LOCUS       NM_008557                524 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FXYD domain-containing ion transport regulator 3
            (Fxyd3), mRNA.
ACCESSION   NM_008557
VERSION     NM_008557.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Yin,Y., Haller,M.E., Chadchan,S.B., Kommagani,R. and Ma,L.
  TITLE     Signaling through retinoic acid receptors is essential for
            mammalian uterine receptivity and decidualization
  JOURNAL   JCI Insight 6 (17), e150254 (2021)
   PUBMED   34292881
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 524)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 524)
  AUTHORS   Xue,Y., Lai,L., Lian,W., Tu,X., Zhou,J., Dong,P., Su,D., Wang,X.,
            Cao,X., Chen,Y. and Wang,Q.
  TITLE     SOX9/FXYD3/Src Axis Is Critical for ER+ Breast Cancer Stem Cell
            Function
  JOURNAL   Mol Cancer Res 17 (1), 238-249 (2019)
   PUBMED   30206184
REFERENCE   5  (bases 1 to 524)
  AUTHORS   Vallois,D., Niederhauser,G., Ibberson,M., Nagaraj,V., Marselli,L.,
            Marchetti,P., Chatton,J.Y. and Thorens,B.
  TITLE     Gluco-incretins regulate beta-cell glucose competence by epigenetic
            silencing of Fxyd3 expression
  JOURNAL   PLoS One 9 (7), e103277 (2014)
   PUBMED   25058609
  REMARK    GeneRIF: Because gluco-incretin secretion depends on feeding the
            epigenetic regulation of Fxyd3 expression may link nutrition in
            early life to establishment of adult beta-cell glucose competence.
            Erratum:[PLoS One. 2014;9(12):e116451. Nagaray, Vini [corrected to
            Nagaraj, Vini]]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 524)
  AUTHORS   Crambert,G., Li,C., Claeys,D. and Geering,K.
  TITLE     FXYD3 (Mat-8), a new regulator of Na,K-ATPase
  JOURNAL   Mol Biol Cell 16 (5), 2363-2371 (2005)
   PUBMED   15743908
  REMARK    GeneRIF: regulator of Na,K-ATPase
REFERENCE   7  (bases 1 to 524)
  AUTHORS   Runkel,F., Michels,M. and Franz,T.
  TITLE     Fxyd3 and Lgi4 expression in the adult mouse: a case of endogenous
            antisense expression
  JOURNAL   Mamm Genome 14 (10), 665-672 (2003)
   PUBMED   14694902
  REMARK    GeneRIF: Fxyd3 and Lgi4 transcripts potentially form
            double-stranded RNA molecules in many cell types in vivo, which may
            impact on their respective expression
REFERENCE   8  (bases 1 to 524)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
REFERENCE   9  (bases 1 to 524)
  AUTHORS   Morrison,B.W., Moorman,J.R., Kowdley,G.C., Kobayashi,Y.M.,
            Jones,L.R. and Leder,P.
  TITLE     Mat-8, a novel phospholemman-like protein expressed in human breast
            tumors, induces a chloride conductance in Xenopus oocytes
  JOURNAL   J Biol Chem 270 (5), 2176-2182 (1995)
   PUBMED   7836447
REFERENCE   10 (bases 1 to 524)
  AUTHORS   Morrison,B.W. and Leder,P.
  TITLE     neu and ras initiate murine mammary tumors that share genetic
            markers generally absent in c-myc and int-2-initiated tumors
  JOURNAL   Oncogene 9 (12), 3417-3426 (1994)
   PUBMED   7970700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC158993.2, AA959274.1,
            EH101686.1 and BG067532.2.
            
            On Aug 11, 2009 this sequence version replaced NM_008557.1.
            
            Summary: This gene encodes a member of a family of small membrane
            proteins that share a 35-amino acid signature sequence domain,
            beginning with the sequence PFXYD and containing 7 invariant and 6
            highly conserved amino acids. The encoded protein is a
            transmembrane protein that functions as a specific regulator of
            Na,K-ATPase. [provided by RefSeq, Aug 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI081078.1, BG067532.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC158993.2         38809-38851         c
            44-425              AA959274.1         1-382
            426-522             EH101686.1         282-378
            523-524             BG067532.2         1-2                 c
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.29 cM"
     gene            1..524
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /note="FXYD domain-containing ion transport regulator 3"
                     /db_xref="GeneID:17178"
                     /db_xref="MGI:MGI:107497"
     exon            1..77
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /inference="alignment:Splign:2.1.0"
     exon            78..131
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..358
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /note="mammary tumor 8 kDa protein; chloride conductance
                     inducer protein Mat-8; sodium/potassium-transporting
                     ATPase subunit FXYD3"
                     /codon_start=1
                     /product="FXYD domain-containing ion transport regulator 3
                     precursor"
                     /protein_id="NP_032583.1"
                     /db_xref="CCDS:CCDS21125.1"
                     /db_xref="GeneID:17178"
                     /db_xref="MGI:MGI:107497"
                     /translation="MQEVVLSLLVLLAGLPTLDANDPENKNDPFYYDWYSLRVGGLIC
                     AGILCALGIIVLMSGKCKCKFRQKPSHRPGEGPPLITPGSAHNC"
     exon            132..164
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /inference="alignment:Splign:2.1.0"
     exon            165..188
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /inference="alignment:Splign:2.1.0"
     exon            189..263
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /inference="alignment:Splign:2.1.0"
     exon            264..300
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /inference="alignment:Splign:2.1.0"
     exon            301..338
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /inference="alignment:Splign:2.1.0"
     exon            339..524
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      503..508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /note="hexamer: TATAAA"
     polyA_site      522
                     /gene="Fxyd3"
                     /gene_synonym="Mat8"
                     /note="major polyA site"
ORIGIN      
        1 ataaaggctg tcccggcttg gcaagtccat actctgcttt ctcccggaac cacctctcag
       61 cctgttgagc tactcaggtc aaggctttga catgcaagag gttgttctga gcctgttggt
      121 ccttctagca ggcctgccta ctttggatgc caatgaccct gaaaataaaa atgatccttt
      181 ctactatgat tggtacagcc tccgagtcgg cgggctcatt tgtgcaggga ttctctgtgc
      241 cctgggcatt atagtcctta tgagtggcaa atgcaaatgc aagttcagac agaaacccag
      301 tcaccgccca ggagaagggc cacctctcat cacaccaggc tcagctcaca actgctgaag
      361 atggaccagt taaaagagca caggtcctgg ctctgaaggt gggcttgaac tccgagctgg
      421 ctgttctcct cccctcctga cactgccttc cccgagcctc atctcacccc tcgtggtagc
      481 aggctctttg ttcagttttt aatataaaat gatttcacat catg
//
