LOCUS       NM_001403450            1699 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus fuzzy planar cell polarity protein (Fuz), transcript
            variant 1, mRNA.
ACCESSION   NM_001403450 XM_006541192
VERSION     NM_001403450.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Kim,S.E., Kim,H.Y., Wlodarczyk,B.J. and Finnell,R.H.
  TITLE     Linkage between Fuz and Gpr161 genes regulates sonic hedgehog
            signaling during mouse neural tube development
  JOURNAL   Development 151 (19) (2024)
   PUBMED   39369306
  REMARK    GeneRIF: Linkage between Fuz and Gpr161 genes regulates sonic
            hedgehog signaling during mouse neural tube development.
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Sharma,R., Kalot,R., Levin,Y., Babayeva,S., Kachurina,N.,
            Chung,C.F., Liu,K.J., Bouchard,M. and Torban,E.
  TITLE     The CPLANE protein Fuzzy regulates ciliogenesis by suppressing
            actin polymerization at the base of the primary cilium via p190A
            RhoGAP
  JOURNAL   Development 151 (6) (2024)
   PUBMED   38546045
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Lodge,E.J., Barrell,W.B., Liu,K.J. and Andoniadou,C.L.
  TITLE     The Fuzzy planar cell polarity protein (FUZ), necessary for primary
            cilium formation, is essential for pituitary development
  JOURNAL   J Anat 244 (2), 358-367 (2024)
   PUBMED   37794731
  REMARK    GeneRIF: The Fuzzy planar cell polarity protein (FUZ), necessary
            for primary cilium formation, is essential for pituitary
            development.
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Langousis,G., Cavadini,S., Boegholm,N., Lorentzen,E., Kempf,G. and
            Matthias,P.
  TITLE     Structure of the ciliogenesis-associated CPLANE complex
  JOURNAL   Sci Adv 8 (15), eabn0832 (2022)
   PUBMED   35427153
REFERENCE   6  (bases 1 to 1699)
  AUTHORS   Dai,D., Zhu,H., Wlodarczyk,B., Zhang,L., Li,L., Li,A.G.,
            Finnell,R.H., Roop,D.R. and Chen,J.
  TITLE     Fuz controls the morphogenesis and differentiation of hair
            follicles through the formation of primary cilia
  JOURNAL   J Invest Dermatol 131 (2), 302-310 (2011)
   PUBMED   20962855
  REMARK    GeneRIF: Fuz controls the morphogenesis and differentiation of hair
            follicles through the formation of primary cilia.
REFERENCE   7  (bases 1 to 1699)
  AUTHORS   Du,H., Wolf,J., Schafer,B., Moldoveanu,T., Chipuk,J.E. and
            Kuwana,T.
  TITLE     BH3 domains other than Bim and Bid can directly activate Bax/Bak
  JOURNAL   J Biol Chem 286 (1), 491-501 (2011)
   PUBMED   21041309
REFERENCE   8  (bases 1 to 1699)
  AUTHORS   Heydeck,W., Zeng,H. and Liu,A.
  TITLE     Planar cell polarity effector gene Fuzzy regulates cilia formation
            and Hedgehog signal transduction in mouse
  JOURNAL   Dev Dyn 238 (12), 3035-3042 (2009)
   PUBMED   19877275
  REMARK    GeneRIF: Fuz plays an important role in cilia formation, Hh signal
            transduction, and embryonic development in mammals.
REFERENCE   9  (bases 1 to 1699)
  AUTHORS   Gray,R.S., Abitua,P.B., Wlodarczyk,B.J., Szabo-Rogers,H.L.,
            Blanchard,O., Lee,I., Weiss,G.S., Liu,K.J., Marcotte,E.M.,
            Wallingford,J.B. and Finnell,R.H.
  TITLE     The planar cell polarity effector Fuz is essential for targeted
            membrane trafficking, ciliogenesis and mouse embryonic development
  JOURNAL   Nat Cell Biol 11 (10), 1225-1232 (2009)
   PUBMED   19767740
REFERENCE   10 (bases 1 to 1699)
  AUTHORS   Singla,V. and Reiter,J.F.
  TITLE     The primary cilium as the cell's antenna: signaling at a sensory
            organelle
  JOURNAL   Science 313 (5787), 629-633 (2006)
   PUBMED   16888132
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158231.2.
            
            On Mar 30, 2022 this sequence version replaced XM_006541192.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422589.385321.1,
                                           SRR17253011.2784315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AC158231.2         168792-169061
            271-392             AC158231.2         169246-169367
            393-477             AC158231.2         169614-169698
            478-561             AC158231.2         169960-170043
            562-666             AC158231.2         170219-170323
            667-864             AC158231.2         171202-171399
            865-960             AC158231.2         171475-171570
            961-1067            AC158231.2         171684-171790
            1068-1132           AC158231.2         171873-171937
            1133-1207           AC158231.2         172011-172085
            1208-1699           AC158231.2         172832-173323
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.99 cM"
     gene            1..1699
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /note="fuzzy planar cell polarity protein"
                     /db_xref="GeneID:70300"
                     /db_xref="MGI:MGI:1917550"
     exon            1..270
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1422
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein fuzzy homolog"
                     /codon_start=1
                     /product="protein fuzzy homolog isoform 1"
                     /protein_id="NP_001390379.1"
                     /db_xref="GeneID:70300"
                     /db_xref="MGI:MGI:1917550"
                     /translation="MGDEGPGSPVHLLCLAASSGVPLFCRSSSGGAPSRQQLPFSVIG
                     SLNGVHMFGQNLDVQLNSARTEDTTVVWKNFHDSITLIVLSSEEGTSELRLERMLHMV
                     FGAMVLIVGLEELTNIRNVERLKKELRVRLWDASYCLIDSFLGNSELIGDLTQCVDCV
                     IPPEGSAMQETLSGFAEATGTAFVSLLVSGRVVAATEGWWRLGMPEAVLLPWLVGSLP
                     PQAARDYPVYLPHGSPTVPHRLLTLTLLRGLELCLLCGPRPPLGQLDPQLMERWWQPL
                     LEPLRACLPLGPRALPEGFPLHSDILGLLLLHLELRRCLFTVEPSKDKEPSPEQRRRL
                     LRNFYTLVATTHFPPEPGPAEKQEDTVYPAQMPRACYLVLGPGMGWQLVAVQLGLRLL
                     LLLLSPHTPTHGLRSLATRTLQALTPLL"
     exon            271..392
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            393..477
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            478..561
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            562..666
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            667..864
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            865..960
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1067
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1132
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1207
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1699
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1658..1663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /note="hexamer: AATAAA"
     polyA_site      1699
                     /gene="Fuz"
                     /gene_synonym="2600013E07Rik; b2b1273Clo"
                     /note="major polyA site"
ORIGIN      
        1 gttggagggg ctgagttgat gaaggcagga atttagccat ccggcttctc gccctctggc
       61 ggctccaaac ggcaggccga cttgctttca ctacccgcat gctcctagat ccacaccgag
      121 agtctccagg ggggtgactt gtcgggtgcg ggcttccaga tgggggatga ggggccggga
      181 agcccggtgc atctgctgtg cctcgcagcc tctagcgggg ttcccctgtt ttgtcggagt
      241 agcagcggcg gcgccccctc ccgtcaacag cttcctttct ctgtcatcgg ctctctcaat
      301 ggagtccaca tgttcggcca gaatctggat gtgcaactga actctgcaag aacggaagac
      361 acaaccgtag tgtggaagaa cttccatgac agtatcactc tcattgttct gtcatctgag
      421 gagggcacct ctgagctgag gctggaaaga atgctccaca tggtgtttgg ggccatggtt
      481 ctcattgtgg gacttgagga gctgaccaat atccggaatg tagaaagact gaagaaagaa
      541 ttgagggtga ggctgtggga tgccagctac tgtctcatcg acagcttcct ggggaactca
      601 gaactcatcg gagacctgac ccagtgtgtg gactgtgtca ttcctccaga ggggtctgcc
      661 atgcaggaaa ccctttcagg gtttgcagag gccactggca cagcctttgt cagcctgctt
      721 gtatcaggcc gagtggtggc agcgacagag ggctggtggc gcctaggcat gcctgaagct
      781 gtactactcc cctggctggt ggggtccttg ccaccacaag ctgctcgaga ctacccggtg
      841 tatctgcccc acgggagccc cacggtccca cacaggttgt tgaccttgac gctgctgcgt
      901 ggcctggagc tgtgtctgct gtgcgggccg cgcccgcccc ttggccagct ggacccacag
      961 ttaatggaac gctggtggca gcctctactg gagcccctcc gggcctgcct gccactgggc
     1021 cctagggcgc tacccgaagg gttcccacta cacagcgata ttcttggtct gttgttactc
     1081 cacttggaac tgcgacgctg cctctttact gtggagccct ccaaggataa agagccttcc
     1141 cctgagcagc gcaggcgcct ccttagaaac ttctacacgc tggtggccac cacccacttc
     1201 ccgccagaac cagggcctgc agagaaacaa gaggacacag tctacccagc ccagatgccc
     1261 agagcctgtt atctcgtgct agggccaggc atggggtggc agctggtggc tgtgcaacta
     1321 gggctccggc tgctactatt gctgctctcc cctcacaccc ccacccacgg gctgcgaagc
     1381 ctagccaccc gcactctgca agccctcacc ccgctcctct gatcactcag ggtgggcagt
     1441 caatagctgg ggtaatatta gcgtctctct gtttattcgc tcacaataat acacagcccc
     1501 tggatgggga aagggaggaa gggggagggt gacagggaag gggggggaga ggtacctact
     1561 tcctcggccc ctctcccctc tgtgcttcgg gggacaaggg agggagggtg cttcccttga
     1621 ccccccccta gaatgtaaac agcagcagat gaacaaaaat aaaatacaaa aggccagagg
     1681 gagctcccag gcgccccca
//
