LOCUS       NM_010243              11990 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus fucosyltransferase 9 (Fut9), mRNA.
ACCESSION   NM_010243 XM_001475095 XM_001475339
VERSION     NM_010243.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11990)
  AUTHORS   Abdullah,A., Hayashi,Y., Morimura,N., Kumar,A., Ikenaka,K.,
            Togayachi,A., Narimatsu,H. and Hitoshi,S.
  TITLE     Fut9 Deficiency Causes Abnormal Neural Development in the Mouse
            Cerebral Cortex and Retina
  JOURNAL   Neurochem Res 47 (9), 2793-2804 (2022)
   PUBMED   35753011
REFERENCE   2  (bases 1 to 11990)
  AUTHORS   Morarach,K., Mikhailova,A., Knoflach,V., Memic,F., Kumar,R., Li,W.,
            Ernfors,P. and Marklund,U.
  TITLE     Diversification of molecularly defined myenteric neuron classes
            revealed by single-cell RNA sequencing
  JOURNAL   Nat Neurosci 24 (1), 34-46 (2021)
   PUBMED   33288908
REFERENCE   3  (bases 1 to 11990)
  AUTHORS   Blanas,A., Cornelissen,L.A.M., Kotsias,M., van der Horst,J.C., van
            de Vrugt,H.J., Kalay,H., Spencer,D.I.R., Kozak,R.P. and van
            Vliet,S.J.
  TITLE     Transcriptional activation of fucosyltransferase (FUT) genes using
            the CRISPR-dCas9-VPR technology reveals potent N-glycome
            alterations in colorectal cancer cells
  JOURNAL   Glycobiology 29 (2), 137-150 (2019)
   PUBMED   30476078
  REMARK    GeneRIF: It sought to transcriptionally activate the Fut9 gene in
            the well-known murine colorectal cancer cell line, MC38, which
            lacks expression of the FUT4 and FUT9 enzymes.
REFERENCE   4  (bases 1 to 11990)
  AUTHORS   Noro,E., Togayachi,A., Sato,T., Tomioka,A., Fujita,M., Sukegawa,M.,
            Suzuki,N., Kaji,H. and Narimatsu,H.
  TITLE     Large-Scale Identification of N-Glycan Glycoproteins Carrying Lewis
            x and Site-Specific N-Glycan Alterations in Fut9 Knockout Mice
  JOURNAL   J Proteome Res 14 (9), 3823-3834 (2015)
   PUBMED   26244810
  REMARK    GeneRIF: N-linked glycan mass spectrometry profile of wild-type
            mouse kidney glycoproteins revealed the presence of abundant
            terminal fucoses, which were lost following knockout of the Fut9
            gene
REFERENCE   5  (bases 1 to 11990)
  AUTHORS   Kashiwazaki,H., Kakizaki,M., Ikehara,Y., Togayachi,A., Narimatsu,H.
            and Watanabe,R.
  TITLE     Mice lacking alpha1,3-fucosyltransferase 9 exhibit modulation of in
            vivo immune responses against pathogens
  JOURNAL   Pathol Int 64 (5), 199-208 (2014)
   PUBMED   24888773
  REMARK    GeneRIF: Mice lacking alpha1,3-fucosyltransferase 9 exhibit
            modulation of in vivo immune responses against pathogens.
REFERENCE   6  (bases 1 to 11990)
  AUTHORS   Kudo,T., Kaneko,M., Iwasaki,H., Togayachi,A., Nishihara,S., Abe,K.
            and Narimatsu,H.
  TITLE     Normal embryonic and germ cell development in mice lacking alpha
            1,3-fucosyltransferase IX (Fut9) which show disappearance of
            stage-specific embryonic antigen 1
  JOURNAL   Mol Cell Biol 24 (10), 4221-4228 (2004)
   PUBMED   15121843
REFERENCE   7  (bases 1 to 11990)
  AUTHORS   Nishihara,S., Iwasaki,H., Nakajima,K., Togayachi,A., Ikehara,Y.,
            Kudo,T., Kushi,Y., Furuya,A., Shitara,K. and Narimatsu,H.
  TITLE     Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression
            in brain
  JOURNAL   Glycobiology 13 (6), 445-455 (2003)
   PUBMED   12626397
  REMARK    GeneRIF: Alpha1,3-fucosyltransferase IX (Fut9)regulates expression
            of the Lewis X (Lex) carbohydrate structure in brain development
REFERENCE   8  (bases 1 to 11990)
  AUTHORS   Roos,C., Kolmer,M., Mattila,P. and Renkonen,R.
  TITLE     Composition of Drosophila melanogaster proteome involved in
            fucosylated glycan metabolism
  JOURNAL   J Biol Chem 277 (5), 3168-3175 (2002)
   PUBMED   11698403
REFERENCE   9  (bases 1 to 11990)
  AUTHORS   Kaneko,M., Kudo,T., Iwasaki,H., Ikehara,Y., Nishihara,S.,
            Nakagawa,S., Sasaki,K., Shiina,T., Inoko,H., Saitou,N. and
            Narimatsu,H.
  TITLE     Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved
            between human and mouse; molecular cloning, characterization and
            tissue distribution of human Fuc-TIX
  JOURNAL   FEBS Lett 452 (3), 237-242 (1999)
   PUBMED   10386598
REFERENCE   10 (bases 1 to 11990)
  AUTHORS   Kudo,T., Ikehara,Y., Togayachi,A., Kaneko,M., Hiraga,T., Sasaki,K.
            and Narimatsu,H.
  TITLE     Expression cloning and characterization of a novel murine alpha1,
            3-fucosyltransferase, mFuc-TIX, that synthesizes the Lewis x (CD15)
            epitope in brain and kidney
  JOURNAL   J Biol Chem 273 (41), 26729-26738 (1998)
   PUBMED   9756916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB626126.1, BX323863.6 and AL935336.11.
            
            On or before Dec 21, 2007 this sequence version replaced
            XM_001475095.1, XM_001475339.1, NM_010243.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB626126.1, SRR1660819.40723.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-640               BB626126.1         1-640
            641-8385            BX323863.6         2001-9745           c
            8386-11990          AL935336.11        164995-168599       c
FEATURES             Location/Qualifiers
     source          1..11990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 10.59 cM"
     gene            1..11990
                     /gene="Fut9"
                     /gene_synonym="mFuc-TIX; mFUT9"
                     /note="fucosyltransferase 9"
                     /db_xref="GeneID:14348"
                     /db_xref="MGI:MGI:1330859"
     exon            1..415
                     /gene="Fut9"
                     /gene_synonym="mFuc-TIX; mFUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            416..502
                     /gene="Fut9"
                     /gene_synonym="mFuc-TIX; mFUT9"
                     /inference="alignment:Splign:2.1.0"
     exon            503..11990
                     /gene="Fut9"
                     /gene_synonym="mFuc-TIX; mFUT9"
                     /inference="alignment:Splign:2.1.0"
     CDS             511..1590
                     /gene="Fut9"
                     /gene_synonym="mFuc-TIX; mFUT9"
                     /EC_number="2.4.1.152"
                     /note="fuc-TIX; fucT-IX; fucosyltransferase IX;
                     galactoside 3-L-fucosyltransferase;
                     alpha-(1,3)-fucosyltransferase 9"
                     /codon_start=1
                     /product="4-galactosyl-N-acetylglucosaminide
                     3-alpha-L-fucosyltransferase 9"
                     /protein_id="NP_034373.1"
                     /db_xref="CCDS:CCDS18011.1"
                     /db_xref="GeneID:14348"
                     /db_xref="MGI:MGI:1330859"
                     /translation="MTSTSKGILRPFLIVCIILGCFMACLLIYIKPTNSWVFSPMESA
                     SSVLKMKNFFSTKTDYFNETTILVWVWPFGQTFDLTSCQAMFNIQGCHLTTDRSLYNK
                     SHAVLIHHRDISWDLTNLPQQARPPFQKWIWMNLESPTHTPQKSGIEHLFNLTLTYRR
                     DSDIQVPYGFLTVSTNPFVFEVPSKEKLVCWVVSNWNPEHARVKYYNELSKSIEIHTY
                     GQAFGEYVNDKNLIPTISTCKFYLSFENSIHKDYITEKLYNAFLAGSVPVVLGPSREN
                     YENYIPADSFIHVEDFNSPSELAKYLKEVDKNNKLYLSYFNWRKDFTVNLPRFWESHA
                     CLACDHVKRHQEYKSVGNLEKWFWN"
     regulatory      11966..11971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fut9"
                     /gene_synonym="mFuc-TIX; mFUT9"
                     /note="hexamer: AATAAA"
     polyA_site      11990
                     /gene="Fut9"
                     /gene_synonym="mFuc-TIX; mFUT9"
                     /note="major polyA site"
ORIGIN      
        1 attttggagc tcctctggtg ggaacctgta cccggctgct atgctcctcc cttctcttcc
       61 caactctcgg tgatcatctc catctcccct cgcgcatccc ttcccccctc cctgctttct
      121 ttgctctccc tccctgccgc gtgcctgctc ccctccccct ctcctggctg ctctgggcag
      181 cagcaacctc ggcagcccgg gagatgggaa gagagcgcgc ggggcgctgc agctctggag
      241 ccctggatct ttcctcaccc ggtgccttga gaccccgccg ccgctctcgc ctcttggcta
      301 cccccggact ccggctacgc tactaggaca gcgccgccac caccgccagc cctcgtcccg
      361 cccgcgccgc gctgccctcc cgcgccctgg atggagcttt ccctcgctgg gatcgcttta
      421 gaatgtgata actcacgcat ctgatagcac cgtggagtag ttcagcactc atctctgctt
      481 tccatgctat gttctctaca ctgaaaaatt atgacatcaa catccaaagg cattcttcgc
      541 ccatttctaa tcgtctgcat catcctgggc tgcttcatgg catgtctgct catttatatc
      601 aagcccacca acagctgggt cttcagtcca atggagtctg caagttctgt gctgaaaatg
      661 aaaaatttct tctccacaaa aactgattat tttaacgaaa ctaccattct ggtttgggta
      721 tggccatttg ggcagacctt tgaccttaca tcctgccaag caatgttcaa tatccaaggg
      781 tgccatctca caacagaccg ctcattgtac aacaaatccc atgcggtcct gattcaccat
      841 agagacatca gctgggatct gactaactta cctcagcagg ccaggccacc ctttcagaaa
      901 tggatttgga tgaatttaga gtcacccact cacacccccc aaaagagtgg cattgaacac
      961 ttgttcaacc tgactctaac ttatcgccgt gattcagata tccaagtgcc ttatggcttc
     1021 ttgacggtga gcacaaatcc ctttgtgttt gaagtgccaa gcaaggagaa gttggtgtgc
     1081 tgggttgtga gtaactggaa ccctgagcat gccagggtca agtattacaa cgagctcagc
     1141 aagagtattg aaatccacac ctatggccaa gcattcggag aatacgtgaa cgataaaaat
     1201 ctgattccca ccatatctac ttgtaaattt tatctttcat ttgaaaactc aattcacaaa
     1261 gattacatca cagaaaagct ctacaatgca tttttggctg gttcagtacc tgttgtcctg
     1321 ggtccatcta gggaaaacta tgagaattat attccagctg attcattcat tcatgtggaa
     1381 gattttaact ctcccagtga gttagcaaaa tatctgaagg aagttgacaa aaacaataag
     1441 ttgtacctta gttactttaa ctggagaaag gattttactg taaacctacc acggttttgg
     1501 gaatcacatg catgcctggc atgcgaccat gtaaaaaggc atcaagaata taagtctgtt
     1561 ggtaatttag agaaatggtt ttggaattaa agtgtccatc attgtcacag tgaaaaagat
     1621 taatgagaca taattcaagt tttcaggata agaagaaaca cgctgcattt ggggcaccgt
     1681 ttaattttcc tgccctccct tgaggaccat gtatattttg gtgaaatttt taagagatca
     1741 gaattagcaa tcactcaatt tggttttaaa ttatcctgta tatatgtgat aacgagcact
     1801 ggaaataatt tatttgtcac tctcatttat aaacattgtt tttacatttt atagttgact
     1861 gtaaagtaaa tttatgattt acttgtttct acatcaatca gatctttaat ctatttggga
     1921 gataaaaata catatcctaa aatatgaggg actttttgcc aagtattata aagtatagat
     1981 tctagcttgt ataatgctaa caaagaagaa ttattgaatc acttaattct taatctcttt
     2041 gacttcaaag ttgaacacta ctgacaactg atagagtttt tacttgtacc acatttgtga
     2101 aggggagcta attgatgtag caaataagaa agatatgaag cagaaatgtt attagacttc
     2161 acattcattt ttattaagtt gtttagcaaa tgtagattcc caatatttta agttaaagaa
     2221 aacaagaatt ttcagataaa caatttatat ggttttaggg agatttgatt gtttgttttg
     2281 tgggtttagt ccctaataat acctaagaga atcttttgat agttcccttt caaatcatga
     2341 agataaccac tattttaaaa ataaataatt tcctcttata acaataaaaa aatgatatct
     2401 tcaaatacaa ataaatgtat aaattatacc atttatagaa cgctagttac ttcattcatt
     2461 tgaaatattt tttccaaagc atccatattt aagttttatt ttactgtatt tgttaataaa
     2521 tagaagtaaa acttgaaaga tctatctgat catttaaaag agtttaaaat tcttaccaat
     2581 gggtcagata tgtcacaaaa cacaataaag tgggaaccta caaggaatac agtgctgaca
     2641 cagagtaaga tttcaatatg tattttttaa ataaattatc agtattaaaa aagtaatggg
     2701 taaatttttg tttttgataa aggaacagtt ctagccaaga gctattaatt aaaatttatc
     2761 atttttatac catttaagat aatatccata catagaatat gttgttatta tattcagggc
     2821 tttacacaac caatgtaaat ttattgcact gaatttggga gcatgttatc tatgaacttt
     2881 catctgcctg caaaattctc ttctgtaagt gtagaggaga taactgggca tatgcaaata
     2941 caatagatta gggaaaaaat gtgattctga agactctgac agaaaatttt tcttcaaagt
     3001 gtttctaaag cctgcattct attctgttca aaacctacag aaaaaaaaat aatgttctga
     3061 tgacatttat ttggatcttt tgtggctctt tatatttctc tattatgtat tgcaattagc
     3121 caaactcagg ctaattctcc tcatctacag agaagattca tttcagtttg acaagcagga
     3181 agtatgtgct caatgagaca taagctccct tagcatggaa tcatttgagc aaagaaagac
     3241 cacagaatta aacgaagagt atgatctcat atttttttaa agacatagtt acacaggtga
     3301 tattgttgat ccccaactgc cacagaggta aagatgaaaa tgtgttgtca ctgcagggtg
     3361 acaatggaga cttagttaaa aaaaaaaaat actaaacaat actagtaaat ttactccatt
     3421 ctttacctac tcaacatgtg tttgaatggc aagctttgtc tactcacttg atccaacata
     3481 tatttttctc tagattatct tttttccaca catcgttttt acatgtatac caagaaatca
     3541 tatatataca tagatactct cataaaggct ctaatcatat atttatttgc ttaaaagtca
     3601 aattcatgca tttacttatg atttttttga tccaaaaatg gtagagagct aagcatggat
     3661 tgctaaattt agaatatgct ctcagtgaaa gctggaaagc atttgatgtt gctttcatcc
     3721 accattgcta tattggatgc taagagacct gaaggcagtt gcctcttttg ttggctatga
     3781 atttgagctc attcttggac tggaagtaca attaaatgcc aatagtgtaa gccaagccaa
     3841 ggtattaagt atttcacaag tgcatctaca tatttagaac ctgatgccaa gccacagaac
     3901 gtctgaactt tacgtccata gttagagcga gctttttaac tagaatatac aacaatattc
     3961 ataagtcaac ctcttctttt ctgtgaacta actcgttatt tatttatgac atatttattc
     4021 ctgatatgtt gagagacagg catgtcaacc ccacacgtag tgatgataga aattagaatt
     4081 taaggatcct attgctatga ctctcatttc tctctgccct atccatacct tattgtacaa
     4141 atatatctca attcctataa atgtgaatat cctctggcat tatttagtcc ctgtaggcta
     4201 gtatgttctg ggaggacttt agtttttgga aatatattga acagaatttg agatgttgac
     4261 actctttctg atattgtttt agctgttgaa ctttagcaga aggaatgagc ttcactatgt
     4321 gtgagtggaa aatgtaccac tgacaagata tgctattggc tgctctgtta ataaatcctg
     4381 tgactcatac tttctgtaag catatctctt atgaaagatt gattgattca accaaattgg
     4441 cttgctgctg gtataataaa agcagataat atgcctagag atccaggatg gctctaaaca
     4501 gatcatgagc aagttatcac ctaaaagtgc agaaagtcct tatcaccagt gctctgagta
     4561 tttaattgct atttagttca ggccttatta ataggaatac aaaaataatt attttaagcc
     4621 ttactgaaga gaaatatact gacttatcta gttagctgca ttgtatttta gagagtgaag
     4681 atcttgatag ccatatattt taggacagcc atcacctaat gaagtagaaa gtataaaaga
     4741 tactctcact gggaaaccag catcagttta caagatttct atttactgtg agaagctcag
     4801 tcctagagtg tacaaagctt gaaccagaac tgttgaggta gaaatggaca gaatacttga
     4861 ggaattattc actcactctt taaacttttg tctttaattg gagattaaat aaagaatgaa
     4921 taaaaacagg aaataagcta ctcagatttt cttttttatt gaactttttt cagagtagac
     4981 ttcatggctg ctactcacca agaaagcgtt tttgtgagtt aatgtttcaa aacattttag
     5041 ttctccacat ttttatttca tgctttatga tgtcagctcc cctcaactca aagctcaaga
     5101 gaaggaggtt tgttaaaaat tgcaatcaag gtctagatat aagagatttc agaagctaaa
     5161 ggataagcat ttgttcatac aggaggggtt attaatggtt gcctagtaaa taattacctc
     5221 aatgaaatta gtggacatga aagatacatt taatgtaatc gaaataacag tttcttcatt
     5281 cgaaatgggg ataatctctt ctgttcaaat tgcttctaga ttcagagaac agacaggtta
     5341 agtccttctt atcatatgtt taaaaaaaaa caaaagaaat aaatattatg aaagattaaa
     5401 ctagatttga aacttcttag aattctattt taatattaac cattcaccaa ctgttaacct
     5461 aataaagatg aaattaggac ataaagagaa ttgaaaaatg aagcatcagg ataggcaaat
     5521 gtgtattacc aaactgtggg gagagaaaca gatttaccct tcattcttgc caatttgatt
     5581 tgttgtatag tgaacatact gcaaacatca tctcaatcaa gtggtttttg ctgtgggcat
     5641 ctctcttctg gagtctttat ggcactgtga aaatggctaa gctctgctac tatccaaagt
     5701 atggtcctgt gtaattaata ttcaatccat ccatatttat aagcagttaa tagagtctaa
     5761 atggtagaca cactgttgaa ctagaaatat gagtaagtct accctagact atcattgcaa
     5821 caaattgaag ccttgagaaa ctcacttgac ctctctggat aaccttgtta gtaagaattc
     5881 cttcagcaca actgctttat aatatgaggc ctaagttgat atgtgcatat atttgagttc
     5941 ccttgtctat ccaaaaatat ttttgaaagt tagtactcca aataaaattc cctttctttt
     6001 ctctagaaca ataaagaaca ggttctttac tgaaacttac aatatagtaa gtgttcaatt
     6061 aacgaatctt tctcctttat atttttcttc ctcttaggtc tcttgcaaca tacagtttct
     6121 tacacttagt tatctacaga aaacaaccat atattgaacc ccattctaaa acaattcaca
     6181 ttttttatac tatatgtatt cttactataa taatctaaaa ctatttattg atgcaaactc
     6241 aggaattcag tggaagcatg tcgagttcct tcatcaacag gaatatagag tttgagtgta
     6301 tatgattgac tatatttaga aaacttattc ttttgactca aggctaattt atttccattc
     6361 atttaacaca ctttgggtat attttcattt aaaagtaaat tccataccac tactgtttta
     6421 aagcattact caaggcactg ttcctaagcc atgtaatcta gagtttgcag agataattat
     6481 taataatact gacagctggt ccattttcca tgtaattgga acatttttat ttaaggaaac
     6541 aaaacaaaac cacaaaaaaa caaacaaaca agaaaagcaa aaacaaacaa acaaaaaaac
     6601 aaaacaaaac gataaaggaa gaagacagaa accatggcat tactacaaag taatcctatg
     6661 cctcccagag gttctctgac tcacatctgc tttgagaaat tcctacatca atggcataag
     6721 aattatttac atcatttgaa agatcgtcat aatacatagg atgacctagg tctgtatttt
     6781 taaggagtcc atagacaatt caaacatgtt gctagttttg gaagtctggg tcctgtctat
     6841 taaatagaag taattctata ctcaaacaat acaggcatga gatattgcct ttccttagct
     6901 cacttggatt ctccttaaat atattggtag gtgttactat atttcaaagt ccaagatgtt
     6961 cctcaatctt agttgtgtct tgtacagtgg tgctgctctt cagctatgat ttagggaaaa
     7021 ctatcatttc ctgaaaatta tttttcacaa tctttcttag atttttaaat gcactttttt
     7081 tttcagtttt aagtacaaaa aacaaaggta ggcaattatt aggttctctt gcagccatca
     7141 aaattgcaca tatttgatca atttctttcc cgagtctcag aagcttattg ataggtagga
     7201 tatggcaaca tgttataaca ctttggattg tccacaatca tgagttcaat attaaatgtg
     7261 agctattcac tcactagctc actctctgtg cctgatctca tctctgttgt tatcatgatt
     7321 tgtatgtgta cagtaggggt agcctatttt gaaaacaaat gaattcatct ctaaaacctt
     7381 agacaattat atgtatgtgt atcctgtgat gttctaccac tgagatatat gcctttggtc
     7441 attaaaaaaa agagaaaata agagaaattt agaatacata aaaatttcag ctctgacatc
     7501 tattgctatt aggctggcag cttagctcgt aagaattgct gaaaatttaa acaagccaaa
     7561 gggtgaatat tcaatagaag agaaacaaac atagtgtgga agattgcatt gacatcactg
     7621 aaatcagaat ggctactcct cgatagaagg gatttacaca aacctagtga tgaagcctgc
     7681 ggtaacatct actgaaatta gaaagtactg ggaggcaagt gggggtggtg gcactgatga
     7741 tctcactaac cacatagagc gtttcctaaa ataagcagac ttaatcttca ctgttacgag
     7801 aaatcagtaa attaatatta atttagcttg ctagccattt atacagctga agtccatgga
     7861 cagaatcaca gaaagattct cagagatcat tttctagtga ggaaattgcc cttagaaata
     7921 tccatcaact tgactaaata tttcatgtca actgttggct taggcacaga agcagctgat
     7981 gatagattac aagagaatag agtctccctt tacctttcct taagatttaa ttaaaaaaag
     8041 ggaagagttc aaaaatgtga cgatataaac tcattaaaca gaaattaaat tgttcagtga
     8101 tgcagaaatc gagcaatgaa aataagttta ggaggctgtg attaagactc gacaaattct
     8161 atgatacata agattttgac atgaacattc tcaactgcat acatataatt ttttagttga
     8221 atggccccaa aaagaaacat ttaaggaaaa tttccacatg ttaaaaaaag gatagtaact
     8281 aaaatagcat attaattatt ttaaattatg tttctttaaa aaatgctaga aatgtcatat
     8341 tttcattatg acatcaaaat acttcaaaat ttgaattggt ttactgaatt ctcagacaac
     8401 caaatgtttt taaattattc gaacatgtaa agtacatgac ctaatagact tggagtttca
     8461 ttgcaaaaaa catacaagtt ctactagaaa aaaagtttta caggtgattt ctatacgata
     8521 taaagtggta gaaacgtgtt actgtttcta aacaggccac cattctcttc gattaatgag
     8581 gttatagcag ctagacaatc agacttggaa aaatgatttg caaaatctca gttaacatcc
     8641 aagacccagt actactaatt atgtaagaaa taggagctgg ttacaatgca cccctcatct
     8701 caaactggtc tcaataactc ccttcagttc atggttaaga aaatcctaga gaagcctttc
     8761 atgttactgt gagatcagca aaggtatact catgtgggtt cacatatgat gtgaacaatg
     8821 gacaatataa gacccaaatc aagaatatcc acttgtctac ataaaagtgg aggacatcta
     8881 cattataaga aaacatgatt ggtaacagat tctaatgtca tgttttttgt ttttgttttt
     8941 tttataaaat aaccaaggga ctaggattat gtttttcctc cttttttctt tctatctctt
     9001 aaaatcaggt atgataggag tcagggatta cagagtatga caatgtaaaa aaattaatat
     9061 ttttgtagac tcctaaagaa taaaaaaaca ttgaatatgc ttttaaaatg taattatctt
     9121 ctcagtagtt atgaggctta ttctgcatgt ataccagcat gggataaagg agtacttttt
     9181 aatgataaag agcttaaaag tctaagtata gacctaggtt taccaagatt cagaaagaag
     9241 aaagcatcaa gaagaaacaa gaaaatgtga aacagactca taatcaaagt ccatccgttt
     9301 agctcccagc acctatagtg taatttgcta gcatttctga gccacagatt tctcatctgt
     9361 tatcaaaagg tgataggcag tacattagat acacctaaga aagtcttcat aatagcattg
     9421 atctgaaacc ctggtttaag tgttggactg ccatatattc tgaacttttc cttcgtgttc
     9481 tcttctaggg ggctttgttc aatgagtggt agggaagggt aagggggaaa tttgatactg
     9541 ttttaagtgc tgctaaagaa gaaagttgta gagaagtatc acaaaggaag aacggagaat
     9601 gtgtctacca tcttgattcc attgaaggcc gccatacagg ccatagccaa tgcttgccct
     9661 gagtggttta aataatttca taaaggattt tatactcaat gaattgaggg caaagcaatc
     9721 acactggaac aaaaatgtgc caatttttcc aatatgcaaa ttgtaatgat cggtaattca
     9781 taaaactact ttgagagcaa ttgaatattt tagtattgta atttgcacta tgatattacg
     9841 atgttcaggc aaactaaaat actctgaaat ctaatgccaa atgtacagtt cataggttca
     9901 tggtacttcg tataagtgtt tcattgcatt gcgacagttg tttaatagca ttaactttcc
     9961 ctgggtgtgt tgttatgatg cagatctaac agggttattg taagcacact aattagtcat
    10021 ctggggtttt atagataaaa tcatacattg atcagaaatc acttttctac ttattttttt
    10081 gtagagtatt tttccacact tgaaaaaaca tgattatttt atatcaaaca tcagttttcc
    10141 tttaaaatct tattttagta gccaatgcat gtttgaaata agatgttaaa tattatgtgc
    10201 caatagtaag attgtgtttg taagtgaaaa atgcatgcta taatgaatca tacagctttg
    10261 gtggcatatt ctactgccac cttatatgca agctttctct taacctgtgt gcatggtcca
    10321 catgctttca agagtccttt tttaatattt acaaagtgac atgtgatttt tagtgctgat
    10381 gagccagtga gccaagatgc aatcctgttc tgctttcatt tttcttcttt acattatgtt
    10441 gtaaattttc tcagaaaact ttttcttgga gttgttggca ataaactaca acaaatgaaa
    10501 gaattggctg gtaaatctta cagacaactt accgttacaa agcatgaaga tgtgagaaga
    10561 tcattttaca agcttcatta tatgaacaca atactctggc atcttttttg tgtagttaag
    10621 aagagcttat cgtttctgaa acactgccaa agtcagtact actgccaaaa gggagggaca
    10681 cctgcattac actaaactga ataataacag actatccaga ctgtatagac tgccaatcag
    10741 tacagtaaag tgggagggat atacccactc ttttgtttct tattaattag agaaatgtat
    10801 aaggaatatg aattttggca acagagacat ggctttacat gctgataact catggaaata
    10861 tttgaaataa aactcattcc attcttgaaa aaaatatgcc caggcatttt gtttgtttca
    10921 gaaatgtact tgtgtttttg aaagctctaa tttcaaacaa gtaatatatg tagaccaact
    10981 gttccttcta caaataatgt catttattgt aacacataat gggtagaaca tagctttcag
    11041 tcagttattc gaatcaccag tataaatatt cataatgttt gaaggtgatt tcactgtgag
    11101 gttatgaaag caatggaaac cctagttatt tgtttgggtt tttatgtgtc tatttataga
    11161 aaaatgcttc ttttaagtct aattttaaca acatcaacta agttaatcta atgctaagaa
    11221 aattgactct acttactatt tcaagtcaca gtcctgaaac tgagtcttgc tgcaatccaa
    11281 aaataaaaca ttgattcaaa cgaagagcag cctactctgc catggaaagg gcagctacag
    11341 cagtcatgat atcatagatg tgagcagggt aaagaattcc tacaccatcc atgacattgt
    11401 aggtgtgtga aaggactaca ccattcatga tactgtaggt gtgtaacact cagccaatat
    11461 ttgatctggg ctctcagttt catattgcat gcatcccttc atttaattaa cttgtaaata
    11521 acaacacttc gtggcagcta agcaaatatt ttaataagcc atgaaagaca agatataaga
    11581 actctgtact ttcaggtatt tagaaaaaaa aaatgtactt gccataagtt aaagcagagt
    11641 tgccatttga aatttccttc ccttaaaaat atgctgtaac accatgtgtt cattgttgtc
    11701 ttttcagcct tataaatata tgatgtgact actacatctt tgtgaaattt tgtttaacaa
    11761 ttaatggttt taacaatctg aacaacaatt caaggcagaa gtaaatgcat aaggaatttg
    11821 agcctgtttg taagaagtct actccttatg ttatatttac tatattcaat gtaaatacct
    11881 cactgataaa acactggagc tagtgaatgt gtaaataatt atgttctatt tgggcctaat
    11941 gcattcctgt aatgtgaata tttaaaataa aagaattcaa tttaaatgca
//
