LOCUS       NM_016893               2923 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus fucosyltransferase 8 (Fut8), transcript variant 1,
            mRNA.
ACCESSION   NM_016893 XM_011244144 XM_011244145
VERSION     NM_016893.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2923)
  AUTHORS   Guo,H., Sun,Q., Huang,X., Wang,X., Zhang,F., Qu,W., Liu,J.,
            Cheng,X., Zhu,Q., Yi,W., Shu,Q. and Li,X.
  TITLE     Fucosyltransferase 8 regulates adult neurogenesis and cognition of
            mice by modulating the Itga6-PI3K/Akt signaling pathway
  JOURNAL   Sci China Life Sci 67 (7), 1427-1440 (2024)
   PUBMED   38523237
  REMARK    GeneRIF: Fucosyltransferase 8 regulates adult neurogenesis and
            cognition of mice by modulating the Itga6-PI3K/Akt signaling
            pathway.
REFERENCE   2  (bases 1 to 2923)
  AUTHORS   Homan,K., Onodera,T., Hanamatsu,H., Furukawa,J.I., Momma,D.,
            Matsuoka,M. and Iwasaki,N.
  TITLE     Articular cartilage corefucosylation regulates tissue resilience in
            osteoarthritis
  JOURNAL   Elife 12, 92275 (2024)
   PUBMED   38466626
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2923)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2923)
  AUTHORS   Li,Z., Hao,J., Li,L., Shen,N., Wang,D., Wang,N., Wen,X., Wang,W.,
            Qin,B., Tang,Q., Guo,X., Song,H., Du,X., Yang,F. and Lin,H.
  TITLE     Loss of FUT8 in renal tubules ameliorates ischemia-reperfusion
            injury-induced renal interstitial inflammation transition to
            fibrosis via the TLR3-NF-kappaB pathway
  JOURNAL   FASEB J 37 (8), e23091 (2023)
   PUBMED   37432656
  REMARK    GeneRIF: Loss of FUT8 in renal tubules ameliorates
            ischemia-reperfusion injury-induced renal interstitial inflammation
            transition to fibrosis via the TLR3-NF-kappaB pathway.
REFERENCE   5  (bases 1 to 2923)
  AUTHORS   Cantero-Recasens,G., Burballa,C., Ohkawa,Y., Fukuda,T., Harada,Y.,
            Curwin,A.J., Brouwers,N., Thun,G.A., Gu,J., Gut,I., Taniguchi,N.
            and Malhotra,V.
  CONSRTM   IBD Character Consortium
  TITLE     The ulcerative colitis-associated gene FUT8 regulates the quantity
            and quality of secreted mucins
  JOURNAL   Proc Natl Acad Sci U S A 119 (43), e2205277119 (2022)
   PUBMED   36252012
  REMARK    GeneRIF: The ulcerative colitis-associated gene FUT8 regulates the
            quantity and quality of secreted mucins.
REFERENCE   6  (bases 1 to 2923)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2923)
  AUTHORS   Roos,C., Kolmer,M., Mattila,P. and Renkonen,R.
  TITLE     Composition of Drosophila melanogaster proteome involved in
            fucosylated glycan metabolism
  JOURNAL   J Biol Chem 277 (5), 3168-3175 (2002)
   PUBMED   11698403
REFERENCE   8  (bases 1 to 2923)
  AUTHORS   Javaud,C., Dupuy,F., Maftah,A., Michalski,J.C., Oriol,R.,
            Petit,J.M. and Julien,R.
  TITLE     Ancestral exonic organization of FUT8, the gene encoding the
            alpha6-fucosyltransferase, reveals successive peptide domains which
            suggest a particular three-dimensional core structure for the
            alpha6-fucosyltransferase family
  JOURNAL   Mol Biol Evol 17 (11), 1661-1672 (2000)
   PUBMED   11070054
REFERENCE   9  (bases 1 to 2923)
  AUTHORS   Hayashi,H., Yoneda,A., Asada,M., Ikekita,M. and Imamura,T.
  TITLE     Molecular cloning of mouse alpha-1,6-fucosyltransferase and
            expression of its mRNA in the developing cerebrum
  JOURNAL   DNA Seq 11 (1-2), 91-96 (2000)
   PUBMED   10902914
REFERENCE   10 (bases 1 to 2923)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU702757.1, AK051811.1, AK048520.1 and CJ320809.1.
            
            On or before Jun 26, 2023 this sequence version replaced
            XM_011244145.3, XM_011244144.4, NM_016893.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051811.1, SRR7345562.3107269.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BU702757.1         32-75
            45-2459             AK051811.1         2-2416
            2460-2914           AK048520.1         2598-3052
            2915-2923           CJ320809.1         433-441
FEATURES             Location/Qualifiers
     source          1..2923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.46 cM"
     gene            1..2923
                     /gene="Fut8"
                     /note="fucosyltransferase 8"
                     /db_xref="GeneID:53618"
                     /db_xref="MGI:MGI:1858901"
     exon            1..96
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            97..191
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            192..284
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            285..718
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            719..834
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            835..997
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1112
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1350
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1597
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1774
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1925
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2923
                     /gene="Fut8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2890..2895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fut8"
                     /note="hexamer: AACAAA"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fut8"
                     /note="hexamer: AATAAA"
     polyA_site      2903
                     /gene="Fut8"
     polyA_site      2916
                     /gene="Fut8"
                     /note="major polyA site"
ORIGIN      
        1 ctcccgccca gctcgccctc ccggacggtc tgtcggaggt agcccttcgg cactcggctc
       61 agcatcgcgg gcgtcaggat ccccgagtgc gagcgggttg ctgttctggc tgaggccatc
      121 tatggccctg gtagtgtttt cattcaagac aaagtccatt ccatctttat ttattagctg
      181 agcaaattca gctaataatt ttcaagaccc agattcaagc aataaaacat ttctctgcaa
      241 taccatgtgg ttttcttcaa catcataatt ctatggggag gaagcatgta ggatccatga
      301 agcacaggac attcaagcct cccgcccgcg tcaccaggaa gatctctttg taagaataac
      361 cacaggattg atttccagag agattagcct gtctgaagca ttatgtgttg aagcaaaaga
      421 aacctatttt cttgtgtggc taactagaac cagagtacaa tgtttccagt tctttgagct
      481 ccaggaagat agaggacaga gttgaaactc tgaaaatgcg ggcatggact ggttcctggc
      541 gttggattat gctcattctt tttgcctggg ggaccttgtt attttatata ggtggtcatt
      601 tggttcgaga taatgaccac cctgatcact ccagcagaga actctccaag attcttgcaa
      661 agcttgaacg cttaaaacag caaaatgaag acttgaggcg aatggctgag tctctccgaa
      721 taccagaagg ccccattgac caggggacag ctacaggaag agtccgtgtt ttagaagaac
      781 agcttgttaa ggccaaagaa cagattgaaa attacaagaa acaagctaga aatggtctgg
      841 ggaaggatca tgaaatctta agaaggagga ttgaaaatgg agctaaagag ctctggtttt
      901 ttctacaaag cgaactgaag aaattaaagc atttagaagg aaatgaactc caaagacatg
      961 cagatgaaat tcttttggat ttaggacacc atgaaaggtc tatcatgaca gatctatact
     1021 acctcagtca aacagatgga gcaggggatt ggcgtgaaaa agaggccaaa gatctgacag
     1081 agctggtcca gcggagaata acatatctcc agaatcctaa ggactgcagc aaagccagga
     1141 agctggtgtg taacatcaat aaaggctgtg gctatggttg tcaactccat cacgtggtct
     1201 actgtttcat gattgcttat ggcacccagc gaacactcat cttggaatct cagaattggc
     1261 gctatgctac tggtggatgg gagactgtgt ttagacctgt aagtgagaca tgtacagaca
     1321 gatctggcct ctccactgga cactggtcag gtgaagtaaa tgacaaaaac attcaagtgg
     1381 tcgagctccc cattgtagac agcctccatc ctcggcctcc ttacttacca ctggctgttc
     1441 cagaagacct tgcagaccga ctcctaagag tccatggtga ccctgcagtg tggtgggtgt
     1501 cccagtttgt caaatacttg attcgtccac aaccttggct ggaaaaggaa atagaagaag
     1561 ccaccaagaa gcttggcttc aaacatccag ttattggagt ccatgtcaga cgcacagaca
     1621 aagtgggaac agaagcagcc ttccacccca tcgaggagta catggtacac gttgaagaac
     1681 attttcagct tctcgcacgc agaatgcaag tggataaaaa aagagtatat ctggctactg
     1741 atgatcctac tttgttaaag gaggcaaaga caaagtactc caattatgaa tttattagtg
     1801 ataactctat ttcttggtca gctggactac acaatcggta cacagaaaat tcacttcggg
     1861 gtgtgatcct ggatatacac tttctctcac aggctgactt tctagtgtgt actttttcat
     1921 cccaggtctg tcgggttgct tatgaaatca tgcaaaccct gcatcctgat gcctctgcga
     1981 acttccattc tttggatgac atctactatt ttggaggcca aaatgcccac aatcagattg
     2041 ctgtttatcc tcacaaacct cgaactgaag aggaaattcc aatggaacct ggagatatca
     2101 ttggtgtggc tggaaaccat tgggatggtt attctaaagg tatcaacaga aaacttggaa
     2161 aaacaggctt atatccctcc tacaaagtcc gagagaagat agaaacagtc aagtatccca
     2221 catatcctga agctgaaaaa tagagatgaa gtagaagaga ttaacaacag aactcacttc
     2281 agaccatctc ggccaagcag aagacgcaga ctaacacgtg gttcattgat agacacgctc
     2341 cacaccaaga gcaagcggga accctcagat gctgcactgg tggaacgcct ctttatgaag
     2401 ggctgtggtg ccctcaagcc catacacagt acaataatgt actcacacat aacacgcaaa
     2461 gggattattt tctactttgc ccctttaaat attatgtccc cattgaacaa acactgccac
     2521 attgtgtaat ttaagtgaca cagacatttt gtgtgagact taaaacatgg tgcctatatc
     2581 tgagagacct ctgtgactta ccgagaagat gtgaacagct cccttctctg gggaagctgg
     2641 tggtggtgtg gccactgaat tcactccagt caacagattc aaaatgagaa tggatgtttt
     2701 tcctttatat ggttgtctgg attttttttt aagtaatttc atcagttcag tttatccacc
     2761 tcatcattaa taaatgaagg atgcatcaat aaaataaaat gaaatattca ctctccatta
     2821 ggaagttttg taaaacaatg ccatgaacaa attctttagt actcaatgtt tctggacatt
     2881 ctctttgata acaaaaaaat aaatttcaaa aaggaatttt gtg
//
