gtgcgagcgc
     1201 gcacgccagg gctgcgaggc gctcatgaac aagttcggct tccagtggcc agacacactc
     1261 aagtgcgaga agttcccggt gcacggcgca ggagagctgt gcgtgggcca gaacacgtcc
     1321 gacaaaggca ccccaactcc ctccttgcta ccagagttct ggaccagtaa tccgcagcac
     1381 ggcggcggtg gttaccgcgg cggctacccg gggggtgccg ggacggtgga gcggggaaag
     1441 ttctcctgcc cgcgcgccct cagggtgccc tcctacctca actaccactt tctgggggag
     1501 aaggactgcg gcgcaccctg cgaacccacc aaggtttacg ggctcatgta cttcgggcca
     1561 gaggagctgc gcttctcgcg cacctggata ggcatctggt ccgtgctgtg ctgcgcctcc
     1621 acgctcttca cggtgctcac gtacctagtg gacatgcggc gcttcagcta cccggaacgg
     1681 cccatcattt tcctgtccgg ctgttacaca gcggtggcgg tggcctacat cgctggcttt
     1741 ctgttggagg accgggtggt gtgcaacgac aagtttgcag aggacggggc gcgcacggtg
     1801 gcgcagggca ctaagaaaga aggctgcact atactcttta tgatgctcta cttcttcagc
     1861 atggccagct ccatctggtg ggtgatcctg tccctcacct ggttcctggc agccggcatg
     1921 aagtggggcc acgaagccat cgaggccaac tcacagtatt tccatttagc cgcctgggct
     1981 gtgccagcca tcaaaactat aaccatcttg gcgttgggcc aggtggatgg cgacgtactg
     2041 agcggagtgt gttttgtggg gctcaacaac gtggacgcac tgcgtggctt tgtgctggcg
     2101 cctctcttcg tttatctgtt cattggcact tctttcctgc tggccggttt cgtgtcactc
     2161 ttccgcatcc gcaccatcat gaagcatgac ggcaccaaga cagagaagct ggagaagctc
     2221 atggtgcgca tcggagtctt cagtgtcctc tacactgtgc cggccaccat cgtcatcgcc
     2281 tgctacttct atgaacaggc ctttcgggac cagtgggagc gcagctgggt ggcccagagc
     2341 tgcaagagtt atgccatccc ttgccctcac ctccagggag gtggaggagt cccaccacac
     2401 ccgcccatga gcccagactt tacagtcttc atgatcaagt atctcatgac gctgattgtg
     2461 ggcatcacat cgggcttctg gatctggtcc ggcaagacac tgaattcctg gaggaagttc
     2521 tacacgaggc ttaccaacag caaacagggg gagactaccg tctgaaaccc agactcttac
     2581 cttacccttt tttggcctga tcctagccat cgcctggaag ctggccccaa ggaattcctg
     2641 ccaagcctgg ccactccagg cttcctcgcc agccactgac ttttgcaggc ccctttccca
     2701 acaaacagca caggttctgc aaaagcttcc gtccctgggg taaaggaacg agagggccca
     2761 actgatcgag gtgtatgtgt atgtgcgtgt ggaccgatct ctctagccct ctctgatacc
     2821 aggattgtac gcttttatga ttgtaaatag cctgtgtaag atttttgtac gtatatttgt
     2881 atttaaagac tatcgaacac gcagtttttt tttcttttta aaaatgttta attatttagg
     2941 gcaatttacg tatttggagc ttttctcact tgcccttttc tgcagattgc agaggaggta
     3001 aaacagagca cacttgacta agtgctttgc cctgtgccct catctttgtc aagggagcat
     3061 gggcctgcct ctccagggtc atttccttca gcatctcccg cccctcccct tccttgcttg
     3121 cagtgggaaa ttttaaggtg cagaactctg taaagcttcc agatcccgag gtgggccccg
     3181 cccattccag atcctcccct tttcagcggt agagtgtgga tggctgtccc tgtgacttcc
     3241 tgatgctgct tatttgagat ccaccttcca gctttattag aggaccccag tatgggctct
     3301 gccagttgac ccagcctccc tgtaccccgg tgtcccttgc ccagtgtctt tctccttgca
     3361 cctaagttgt tcagagggag tgcagtaacc gaccgatagc gaactttgga gagtctgact
     3421 ttttatggat gagctcattt ttactctcta gtatctggaa cttgctctgg gtctggtcat
     3481 catcatggaa agagcagcaa gctttgtggg ttgggagagg ctaaagagag aggttataaa
     3541 acattagttc taattgcatt ctgatgtctg gcaacctact ttcttccccc tgtgatgctg
     3601 cctgcttcta gattttaccc ttctatgaaa tgcagacctc gaggttgcct gggaagcttg
     3661 gtgaaggaat ggtttacctt ccttaacagg atagtagaac atacacagag tatggaaacc
     3721 taaggagatt tcagtgaagt ggagttactc caagtgaaac gctgttttct ggttttagcc
     3781 aaactgcaat tagatgtgtc tttgcaatct aaaagttgta cacaatcaac aatacacttt
     3841 gcttactcct cagcagcaca ttctgaggga gaaacagtca cacccccgca gaaagcctgg
     3901 ttggacttcc gaagacagag gcggtggact gacggatggg tgagagagac aaacacgacc
     3961 taggcatgca tgctgaaggg gaagtgtgtc cattcctact gcatcccatc ttgtgtgctc
     4021 ctgtctggat ttacggcagt gtgtcaaatg taaatctctc aaagccattt aaaaatactc
     4081 actttagtta tggatgaaga agaggagaaa agcagtcctc ctgattgtag tgtttaaacc
     4141 ttaagagttt atcacaaatg ccgatacata cataggacct aaatttatct atgtctgtca
     4201 taccctaaaa tgacattggt ttttggattt ggtatgcatt attattgtta ttattgttat
     4261 tattattctc accaccatga gatcatctat atttatagag gaatagaagt ttatatatat
     4321 aaaatgccat atttttaatt tcgcaaataa aaaaatgaaa gttttgtaca aaattacaaa
     4381 aaaaaaaaaa aaaaa
//
