LOCUS       NM_022007                679 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus FXYD domain-containing ion transport regulator 7
            (Fxyd7), mRNA.
ACCESSION   NM_022007
VERSION     NM_022007.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 679)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 679)
  AUTHORS   Jing,J., Feng,J., Yuan,Y., Guo,T., Lei,J., Pei,F., Ho,T.V. and
            Chai,Y.
  TITLE     Spatiotemporal single-cell regulatory atlas reveals neural crest
            lineage diversification and cellular function during tooth
            morphogenesis
  JOURNAL   Nat Commun 13 (1), 4803 (2022)
   PUBMED   35974052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 679)
  AUTHORS   Wang,Y., Wu,H., Fontanet,P., Codeluppi,S., Akkuratova,N.,
            Petitpre,C., Xue-Franzen,Y., Niederreither,K., Sharma,A., Da
            Silva,F., Comai,G., Agirman,G., Palumberi,D., Linnarsson,S.,
            Adameyko,I., Moqrich,A., Schedl,A., La Manno,G., Hadjab,S. and
            Lallemend,F.
  TITLE     A cell fitness selection model for neuronal survival during
            development
  JOURNAL   Nat Commun 10 (1), 4137 (2019)
   PUBMED   31515492
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 679)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 679)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 679)
  AUTHORS   Kerns,R.T., Ravindranathan,A., Hassan,S., Cage,M.P., York,T.,
            Sikela,J.M., Williams,R.W. and Miles,M.F.
  TITLE     Ethanol-responsive brain region expression networks: implications
            for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J
            mice
  JOURNAL   J Neurosci 25 (9), 2255-2266 (2005)
   PUBMED   15745951
REFERENCE   7  (bases 1 to 679)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
REFERENCE   8  (bases 1 to 679)
  AUTHORS   Crambert,G., Li,C., Swee,L.K. and Geering,K.
  TITLE     FXYD7, mapping of functional sites involved in endoplasmic
            reticulum export, association with and regulation of Na,K-ATPase
  JOURNAL   J Biol Chem 279 (29), 30888-30895 (2004)
   PUBMED   15133029
  REMARK    GeneRIF: FXYD7 is a new member of proteins with a regulated ER
            export and has a particular regulatory function in brain
REFERENCE   9  (bases 1 to 679)
  AUTHORS   Beguin,P., Crambert,G., Monnet-Tschudi,F., Uldry,M.,
            Horisberger,J.D., Garty,H. and Geering,K.
  TITLE     FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta
            isozymes
  JOURNAL   EMBO J 21 (13), 3264-3273 (2002)
   PUBMED   12093728
  REMARK    GeneRIF: Expressed in Xenopus oocytes, mouse FXYD7 can interact
            with Na,K-ATPase alpha 1-beta 1, alpha 2-beta 1 and alpha 3-beta 1
            but not with alpha-beta 2 isozymes whereas, in brain, it is only
            associated with alpha 1-beta isozymes.
REFERENCE   10 (bases 1 to 679)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Kathleen Sweadner. The reference sequence was
            derived from AI892161.1.
            
            Summary: This reference sequence was derived from multiple
            replicate ESTs and validated by similar human genomic sequence.
            This gene encodes a member of a family of small membrane proteins
            that share a 35-amino acid signature sequence domain, beginning
            with the sequence PFXYD and containing 7 invariant and 6 highly
            conserved amino acids. The approved human gene nomenclature for the
            family is FXYD-domain containing ion transport regulator.
            Transmembrane topology has been established for two family members
            (FXYD1 and FXYD2), with the N-terminus extracellular and the
            C-terminus on the cytoplasmic side of the membrane. FXYD2, also
            known as the gamma subunit of the Na,K-ATPase, regulates the
            properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
            FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
            induce channel activity in experimental expression systems. This
            gene product, FXYD7, is novel and has not been characterized as a
            protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D.,
            sweadner@helix.mgh.harvard.edu., Dec 2000].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048737.1, AK004113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.29 cM"
     gene            1..679
                     /gene="Fxyd7"
                     /gene_synonym="1110035I01Rik"
                     /note="FXYD domain-containing ion transport regulator 7"
                     /db_xref="GeneID:57780"
                     /db_xref="MGI:MGI:1889006"
     exon            1..99
                     /gene="Fxyd7"
                     /gene_synonym="1110035I01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..311
                     /gene="Fxyd7"
                     /gene_synonym="1110035I01Rik"
                     /codon_start=1
                     /product="FXYD domain-containing ion transport regulator
                     7"
                     /protein_id="NP_071290.1"
                     /db_xref="CCDS:CCDS21122.1"
                     /db_xref="GeneID:57780"
                     /db_xref="MGI:MGI:1889006"
                     /translation="MATPTQSPTNVPEETDPFFYDYATVQTVGMTLATIMFVLGIIII
                     LSKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV"
     exon            100..129
                     /gene="Fxyd7"
                     /gene_synonym="1110035I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            130..204
                     /gene="Fxyd7"
                     /gene_synonym="1110035I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            205..247
                     /gene="Fxyd7"
                     /gene_synonym="1110035I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            248..288
                     /gene="Fxyd7"
                     /gene_synonym="1110035I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            289..678
                     /gene="Fxyd7"
                     /gene_synonym="1110035I01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      651..656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fxyd7"
                     /gene_synonym="1110035I01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      678
                     /gene="Fxyd7"
                     /gene_synonym="1110035I01Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctgcttccag ctgctgcagc cgcgccttcg ctgcctcagc attcagcaac cccctgctca
       61 ggctcagcat ggccacccca acccagagcc ccacaaacgt tcctgaagaa acagatcctt
      121 ttttctatga ctatgccact gtgcagactg tggggatgac cctggccact atcatgttcg
      181 tgctggggat catcatcatc ctgagcaaga aggtgaagtg caggaaggcg gattccaggt
      241 ctgagagccc aacatgcaaa tcctgtaagt cggaactgcc ctcctcagcc cctggaggtg
      301 gcggtgtgta ggatcctctg cagatttcca ctgctgtccc tggccagagt gcaggaacca
      361 gaggacccag agaaggcggt ggggacccag cctggcgcca gggagtgtgc ccccaatcag
      421 ccgccagacc caccccaagg ccggagccaa tgcaccccgc tctccctccc caggccttgg
      481 caacaacgat cctatttgta ccctagaccc agagactcag gcctccagct cctgggatcc
      541 aggagtccat ccccagtccc ctgggatcct agtgtccctc cctcctgcat ctcctggtct
      601 ccttctccag gaccttccca gcttcccctc agggtccaca tcttgagctt aataaatgtg
      661 cattcgtttt ttcccccca
//
