LOCUS       NM_011814               3002 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FMR1 autosomal homolog 2 (Fxr2), mRNA.
ACCESSION   NM_011814 XM_918176
VERSION     NM_011814.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3002)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3002)
  AUTHORS   Lo,A.C., Rajan,N., Gastaldo,D., Telley,L., Hilal,M.L., Buzzi,A.,
            Simonato,M., Achsel,T. and Bagni,C.
  TITLE     Absence of RNA-binding protein FXR2P prevents prolonged phase of
            kainate-induced seizures
  JOURNAL   EMBO Rep 22 (4), e51404 (2021)
   PUBMED   33779029
REFERENCE   4  (bases 1 to 3002)
  AUTHORS   McSweeney,C., Dong,F., Chen,M., Vitale,J., Xu,L., Crowley,N.,
            Luscher,B., Zou,D. and Mao,Y.
  TITLE     Full function of exon junction complex factor, Rbm8a, is critical
            for interneuron development
  JOURNAL   Transl Psychiatry 10 (1), 379 (2020)
   PUBMED   33154347
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3002)
  AUTHORS   Qie,S., Majumder,M., Mackiewicz,K., Howley,B.V., Peterson,Y.K.,
            Howe,P.H., Palanisamy,V. and Diehl,J.A.
  TITLE     Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head
            and neck squamous cell carcinoma
  JOURNAL   Nat Commun 8 (1), 1534 (2017)
   PUBMED   29142209
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3002)
  AUTHORS   Bontekoe,C.J., McIlwain,K.L., Nieuwenhuizen,I.M., Yuva-Paylor,L.A.,
            Nellis,A., Willemsen,R., Fang,Z., Kirkpatrick,L., Bakker,C.E.,
            McAninch,R., Cheng,N.C., Merriweather,M., Hoogeveen,A.T.,
            Nelson,D., Paylor,R. and Oostra,B.A.
  TITLE     Knockout mouse model for Fxr2: a model for mental retardation
  JOURNAL   Hum Mol Genet 11 (5), 487-498 (2002)
   PUBMED   11875043
  REMARK    GeneRIF: This protein shows high expression in brain and testis.
            The protein was tested in a behavioral test battery in knockout
            mice. The mice showed behavioral abnormalities.
REFERENCE   7  (bases 1 to 3002)
  AUTHORS   Kirkpatrick,L.L., McIlwain,K.A. and Nelson,D.L.
  TITLE     Comparative genomic sequence analysis of the FXR gene family: FMR1,
            FXR1, and FXR2
  JOURNAL   Genomics 78 (3), 169-177 (2001)
   PUBMED   11735223
REFERENCE   8  (bases 1 to 3002)
  AUTHORS   Schenck,A., Bardoni,B., Moro,A., Bagni,C. and Mandel,J.L.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
REFERENCE   9  (bases 1 to 3002)
  AUTHORS   Ceman,S., Brown,V. and Warren,S.T.
  TITLE     Isolation of an FMRP-associated messenger ribonucleoprotein
            particle and identification of nucleolin and the fragile X-related
            proteins as components of the complex
  JOURNAL   Mol Cell Biol 19 (12), 7925-7932 (1999)
   PUBMED   10567518
REFERENCE   10 (bases 1 to 3002)
  AUTHORS   Miyashita,A., Shimizu,N., Endo,N., Hanyuu,T., Ishii,N., Ito,K.,
            Itoh,Y., Shirai,M., Nakajima,T., Odani,S. and Kuwano,R.
  TITLE     Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are
            clustered in a 40 kb region of mouse chromosome 11
  JOURNAL   Gene 237 (1), 53-60 (1999)
   PUBMED   10524236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062971.1.
            
            On Dec 23, 2005 this sequence version replaced NM_011814.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062971.1, AK154243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     gene            1..3002
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /note="FMR1 autosomal homolog 2"
                     /db_xref="GeneID:23879"
                     /db_xref="MGI:MGI:1346074"
     exon            1..428
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..2372
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /codon_start=1
                     /product="RNA-binding protein FXR2"
                     /protein_id="NP_035944.2"
                     /db_xref="CCDS:CCDS24901.1"
                     /db_xref="GeneID:23879"
                     /db_xref="MGI:MGI:1346074"
                     /translation="MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFEN
                     NWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFY
                     VIEYAACDATYNEIVTLERLRPVNPSPLATKGSFFKVTMAVPEDLREACSNENVHKEF
                     KKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKH
                     LETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYG
                     ETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDK
                     KNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGF
                     RPPGSGRGGSGGGSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGGPAYGPSSD
                     PSTASETESEKREESNRAGPGDRDPPSRGEESRRRPIGGRGRGPPPVPRPTSRYNSSS
                     ISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGL
                     ESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQS
                     RQRPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSLVNGVS"
     exon            429..481
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            482..575
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            576..647
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            648..796
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            797..890
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1007
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1178
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1257
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1367
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1454
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1683
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1881
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2082
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2178
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2276
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2970
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2951..2956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /note="hexamer: AATAAA"
     polyA_site      2970
                     /gene="Fxr2"
                     /gene_synonym="Fxr2h; FXR2P"
                     /note="major polyA site"
ORIGIN      
        1 gggaggtgga ggccgtggag cggcagcggc gggtcccggg accgaggcag cagcgggggc
       61 gccggcgggc ggaagctgag gtgacgaagg cggcggcggc ggcggcggcc gtttccctca
      121 cggtggcgga gaccaaggca gcggcggcgg cggcggacgg ggagcggccc ggccccggcc
      181 ccctgctcgt cggctgtagc agggccgccg tggggccggc ccggctcccg ccccccgcgg
      241 ctccccctcc ggctcctcct ccagggagac gccggggacc cggcccggcc cgcactcagg
      301 gctctgtttc agctgctgcc gggccagtcg gaggtggtgg cggcgccatg ggcggcctgg
      361 cctctggggg ggatgtggag ccgggactgc ccgtcgaggt gcggggctcc aacggggcct
      421 tctacaaggg ctttgtaaag gatgtccatg aagactctgt cactatcttc tttgagaaca
      481 actggcagag tgagagacag attccctttg gggatgtccg actaccgcct ccagctgact
      541 acaataagga aatcacagaa ggagatgaag tagaggtcta ttcgagagcc aatgaacagg
      601 aaccttgtgg ctggtggctg gcccgggtgc ggatgatgaa gggagatttc tatgtcattg
      661 agtacgctgc ctgtgatgct acctacaatg agattgtcac tctggaacga cttcggccag
      721 tcaatcccag tccccttgca accaaaggca gcttcttcaa ggttaccatg gctgtgcctg
      781 aggacctcag ggaggcctgc tccaatgaaa atgtccataa ggagttcaag aaagcactgg
      841 gagccaactg catctttctc aacatcacaa acagtgagct ctttattctg tcaaccacag
      901 aagcccctgt gaagagggca tctttgttgg gtgatatgca tttccgaagc cttcgcacca
      961 aattgctgct catgtcccgc aatgaagaag ctactaagca cctagagaca agtaagcagc
     1021 tggcagcagc cttccaagag gagttcacag tgcgagagga cctgatgggt ctggcgatcg
     1081 gaacgcacgg tgccaacatc cagcaggctc ggaaagtgcc cggagtgact gccattgagt
     1141 tgggtgaaga gacctgcact ttccgaatct atggggagac accagaggca tgcagacagg
     1201 ctcgaagcta ccttgaattt tccgaggact ctgtacaagt gcccaggaac ctggttggca
     1261 aagtgatcgg aaagaacggg aaagtgattc aggagattgt ggataagtct ggtgtggtga
     1321 gggttcgtgt ggaaggagat aacgacaaga agaaccccag ggaggaggga atggttccct
     1381 tcatatttgt tggcacccga gagaacatca gcaatgccca ggcactgctt gagtatcacc
     1441 tctcctacct gcaggaggtt gaacagcttc gcctggagag actgcagatt gacgaacagc
     1501 ttcggcagat tgggctgggc tttcgccctc ctgggagtgg acggggtggc agtggtggtg
     1561 gcagtgacaa ggcgggctat accacagacg aaagctcctc ctcttccctg cacacgacca
     1621 gaacctatgg gggcagctat gggggccggg gccggggccg gaggactggt ggtcctgcct
     1681 atggccccag ctcagacccc tccacagctt cagagacaga gtcagaaaag agagaggagt
     1741 ctaatcgagc aggacctggt gacagagatc ccccaagccg tggagaagaa agcaggaggc
     1801 ggccgattgg gggccgggga aggggacccc cacctgttcc ccggcctacc tcaagatata
     1861 actcatcatc tattagctca gtgctaaagg atccagacag caatccttac agcctcttgg
     1921 acacatctga accagagcct ccagttgatt cggagcctgg tgaacctcct ccagcaagtg
     1981 cccgtcgtcg ccgttcccgc cgccgccgta ctgatgaaga caggactgtc atggacggag
     2041 gcctggagtc tgatggtcct aacatgacag agaatggcct ggaagatgaa tcaagacccc
     2101 agagacgaaa tcgcagccgc cgccgccgta atcgtggtaa ccggactgat gggtccatca
     2161 gtggagaccg ccaaccagtg actgtggctg actatatctc acgggcagag tctcagagcc
     2221 gccagcggcc cctggaacgc acgaaaccct cagaggattc tctttcagga cagaagggtg
     2281 actctgtcag caagcttccc aagggcccct cagagaatgg ggagctctct gcccccttgg
     2341 agttgggtag tttggtgaat ggagtttcat aaaacctccg gtccacatcc ctcctttctc
     2401 catctcgctt gctgcccacc accatggccc tcatgggtcc aactgacctg cgctggagct
     2461 gctcttatct acgggggagg ggggtggcac agcagcttgg gtccccccca acctccagga
     2521 gctagtggag gggtgtgtaa cagggtcata cccctccctc ttgtccaccc tacccccagg
     2581 gtgagggagc ctccccttcc ctttcagact ggatgtgcct ttatcctcta atgccccgac
     2641 ctctgaacac ccccattctc cgcctgttgg tgggggtgct ccttgaccca cccagatttg
     2701 acagttcagg ggggctcccc tgctatccct cctcccatcc tgtacccccc atttctgggg
     2761 cctcatcact gtggaagacg gggatagtga gggtattcgt gggtgggagg catggggaag
     2821 gttttggaat agaaccaggg gtatgtatga aggggggtga caaggtctcc caggggagtt
     2881 gggaggaaat aaccttgtct ggtggatgag aaggcgtatt tatttttcac tgtacagtat
     2941 ttaaaaagag aataaaaaaa tccaaatggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3001 aa
//
