LOCUS       NM_007503                546 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Mus musculus FXYD domain-containing ion transport regulator 2
            (Fxyd2), transcript variant a, mRNA.
ACCESSION   NM_007503
VERSION     NM_007503.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 546)
  AUTHORS   Cao,X.Y., Liu,Y., Kan,J.S., Huang,X.X., Kambey,P.A., Zhang,C.T. and
            Gao,J.
  TITLE     Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced
            neuroinflammation by up-regulating FXYD2 expression
  JOURNAL   Brain Res Bull 212, 110970 (2024)
   PUBMED   38688414
  REMARK    GeneRIF: Microglial SIX2 suppresses lipopolysaccharide
            (LPS)-induced neuroinflammation by up-regulating FXYD2 expression.
REFERENCE   2  (bases 1 to 546)
  AUTHORS   Chernova,I., Song,W., Steach,H., Hafez,O., Al Souz,J., Chen,P.M.,
            Chandra,N., Cantley,L., Veselits,M., Clark,M.R. and Craft,J.
  TITLE     The ion transporter Na+-K+-ATPase enables pathological B cell
            survival in the kidney microenvironment of lupus nephritis
  JOURNAL   Sci Adv 9 (5), eadf8156 (2023)
   PUBMED   36724234
REFERENCE   3  (bases 1 to 546)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   4  (bases 1 to 546)
  AUTHORS   Liu,Y.B., Tewari,A., Salameh,J., Arystarkhova,E., Hampton,T.G.,
            Brashear,A., Ozelius,L.J., Khodakhah,K. and Sweadner,K.J.
  TITLE     A dystonia-like movement disorder with brain and spinal neuronal
            defects is caused by mutation of the mouse laminin beta1 subunit,
            Lamb1
  JOURNAL   Elife 4, e11102 (2015)
   PUBMED   26705335
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 546)
  AUTHORS   Wang,F., Cai,B., Li,K.C., Hu,X.Y., Lu,Y.J., Wang,Q., Bao,L. and
            Zhang,X.
  TITLE     FXYD2, a gamma subunit of Na, K-ATPase, maintains persistent
            mechanical allodynia induced by inflammation
  JOURNAL   Cell Res 25 (3), 318-334 (2015)
   PUBMED   25633594
  REMARK    GeneRIF: FXYD2 activity may be a fundamental mechanism underlying
            the persistent hypersensitivity to pain induced by inflammation.
REFERENCE   6  (bases 1 to 546)
  AUTHORS   Meij,I.C., Koenderink,J.B., van Bokhoven,H., Assink,K.F.,
            Groenestege,W.T., de Pont,J.J., Bindels,R.J., Monnens,L.A., van den
            Heuvel,L.P. and Knoers,N.V.
  TITLE     Dominant isolated renal magnesium loss is caused by misrouting of
            the Na(+),K(+)-ATPase gamma-subunit
  JOURNAL   Nat Genet 26 (3), 265-266 (2000)
   PUBMED   11062458
REFERENCE   7  (bases 1 to 546)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
REFERENCE   8  (bases 1 to 546)
  AUTHORS   Minor,N.T., Sha,Q., Nichols,C.G. and Mercer,R.W.
  TITLE     The gamma subunit of the Na,K-ATPase induces cation channel
            activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6521-6525 (1998)
   PUBMED   9600999
REFERENCE   9  (bases 1 to 546)
  AUTHORS   Jones,D.H., Davies,T.C. and Kidder,G.M.
  TITLE     Embryonic expression of the putative gamma subunit of the sodium
            pump is required for acquisition of fluid transport capacity during
            mouse blastocyst development
  JOURNAL   J Cell Biol 139 (6), 1545-1552 (1997)
   PUBMED   9396759
REFERENCE   10 (bases 1 to 546)
  AUTHORS   Mercer,R.W., Biemesderfer,D., Bliss,D.P. Jr., Collins,J.H. and
            Forbush,B. 3rd.
  TITLE     Molecular cloning and immunological characterization of the gamma
            polypeptide, a small protein associated with the Na,K-ATPase
  JOURNAL   J Cell Biol 121 (3), 579-586 (1993)
   PUBMED   8387529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162176.2.
            
            On Mar 10, 2020 this sequence version replaced NM_007503.3.
            
            Summary: This gene encodes a member of a family of small membrane
            proteins that share a 35-amino acid signature sequence domain,
            beginning with the sequence PFXYD and containing 7 invariant and 6
            highly conserved amino acids. The approved human gene nomenclature
            for the family is FXYD-domain containing ion transport regulator.
            Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,
            also known as the gamma subunit of the Na,K-ATPase, regulates the
            properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
            FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
            induce channel activity in experimental expression systems.
            Transmembrane topology has been established for two family members
            (FXYD1 and FXYD2), with the N-terminus extracellular and the
            C-terminus on the cytoplasmic side of the membrane. The Type III
            integral membrane protein encoded by this gene is the gamma subunit
            of the Na,K-ATPase present on the plasma membrane. Although the
            Na,K-ATPase does not depend on the gamma subunit to be functional,
            it is thought that the gamma subunit modulates the enzyme's
            activity by inducing ion channel activity. Multiple transcript
            variants have been described for this gene that are expressed in
            tissue-specific and developmental stage-specific patterns and
            encode proteins that differ at the N-terminus. [provided by RefSeq,
            Sep 2009].
            
            Transcript Variant: This variant (a) represents the most frequently
            occurring transcript and it encodes the longest protein (isoform
            a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024614.1, BF781502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC162176.2         195947-196023
            78-116              AC162176.2         197963-198001
            117-191             AC162176.2         198157-198231
            192-228             AC162176.2         199370-199406
            229-259             AC162176.2         199560-199590
            260-546             AC162176.2         199849-200135
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..546
                     /gene="Fxyd2"
                     /gene_synonym="Atp1g1"
                     /note="FXYD domain-containing ion transport regulator 2"
                     /db_xref="GeneID:11936"
                     /db_xref="MGI:MGI:1195260"
     exon            1..77
                     /gene="Fxyd2"
                     /gene_synonym="Atp1g1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..253
                     /gene="Fxyd2"
                     /gene_synonym="Atp1g1"
                     /note="isoform a is encoded by transcript variant a;
                     sodium pump gamma chain; sodium/potassium-transporting
                     ATPase gamma chain; sodium/potassium-transporting ATPase
                     subunit gamma; Na(+)/K(+) ATPase subunit gamma; ATPase,
                     Na+/K+ transporting, gamma 1 polypeptide"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     gamma isoform a"
                     /protein_id="NP_031529.2"
                     /db_xref="GeneID:11936"
                     /db_xref="MGI:MGI:1195260"
                     /translation="MAGEISDLSANSGGSAKGTENPFEYDYETVRKGGLIFAGLAFVV
                     GLLIILSKRFRCGGGKKHRQVNEDEL"
     exon            78..116
                     /gene="Fxyd2"
                     /gene_synonym="Atp1g1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..191
                     /gene="Fxyd2"
                     /gene_synonym="Atp1g1"
                     /inference="alignment:Splign:2.1.0"
     exon            192..228
                     /gene="Fxyd2"
                     /gene_synonym="Atp1g1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..259
                     /gene="Fxyd2"
                     /gene_synonym="Atp1g1"
                     /inference="alignment:Splign:2.1.0"
     exon            260..546
                     /gene="Fxyd2"
                     /gene_synonym="Atp1g1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      496..501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fxyd2"
                     /gene_synonym="Atp1g1"
                     /note="hexamer: AATGAA"
     polyA_site      546
                     /gene="Fxyd2"
                     /gene_synonym="Atp1g1"
                     /note="major polyA site"
ORIGIN      
        1 atagtagagg ccacaggaag accgtcgtgg agaagccccg atggctgggg aaatatcaga
       61 tctgtcagcg aacagtggtg gcagtgccaa ggggacagag aatcccttcg agtacgacta
      121 tgaaaccgtc cgcaaaggag gcctgatctt cgcgggcctg gccttcgtcg tgggcctcct
      181 catcattctc agcaaaaggt tccgctgtgg gggcggtaag aaacataggc aggtcaatga
      241 agatgaactg tgacagaaga gccggcagtg cccacgggtg catgggcacc agcgatgacc
      301 accttcccca gctgcgcacc acagacccca gcacagtcag catgggctga aggaagtgcc
      361 aggcatcctg ggaacccctt catggtcatc ccctcctgcc tcagatcctt aacttcctct
      421 cttccccagc ttctctaaca ccccactccc tgttccaagt tgaggagcat gtgtagcctc
      481 atccccctgg ttttcaatga atccttgtat aagcaactgc caatgaaatc gggctcgctg
      541 tggtca
//
