LOCUS       NM_011815               4997 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FYN binding protein 1 (Fyb1), transcript variant 1,
            mRNA.
ACCESSION   NM_011815 XM_974556
VERSION     NM_011815.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4997)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4997)
  AUTHORS   Xiong,Y., Li,Y., Cui,X., Zhang,L., Yang,X. and Liu,H.
  TITLE     ADAP restraint of STAT1 signaling regulates macrophage phagocytosis
            in immune thrombocytopenia
  JOURNAL   Cell Mol Immunol 19 (8), 898-912 (2022)
   PUBMED   35637282
  REMARK    GeneRIF: ADAP restraint of STAT1 signaling regulates macrophage
            phagocytosis in immune thrombocytopenia.
REFERENCE   3  (bases 1 to 4997)
  AUTHORS   Boning,M.A.L., Parzmair,G.P., Jeron,A., Dusedau,H.P., Kershaw,O.,
            Xu,B., Relja,B., Schluter,D., Dunay,I.R., Reinhold,A., Schraven,B.
            and Bruder,D.
  TITLE     Enhanced Susceptibility of ADAP-Deficient Mice to Listeria
            monocytogenes Infection Is Associated With an Altered Phagocyte
            Phenotype and Function
  JOURNAL   Front Immunol 12, 724855 (2021)
   PUBMED   34659211
  REMARK    GeneRIF: Enhanced Susceptibility of ADAP-Deficient Mice to Listeria
            monocytogenes Infection Is Associated With an Altered Phagocyte
            Phenotype and Function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4997)
  AUTHORS   Peterson,E.J., Woods,M.L., Dmowski,S.A., Derimanov,G., Jordan,M.S.,
            Wu,J.N., Myung,P.S., Liu,Q.H., Pribila,J.T., Freedman,B.D.,
            Shimizu,Y. and Koretzky,G.A.
  TITLE     Coupling of the TCR to integrin activation by Slap-130/Fyb
  JOURNAL   Science 293 (5538), 2263-2265 (2001)
   PUBMED   11567141
  REMARK    GeneRIF: Important for coupling TCR-mediated actin cytoskeletal
            rearrangement with activation of integrin function and for T cells
            to respond fully to activating signals.
REFERENCE   5  (bases 1 to 4997)
  AUTHORS   Griffiths,E.K., Krawczyk,C., Kong,Y.Y., Raab,M., Hyduk,S.J.,
            Bouchard,D., Chan,V.S., Kozieradzki,I., Oliveira-Dos-Santos,A.J.,
            Wakeham,A., Ohashi,P.S., Cybulsky,M.I., Rudd,C.E. and
            Penninger,J.M.
  TITLE     Positive regulation of T cell activation and integrin adhesion by
            the adapter Fyb/Slap
  JOURNAL   Science 293 (5538), 2260-2263 (2001)
   PUBMED   11567140
  REMARK    GeneRIF: Regulates TCR-induced integrin clustering and adhesion.
REFERENCE   6  (bases 1 to 4997)
  AUTHORS   Black,D.S., Marie-Cardine,A., Schraven,B. and Bliska,J.B.
  TITLE     The Yersinia tyrosine phosphatase YopH targets a novel
            adhesion-regulated signalling complex in macrophages
  JOURNAL   Cell Microbiol 2 (5), 401-414 (2000)
   PUBMED   11207596
REFERENCE   7  (bases 1 to 4997)
  AUTHORS   Krause,M., Sechi,A.S., Konradt,M., Monner,D., Gertler,F.B. and
            Wehland,J.
  TITLE     Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP),
            Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the
            Arp2/3 complex link T cell receptor (TCR) signaling to the actin
            cytoskeleton
  JOURNAL   J Cell Biol 149 (1), 181-194 (2000)
   PUBMED   10747096
REFERENCE   8  (bases 1 to 4997)
  AUTHORS   Veale,M., Raab,M., Li,Z., da Silva,A.J., Kraeft,S.K.,
            Weremowicz,S., Morton,C.C. and Rudd,C.E.
  TITLE     Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130)
            interacts with SLP-76 and up-regulates interleukin 2 production
  JOURNAL   J Biol Chem 274 (40), 28427-28435 (1999)
   PUBMED   10497204
REFERENCE   9  (bases 1 to 4997)
  AUTHORS   Timms,J.F., Swanson,K.D., Marie-Cardine,A., Raab,M., Rudd,C.E.,
            Schraven,B. and Neel,B.G.
  TITLE     SHPS-1 is a scaffold for assembling distinct adhesion-regulated
            multi-protein complexes in macrophages
  JOURNAL   Curr Biol 9 (16), 927-930 (1999)
   PUBMED   10469599
REFERENCE   10 (bases 1 to 4997)
  AUTHORS   da Silva,A.J., Li,Z., de Vera,C., Canto,E., Findell,P. and
            Rudd,C.E.
  TITLE     Cloning of a novel T-cell protein FYB that binds FYN and
            SH2-domain-containing leukocyte protein 76 and modulates
            interleukin 2 production
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7493-7498 (1997)
   PUBMED   9207119
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC161196.4 and AC158901.5.
            
            On May 23, 2013 this sequence version replaced NM_011815.4.
            
            Summary: The protein encoded by this gene is an adapter molecule
            that affects T cell receptor signaling and contains multiple
            protein-protein interaction domains. It is thought to couple T cell
            receptor stimulation with activation of integrin function.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF061744.2, BC141352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1200              AC161196.4         42341-43540         c
            1201-1357           AC161196.4         3637-3793           c
            1358-1404           AC158901.5         102413-102459       c
            1405-1424           AC158901.5         100247-100266       c
            1425-1459           AC158901.5         99720-99754         c
            1460-1580           AC158901.5         97615-97735         c
            1581-1740           AC158901.5         93565-93724         c
            1741-1885           AC158901.5         91946-92090         c
            1886-1908           AC158901.5         89952-89974         c
            1909-1978           AC158901.5         88768-88837         c
            1979-2116           AC158901.5         87632-87769         c
            2117-2142           AC158901.5         85869-85894         c
            2143-2209           AC158901.5         83611-83677         c
            2210-2309           AC158901.5         80628-80727         c
            2310-2472           AC158901.5         79987-80149         c
            2473-2506           AC158901.5         73966-73999         c
            2507-2538           AC158901.5         71817-71848         c
            2539-4997           AC158901.5         66923-69381         c
FEATURES             Location/Qualifiers
     source          1..4997
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 3.19 cM"
     gene            1..4997
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /note="FYN binding protein 1"
                     /db_xref="GeneID:23880"
                     /db_xref="MGI:MGI:1346327"
     exon            1..1200
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1357
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1404
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1424
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1459
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1580
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1740
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1885
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1908
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1978
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2116
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2142
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2209
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2309
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2472
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2506
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2538
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..4997
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2676..2681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /note="hexamer: TATAAA"
     polyA_site      2706
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /note="major polyA site"
     regulatory      4973..4978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
                     /note="hexamer: AATAAA"
     polyA_site      4997
                     /gene="Fyb1"
                     /gene_synonym="ADAP; B630013F22Rik; Fyb; FYB-120/130;
                     p120/130; p120/p130; Slap130"
ORIGIN      
        1 cttgaaggta cagtatttta aattgcaagt gagatttctg actctcagct ggtttttgtt
       61 ccctgtgctt gtaggatgga aaaacagatg taaaatccct catggcgaag ttcaacacgg
      121 ggagtaaccc gacagaggag gccgccacca gcagcaggcc cttcaaagtt gcaggacaaa
      181 gctcgccttc tggaatacaa tcaagaaaga atttatttga caaccaagga aatgccagcc
      241 cgcccgcagg acccagcagc atgcctaaat ttgggaccac aaaaccaccc ttggcagcga
      301 aacctaccta cgaggagaag cctgagaagg aacctaaacc cccgttttta aaacctactg
      361 gagggagccc aagatttgga acacagccaa actcagtttc tagagaccct gaggtcaaag
      421 tggggttcct gaaacctgta agccccaaac ccaccagctt gaccaaagaa gattccaaac
      481 ctgtggtttt acggccacct gggaataaac ttcacaattt gaaccaagag tctgacttaa
      541 agacgccagg accgaagcca gggcccgctc ccccagtccc agaaaacgaa ctgaagccag
      601 gattctcaaa ggtagctgga gctaagagca agttcatgcc agcggcacaa gatactgact
      661 ccaaaccccg atttcccaga cacacctttg gccagaagcc atccctaagc acagaggact
      721 cccaggaaga gaacacttct aagaacgtgc ctgtccagaa aggatcccca gtgcagttgg
      781 gcgccaagtc caagggcgcc cctttcaaac cacctaagga agacccagag gataaagacc
      841 atggagcacc aagttcaccc tttcctggag tggttctgaa acctgctgcg agcagaggga
      901 gcccgggtct ctccaaaaac tttgaagaaa aaaaagaaga taggaaaaca gaccttgcaa
      961 agaacatctt tctgaacaaa ctgaatcaag aagagccggc cagattccct aaggcccctt
     1021 ccaagctgac agcggggaca ccgtggggcc aaagtcagga gaaagaagga gacaagaatt
     1081 ctgcaacccc gaagcagaag gccctgccac ccctgtccgt cttgggcccg cctccaccca
     1141 agcccaacag accacccaac gttgacctga ccagattccg aaaggctgac tctgcaaaca
     1201 gtgccaccaa aagccagaca ccttactcga caacttccct gccaccacct ccgcctacac
     1261 atccagccag ccagccacct ctgccagcgt ctcacccagc gcatccgcca gtccccagcc
     1321 tgccccccag aaacatcaaa cctccccttg acctgaaaca tcctataaat gacgaaaatc
     1381 aagatggtgt catgcactct gatggtactg gaaatctaga agaggaacaa gagagtgaag
     1441 gggaaacata cgaagacata gattcatcta aggaacgaga caagaaacgg gaaaaagaag
     1501 aaaagaagag gttggaacta gaacgaaagg agcagaagga gagagagaag aaagagcaag
     1561 aactgaagaa gaaattcaag ctcacgggcc ccattcaagt catccaccat gcaaaagcct
     1621 gctgcgatgt caaaggagga aagaatgagc tgagcttcaa acaaggagag gacattgaga
     1681 ttatccgcat cacagacaac ccagaaggaa aatggctggg caggactgca agggggtcat
     1741 atggttatat taaaacaact gccgtggaga ttgactatga ttcgctgaaa cggaagaaga
     1801 actccctcaa tgctgtccca ccaagacttg ttgaagatga ccaggatgtc tatgatgatg
     1861 tggctgagca ggatgcccct aacagccacg gtcagagcgg aagtggaggg atgttccccc
     1921 cgccaccaac agacgacgag atctatgacg gaatagagga ggaagatgat gacgatggat
     1981 ccgtgccaca ggttgacgag aagactaacg catggtcctg ggggattttg aagatgttaa
     2041 agggaaaaga tgacagaaag aaaagcattc gagagaaacc taaagtctct gaatcagaca
     2101 ataatgaagg ttcatctctc ccttctcagc ataagcaact ggatgtggga gaagaagttt
     2161 acgatgatgt ggatgcctca gacttccctc ctccacctgc agagatgagt caaggaatga
     2221 gtgttggaag ggcaaaaacg gaagagaaag atcccaagaa gctaaaaaag caagaaaagg
     2281 aagaaaaaga cctcaggaaa aaatttaagt acgacggtga aattcgagtt ctatattcaa
     2341 ctaaagttgc gtcctcctta acctctaaaa agtggggagc gagagatctg cagataaaac
     2401 ctggggagtc actcgaagtt atacaaagca cagatgacac caaagttctc tgcaggaatg
     2461 aagagggcaa atatggttat gtccttcgga gttacctggt ggacaatgat ggagaaatct
     2521 atgacgacat cgctgatggt tgcatctatg acaatgacta gcactctgct ctgttcattc
     2581 cactgtgcct cttagtggcc aacatgaatt ttaattagaa tgttcttggg tattatagaa
     2641 aaaaatgtga acatacaaaa tgaaatgtca atctctataa agttttgaaa ttttaaacct
     2701 ggaaaatgaa ctctgtttaa tatgttggaa gatcaggaat gggctttttt cccttcttcc
     2761 ttccttcctc tttgttgttg ttgttgctgt tgctgttgct gttgctgttg ctgttgctgt
     2821 tgttgtgatc aagggtttct tactgtgtca ttcatgcctt tttcctgcct cagcctccaa
     2881 agggctgaaa taatcaacct gagccaccac agctggctta aggatcccat tttgcttccg
     2941 cacttctctt agaccagcag cagaatctcc tctgccatag gctctttaaa gaaataaaga
     3001 aacaggaatg taaagaagga gttttcaatc ccacaagcag ccagccttca cttgtcatca
     3061 gattacctac ccaaaaaata gacagagcaa gcgcctctca agctgaacga caagagtagt
     3121 ggcagaacat ttgtatcaaa ttggttcctt tgtgttcact atgaaatcat atgttaatta
     3181 tttgataagc atgctttctg ctctgtatgc acatctaaga ttaacctgtg tacaagagtc
     3241 taaaatctta tttctgtgga tctgtacaca catcgttgac ttctgtgctc tgtttaaata
     3301 ccatccttac ctagagaaat ggaggaggct accggacagt tgcaaacact gtaaggaaga
     3361 accctgagac ccgctctcct tcacagtggc gctttactgt gtagtctctt gggaagggtt
     3421 ttgtgctttg cttctgcaga actttgtgat gtttataacc actttactag aaaattgttg
     3481 agcagaggga acgcagggca agaaatccca gtgctcccag tgcttagcct gggtgctccc
     3541 cgctgagacc tgtccctcac cacctcttcc aaactgcaaa gcattggctt tcatatgcta
     3601 agaacactaa gcaccgttat gcaaaacaga gccccccaca tccaagtcga taacagatga
     3661 ggtaacactg ttttaaaatg actgagtcct gaggctggtt ctattgttga ccatgctgca
     3721 accttggcaa tattcattac tcgtccactg ttcttgtaaa ataggcgtca actaagtttg
     3781 tcccagcatt tttttctact gccagcttca agcttttaca gttttacctc catctcagat
     3841 gcacaattca gaagttcttt tgtgtttttc tatttgaaat cactgattaa ataataatac
     3901 attatataag taaactgcaa aagtccattg gcgtttccga agagggaccc cattacattt
     3961 ttttaaaatc aaaaattctc tgggatagag aaataactca gttggtaaaa gtgtttgcag
     4021 gcaagcttga agatggaatt caatccacag atcccaggtg aaaaccgaat gtggagacct
     4081 gtactcgcca tattagtgct gaggaggcag aggtgggagg ttcctgtgga tcagtggaca
     4141 ctctgtctat cctaattgct gagtcccaca ccaaggacag acatctctaa ggagatgaac
     4201 agcacctgag gaacaagagc tgaggagtcc tttggaccct acacatatat gtcctctcac
     4261 atataggaac atgtgcatac ggattaaaaa atctgtaaaa atagcccaaa gccttcaaat
     4321 ggttagagtt tctattactt tgttgttgtt gttttgtttt gttttttgaa acaaggtttc
     4381 cctgtgtgac cctagctgtt ctggaacttg ctctgtagac caggctggcc ttgaactcac
     4441 acagatccac ctgcctctgc ctccctagtg gtggaactaa ctaacggtgt gctactgccc
     4501 agccaagtga tttgaaattt taaagactgt cagcagtagc tacagctcaa tttataggat
     4561 acaggctctg agtctcctgg gctgggaact actcatctca actcatctca gattaggaag
     4621 tatttggcag tattagccat catgtgtccc tgtgataaat tcttgtatca ctagataaat
     4681 atgacgtggc tcaaagtggc catttggtag ctttggcatc aaatataaat tatatgctgc
     4741 ctgccttttc agtaattttc cctgattaag attagcacaa ttcaatgcta aaatcccaaa
     4801 ttagatcaag agaatatttc agcttcgatg tatagtcaag gaaatggaca gatacctagg
     4861 agaaatttgt gtaataatta tttaatatat atttgaggtg ttaattttaa tatactaaat
     4921 atgattttgt tgtagattgt gtgtggactt ttgttgtatg agaagagctg ccaataaaat
     4981 actttttcag caagtga
//
