LOCUS       NM_010244               1380 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus Friend virus susceptibility 1 (Fv1), mRNA.
ACCESSION   NM_010244
VERSION     NM_010244.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Boso,G., Lam,O., Bamunusinghe,D., Oler,A.J., Wollenberg,K., Liu,Q.,
            Shaffer,E. and Kozak,C.A.
  TITLE     Patterns of Coevolutionary Adaptations across Time and Space in
            Mouse Gammaretroviruses and Three Restrictive Host Factors
  JOURNAL   Viruses 13 (9), 1864 (2021)
   PUBMED   34578445
  REMARK    GeneRIF: Patterns of Coevolutionary Adaptations across Time and
            Space in Mouse Gammaretroviruses and Three Restrictive Host
            Factors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Yap,M.W., Young,G.R., Varnaite,R., Morand,S. and Stoye,J.P.
  TITLE     Duplication and divergence of the retrovirus restriction gene Fv1
            in Mus caroli allows protection from multiple retroviruses
  JOURNAL   PLoS Genet 16 (6), e1008471 (2020)
   PUBMED   32525879
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1380)
  AUTHORS   Young,G.R., Yap,M.W., Michaux,J.R., Steppan,S.J. and Stoye,J.P.
  TITLE     Evolutionary journey of the retroviral restriction gene Fv1
  JOURNAL   Proc Natl Acad Sci U S A 115 (40), 10130-10135 (2018)
   PUBMED   30224488
  REMARK    GeneRIF: Regions of Fv1 adapt cooperatively, highlighting its
            preference for repeated structures and suggesting that this
            functionally constrained aspect of the retroviral capsid lattice
            presents a common target in the evolution of intrinsic immunity.
REFERENCE   4  (bases 1 to 1380)
  AUTHORS   Boso,G., Buckler-White,A. and Kozak,C.A.
  TITLE     Ancient Evolutionary Origin and Positive Selection of the
            Retroviral Restriction Factor Fv1 in Muroid Rodents
  JOURNAL   J Virol 92 (18), e00850-18 (2018)
   PUBMED   29976659
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1380)
  AUTHORS   Li,W., Yap,M.W., Voss,V. and Stoye,J.P.
  TITLE     Expression levels of Fv1: effects on retroviral restriction
            specificities
  JOURNAL   Retrovirology 13 (1), 42 (2016)
   PUBMED   27342974
  REMARK    GeneRIF: data indicate that for some but not all Fv1 proteins, gain
            of restriction activities could be achieved by increasing the
            expression level of Fv1; however such a concentration dependent
            effect is not seen with most Fv1s and cannot explain the recently
            reported activities against non-MLVs
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1380)
  AUTHORS   Taylor,B.A., Bedigian,H.G. and Meier,H.
  TITLE     Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in
            recombinant inbred lines
  JOURNAL   J Virol 23 (1), 106-109 (1977)
   PUBMED   196096
REFERENCE   7  (bases 1 to 1380)
  AUTHORS   Steeves,R. and Lilly,F.
  TITLE     Interactions between host and viral genomes in mouse leukemia
  JOURNAL   Annu Rev Genet 11, 277-296 (1977)
   PUBMED   202189
  REMARK    Review article
REFERENCE   8  (bases 1 to 1380)
  AUTHORS   Stephenson,J.R. and Aaronson,S.A.
  TITLE     Induction of an endogenous B-tropic type C RNA virus from SWR/J
            mouse embryo cells in tissue culture
  JOURNAL   Virology 70 (2), 352-359 (1976)
   PUBMED   57668
REFERENCE   9  (bases 1 to 1380)
  AUTHORS   Rein,A., Kashmiri,S.V., Bassin,R.H., Gerwin,B.L. and
            Duran-Troise,G.
  TITLE     Phenotypic mixing between N- and B-tropic murine leukemia viruses:
            infectious particles with dual sensitivity to Fv-1 restriction
  JOURNAL   Cell 7 (3), 373-379 (1976)
   PUBMED   181144
REFERENCE   10 (bases 1 to 1380)
  AUTHORS   Odaka,T.
  TITLE     Genetic transmission of endogenous N- and B-tropic murine leukemia
            viruses in low-leukemic strain C57BL/6
  JOURNAL   J Virol 15 (2), 332-337 (1975)
   PUBMED   163359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X97719.1.
            
            On Jul 25, 2006 this sequence version replaced NM_010244.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1380              X97719.1           2167-3546
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.56 cM"
     gene            1..1380
                     /gene="Fv1"
                     /gene_synonym="Fv-1; Fv1d; Rv-1; Rv1"
                     /note="Friend virus susceptibility 1"
                     /db_xref="GeneID:14349"
                     /db_xref="MGI:MGI:95595"
     CDS             1..1380
                     /gene="Fv1"
                     /gene_synonym="Fv-1; Fv1d; Rv-1; Rv1"
                     /note="Rauscher leukemia virus susceptibility 1;
                     retrovirus restriction protein; Fv1 gammaretrovirus
                     restriction factor; Fv1 restriction factor"
                     /codon_start=1
                     /product="Friend virus susceptibility protein 1"
                     /protein_id="NP_034374.2"
                     /db_xref="CCDS:CCDS38964.1"
                     /db_xref="GeneID:14349"
                     /db_xref="MGI:MGI:95595"
                     /translation="MNFPRALAGFSSWLFKPELAEDSPDNDSPDNDTVNPWRELLQKI
                     NVADLPDSSFSSGKELNDSVYHTFEHFCKIRDYDAVGELLLAFLDKVTKERDQFRDEI
                     SQLRMHINDLKASKCVLGETLLSYRHRIEVGEKQTEALIVRLADVQSQVMCQPARKVS
                     ADKVRALIGKEWDPVTWDGDVWEDIDSEGSEEAELPTVLASPSLSEESGYALSKERTQ
                     QDKADAPQIQSSTSLVTSEPVTRPKSLSDLTSQKHRHTNHELNSLAHSNRQKAKEHAR
                     KWILRVWDNGGRLTILDQIEFLSLGPLSLDSEFNVIARTVEDNGVKSLFDWLAEAWVQ
                     RWPTTRELQSPDTLEWYSIEDGIERLRELGMIEWLCVKATCPQWRGPEDVPITRAMRI
                     TFVRETRETWKSFVFSLLCIKDITVGSVAAQLHDLIELSLKPTAAGLTSVGSVGVLSL
                     SPWKHQSNS"
     exon            1..1380
                     /gene="Fv1"
                     /gene_synonym="Fv-1; Fv1d; Rv-1; Rv1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaatttcc cacgtgcgct tgctggtttc tcgagctggc tcttcaaacc tgaacttgcc
       61 gaggactctc cggataatga ctctccggat aatgacactg ttaacccatg gcgtgagctg
      121 ctgcagaaga taaatgtggc cgatctcccc gattcatcct tttcgagcgg taaggaactt
      181 aatgactctg tgtaccatac ttttgaacat ttctgcaaga ttagggacta tgacgcagtt
      241 ggcgagctgc ttctggcatt tctggataaa gtaacaaagg aaagggacca attcagagat
      301 gaaatttccc agctccgaat gcacataaat gatctaaagg cttctaagtg tgtcctgggg
      361 gagactcttc tttcctaccg ccacaggatt gaagttgggg aaaaacagac tgaagccctc
      421 attgtgaggt tagctgatgt gcaatcccag gtcatgtgtc agcctgcccg gaaagtgtct
      481 gcagataagg tgagggcact gattggtaaa gaatgggatc cggtaacctg ggatggagat
      541 gtgtgggagg acatagattc tgaagggtct gaggaagctg agttgcccac tgtcttggcc
      601 tctccatcct tgtctgagga aagtggttat gccttgtcta aagaacgcac ccagcaggac
      661 aaagcagatg cccctcagat ccagtcttca acatccttag ttacttctga acctgtcacc
      721 agacccaagt ctctgtctga ccttacaagt cagaaacacc gccatactaa tcatgaactc
      781 aattcacttg ctcactcaaa tcgccaaaag gcaaaggaac atgctaggaa atggatttta
      841 agggtgtggg ataatggtgg gaggctcaca atactggatc agattgaatt tctcagttta
      901 ggtcctttga gccttgatag tgagtttaat gtcatagccc gcactgttga agataatggt
      961 gtgaagagtt tgtttgattg gttggctgaa gcatgggtcc agagatggcc tactacaaga
     1021 gagctgcagt cgcctgacac cctggagtgg tattctattg aggatgggat tgaaaggctt
     1081 agggaacttg gaatgataga gtggctttgt gtaaaagcta cttgtccaca gtggaggggc
     1141 ccggaagatg tacccatcac gagagctatg aggataactt ttgtccggga aactagagag
     1201 acttggaaga gctttgtatt tagcctcctc tgtataaagg acataacagt ggggagcgtg
     1261 gctgctcagt tgcatgatct aatagaatta agtttaaagc caacagcagc tggcttgact
     1321 tctgtaggct ctgtgggggt tctctctctc tctccctgga aacatcaaag caacagttaa
//
