LOCUS       NM_001271993            3073 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus fucosyltransferase 2 (Fut2), transcript variant 1,
            mRNA.
ACCESSION   NM_001271993
VERSION     NM_001271993.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3073)
  AUTHORS   Hong,G., Zhao,Y., Li,Q. and Liu,S.
  TITLE     Fut2 deficiency aggravates chronic colitis through 2-oxindole-AHR
            mediated cGAS-STING pathway
  JOURNAL   Int Immunopharmacol 137, 112512 (2024)
   PUBMED   38897123
  REMARK    GeneRIF: Fut2 deficiency aggravates chronic colitis through
            2-oxindole-AHR mediated cGAS-STING pathway.
REFERENCE   2  (bases 1 to 3073)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3073)
  AUTHORS   Guo,X.K., Wang,J., van Hensbergen,V.P., Liu,J., Xu,H. and Hu,X.
  TITLE     Interactions between host and intestinal crypt-resided biofilms are
            controlled by epithelial fucosylation
  JOURNAL   Cell Rep 42 (7), 112754 (2023)
   PUBMED   37405914
REFERENCE   4  (bases 1 to 3073)
  AUTHORS   He,L., Guo,Z., Wang,W., Tian,S. and Lin,R.
  TITLE     FUT2 inhibits the EMT and metastasis of colorectal cancer by
            increasing LRP1 fucosylation
  JOURNAL   Cell Commun Signal 21 (1), 63 (2023)
   PUBMED   36973740
  REMARK    GeneRIF: FUT2 inhibits the EMT and metastasis of colorectal cancer
            by increasing LRP1 fucosylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3073)
  AUTHORS   Wang,W., Tang,X., Duan,C., Tian,S., Han,C., Qian,W., Jiang,X.,
            Hou,X. and Lin,R.
  TITLE     Intestinal epithelium-specific Fut2 deficiency promotes colorectal
            cancer through down-regulating fucosylation of MCAM
  JOURNAL   J Transl Med 21 (1), 82 (2023)
   PUBMED   36739428
  REMARK    GeneRIF: Intestinal epithelium-specific Fut2 deficiency promotes
            colorectal cancer through down-regulating fucosylation of MCAM.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3073)
  AUTHORS   Domino,S.E., Zhang,L. and Lowe,J.B.
  TITLE     Molecular cloning, genomic mapping, and expression of two secretor
            blood group alpha (1,2)fucosyltransferase genes differentially
            regulated in mouse uterine epithelium and gastrointestinal tract
  JOURNAL   J Biol Chem 276 (26), 23748-23756 (2001)
   PUBMED   11323419
REFERENCE   7  (bases 1 to 3073)
  AUTHORS   Lin,B., Saito,M., Sakakibara,Y., Hayashi,Y., Yanagisawa,M. and
            Iwamori,M.
  TITLE     Characterization of three members of murine
            alpha1,2-fucosyltransferases: change in the expression of the Se
            gene in the intestine of mice after administration of microbes
  JOURNAL   Arch Biochem Biophys 388 (2), 207-215 (2001)
   PUBMED   11368156
REFERENCE   8  (bases 1 to 3073)
  AUTHORS   Bureau,V., Marionneau,S., Cailleau-Thomas,A., Le Moullac-Vaidye,B.,
            Liehr,T. and Le Pendu,J.
  TITLE     Comparison of the three rat GDP-L-fucose:beta-D-galactoside
            2-alpha-L-fucosyltransferases FTA, FTB and FTC
  JOURNAL   Eur J Biochem 268 (4), 1006-1019 (2001)
   PUBMED   11179967
REFERENCE   9  (bases 1 to 3073)
  AUTHORS   Lin,B., Hayashi,Y., Saito,M., Sakakibara,Y., Yanagisawa,M. and
            Iwamori,M.
  TITLE     GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II,
            and not MFUT-I or -III, is induced in a restricted region of the
            digestive tract of germ-free mice by host-microbe interactions and
            cycloheximide
  JOURNAL   Biochim Biophys Acta 1487 (2-3), 275-285 (2000)
   PUBMED   11018479
REFERENCE   10 (bases 1 to 3073)
  AUTHORS   Domino,S.E., Hiraiwa,N. and Lowe,J.B.
  TITLE     Molecular cloning, chromosomal assignment and tissue-specific
            expression of a murine alpha(1,2)fucosyltransferase expressed in
            thymic and epididymal epithelial cells
  JOURNAL   Biochem J 327 (Pt 1) (Pt 1), 105-115 (1997)
   PUBMED   9355741
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK033586.1, BY142283.1,
            BC145831.1, AK033520.1 and BQ032725.1.
            
            Summary: This gene is one of three genes in mouse which encode a
            galactoside 2-L-fucosyltransferase. These genes differ in their
            developmental- and tissue-specific expression. The encoded type II
            membrane protein is anchored in the Golgi apparatus and controls
            the final step in the creation of alpha (1,2) fucosylated
            carbhohydrates by the addition of a terminal fucose in an alpha
            (1,2) linkage. This enzyme is involved in the synthesis of the
            Lewis antigen as well as the H-antigen, a precursor of the A and B
            antigens of the ABH histo-blood group. The biological function of
            the fucosylated carbhohydrate products is thought to involve
            cell-adhesion and interactions with microorganisms. Disruption of
            this gene results in altered glycosylation of gastric mucosa and
            uterine epithelia. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY788993.1, BY789624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AK033586.1         3-53
            52-344              BY142283.1         2-294
            345-2926            BC145831.1         95-2676
            2927-3055           AK033520.1         2738-2866
            3056-3073           BQ032725.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3073
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.41 cM"
     gene            1..3073
                     /gene="Fut2"
                     /gene_synonym="MFUT-II"
                     /note="fucosyltransferase 2"
                     /db_xref="GeneID:14344"
                     /db_xref="MGI:MGI:109374"
     exon            1..197
                     /gene="Fut2"
                     /gene_synonym="MFUT-II"
                     /inference="alignment:Splign:2.1.0"
     exon            198..301
                     /gene="Fut2"
                     /gene_synonym="MFUT-II"
                     /inference="alignment:Splign:2.1.0"
     exon            302..3059
                     /gene="Fut2"
                     /gene_synonym="MFUT-II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3034..3039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fut2"
                     /gene_synonym="MFUT-II"
                     /note="hexamer: AATAAA"
     polyA_site      3059
                     /gene="Fut2"
                     /gene_synonym="MFUT-II"
                     /note="major polyA site"
ORIGIN      
        1 cagcctctct ggttctagga tgtcagcagg tacaccctgg gtggagtttc tatccagggc
       61 tgtggttaaa ctcaggaagt ttccttggtc ctgaacgaag agccaagctg gaagatacac
      121 actgccgtcc agtccgcaga gccacgctgc ggttcgtcca ttcctaggtc atttccctgt
      181 taccacagcc agaagaggat tgctgtagag cccagagaga cgccaccttg atctcccaga
      241 gactggagag tctcccccgg gatccttatc tgtgaacttt cggctaaggt acatctatca
      301 gccatggcga gtgcccaggt acctttctcc tttcctctgg cccacttcct catctttgtc
      361 tttgtgactt ccaccatcat ccacctccag caacgaatag tgaagctcca aaccctgtca
      421 gagaaggaat tacaggcggt tcaaatgtcc tcaccaaacg cggcaagaac agacatgcag
      481 cagagtgcca agctgcaggg catattcacg atcaattcca tcggccgcct ggggaaccag
      541 atgggcgaat atgctacatt gtttgcactg gccaggatga acggtcggct tgccttcatc
      601 cctgaatcca tgcacaacgc tctagcgccc atcttcagga tcagtctccc ggtgttacac
      661 agcgacacag ccagaaggat cccgtggcag aattaccacc tcaacgactg gatggaggag
      721 cgttaccgcc acatcccggg gcagtatgtg cgtttcacgg gatacccgtg ctcctggacc
      781 ttctaccacc acctgcgccc agagatcctg aaggagttca ccctgcacga ccatgtgcgt
      841 gaggaggccc aggctttcct gcgtggcctg cgggtgaatg ggagccagcc gagtaccttt
      901 gtgggtgtcc atgtgcgccg aggggactat gtgcatgtca tgcccaaggt gtggaagggc
      961 gtggtggctg accggggtta cctagaaaag gccctggaca ggttccgggc acgctattca
     1021 tctccagtct tcgtggttac aagcaacggt atggcctggt gccgggagaa catcaacacc
     1081 tccctaggag acgtggtgtt tgcgggcaat ggtattgagg gctcaccagc caaggacttc
     1141 gcgctcctca cccagtgcaa ccacaccatc atgaccattg gaacctttgg gatttgggct
     1201 gcctacctgg caggtggtga taccatctac ctagccaact acacccttcc ggattctccg
     1261 ttcctcaaaa tctttaagcc agcagcagcc ttcctccccg agtggatggg catccccgca
     1321 gacctgtccc cactccttaa gcactaacaa ccagcctgtc cttggtccca tttccatctc
     1381 aaggcagaag gagtcacttg gtacatccca ggaagggcct tctactggga agatgtgtgc
     1441 cttggactgc caacgagaac taatatgtgc agaaaacgta ttacatgtta gatacaagtt
     1501 ccaacattca ttaacagctc agacattatc aatggctcct gttcctgaaa actaacaggc
     1561 cttcaccttt tttcagcaca gctgtctcat ggtgccagcc gggctgccac ccacagacag
     1621 tctcttccag aggcagcaag aaaaggtgtg ttatcgattt tactttaggt tccttttgaa
     1681 gggtaaggca aactcttgtt tatacacttt ttgtcattag catttccatg gcggggcagc
     1741 atgcgacagg caataaccat gtaaggaagc ctgagaaagg agaggaggct ggcttgctct
     1801 ttttatagca actgcttttc accaactgac aggagtctgc tgagaactgc taaccccttt
     1861 gaaagtggtg ccttcagtga cctcagaacg tcttatcatc tgttaagatt cttttttttt
     1921 tttaattatg gatatatatg tgggtgtgtg cagtaccttc agaggccaga cctgggcgtt
     1981 gggttcctgg gaactggaat cataagcagc tggctctgcc tcccgaaggt ctcaccgaca
     2041 gtggaccaaa ggccaggcca gtgaaagcca cacctctcca agcatccagc cagctcttct
     2101 gtccccttga caagagttgt gtcaccgtga gctcacgtgg ctcattatga gtcaagggga
     2161 gggagaacgc tgggattggt ttagcctagg atccaaaata ggagttcttc actgcacaga
     2221 tcaaaaggga tgcgggagct accgtggacc cacagtcccc tcaccaagtt gcttgtcctt
     2281 gggactttgc ctactctgtc catctgagaa gaactgagtg agtagaattc agatgcatgt
     2341 ccacttctgt agccctggcc ggacacccca ggcctaggga actcctccag atgtttcaga
     2401 gtgtcttacc atcttgttaa acttcacgtg tgaacacaca tcatgctatc tctcacacaa
     2461 ttaaagaata caacctatgt agccaccatt atgaaaacag ccagggtgat gcagggggcg
     2521 ggggcgggcg ggggaagaag ccttgcaaag gtgttagctc aggacagcag aatcccaagg
     2581 tgtctctcca gaccccctgc taaattggaa gtgctgatcc tgtgcatgag aagtagcctg
     2641 gagtggccac ggtggcacct gcctttcatc cttgcactgt gaaggctaag gcaggaggcc
     2701 agcctggtct atatcctaaa accctgtctc aaaagataaa attctcaaac tgggtatagt
     2761 ggtgcacagc ggtggtccca gcattaggta agtgcagaaa gatcaagagt tggaagtcat
     2821 ccacagctac acggaatggc agaccagtct gagctgcatg agaagcccct taccccatct
     2881 cagaaacaga aagaaaatta cagaaatcta agctccgcag tggcagtata cactcaggag
     2941 gcagcggcca gtagatcttt gggtttgagg atagcctggg ctacacagaa gtcctatgtc
     3001 acgaattttt tttttttttc aaaatccaaa acaaataaaa atgtgcctct ccatcacaaa
     3061 aaaaaaaaaa aaa
//
