LOCUS       NM_010242               3664 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus fucosyltransferase 4 (Fut4), mRNA.
ACCESSION   NM_010242
VERSION     NM_010242.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3664)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3664)
  AUTHORS   Liu,W., Xiong,W., Liu,W., Hirakawa,J. and Kawashima,H.
  TITLE     A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans
            attenuates murine allergic rhinitis by suppressing Th2 immune
            responses
  JOURNAL   Sci Rep 13 (1), 15740 (2023)
   PUBMED   37735247
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3664)
  AUTHORS   Zhou,Z., Yin,H., Suye,S., Ren,Z., Yan,L., Shi,L. and Fu,C.
  TITLE     Fance deficiency inhibits primordial germ cell proliferation
            associated with transcription-replication conflicts accumulate and
            DNA repair defects
  JOURNAL   J Ovarian Res 16 (1), 160 (2023)
   PUBMED   37563658
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3664)
  AUTHORS   Li,Q., Jiao,J., Heng,Y., Lu,Q., Zheng,Y., Li,H., Cai,J., Mei,M. and
            Bao,S.
  TITLE     Prmt5 promotes ciliated cell specification of airway epithelial
            progenitors via transcriptional inhibition of Tp63
  JOURNAL   J Biol Chem 299 (8), 104964 (2023)
   PUBMED   37364687
REFERENCE   5  (bases 1 to 3664)
  AUTHORS   Lee,J., Kim,Y., Ataliotis,P., Kim,H.G., Kim,D.W., Bennett,D.C.,
            Brown,N.A., Layman,L.C. and Kim,S.H.
  TITLE     Coordination of canonical and noncanonical Hedgehog signalling
            pathways mediated by WDR11 during primordial germ cell development
  JOURNAL   Sci Rep 13 (1), 12309 (2023)
   PUBMED   37516749
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3664)
  AUTHORS   Filali,M., Lalonde,R., Bensoula,A.N., Guastavino,J.M. and
            Lestienne,F.
  TITLE     Spontaneous alternation, motor activity, and spatial learning in
            hot-foot mutant mice
  JOURNAL   J Comp Physiol A 178 (1), 101-104 (1996)
   PUBMED   8568721
REFERENCE   7  (bases 1 to 3664)
  AUTHORS   Gersten,K.M., Natsuka,S., Trinchera,M., Petryniak,B., Kelly,R.J.,
            Hiraiwa,N., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Lowe,J.B.
  TITLE     Molecular cloning, expression, chromosomal assignment, and
            tissue-specific expression of a murine
            alpha-(1,3)-fucosyltransferase locus corresponding to the human
            ELAM-1 ligand fucosyl transferase
  JOURNAL   J Biol Chem 270 (42), 25047-25056 (1995)
   PUBMED   7559635
REFERENCE   8  (bases 1 to 3664)
  AUTHORS   Marcus,R.C. and Mason,C.A.
  TITLE     The first retinal axon growth in the mouse optic chiasm: axon
            patterning and the cellular environment
  JOURNAL   J Neurosci 15 (10), 6389-6402 (1995)
   PUBMED   7472403
REFERENCE   9  (bases 1 to 3664)
  AUTHORS   Fox,N., Damjanov,I., Martinez-Hernandez,A., Knowles,B.B. and
            Solter,D.
  TITLE     Immunohistochemical localization of the early embryonic antigen
            (SSEA-1) in postimplantation mouse embryos and fetal and adult
            tissues
  JOURNAL   Dev Biol 83 (2), 391-398 (1981)
   PUBMED   6113181
REFERENCE   10 (bases 1 to 3664)
  AUTHORS   Solter,D. and Knowles,B.B.
  TITLE     Monoclonal antibody defining a stage-specific mouse embryonic
            antigen (SSEA-1)
  JOURNAL   Proc Natl Acad Sci U S A 75 (11), 5565-5569 (1978)
   PUBMED   281705
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK041752.1.
            
            On Apr 5, 2007 this sequence version replaced NM_010242.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK041752.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3664              AK041752.1         1-3664
FEATURES             Location/Qualifiers
     source          1..3664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.3 cM"
     gene            1..3664
                     /gene="Fut4"
                     /gene_synonym="CD15; FAL; FucT-IV; LeX; SSEA-1; Ssea1"
                     /note="fucosyltransferase 4"
                     /db_xref="GeneID:14345"
                     /db_xref="MGI:MGI:95594"
     exon            1..3664
                     /gene="Fut4"
                     /gene_synonym="CD15; FAL; FucT-IV; LeX; SSEA-1; Ssea1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1428
                     /gene="Fut4"
                     /gene_synonym="CD15; FAL; FucT-IV; LeX; SSEA-1; Ssea1"
                     /EC_number="2.4.1.152"
                     /note="stage-specific embryonic antigen 1; galactoside
                     3-L-fucosyltransferase; Lewis x; alpha
                     1,3-fucosyltransferase; fuc-TIV; fucosyltransferase IV;
                     alpha (1,3) fucosyltransferase, myeloid specific;
                     3-fucosyl-N-acetyl-lactosamine epitope;
                     4-galactosyl-N-acetylglucosaminide
                     3-alpha-L-fucosyltransferase"
                     /codon_start=1
                     /product="alpha-(1,3)-fucosyltransferase 4"
                     /protein_id="NP_034372.1"
                     /db_xref="CCDS:CCDS22825.1"
                     /db_xref="GeneID:14345"
                     /db_xref="MGI:MGI:95594"
                     /translation="MAPARQELQHESRCRPSRTVDAWRAAVATRGRHMETPGYRRRTR
                     CGGWGLPRSVSSLAAVGLLCTALTTFICWGQLPPLPWASPAPQRLVGVLLWWEPFRGR
                     GGYPKSPPDCSLRFNISGCRLLTDRAAYGEAQAVLFHHRDLVKELHDWPPPWGARERT
                     DKALVLRVFDDQEGAVTLTGKALETVGSRPPGQRWVWMNFESPSHTPGLRGLAKDLFN
                     WTLSYRTDSDVFVPYGFLYSRSDPTEQPSGLGPQLARKRGLVAWVVSNWNEHQARVRY
                     YHQLSRHVSVDVFGRTGPGRPVPAIGLLHTVARYKFYLAFENSRHVDYITEKLWRNAF
                     LAGAVPVVLGPDRANYERFVPRGAFIHVDDFPNAASLAAYLLFLDRNVAVYRRYFRWR
                     RSFAVHITSFWDEQWCRTCQAVQTSGDQPKSIHNLADWFQR"
     regulatory      3232..3237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fut4"
                     /gene_synonym="CD15; FAL; FucT-IV; LeX; SSEA-1; Ssea1"
                     /note="hexamer: ATTAAA"
     polyA_site      3251
                     /gene="Fut4"
                     /gene_synonym="CD15; FAL; FucT-IV; LeX; SSEA-1; Ssea1"
                     /note="major polyA site"
ORIGIN      
        1 gagaacagtg tctggaaggg tcagggtggc gctgggccag ggctgccggc ccggctcacc
       61 ttatcctgga cttgggaggg gcgaggcacc gcccgtgggt ccgccgatgc cccgcccgcc
      121 ccctccatgg ctccggcccg gcaagagcta cagcatgaga gccggtgccg cccctcacgg
      181 acggtggacg cgtggcgagc cgcggtggcc actcgtggac gccacatgga gacgccgggg
      241 taccggcgtc gcacacggtg tggaggctgg ggactacccc ggagcgtctc ttcgctggcg
      301 gcagtgggac tactgtgcac cgcgttgacc accttcatct gctggggaca gttgccgcca
      361 ctgccctggg cgtccccagc tccgcaacgc ctggtgggtg tgctgctctg gtgggaaccc
      421 tttagggggc gcggcggcta ccccaagtct ccccccgatt gcagcctgcg cttcaacatc
      481 agcggctgcc gcttgctcac cgaccgcgcg gcctacgggg aggctcaggc agtgctgttc
      541 caccaccgcg acctggtgaa ggaactccac gactggcccc cgccctgggg cgcccgagaa
      601 cgcacggata aggcgctggt actacgcgtg ttcgacgacc aggagggagc agtgacgcta
      661 actggcaaag ccctggagac cgtaggttct cgtccccctg ggcagaggtg ggtgtggatg
      721 aacttcgaat cgccctccca tactccaggg ctgcggggct tggccaagga cctcttcaat
      781 tggacactgt cctaccggac cgactcggat gtcttcgtgc cctatggctt cctctattcc
      841 aggagcgatc caactgaaca gccttcaggc ttgggccccc agctggcccg caagcgagga
      901 ctggtggcct gggttgtgag caactggaac gagcaccagg cacgggtccg ttactaccac
      961 cagctgagtc ggcacgtgtc tgtggacgtg tttggtcgga cgggacccgg acggccagtg
     1021 ccagccatcg ggctgctgca cactgtggcc cgctacaagt tttatctagc ctttgagaac
     1081 tcacggcacg tggattacat caccgagaag ctgtggcgga atgcctttct ggctggggcc
     1141 gtgccagtgg tgctcggccc agatcgtgcc aactatgagc gcttcgtgcc tcgtggcgcc
     1201 ttcatccacg tggacgattt ccctaatgct gcttccctgg ctgcctacct gctctttctc
     1261 gaccgaaacg tggctgtcta tcgccgctac ttccgctggc gccggagctt tgcagtgcac
     1321 atcacctctt tctgggatga gcaatggtgc cggacatgcc aagctgtgca gacctctggg
     1381 gaccagccca agagcatcca caacttggca gactggttcc agcgatgagg ccattctgct
     1441 gtgaactgac tacatcgcct tggctgcgtt ttctaaatac ccaatttttc tttatgtgaa
     1501 gatgagttac caattaatat tatttagcac aagggtggga aaattcccag gccctcgtgg
     1561 cttttttaca gagaggtggt ctggctttct ggtaaggggc tgcggtgtcc tgggtgaagg
     1621 aggctggccc ttccttacct gtcacccatg tgaagaagtg gcctatcctg gccacaggcc
     1681 ttatcaggtg cccatgtggc tgctaaagtt tagacatatt tgttctctgg tcatggttgc
     1741 ttggaacaat gaagagcaga ccacaggttt ttgaaagccg gtgggtatga gatagtggaa
     1801 ggattgtgcc cacaggtggg gttttctttg gtggttggat tcctcaaacc gtctgaacct
     1861 ggaaaagaca agaagccatt gagttccttc accagccatg tgtgtcccca gccctgtgaa
     1921 tagaaacaag agtcaagatt atcttcagag gaaaattaag atgaagactt gggtgcacct
     1981 cgcttcctgc tagaatcctt ctcctgaaaa gctgcatgaa gtgacacccc aaattcaggg
     2041 tcccaaaaga gtgaaagtac ttagtagaaa tgaatgaaaa gtgaaaagtc cctttacaat
     2101 gtgaatgacc gtcttctaat tacttcttct gtctttagag cttcccacga cctggattgg
     2161 gaaaacatta aaaaacaccg atatggaaga gtcacaagca atcttcccac tcatttccca
     2221 gccagtgctt acgaatggaa gagacataaa tggcgacatg ttgtccacaa atgtgcttat
     2281 tctgtgtctc tgttggggct gaaatttaac ctggaatgtg agttcttcag cagcgatggc
     2341 tgctgtgcag agagaacagt aaagattttg gtggactctg agtttgtgca caaggaaaag
     2401 gaaagcttta gtggagtctg tctgtggttg gctgggttct gtccaggttt tgttcaatgg
     2461 agctgagcta gtgcttatta cgattagttg tctgttcttt gtctccgccc cccccccctt
     2521 ccctgcttct aggtacactc actcattcca gtgccttgag ccctgcgctg tgggaccaat
     2581 cttgaaaaca tagtcgttga ttttccacgt tcaacagatg tcagggcatg cctgctggtg
     2641 ccaaacactg ggcttgagct cccaggggaa ggaaggtaaa gaaaggtgtg aggaattgcc
     2701 tcctctttgg ggctcctaca atctactact gccacagggg aatagggatt ttggttacac
     2761 aaagtattgt tcctaaatca gccagttgac tgaggcctca agttatgaaa ctgggacccg
     2821 cacagacact gttacgggca gggcccaaga ttaactgact gtatacaaag ttctgcccct
     2881 gttaggtcag gacagttatt tgaatcttag atcaggttca caaccaagag ctttcgttac
     2941 atataggctt gcaaaacttc ttaggcccag gcgcttccag cccattttcc ataaaaggag
     3001 taattaaaag ctgtgactaa cattgcctca ttaaagtgtt atagtgtgga cagagccaca
     3061 gttgcagaac accagccgcc caacaaaggg aaacaaaagt tctgggggtt gtgtttgctt
     3121 actttggttt ttcagacagg gtttcttcat atagccctgg aactctcttt gtaaaccagg
     3181 ctggccttga actcaaagag atccacctgc ctttggcttc cttgggtggg aattaaaggt
     3241 gtgtgccaca atgcccagct tcaaagttat gttttaaaga tgaatgttaa tgagatattg
     3301 gccaggcgtc ttagtattgt cggaagtcta cactgggtag caggaggctg tgggatttgg
     3361 tggtctgggt tagttttgct ttccagttgg gatgaggaat gagcccaagc attaaggtcc
     3421 tcttctgtga ctcgtggagg agggtgcctg aagacctact gtgtgacata agcaatgccg
     3481 ccttgtgttt actgggcagt tggttcaata tggttatgca taagcatact gcctactttg
     3541 cagggatttt gtttacccta atatacattt tatatctgaa attaaattca agatctatta
     3601 cagaatgaat aaaacaaagg aaagttagtc atatattgcc tatttcaaat aaatccttaa
     3661 aact
//
