LOCUS       NM_022004               1804 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus FXYD domain-containing ion transport regulator 6
            (Fxyd6), mRNA.
ACCESSION   NM_022004
VERSION     NM_022004.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1804)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 1804)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1804)
  AUTHORS   Turrero Garcia,M., Stegmann,S.K., Lacey,T.E., Reid,C.M.,
            Hrvatin,S., Weinreb,C., Adam,M.A., Nagy,M.A. and Harwell,C.C.
  TITLE     Transcriptional profiling of sequentially generated septal neuron
            fates
  JOURNAL   Elife 10, e71545 (2021)
   PUBMED   34851821
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1804)
  AUTHORS   Pereira Luppi,M., Azcorra,M., Caronia-Brown,G., Poulin,J.F.,
            Gaertner,Z., Gatica,S., Moreno-Ramos,O.A., Nouri,N., Dubois,M.,
            Ma,Y.C., Ramakrishnan,C., Fenno,L., Kim,Y.S., Deisseroth,K.,
            Cicchetti,F., Dombeck,D.A. and Awatramani,R.
  TITLE     Sox6 expression distinguishes dorsally and ventrally biased
            dopamine neurons in the substantia nigra with distinctive
            properties and embryonic origins
  JOURNAL   Cell Rep 37 (6), 109975 (2021)
   PUBMED   34758317
REFERENCE   5  (bases 1 to 1804)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   6  (bases 1 to 1804)
  AUTHORS   Delprat,B., Schaer,D., Roy,S., Wang,J., Puel,J.L. and Geering,K.
  TITLE     FXYD6 is a novel regulator of Na,K-ATPase expressed in the inner
            ear
  JOURNAL   J Biol Chem 282 (10), 7450-7456 (2007)
   PUBMED   17209044
  REMARK    GeneRIF: FXYD6 is a novel regulator of Na,K-ATPase expressed in the
            inner ear.
REFERENCE   7  (bases 1 to 1804)
  AUTHORS   Mulligan,M.K., Ponomarev,I., Hitzemann,R.J., Belknap,J.K.,
            Tabakoff,B., Harris,R.A., Crabbe,J.C., Blednov,Y.A., Grahame,N.J.,
            Phillips,T.J., Finn,D.A., Hoffman,P.L., Iyer,V.R., Koob,G.F. and
            Bergeson,S.E.
  TITLE     Toward understanding the genetics of alcohol drinking through
            transcriptome meta-analysis
  JOURNAL   Proc Natl Acad Sci U S A 103 (16), 6368-6373 (2006)
   PUBMED   16618939
REFERENCE   8  (bases 1 to 1804)
  AUTHORS   Geering,K.
  TITLE     FXYD proteins: new regulators of Na-K-ATPase
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F241-F250 (2006)
   PUBMED   16403837
  REMARK    Review article
REFERENCE   9  (bases 1 to 1804)
  AUTHORS   Yamaguchi,F., Yamaguchi,K., Tai,Y., Sugimoto,K. and Tokuda,M.
  TITLE     Molecular cloning and characterization of a novel
            phospholemman-like protein from rat hippocampus
  JOURNAL   Brain Res Mol Brain Res 86 (1-2), 189-192 (2001)
   PUBMED   11165386
REFERENCE   10 (bases 1 to 1804)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Kathleen Sweadner. The reference sequence was
            derived from BY081454.1, BQ891313.1, AK003888.1 and BG093642.1.
            
            On Jul 25, 2006 this sequence version replaced NM_022004.5.
            
            Summary: This reference sequence was derived from multiple
            replicate ESTs and validated by similar human genomic sequence.
            This gene encodes a member of a family of small membrane proteins
            that share a 35-amino acid signature sequence domain, beginning
            with the sequence PFXYD and containing 7 invariant and 6 highly
            conserved amino acids. The approved human gene nomenclature for the
            family is FXYD-domain containing ion transport regulator.
            Transmembrane topology has been established for two family members
            (FXYD1 and FXYD2), with the N-terminus extracellular and the
            C-terminus on the cytoplasmic side of the membrane. FXYD2, also
            known as the gamma subunit of the Na,K-ATPase, regulates the
            properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
            FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
            induce channel activity in experimental expression systems. This
            gene product, Fxyd6, is novel and has not been characterized as a
            protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D.,
            sweadner@helix.mgh.harvard.edu., Jul 2006].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042579.1, SRR1660815.277566.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               BY081454.1         2-356
            356-1128            BQ891313.1         70-842
            1129-1786           AK003888.1         892-1549
            1787-1804           BG093642.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..1804
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /note="FXYD domain-containing ion transport regulator 6"
                     /db_xref="GeneID:59095"
                     /db_xref="MGI:MGI:1890226"
     exon            1..304
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /inference="alignment:Splign:2.1.0"
     exon            305..364
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..594
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /note="phosphohippolin; PLM-like protein"
                     /codon_start=1
                     /product="FXYD domain-containing ion transport regulator 6
                     precursor"
                     /protein_id="NP_071287.1"
                     /db_xref="CCDS:CCDS23133.1"
                     /db_xref="GeneID:59095"
                     /db_xref="MGI:MGI:1890226"
                     /translation="METVLVLCSLLAPVVLASAAEKEKEKDPFYYDYQTLRIGGLVFA
                     VVLFSVGILLILSRRCKCSFNQKPRAPGDEEAQVENLITTNAAEPQKAEN"
     exon            365..403
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /inference="alignment:Splign:2.1.0"
     exon            404..478
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /inference="alignment:Splign:2.1.0"
     exon            479..515
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /inference="alignment:Splign:2.1.0"
     exon            516..565
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /inference="alignment:Splign:2.1.0"
     exon            566..615
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /inference="alignment:Splign:2.1.0"
     exon            616..1792
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1762..1767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /note="hexamer: AATAAA"
     polyA_site      1788
                     /gene="Fxyd6"
                     /gene_synonym="0610030I18Rik; Php"
                     /note="major polyA site"
ORIGIN      
        1 agctgctggc aaatccgctc cggcgctggg cgcctcctcc gcgcgtctcc tgttgcttct
       61 tcaagcctca cttccctttg cgaagagctc gcagagagaa gggcgcgggc gacatcacag
      121 gggtctgcaa ggggacccag aagccagtgg acgagggcga ccggggaggc caaccagtca
      181 gccccctctg ggaggcggga aagctgcaag ccgcgcccac cgccctgccc ccagcgcgcc
      241 actcccggct gcttggactc tgctagtcct tctgggatcc gctcggaggg gacccaacgc
      301 ctagacacca tggagacggt gctggtcctc tgcagcttgc tggcccctgt ggtcctggcg
      361 agtgcagctg agaaggagaa agaaaaggat cctttctatt acgactacca gaccctgagg
      421 attggggggt tggtgtttgc tgtggtcctc ttctccgttg ggatacttct catcctcagt
      481 cgcaggtgca agtgcagttt caatcagaag cccagggctc caggtgacga agaggcccag
      541 gtggagaacc tcatcactac aaacgctgcg gagccccaga aggcagagaa ctgaggtgca
      601 gcctccagcg tgaagcctcc agaagccaag gccagctacc tgacgcttca gagactgatg
      661 tcgaggcttg agaaaaccgg ctacttcata ccagaccttt ccctaggaga agccaagaat
      721 gcgtgttccc tgtgcctctc cctgcccccc actaacccca gtcctatatt aatgatgcaa
      781 cacttctcac tgcagccggg ctctggaccc tgtctgtgcc gtgtctgtgc cgtgtctgtg
      841 ccgtgtctgt gtgtgtctgc tgactgtggt cgaccgtgga tttcattgtt tctgtgaact
      901 gtgtgcttcc tctcccacgc taccatcggc gccttgtgtc ctcctgtgac ctccatctcc
      961 tcttgctctc tggagtctgc tctgttcctg aggagcccta gtcccatctc tggattgaga
     1021 gagagttagt tgtccccagg gcaggagtcc ccagcggacc cagggctgag aaagtttgtt
     1081 gctattcttt gtggactctc agaagaaact tgctctggat tccaccagtt cagaaggtct
     1141 gtttgcagct ggagagtcat tgctgcagga tctgccttcc agggctcctt ttccttttag
     1201 ggtgtccact gcagagtccc catctgcccc accctttagg gaacacccag gaaatcttgc
     1261 ctctggggaa cgagctcctc tcttatcttc cgagcaataa cctggtaggc tctggagtcc
     1321 ccctgccttc atccaccttt cctgcttcta agacttccat ctctggcccg atttatctga
     1381 gcagaggact cctttcttct ccgaagctgg tctctagcag gagatagtca aggggacagg
     1441 cagtggaaag ggtggggacg gttctgtctc tctgcctggt ggtgtggata tggcagactt
     1501 tgcagtttct tgtccctgcc tgtcaggggt cagagtggag agggatggaa gggttcaggg
     1561 gcagcggggc tgagggtcag agagcaacag ggtatgagca gcctggatgc aaaggccaga
     1621 agtcaaaagt catcagagtg gaaactcaca ccggagcctg cccaacctgc ctaatgtgtt
     1681 cccttggaaa ctaaccaagc cacactgtgt actgggactg ctgatctctg tcttgtgatc
     1741 tatatcctct gacaacagaa aaataaataa atacagcatt gtttcctagt gaaaaaaaaa
     1801 aaaa
//
