LOCUS       NM_001289453            1892 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus fucosyltransferase 7 (Fut7), transcript variant 4,
            mRNA.
ACCESSION   NM_001289453 XM_006497705
VERSION     NM_001289453.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1892)
  AUTHORS   Liu,W., Xiong,W., Liu,W., Hirakawa,J. and Kawashima,H.
  TITLE     A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans
            attenuates murine allergic rhinitis by suppressing Th2 immune
            responses
  JOURNAL   Sci Rep 13 (1), 15740 (2023)
   PUBMED   37735247
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1892)
  AUTHORS   Khan,I.M., Ulrich,B.J., Nelson,A.S., Sehra,S., Kansas,G.S. and
            Kaplan,M.H.
  TITLE     Selectin Dependence of Allergic Skin Inflammation Is Diminished by
            Maternal Atopy
  JOURNAL   Immunohorizons 5 (8), 703-710 (2021)
   PUBMED   34433625
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1892)
  AUTHORS   Barbier,V., Erbani,J., Fiveash,C., Davies,J.M., Tay,J.,
            Tallack,M.R., Lowe,J., Magnani,J.L., Pattabiraman,D.R.,
            Perkins,A.C., Lisle,J., Rasko,J.E.J., Levesque,J.P. and
            Winkler,I.G.
  TITLE     Endothelial E-selectin inhibition improves acute myeloid leukaemia
            therapy by disrupting vascular niche-mediated chemoresistance
  JOURNAL   Nat Commun 11 (1), 2042 (2020)
   PUBMED   32341362
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1892)
  AUTHORS   Salas-Perdomo,A., Miro-Mur,F., Urra,X., Justicia,C., Gallizioli,M.,
            Zhao,Y., Brait,V.H., Laredo,C., Tudela,R., Hidalgo,A., Chamorro,A.
            and Planas,A.M.
  TITLE     T Cells Prevent Hemorrhagic Transformation in Ischemic Stroke by
            P-Selectin Binding
  JOURNAL   Arterioscler Thromb Vasc Biol 38 (8), 1761-1771 (2018)
   PUBMED   29903733
REFERENCE   5  (bases 1 to 1892)
  AUTHORS   Tinoco,R., Carrette,F., Henriquez,M.L., Fujita,Y. and Bradley,L.M.
  TITLE     Fucosyltransferase Induction during Influenza Virus Infection Is
            Required for the Generation of Functional Memory CD4+ T Cells
  JOURNAL   J Immunol 200 (8), 2690-2702 (2018)
   PUBMED   29491007
REFERENCE   6  (bases 1 to 1892)
  AUTHORS   Homeister,J.W., Thall,A.D., Petryniak,B., Maly,P., Rogers,C.E.,
            Smith,P.L., Kelly,R.J., Gersten,K.M., Askari,S.W., Cheng,G.,
            Smithson,G., Marks,R.M., Misra,A.K., Hindsgaul,O., von Andrian,U.H.
            and Lowe,J.B.
  TITLE     The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert
            collaborative control over selectin-dependent leukocyte recruitment
            and lymphocyte homing
  JOURNAL   Immunity 15 (1), 115-126 (2001)
   PUBMED   11485743
REFERENCE   7  (bases 1 to 1892)
  AUTHORS   Beck,P.L., Xavier,R., Lu,N., Nanda,N.N., Dinauer,M., Podolsky,D.K.
            and Seed,B.
  TITLE     Mechanisms of NSAID-induced gastrointestinal injury defined using
            mutant mice
  JOURNAL   Gastroenterology 119 (3), 699-705 (2000)
   PUBMED   10982764
REFERENCE   8  (bases 1 to 1892)
  AUTHORS   Weninger,W., Ulfman,L.H., Cheng,G., Souchkova,N., Quackenbush,E.J.,
            Lowe,J.B. and von Andrian,U.H.
  TITLE     Specialized contributions by alpha(1,3)-fucosyltransferase-IV and
            FucT-VII during leukocyte rolling in dermal microvessels
  JOURNAL   Immunity 12 (6), 665-676 (2000)
   PUBMED   10894166
REFERENCE   9  (bases 1 to 1892)
  AUTHORS   Maly,P., Thall,A., Petryniak,B., Rogers,C.E., Smith,P.L.,
            Marks,R.M., Kelly,R.J., Gersten,K.M., Cheng,G., Saunders,T.L.,
            Camper,S.A., Camphausen,R.T., Sullivan,F.X., Isogai,Y.,
            Hindsgaul,O., von Andrian,U.H. and Lowe,J.B.
  TITLE     The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte
            trafficking through an essential role in L-, E-, and P-selectin
            ligand biosynthesis
  JOURNAL   Cell 86 (4), 643-653 (1996)
   PUBMED   8752218
REFERENCE   10 (bases 1 to 1892)
  AUTHORS   Smith,P.L., Gersten,K.M., Petryniak,B., Kelly,R.J., Rogers,C.,
            Natsuka,Y., Alford,J.A. 3rd, Scheidegger,E.P., Natsuka,S. and
            Lowe,J.B.
  TITLE     Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid
            aggregate high endothelial venules correlates with expression of
            L-selectin ligands
  JOURNAL   J Biol Chem 271 (14), 8250-8259 (1996)
   PUBMED   8626519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732557.4.
            
            On Jan 22, 2014 this sequence version replaced XM_006497705.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at an
            alternate start codon, compared to variant 3. Variants 1, 2, 4, 5,
            6 and 7 encode the same isoform (a), which is shorter and has a
            distinct N-terminus, compared to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ424190.1, AK154486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AL732557.4         96015-96109
            96-318              AL732557.4         96519-96741
            319-403             AL732557.4         97467-97551
            404-1892            AL732557.4         97659-99147
FEATURES             Location/Qualifiers
     source          1..1892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.25 cM"
     gene            1..1892
                     /gene="Fut7"
                     /gene_synonym="FTVII; Fuc-TVII; FucT-VII"
                     /note="fucosyltransferase 7"
                     /db_xref="GeneID:14347"
                     /db_xref="MGI:MGI:107692"
     exon            1..95
                     /gene="Fut7"
                     /gene_synonym="FTVII; Fuc-TVII; FucT-VII"
                     /inference="alignment:Splign:2.1.0"
     exon            96..318
                     /gene="Fut7"
                     /gene_synonym="FTVII; Fuc-TVII; FucT-VII"
                     /inference="alignment:Splign:2.1.0"
     exon            319..403
                     /gene="Fut7"
                     /gene_synonym="FTVII; Fuc-TVII; FucT-VII"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..1419
                     /gene="Fut7"
                     /gene_synonym="FTVII; Fuc-TVII; FucT-VII"
                     /EC_number="2.4.1.-"
                     /note="isoform a is encoded by transcript variant 4;
                     alpha-(1,3)-fucosyltransferase 7; fucosyltransferase VII;
                     galactoside 3-L-fucosyltransferase"
                     /codon_start=1
                     /product="alpha-(1,3)-fucosyltransferase 7 isoform a"
                     /protein_id="NP_001276382.1"
                     /db_xref="CCDS:CCDS15772.1"
                     /db_xref="GeneID:14347"
                     /db_xref="MGI:MGI:107692"
                     /translation="MNCIGYHPTRRLRAWGGLAGGATFMVIWFFWLWGSAPGSAPVPQ
                     STLTILIWHWPFTNRPPELPGDTCTRYGMASCRLSANRSLLASADAVVFHHRELQTRQ
                     SLLPLDQRPHGQPWVWASMESPSNTHGLHRFRGIFNWVLSYRRDSDIFVPYGRLEPLS
                     GPTSPLPAKSRMAAWVISNFQERQQRAKLYRQLAPHLQVDVFGRASGRPLCANCLLPT
                     LARYRFYLAFENSQHRDYITEKFWRNALAAGAVPVALGPPRATYEAFVPPDAFVHVDD
                     FSSARELAVFLVSMNESRYRGFFAWRDRLRVRLLGDWRERFCTICARYPYLPRSQVYE
                     DLESWFQA"
     exon            404..1892
                     /gene="Fut7"
                     /gene_synonym="FTVII; Fuc-TVII; FucT-VII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1873..1878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fut7"
                     /gene_synonym="FTVII; Fuc-TVII; FucT-VII"
                     /note="hexamer: AATAAA"
     polyA_site      1892
                     /gene="Fut7"
                     /gene_synonym="FTVII; Fuc-TVII; FucT-VII"
                     /note="major polyA site"
ORIGIN      
        1 acttctgagg tgccaatcag cctgcactcg cctctgccct ggccatggca ctgctgtcag
       61 tttcttggta cctgtctcaa cagcagcctt gtcacagcct gctggagggg aatcaaacaa
      121 gcctggacct gaggctggga ctagctttcc tgtttctgga gtggatgcca accccctgcc
      181 caccagcctg cctgtccacg ccagggacac acagactcct tccctttcca gactggaaag
      241 ccccctcctg ggagagcagg aaggaagcaa cctgcaactc ttccagccct ggaccttggg
      301 ctgaacctac agttcaaggg tgcctctgtt ggagaggctg ctgtgatttg aaaatcttct
      361 ttccttggtg acaattccag aaggctccag atgaattgta ttgggtacca ccccaccagg
      421 aggctgcggg cctggggcgg cctagctgga ggagcaacat tcatggtaat ttggtttttc
      481 tggctgtggg gatcagctcc tggaagtgcc cctgtgcctc agtccacact caccatcctt
      541 atctggcact ggcctttcac caaccggccg ccagagctac ctggtgacac ctgcactcgc
      601 tatggcatgg ccagctgccg tctgagtgct aaccggagcc tgctagccag tgctgatgct
      661 gtggtcttcc accaccgtga gctgcaaacc cggcaatctc tcctacccct ggaccagagg
      721 ccacacggac agccttgggt ctgggcctcc atggaatcgc ccagtaatac ccatggtctc
      781 catcgcttcc ggggcatctt caactgggtg ctgagctatc ggcgtgattc agatatcttt
      841 gtaccctacg gtcgcttgga gcctctctct gggcccacat ccccactacc ggccaaaagc
      901 aggatggctg cctgggtgat cagcaatttc caggagcggc agcagcgtgc aaagctgtac
      961 cggcagctgg cccctcatct gcaggtggat gtgttcggtc gcgccagcgg acggccccta
     1021 tgcgctaatt gtctgctgcc cactttggcc cggtaccgct tctacctggc ctttgagaac
     1081 tcacagcatc gggactacat cactgagaag ttctggcgca atgccctggc ggctggtgct
     1141 gtacccgtgg cgctgggacc tcctcgggcc acctacgagg cttttgtgcc accagatgcc
     1201 tttgtacacg tggacgactt cagctctgcc cgtgaactgg ctgtcttcct cgtcagcatg
     1261 aatgagagtc gttatcgtgg cttctttgct tggcgagacc ggctccgtgt gcggctcctg
     1321 ggtgactgga gggagcgctt ctgcaccatc tgtgcccgct acccttactt gccccgcagc
     1381 caggtctatg aagaccttga aagctggttc caggcttgaa ctcctgctgc tgggagaggc
     1441 tggatgggtg ggagactgat gttgaaacca aagagctggg catccaggct tttggtcacc
     1501 atggcactac cccaaggctt ttcctgttca gtgagcagga attcaggata taaggagaaa
     1561 actgggctga gatgccctgg tgggctttag agtaggggcc caggataaga gacaatgaat
     1621 taatgaggag catatgggga aggtggctga gggtccctga cttaccttga cccatggctg
     1681 aaggctccat gcccatggct ggagctggga ccctacactt ctatagtcaa ggtgcttagc
     1741 ctcaaggttg cagatgcacc ctctagtact ctgggtgcag actgtacact gggcgcaggg
     1801 ggttgtggaa ggacagtgca gatgattctg ggcttttgac accacagttc ccccagggaa
     1861 agaggcacta ctaataaaaa cactgacaga aa
//
