LOCUS       NM_001110253            7702 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FYVE and coiled-coil domain containing 1 (Fyco1),
            transcript variant 2, mRNA.
ACCESSION   NM_001110253
VERSION     NM_001110253.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7702)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7702)
  AUTHORS   Khan,S.Y., Ali,M., Kabir,F., Na,C.H., Delannoy,M., Ma,Y., Qiu,C.,
            Costello,M.J., Hejtmancik,J.F. and Riazuddin,S.A.
  TITLE     The role of FYCO1-dependent autophagy in lens fiber cell
            differentiation
  JOURNAL   Autophagy 18 (9), 2198-2215 (2022)
   PUBMED   35343376
  REMARK    GeneRIF: The role of FYCO1-dependent autophagy in lens fiber cell
            differentiation.
REFERENCE   3  (bases 1 to 7702)
  AUTHORS   Satoh,K., Takemura,Y., Satoh,M., Ozaki,K. and Kubota,S.
  TITLE     Loss of FYCO1 leads to cataract formation
  JOURNAL   Sci Rep 11 (1), 13771 (2021)
   PUBMED   34215815
  REMARK    GeneRIF: Loss of FYCO1 leads to cataract formation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7702)
  AUTHORS   Mestres,I., Einsiedel,M., Moller,J. and Cardoso de Toledo,B.
  TITLE     Smad anchor for receptor activation nuclear localization during
            development identifies Layers V and VI of the neocortex
  JOURNAL   J Comp Neurol 528 (13), 2161-2173 (2020)
   PUBMED   32037591
REFERENCE   5  (bases 1 to 7702)
  AUTHORS   Sakurai,S., Tomita,T., Shimizu,T. and Ohto,U.
  TITLE     The crystal structure of mouse LC3B in complex with the FYCO1 LIR
            reveals the importance of the flanking region of the LIR motif
  JOURNAL   Acta Crystallogr F Struct Biol Commun 73 (Pt 3), 130-137 (2017)
   PUBMED   28291748
  REMARK    GeneRIF: The crystal structure of mouse LC3B in complex with the
            FYCO1 LC3-interacting region (LIR) reveals the importance of the
            flanking region of the LIR motif.
REFERENCE   6  (bases 1 to 7702)
  AUTHORS   Kiss,H., Darai,E., Kiss,C., Kost-Alimova,M., Klein,G.,
            Dumanski,J.P. and Imreh,S.
  TITLE     Comparative human/murine sequence analysis of the common eliminated
            region 1 from human 3p21.3
  JOURNAL   Mamm Genome 13 (11), 646-655 (2002)
   PUBMED   12461651
REFERENCE   7  (bases 1 to 7702)
  AUTHORS   Dib-Hajj,S.D., Tyrrell,L., Escayg,A., Wood,P.M., Meisler,M.H. and
            Waxman,S.G.
  TITLE     Coding sequence, genomic organization, and conserved chromosomal
            localization of the mouse gene Scn11a encoding the sodium channel
            NaN
  JOURNAL   Genomics 59 (3), 309-318 (1999)
   PUBMED   10444332
REFERENCE   8  (bases 1 to 7702)
  AUTHORS   Bulfone,A., Martinez,S., Marigo,V., Campanella,M., Basile,A.,
            Quaderi,N., Gattuso,C., Rubenstein,J.L. and Ballabio,A.
  TITLE     Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and
            chick brain development
  JOURNAL   Mech Dev 84 (1-2), 133-138 (1999)
   PUBMED   10473127
REFERENCE   9  (bases 1 to 7702)
  AUTHORS   Przyborski,S.A., Knowles,B.B., Handel,M.A., Gurwitch,S.A. and
            Ackerman,S.L.
  TITLE     Differential expression of the zinc finger gene Zfp105 during
            spermatogenesis
  JOURNAL   Mamm Genome 9 (9), 758-762 (1998)
   PUBMED   9716663
REFERENCE   10 (bases 1 to 7702)
  AUTHORS   Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L.
  TITLE     New member of the Snf1/AMPK kinase family, Melk, is expressed in
            the mouse egg and preimplantation embryo
  JOURNAL   Mol Reprod Dev 47 (2), 148-156 (1997)
   PUBMED   9136115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC242682.3, AC242669.3 and AC165425.2.
            
            [WARNING] On Aug 8, 2024 this sequence was replaced by
            NM_001110253.3.
            
            On May 1, 2013 this sequence version replaced NM_001110253.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: The coding region has been updated to remove a 3-nt
            insertion versus the reference genome sequence, supported by the
            available transcript data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.990884.1,
                                           SRR9219382.95527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC242682.3         16745-16776
            33-119              AC242669.3         33659-33745         c
            120-269             AC242669.3         25337-25486         c
            270-376             AC242669.3         22420-22526         c
            377-502             AC242669.3         20750-20875         c
            503-609             AC242669.3         16671-16777         c
            610-753             AC242669.3         14976-15119         c
            754-844             AC242669.3         13165-13255         c
            845-3148            AC242669.3         10054-12357         c
            3149-3241           AC242669.3         8963-9055           c
            3242-3360           AC242669.3         8424-8542           c
            3361-3528           AC242669.3         7384-7551           c
            3529-3565           AC242669.3         5169-5205           c
            3566-3678           AC165425.2         1-113
            3679-3890           AC165425.2         762-973
            3891-4035           AC165425.2         4100-4244
            4036-4131           AC165425.2         21974-22069
            4132-4342           AC165425.2         25564-25774
            4343-4452           AC165425.2         28457-28566
            4453-7702           AC165425.2         30542-33791
FEATURES             Location/Qualifiers
     source          1..7702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 74.52 cM"
     gene            1..7702
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /note="FYVE and coiled-coil domain containing 1"
                     /db_xref="GeneID:17281"
                     /db_xref="MGI:MGI:107277"
     exon            1..119
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            120..269
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            270..376
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            377..502
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            503..609
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            610..753
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            754..844
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            845..3148
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3241
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3360
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3528
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3678
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3890
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4035
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4131
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            4132..4342
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4452
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     exon            4453..7702
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7673..7678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /note="hexamer: AATAAA"
     polyA_site      7693
                     /gene="Fyco1"
                     /gene_synonym="2810409M01Rik; Mem2; RUFY3; ZFYVE7"
                     /note="major polyA site"
ORIGIN      
        1 gtagtccgcg cgcgctctgg ggctactggg cgcttcatgg cagtcggctc tgtgctcgcc
       61 tactcttccg ctcggcccta gaaagtttcg tttctgccca gcggaggacc cacgagcgtg
      121 tgctaccatg gagtctgacc attgctgacc agcagccaca cagcactgaa gtgatagcct
      181 gcttggacct acacatctaa gaaagaggaa agccatggct tctagcagca ctgagactca
      241 gctccagagg atcatccgtg atctacaaga tgcagcgaca gaactaagcc atgaatttaa
      301 ggaaggcgga gagccaatca cagatgacag caccagtttg cacaagtttt cttacaaact
      361 tgagtatctt ctgcaatttg atcagaagga gaaggcgagc ctcctgggaa gcaagaaaga
      421 ctactgggat tacttttgtg cgtgcctagc caaggtgaaa ggagcaaatg atggcattcg
      481 atttgtcagg tccatctctg agctccgaac atctctgggg aaagggagag ccttcattcg
      541 ctactctttg gtgcaccaga ggctggcaga caccttgcag cagtgcttca tgaacactaa
      601 agtgaccagt gactggtatt atgcaagaag cccctttctg aagccaaagc tgagctctga
      661 cattgtgggt caactgtatg agctgactga ggttcagttt gatctagcac caagaggcta
      721 tgacttggat gccgcctggc caacatttgc caggaggacg ctagccacca gcacgtctgc
      781 ttacatgtgg aaacccccca gccgaagctc cagcatgagt agtttagtga gcaactactt
      841 gcagactcag gagatggcct ccagtcttga cctgaattgt tctctaaaca atgaagcact
      901 agaaagcttc gacgagatgc ggctggagct ggaccagttg gaggttcggg agaaacagct
      961 acaagaacgt gtacagcagc tagacaggga gaaccaagca ctgcgaatgt tggtcagcag
     1021 acaagggggg cagcttcagg tagagaagga gatggggtac cttgcagtcg aggacagcat
     1081 tggccttgtg agcctggtag cagaactcca gaagcagggg gacgtcagcc aggccacagt
     1141 gaagaagcta cagtcatgtc tgcaggcctt ggagctaaat gtagacaaga aagagtacag
     1201 tccctcagcc ttgcagcttg agaacatggc gaaggagctt gacactgtga gaggctcctt
     1261 gggtagggag aaccagctcc tggccagcct ttcagagcgc cttgctaggg cagagaaagg
     1321 ggaaaagaca cctccagaca cagagcttca tcaggagcca gttcctgcgg atctggtgct
     1381 caagttccag gagctgaagg gaaaacttca agccctagaa ggagagaaca ccgaggccca
     1441 ggagctcaac aggcagcaga gtatcaagct agagcaactg gccaaggaac tacagctgaa
     1501 ggaggaggcc cgggctagcc tagcacactt agtgaaggat gtggtcccac ttcaggaaga
     1561 gctgtctgga aagaagcaag agtcagctca gctccgacga cagcttcagg aatccctggc
     1621 ccacttgagc tctgtggagg aggagctggc tgaagccagg cagcaggaaa agcagcatcg
     1681 agaagaaaag cagctactgg agcaggaagc cacgtctctt acatggcagc tgcagctcct
     1741 agagacccag ctaggacagg tgagtcagct tgtaagtgac ctggaggagc agaagaagca
     1801 actcatgcag gagagagacc atctcagcca gagagtgggc acactggagc agctagccga
     1861 ggtgcatggc ccgccacagt ctgcggagat gccggaaaag aggcagcagt gcctccggga
     1921 agaacaggta aacaatagca cagtgtcaga ggcagagcag gaggagttgc agaaggagct
     1981 gcagaacatg gttgaccgca accagctcct cgaaggcaaa ctgcaggcct tgcaaactga
     2041 ctataaggca ctgcagcagc gagaggcagc aatccagggc tctttagcct ccctggaagc
     2101 tgaacaggct agcatccggc acctgggaaa ccagatggaa gcaagcctcc tggctgtgaa
     2161 gaaagccaaa gagactatga aagcccaggt ggcagagaag gaggctgccc tgcagagtaa
     2221 ggagagtgag tgccagaggc tgcaggaaga ggcagatcag tgccggcttc aggcagaggc
     2281 ccaggcccag gagctcagag ctcttgagaa ccagtgccag cagcagattc agctgattga
     2341 ggtcctctct gcagagaaag gccaacaggg actcagcctg ccccaagtca acacagacca
     2401 actggccctg tctcaagcac agctggaaat ccaccagggg gaagcccagc ggttacagaa
     2461 tgaggtggtg gacctccagg ccaagctcca ggtggcccta ggtgatcgag acaagttaca
     2521 gagccagctg ggtgtggctg agacagttct aagggagcac aagaccctgg tgcaacaact
     2581 gaaagagcag aatgaagccc tcaacagggc ccatgttcag gagctgcttc agtgctcaga
     2641 gagagagggg atactacagg aggagagcat ctacaaggcc cagaagcagg aacaagagct
     2701 acgagccctg caggcagagc tgtcacaggt gaggtgcagc tctgagggag cccacctgga
     2761 acatgcagag ctgcaagacc agctgcaccg agccaacaca gacacagctg agcttggtat
     2821 acaggtctgt gcactgacag ctgagaagga tcgaatggag gaggccctgg ccagcctagc
     2881 ccaggagctc caggactcca aagaggcagc actacaggaa cgaaagggct tggagctcca
     2941 agtgatgcaa cttcagcaag agaaggagaa gttgcaggaa aaggtgaagg cagctgagga
     3001 ggcagccagt tcattctctg gtctgcaggc acagctggcc caggctgagc agctagccca
     3061 gagcctccaa gagactgcac accaggaaca agatgccctc aagttccaac taagtgctga
     3121 gattatggac caccagaacc gattaaagac agccaatgaa gagtgtgggc acctcagggc
     3181 ccagctagaa gaacaaggcc agcagctgca aatgactaag gaggctgtgc aggaactgga
     3241 gatcaccaag gcggccatgg aggagaagct gaattgcacc agtagccacc ttgcagagtg
     3301 ccaggccact ttactgcgca aagatgaaga aagcactatg cttcaaacca gtctagaaag
     3361 aacacagaag gaacttgaaa aggctacatc aaaaattcaa gaatattaca acaaactctg
     3421 ccaagaggtg acaaacaggg aaaggaatga ccagaagatg cttgcagacc tcgatgacct
     3481 gaacagaacc aagaaatacc ttgaggagcg gctgatagag ctgctcaggg acaaagatgc
     3541 tctctggcaa aaatccgatg cactggaatt ccagcagaag ctcagtgctg aagagaaatg
     3601 tcttggggac atggaagtca accactgcca tgactgcaag cgggagttca gctggatagt
     3661 gcgacggcac cactgcagga tatgtggccg tatcttctgt tactactgct gtaataacta
     3721 tgttgtgact aagcccagtg gcaagaagga acgctgctgc cgagcctgct tccagaagtt
     3781 cggcgaaggc tctggatcca atgatagcag tggttcaggc actagccagg gagagcccag
     3841 ccccatggtg tcaccagctg aagcaagtcc ccagtccata ggaagccaag ggataaactc
     3901 agtctgcaga ccaccagacg atgctgtgtt tgacatcatc actgatgaag aactgtgcca
     3961 gatccaagaa tctggctcct ccttgcctga aacacccact gaaactgatt caatggaccc
     4021 gaatacggct gaacaggaca ccacatcaaa ctcattaacc cctgaagaca ctgaagacgt
     4081 gcccatgggg caagatgctg aaatctgctt gctgaagtca ggagagctga tgatcaaatt
     4141 acccctcaca gtagaggagg tcgccagctt cggggagggc agcagggagc tgtttgtgag
     4201 gtccagtacc tacagcctga tcaccatcac cgtggctgag cctggcctca ccatcagctg
     4261 ggtcttctct tctgatccca agagcatctc cttcagtgtg gtcttccaag agacagaaga
     4321 cacgccgctc gaccagtgca aggtcctcat tcccaccacc cgatgcaatt cccacaagga
     4381 gaacatccgg ggccagctga aggtccgaat ccctggcatc tacttgctca tctttgacaa
     4441 caccttttca agatttatct ccaaaaaagt gctttaccac ctgactgttg accggcctgt
     4501 gatctacgat ggaagcgatt tcccatagca tcagtacctg aactctaatt agctcttcat
     4561 catccacagg aaacactact cctcctcacc tatctcatta aacatgaaca cgcacactca
     4621 tccacaaaat tttaaatatt aaaaaattag aagcaaaaga aagaaaatca gctgtgcccc
     4681 cagctcagca gttctgcagc tttggcagag gccttgggct ccacagtgcg cttggctcca
     4741 tgcagccgtt actctcaggt cccagagccc ctaagaacaa ggtacaagac tcagcctttt
     4801 catccaaagt gacaccatta accacacctg ggatcacagc tggtaacaat ctactgtgtg
     4861 gtatttttca ggccagacgt ggtcttgata gtatatctac tcttcaacag ccaagattgt
     4921 aggccaaggg ccactgccct ggccactttg tgaagccttg ggtagtccta ggagaaaaac
     4981 actacagggt catcatgtca aagatgcccc cattcgttaa tttccccata agtggggtct
     5041 gcttcttcca ctcagcgact ttgggaggcc agagttgttg tgctgttctc ctgagccttt
     5101 gtctgctcgg gggctttgtt cagcaaggcc actcagcaga tctaaatcac caccaccacc
     5161 accaccacac acacacactc acacacacac acactcacac tcacacacac acactcacac
     5221 acacacacac tcacacacac acactcacac acacactcac acacacacac acacacacac
     5281 tctcacacac acacacacac acacacacac acacactcac acacacacac acacacacac
     5341 tcacacacac acacactcac acatacacac acacacacac acacactcac acacacacac
     5401 actcacacac acacacacac acacacactc aggaaccaaa cagaggtcta ggaaaaagca
     5461 actactacat gaaggcttca gctctgcata tggacagcag gagtccaaat acaggctaag
     5521 ttccctacag tggcaccaaa gctcacgtgt cagcctagag cccatctgtg attataaact
     5581 agagtttctg cctcagctgc agacagctgt ttactaatga gtggggctgg ggtaagacct
     5641 actgtcaatc cctgcaacct ttctatgaaa gaaaagtctt tggtaactta agaggctacc
     5701 tagtggaaga acaggacata acttccattt gtcactccct ccctgtttgc ctacttcctg
     5761 ctagttagct cacacctgat gttgtagaca gtttactgtt tctttttcta ggacaggcaa
     5821 atagatagct tagatagctt cctgttctct ctggcccctt cttactccta ccaccaagaa
     5881 tttacccatg atggcaactt tgttcagtgt gaagaagcca gcatgttcag ctgagccttt
     5941 gaaggctacc ctgggttctt gtgggtctgt atgtggcctg agattgctaa aagccaaatt
     6001 atcttacctt tgaacccttc taccctcttg caaatggaat gctgaagcca gcttgttcaa
     6061 tagatcaaca gcatccagta ccaaatagga tctcattttt attgcttgga ttttccaggg
     6121 tatattggag acactggcca aactcatggc cttctgctgg tgtcactgcc accatcttca
     6181 tcaagagcca tcattcactg agttgctgct gtgttggtgg cctgggaggg gcctgagacc
     6241 ttacatttga gttcatcctg aactcagtca ctcatcagga ggcccatgtg gttcttgtga
     6301 agctcagacc tgaggtgaga ggctccagtg ctgactgcat agtactccac taggcatata
     6361 ccaactctgt ttttaatagt ctatttttgt gctaaatggg ctttgtactg tacttgctcc
     6421 agtctgctga gcactaggtt actagagaac atttggccct gtgtaagtgt gcctttcata
     6481 catagcttta tggttttaag tagtccccag ttttactggg gtttagtcat tggagtaaat
     6541 ttttgaaaaa tgcaattgac aactgaagaa tcattaagga agatgatggc ccagctggat
     6601 ttaattacac caaagatcat aaggaaacat ccttgagatc ttggtgattc tcttcctgag
     6661 ggcagcctct cctctaatga ctcagcctat tcctaacagt caggtcagta gtgttgccag
     6721 ctgcctgctc gccaatacca ctgaagcact atgagacttc acccaccttg agacagagtg
     6781 gccctccgtg tctgagtgga ctttgagagt attgctgact gaagtaccca ggattctagc
     6841 tagtcctaga ccaagagcag gcaaaggaat tctcaaacag gaatctggaa ctgaaaattt
     6901 ccatatggtt ttggaggtag aaatgaagag ccatatataa acaaagatgt tatttctgaa
     6961 caatttcaat tgcccccccc cccaggtaat caaaccactc ctggcccaaa aagaaggaaa
     7021 tcgtgtagat atggtttgat gatcataggg ttttgttttt aaactcaaac tcagtggttc
     7081 aacctgtgag aattctttaa actgagaaaa aaacattctt ggctcacagg ttttggaaaa
     7141 ggaggcagag aggagagaca tctttgactc ctcagaacca gggagtgcaa tacaaagact
     7201 attgagtgct gctcacattt acaaaaacga acactacttg gtagaatctt agcacacttt
     7261 ccttgtctca tttcatttct tctgaggaaa caggaaagtt aattcataat ttccttttcc
     7321 ctctcaagca ctttttaaat ttccagagac ctctgatcaa gggtcatttt tagagccttt
     7381 tgatgtgtgt ttaatctcac tcaatgttct tttggtgact gcagtgatac tgagcctccg
     7441 tgggaaggct taacagttag agtgcacttt aattcattaa ttcacgatcc atgtggcctt
     7501 ataataatgg gtcaaggaac ccatttcatt cttgcctgcc aaagagttac acagaagcac
     7561 atcaaacacc agcacttcac ctgcacgaag ggatgagact gggatccctg agtaaacttc
     7621 tttaatagtg tgtgctatgc catttggaaa tgttttttaa cctcaggttt taaataaagc
     7681 aaatactgtg gcatttggag ta
//
