LOCUS       NM_019503                575 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus FXYD domain-containing ion transport regulator 1
            (Fxyd1), transcript variant 1, mRNA.
ACCESSION   NM_019503
VERSION     NM_019503.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 575)
  AUTHORS   Hansen,T.S., Karimi Galougahi,K., Tang,O., Tsang,M.,
            Scherrer-Crosbie,M., Arystarkhova,E., Sweadner,K., Bursill,C.,
            Bubb,K.J. and Figtree,G.A.
  TITLE     The FXYD1 protein plays a protective role against pulmonary
            hypertension and arterial remodeling via redox and inflammatory
            mechanisms
  JOURNAL   Am J Physiol Heart Circ Physiol 326 (3), H623-H635 (2024)
   PUBMED   38133617
  REMARK    GeneRIF: The FXYD1 protein plays a protective role against
            pulmonary hypertension and arterial remodeling via redox and
            inflammatory mechanisms.
REFERENCE   2  (bases 1 to 575)
  AUTHORS   Bubb,K.J., Tang,O., Gentile,C., Moosavi,S.M., Hansen,T., Liu,C.C.,
            Di Bartolo,B.A. and Figtree,G.A.
  TITLE     FXYD1 Is Protective Against Vascular Dysfunction
  JOURNAL   Hypertension 77 (6), 2104-2116 (2021)
   PUBMED   33934624
  REMARK    GeneRIF: FXYD1 Is Protective Against Vascular Dysfunction.
REFERENCE   3  (bases 1 to 575)
  AUTHORS   Dani,N., Herbst,R.H., McCabe,C., Green,G.S., Kaiser,K., Head,J.P.,
            Cui,J., Shipley,F.B., Jang,A., Dionne,D., Nguyen,L., Rodman,C.,
            Riesenfeld,S.J., Prochazka,J., Prochazkova,M., Sedlacek,R.,
            Zhang,F., Bryja,V., Rozenblatt-Rosen,O., Habib,N., Regev,A. and
            Lehtinen,M.K.
  TITLE     A cellular and spatial map of the choroid plexus across brain
            ventricles and ages
  JOURNAL   Cell 184 (11), 3056-3074 (2021)
   PUBMED   33932339
REFERENCE   4  (bases 1 to 575)
  AUTHORS   Boguslavskyi,A., Tokar,S., Prysyazhna,O., Rudyk,O.,
            Sanchez-Tatay,D., Lemmey,H.A.L., Dora,K.A., Garland,C.J.,
            Warren,H.R., Doney,A., Palmer,C.N.A., Caulfield,M.J., Vlachaki
            Walker,J., Howie,J., Fuller,W. and Shattock,M.J.
  TITLE     Phospholemman Phosphorylation Regulates Vascular Tone, Blood
            Pressure, and Hypertension in Mice and Humans
  JOURNAL   Circulation 143 (11), 1123-1138 (2021)
   PUBMED   33334125
REFERENCE   5  (bases 1 to 575)
  AUTHORS   Aksentijevic,D., Karlstaedt,A., Basalay,M.V., O'Brien,B.A.,
            Sanchez-Tatay,D., Eminaga,S., Thakker,A., Tennant,D.A., Fuller,W.,
            Eykyn,T.R., Taegtmeyer,H. and Shattock,M.J.
  TITLE     Intracellular sodium elevation reprograms cardiac metabolism
  JOURNAL   Nat Commun 11 (1), 4337 (2020)
   PUBMED   32859897
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 575)
  AUTHORS   Geering,K.
  TITLE     FXYD proteins: new regulators of Na-K-ATPase
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F241-F250 (2006)
   PUBMED   16403837
  REMARK    Review article
REFERENCE   7  (bases 1 to 575)
  AUTHORS   Despa,S., Bossuyt,J., Han,F., Ginsburg,K.S., Jia,L.G., Kutchai,H.,
            Tucker,A.L. and Bers,D.M.
  TITLE     Phospholemman-phosphorylation mediates the beta-adrenergic effects
            on Na/K pump function in cardiac myocytes
  JOURNAL   Circ Res 97 (3), 252-259 (2005)
   PUBMED   16002746
  REMARK    GeneRIF: PLM modulates the NKA function in a manner similar to the
            way phospholamban affects the related SR Ca-ATPase (inhibition of
            transport substrate affinity, that is relieved by phosphorylation).
REFERENCE   8  (bases 1 to 575)
  AUTHORS   Jia,L.G., Donnet,C., Bogaev,R.C., Blatt,R.J., McKinney,C.E.,
            Day,K.H., Berr,S.S., Jones,L.R., Moorman,J.R., Sweadner,K.J. and
            Tucker,A.L.
  TITLE     Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase
            activity in phospholemman-deficient mice
  JOURNAL   Am J Physiol Heart Circ Physiol 288 (4), H1982-H1988 (2005)
   PUBMED   15563542
  REMARK    GeneRIF: a primary effect of phospholemman is to modulate the
            Na-K-ATPase and that its reduced activity initiates compensatory
            responses in heart hypertrophy
REFERENCE   9  (bases 1 to 575)
  AUTHORS   Bogaev,R.C., Jia,L.G., Kobayashi,Y.M., Palmer,C.J., Mounsey,J.P.,
            Moorman,J.R., Jones,L.R. and Tucker,A.L.
  TITLE     Gene structure and expression of phospholemman in mouse
  JOURNAL   Gene 271 (1), 69-79 (2001)
   PUBMED   11410367
REFERENCE   10 (bases 1 to 575)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC149055.6, BY064152.1,
            AK002585.1, BY132051.1 and AI853335.1.
            
            On Sep 25, 2009 this sequence version replaced NM_019503.3.
            
            Summary: This gene encodes a member of the FXYD family of small
            membrane proteins that share a 35-amino acid signature sequence
            domain, beginning with the sequence PFXYD and containing 7
            invariant and 6 highly conserved amino acids. The protein encoded
            by this gene is a plasma membrane substrate for several kinases,
            including protein kinase A, protein kinase C, NIMA kinase, and
            myotonic dystrophy kinase. It is thought to form an ion channel or
            regulate ion channel activity and act as an accessory protein of
            Na,K-ATPase. Alternatively spliced transcript variants have been
            described. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK793316.1, BI220706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC149055.6         12301-12301
            2-14                BY064152.1         1-13
            15-404              AK002585.1         2-391
            405-405             BY132051.1         374-374
            406-556             AK002585.1         393-543
            557-557             AC149055.6         16277-16277
            558-575             AI853335.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.29 cM"
     gene            1..575
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /note="FXYD domain-containing ion transport regulator 1"
                     /db_xref="GeneID:56188"
                     /db_xref="MGI:MGI:1889273"
     exon            1..106
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..389
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; phospholemman; sodium/potassium-transporting
                     ATPase subunit FXYD1"
                     /codon_start=1
                     /product="phospholemman isoform a precursor"
                     /protein_id="NP_062376.2"
                     /db_xref="GeneID:56188"
                     /db_xref="MGI:MGI:1889273"
                     /translation="MGAMASPGHILALCVCLLSMASAEAPQEPDPFTYDYHTLRIGGL
                     TIAGILFILGILIILSKRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSSRRR"
     exon            107..171
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /inference="alignment:Splign:2.1.0"
     exon            172..204
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /inference="alignment:Splign:2.1.0"
     exon            205..279
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /inference="alignment:Splign:2.1.0"
     exon            280..316
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /inference="alignment:Splign:2.1.0"
     exon            317..366
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /inference="alignment:Splign:2.1.0"
     exon            367..421
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /inference="alignment:Splign:2.1.0"
     exon            422..559
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /inference="alignment:Splign:2.1.0"
     regulatory      533..538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /note="hexamer: AATAAA"
     polyA_site      557
                     /gene="Fxyd1"
                     /gene_synonym="0610012C17Rik; 1110006M24Rik; Plm; Pml"
                     /note="major polyA site"
ORIGIN      
        1 gggtggagca tccagttctg ggccaggggg tccaaagtgc ttagctccta gggtgcacag
       61 ctggacattt gggggtcttc tgtcaacagg ggacagcgtg aatgggggca atggcatctc
      121 ccggccacat cctggctctg tgtgtgtgtc tcctctccat ggccagtgca gaagctccac
      181 aggaaccgga tccattcacc tacgattacc acaccctgcg gatcggcggc ctcactatcg
      241 ctgggatcct cttcatcttg ggcatcctta tcatccttag caagagatgt cgatgcaaat
      301 tcaaccaaca gcagagaact ggggaacccg acgaagagga gggaactttc cgcagctcca
      361 tccgccgtct gtcatcccgc aggcggtaga acctccacct gactccagga aactcagcca
      421 gagccccctt agcacctgac acctctcccc acccagatgc tcgcctgtga ccacccccag
      481 cgttccctgc atcagccctg cctttcggac accccttgct gctcagacct ctaataaaac
      541 tcggttttcc ttcttgataa aaaaaaaaaa aaaaa
//
