LOCUS       NM_001122893            3544 bp    mRNA    linear   ROD 10-MAR-2024
DEFINITION  Mus musculus Fyn proto-oncogene (Fyn), transcript variant 1, mRNA.
ACCESSION   NM_001122893
VERSION     NM_001122893.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3544)
  AUTHORS   Zhang,Y. and Gong,X.
  TITLE     Fat mass and obesity associated protein inhibits neuronal
            ferroptosis via the FYN/Drp1 axis and alleviate cerebral
            ischemia/reperfusion injury
  JOURNAL   CNS Neurosci Ther 30 (3), e14636 (2024)
   PUBMED   38430221
  REMARK    GeneRIF: Fat mass and obesity associated protein inhibits neuronal
            ferroptosis via the FYN/Drp1 axis and alleviate cerebral
            ischemia/reperfusion injury.
REFERENCE   2  (bases 1 to 3544)
  AUTHORS   Sasaki,T., Yamada,E., Uehara,R., Okada,S., Chikuda,H. and Yamada,M.
  TITLE     Role of Fyn and the interleukin-6-STAT-3-autophagy axis in
            sarcopenia
  JOURNAL   iScience 26 (10), 107717 (2023)
   PUBMED   37744036
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3544)
  AUTHORS   Yang,Y., Yao,M., Zeng,J., Zheng,D., Li,Q., Ni,Y. and Xiao,X.
  TITLE     FYN regulates cell adhesion at the blood-testis barrier and the
            apical ectoplasmic specialization via its effect on Arp3 in the
            mouse testis
  JOURNAL   Front Immunol 13, 915274 (2022)
   PUBMED   36016954
  REMARK    GeneRIF: FYN regulates cell adhesion at the blood-testis barrier
            and the apical ectoplasmic specialization via its effect on Arp3 in
            the mouse testis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3544)
  AUTHORS   Sun,Z.Y., Ma,D.L., Gu,L.H., Chen,X., Zhang,L. and Li,L.
  TITLE     DHF-7 Ameliorates Behavioral Disorders and White Matter Lesions by
            Regulating BDNF and Fyn in a Mouse Model of Schizophrenia Induced
            by Cuprizone and MK-801
  JOURNAL   Int J Neuropsychopharmacol 25 (7), 600-612 (2022)
   PUBMED   35353146
  REMARK    GeneRIF: DHF-7 Ameliorates Behavioral Disorders and White Matter
            Lesions by Regulating BDNF and Fyn in a Mouse Model of
            Schizophrenia Induced by Cuprizone and MK-801.
REFERENCE   5  (bases 1 to 3544)
  AUTHORS   Menzel,V., Ziegler,M., Hante,N., Sake,J.A., Santos-Martinez,M.J.,
            Ehrhardt,C., Kasper,M. and Barth,K.
  TITLE     Fyn-kinase and caveolin-1 in the alveolar epithelial junctional
            adherence complex contribute to the early stages of pulmonary
            fibrosis
  JOURNAL   Eur J Pharm Sci 175, 106236 (2022)
   PUBMED   35710078
  REMARK    GeneRIF: Fyn-kinase and caveolin-1 in the alveolar epithelial
            junctional adherence complex contribute to the early stages of
            pulmonary fibrosis.
REFERENCE   6  (bases 1 to 3544)
  AUTHORS   Grant,S.G., O'Dell,T.J., Karl,K.A., Stein,P.L., Soriano,P. and
            Kandel,E.R.
  TITLE     Impaired long-term potentiation, spatial learning, and hippocampal
            development in fyn mutant mice
  JOURNAL   Science 258 (5090), 1903-1910 (1992)
   PUBMED   1361685
REFERENCE   7  (bases 1 to 3544)
  AUTHORS   Umemori,H., Wanaka,A., Kato,H., Takeuchi,M., Tohyama,M. and
            Yamamoto,T.
  TITLE     Specific expressions of Fyn and Lyn, lymphocyte antigen
            receptor-associated tyrosine kinases, in the central nervous system
  JOURNAL   Brain Res Mol Brain Res 16 (3-4), 303-310 (1992)
   PUBMED   1337939
REFERENCE   8  (bases 1 to 3544)
  AUTHORS   Margolis,B., Silvennoinen,O., Comoglio,F., Roonprapunt,C.,
            Skolnik,E., Ullrich,A. and Schlessinger,J.
  TITLE     High-efficiency expression/cloning of epidermal growth
            factor-receptor-binding proteins with Src homology 2 domains
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8894-8898 (1992)
   PUBMED   1409582
REFERENCE   9  (bases 1 to 3544)
  AUTHORS   Stein,P.L., Lee,H.M., Rich,S. and Soriano,P.
  TITLE     pp59fyn mutant mice display differential signaling in thymocytes
            and peripheral T cells
  JOURNAL   Cell 70 (5), 741-750 (1992)
   PUBMED   1387588
REFERENCE   10 (bases 1 to 3544)
  AUTHORS   Haefliger,J.A., Bruzzone,R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Paul,D.L.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ714273.1, M27266.1, BC092217.1, BQ179147.1, BF662030.1 and
            BE952821.1.
            
            [WARNING] On Mar 13, 2024 this sequence was replaced by
            NM_001122893.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156584.1, SRR1660817.170576.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               BQ714273.1         3-583
            582-866             M27266.1           294-578
            867-1210            BC092217.1         793-1136
            1211-1375           BQ179147.1         410-574
            1376-2578           BC092217.1         1293-2495
            2579-3023           BF662030.1         33-477
            3024-3544           BE952821.1         1-521               c
FEATURES             Location/Qualifiers
     source          1..3544
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 20.51 cM"
     gene            1..3544
                     /gene="Fyn"
                     /note="Fyn proto-oncogene"
                     /db_xref="GeneID:14360"
                     /db_xref="MGI:MGI:95602"
     exon            1..392
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            393..432
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            433..502
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            503..760
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     CDS             514..2127
                     /gene="Fyn"
                     /EC_number="2.7.10.2"
                     /note="isoform a is encoded by transcript variant 1;
                     proto-oncogene tyrosine-protein kinase Fyn; p59-Fyn;
                     proto-oncogene c-Fyn; Src Kinase p59"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fyn isoform a"
                     /protein_id="NP_001116365.1"
                     /db_xref="CCDS:CCDS48538.1"
                     /db_xref="GeneID:14360"
                     /db_xref="MGI:MGI:95602"
                     /translation="MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGV
                     TSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLS
                     FHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAE
                     RQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTR
                     AQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKR
                     LGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS
                     EEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLR
                     SANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW
                     SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE
                     ERPTFEYLQGFLEDYFTATEPQYQPGENL"
     exon            761..857
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            858..956
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1060
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1210
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1375
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1555
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1632
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1786
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1918
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..3536
                     /gene="Fyn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgagaa gccgcggcgg tggcggcggc gcgtcggtgc agttgcgcca tctgtcagga
       61 gcgcagccgg cggggagggg gctccgcaga gaggaggagg ggtcgccgtg cgccgggcct
      121 ccgagacccg cccgctggtc aagagctcag cgaggccgcc tctagccgga gcgtttcgag
      181 gactccccgg gcacacacaa agccgccacc cgcgccaggg agggaccggg ctgccgggcc
      241 ggggacaccg gcgccgcccc ctcggcgctt cgcgaggccc acgagctcct gggccccgcc
      301 gcggagccgc gggagccgcc tgggccgcgc cggaggaggg cggggagagg accatgtgaa
      361 tgtgctccgg agctgagcgc caagccaagc agtgtttgaa aggaacagga tgctgatcta
      421 atcgtggcaa aaagtcagtc cgaccgctgg tttcgaagac atgtggtgta tataaagttt
      481 gtgatagttg gtggaaattt gggagcttgg ataatgggct gtgtgcaatg taaggataaa
      541 gaagcagcga aactgacaga ggagagggac ggcagcctga accagagctc tgggtaccgc
      601 tatggcacag accccacccc tcagcactac cccagcttcg gcgtgacctc catcccgaac
      661 tacaacaact tccacgcagc tgggggccag ggactcaccg tctttggggg tgtgaactcc
      721 tcctctcaca ctgggaccct acgcacgaga ggagggacag gagtgacact gtttgtggcg
      781 ctttatgact atgaagcacg gacggaagat gacctgagtt ttcacaaagg agaaaaattt
      841 caaatattga acagctcgga aggagactgg tgggaagccc gctccttgac aaccggggaa
      901 actggttaca ttcccagcaa ttacgtggct ccagttgact ccatccaggc agaagagtgg
      961 tactttggaa aacttggccg caaagatgct gagagacagc tcctgtcctt tggaaaccca
     1021 agaggtacct ttcttatccg cgagagcgaa accaccaaag gtgcctactc actttccatc
     1081 cgtgattggg atgatatgaa aggggaccac gtcaaacatt ataaaatccg caagcttgac
     1141 aatggtggat actatatcac aacgcgggcc cagtttgaaa cacttcagca actggtacag
     1201 cattactcag agagagccgc aggtctctgc tgccgcctag tagttccctg tcacaaaggg
     1261 atgccaaggc ttaccgatct gtctgtcaaa accaaagatg tctgggaaat ccctcgagaa
     1321 tccctgcagt tgatcaagag actgggaaat gggcagtttg gggaagtatg gatgggtacc
     1381 tggaatggaa atacaaaagt agccataaag acccttaagc caggcaccat gtctccggag
     1441 tccttcctgg aggaggcgca gatcatgaag aagctgaagc atgacaagct ggtgcagctc
     1501 tacgcggtcg tgtctgagga gcccatttac atcgtcacgg agtacatgag caaaggaagt
     1561 ttgcttgact tcttaaaaga tggtgaagga agagctctga agttgccaaa ccttgtggac
     1621 atggcggcac aggttgctgc aggaatggct tacatcgagc gcatgaatta tatccacaga
     1681 gatctgcgat cagcaaacat tctagtgggg aatggactaa tttgcaagat tgctgacttt
     1741 ggattggctc ggttgattga agacaatgaa tacacagcaa gacaaggtgc gaagtttccc
     1801 attaagtgga cagcccccga agcggccctg tatggaaggt tcacaatcaa gtctgacgta
     1861 tggtcttttg gaatcttact cacagagctg gtcaccaaag gaagagtgcc atacccaggc
     1921 atgaacaacc gggaggtgct ggagcaggtg gagagaggct ataggatgcc ctgcccacag
     1981 gactgcccga tctccctgca cgagctcatg atccactgct ggaaaaagga tccggaagag
     2041 cgcccgacct tcgagtactt gcagggcttc ctggaggact actttacggc cacagagccc
     2101 cagtatcagc ccggtgaaaa cctgtgagag cctgcgcttc agacgcctct tcccgaggcc
     2161 tccctacccc tccccattag cttccaattc tgtagccagc tgccccagag cagcgagaac
     2221 cgtccaggat cagattgcat gtgactctga agctgaactt ccacggccct cattaatgac
     2281 acttgtcccc cagtccgaac ctcctctgtg aaccatctga gacagaagcg tgttatttct
     2341 cagacttgga aatgcattgt atcgatgtta tgtcaaaggc caaacctctg ttcagtgtaa
     2401 atagctgctc ctgtgccaac aatcccagtg ctttcctttt ttaaaaaaga aaaagcaaat
     2461 cctatgtgat tttaactctg tcttcacctg attcaactaa aaaaaaaaaa gtattatttt
     2521 ccaaaagtgg cctctttgtc taaaacaata aaattttttt tcatgtttta acaaaaaatg
     2581 atcaggacag gtgtttgggt tttttttccc ttttttatac atatgatata tatgttaaca
     2641 tatgttcctg tacatacacc atgtgggtgc taccatggag actggccagc gtaggccaca
     2701 tagctacagg accggagtgg ggattactgc agaaccctgc cagcaaagca ctggtgtcag
     2761 cctgcaagcc ggtggcctca ttttttgact tctacgaagc atgacgtcct ctccatttgg
     2821 actgcacttt tttggttcct aatcatacct atagattgtt catgtgactt ttttcaggtc
     2881 ccagggccta gtcacgagtt ttagtgccag tttttgctcc agcgaactgt gattcgttct
     2941 tgaaacttag gagtgagcat tttaagcaaa aagcagccag ccagttctac cacaagagct
     3001 gcaagacgga gaccacacaa acttcctgta taaatatgaa tgctgaaggg ttcaggtgtt
     3061 ttccttttat ttaataaatc ttgtaaccac atttaaatgg tctaaaccca tagcattgta
     3121 gtcatggcaa cctactaaac tttctcatgc aactaaaaat tatgggaagg caagggtggg
     3181 gggttgtaca cgtcccattg taaaataagt gttttactgt cctgtactgc taatgagtga
     3241 ctctccgtgt caggagtgct ccagtgaata actatgcact actttacatt tcatgggggt
     3301 gcacaaaaaa aaaaaagtat tacattttta gttgctgttt gtaccaacct cgaattacgt
     3361 atgtttaaca acaaatcaat tcctatttct attgagtttt ttaatactga ctagcaattc
     3421 tgaagtctta attccttttt tttgttaatg atttacttgt gagtttacat ttttaaattg
     3481 tttaactttc ctaatttagt aattaaaaag agagcatttt acatttgaaa aaaaaaaaaa
     3541 aaaa
//
