LOCUS       NM_008051               2580 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus fucosyltransferase 1 (Fut1), transcript variant 1,
            mRNA.
ACCESSION   NM_008051
VERSION     NM_008051.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Chen,S., Hayoun-Neeman,D., Nagar,M., Pinyan,S., Hadad,L.,
            Yaacobov,L., Alon,L., Shachar,L.E., Swissa,T., Kryukov,O.,
            Gershoni-Yahalom,O., Rosental,B., Cohen,S. and Lichtenstein,R.G.
  TITLE     Terminal alpha1,2-fucosylation of glycosphingolipids by FUT1 is a
            key regulator in early cell-fate decisions
  JOURNAL   EMBO Rep 25 (10), 4433-4464 (2024)
   PUBMED   39256596
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   Li,N., Oh,J.H., Suh,J.H., Jin,S.P., Lee,D.H., Lee,Y. and Chung,J.H.
  TITLE     Impact of fucosyltransferase 1-mediated epidermal blood group
            antigen H on anti-inflammatory response in atopic dermatitis
  JOURNAL   Front Immunol 15, 1365430 (2024)
   PUBMED   38840912
  REMARK    GeneRIF: Impact of fucosyltransferase 1-mediated epidermal blood
            group antigen H on anti-inflammatory response in atopic dermatitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Li,N., Lee,Y., Suh,J.H., Oh,J.H., Jin,S.P., Lee,D.H. and Chung,J.H.
  TITLE     Fucosylation deficiency enhances imiquimod-induced psoriasis-like
            skin inflammation by promoting CXCL1 expression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166988 (2024)
   PUBMED   38070583
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Ko,J.H., Ryu,J.S., Oh,J.H. and Oh,J.Y.
  TITLE     Splenocytes with fucosylation deficiency promote T cell
            proliferation and differentiation through thrombospondin-1
            downregulation
  JOURNAL   Immunology 171 (2), 262-269 (2024)
   PUBMED   37957948
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   McKenzie,I.F., Li,Y.Q., Patton,K. and Sandrin,M.S.
  TITLE     Fucosyl transferase (H) transgenic heart transplants to Gal-/- mice
  JOURNAL   Transplantation 70 (8), 1205-1209 (2000)
   PUBMED   11063342
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Lin,B., Hayashi,Y., Saito,M., Sakakibara,Y., Yanagisawa,M. and
            Iwamori,M.
  TITLE     GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II,
            and not MFUT-I or -III, is induced in a restricted region of the
            digestive tract of germ-free mice by host-microbe interactions and
            cycloheximide
  JOURNAL   Biochim Biophys Acta 1487 (2-3), 275-285 (2000)
   PUBMED   11018479
REFERENCE   8  (bases 1 to 2580)
  AUTHORS   Liu,N., Jin,C., Zhu,Z.M., Zhang,J., Tao,H., Ge,C., Yang,S. and
            Zhang,S.
  TITLE     Stage-specific expression of alpha1,2-fucosyltransferase and
            alpha1, 3-fucosyltransferase (FT) during mouse embryogenesis
  JOURNAL   Eur J Biochem 265 (1), 258-263 (1999)
   PUBMED   10491181
REFERENCE   9  (bases 1 to 2580)
  AUTHORS   Sidhu,S.S. and Kimber,S.J.
  TITLE     Hormonal control of H-type alpha(1-2)fucosyltransferase messenger
            ribonucleic acid in the mouse uterus
  JOURNAL   Biol Reprod 60 (1), 147-157 (1999)
   PUBMED   9858499
REFERENCE   10 (bases 1 to 2580)
  AUTHORS   Domino,S.E., Hiraiwa,N. and Lowe,J.B.
  TITLE     Molecular cloning, chromosomal assignment and tissue-specific
            expression of a murine alpha(1,2)fucosyltransferase expressed in
            thymic and epididymal epithelial cells
  JOURNAL   Biochem J 327 (Pt 1) (Pt 1), 105-115 (1997)
   PUBMED   9355741
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK137638.1 and AC149057.7.
            
            On Dec 20, 2012 this sequence version replaced NM_008051.5.
            
            Summary: This gene is one of three genes in mouse which encode a
            galactoside 2-L-fucosyltransferase. These genes differ in their
            developmental- and tissue-specific expression. The encoded type II
            membrane protein is anchored in the Golgi apparatus and controls
            the final step in the creation of alpha (1,2) fucosylated
            carbhohydrates by the addition of a terminal fucose in an alpha
            (1,2) linkage. This enzyme is required for the synthesis of the
            Lewis antigen as well as the H-antigen, a precursor of the A and B
            antigens of the ABH histo-blood group. The biological function of
            the fucosylated carbhohydrate products is thought to involve
            cell-adhesion and interactions with microorganisms. Disruption of
            this gene impairs development of the olfactory nerve and maturation
            of the glomerular layer of the main olfactory bulb. Alternative
            splicing results in multiple transcript variants which encode
            distinct isoforms. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note:This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137638.1, CJ056234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2578              AK137638.1         3-2580
            2579-2580           AC149057.7         47723-47724         c
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.39 cM"
     gene            1..2580
                     /gene="Fut1"
                     /gene_synonym="MFUT-1"
                     /note="fucosyltransferase 1"
                     /db_xref="GeneID:14343"
                     /db_xref="MGI:MGI:109375"
     exon            1..142
                     /gene="Fut1"
                     /gene_synonym="MFUT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..2580
                     /gene="Fut1"
                     /gene_synonym="MFUT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1278
                     /gene="Fut1"
                     /gene_synonym="MFUT-1"
                     /EC_number="2.4.1.69"
                     /EC_number="2.4.1.344"
                     /note="isoform 1 is encoded by transcript variant 1;
                     galactoside 2-alpha-L-fucosyltransferase 1;
                     beta-galactoside alpha-1,2-fucosyltransferase;
                     alpha(1,2)FT 1; GDP-L-fucose:beta-D-galactoside
                     2-alpha-L-fucosyltransferase 1; H transferase; type 1
                     galactoside alpha-(1,2)-fucosyltransferase FUT1; type 2
                     galactoside alpha-(1,2)-fucosyltransferase FUT1;
                     galactoside alpha-(1,2)-fucosyltransferase 1"
                     /codon_start=1
                     /product="galactoside alpha-(1,2)-fucosyltransferase 1
                     isoform 1"
                     /protein_id="NP_032077.2"
                     /db_xref="CCDS:CCDS21254.1"
                     /db_xref="GeneID:14343"
                     /db_xref="MGI:MGI:109375"
                     /translation="MWTPSRRQLCLAFLLVCVLSAGSFFFHLNGGNFFRNGLTLSVLC
                     SDYHLLKSPVAMVCLPHPLQTSNGSPSCPEQSSSLSGTWTITPGGRFGNQMGQYATLL
                     ALAQLNGRQAFIQPEMHAALAPVFRISLPVLDPEVDSLTPWQHLVLHDWMSEEYSHLE
                     DPFLKLSGFPCSWTFFHHLREQIRREFTLHNHLREGAQYLLSGLRIGPAGIRPHTFVG
                     VHVRRGDYLEVMPNRWKGVVGDRAYLQQAMDWFRARHKDPIFVVTSNGMKWCLENIDT
                     SHGDVVFAGNGQEGTPGKDFALLTQCNHTIMTIGTFGFWAAYLAGGDTVYLANFTLPD
                     SEFLKIFRPEAAFLPEWVGINADLSPLQAQFDPWKPDSLFRLV"
ORIGIN      
        1 agtcagtttc aggaaggaag cttgaagcgg agggctacgg agccggggct cctgacttcc
       61 aagcgcggcc gatgaaggct acattttaga actggaagct caggcaaaaa gaattcgctt
      121 gcaccaccag caaggagctc agctatgtgg actcccagcc ggaggcagct ctgcctggca
      181 tttctgttgg tctgtgtgct ctctgccggc tccttctttt tccacctgaa tggaggaaac
      241 ttctttcgaa atggtctaac tctctctgtc ctgtgttcag actatcacct gctgaagtcc
      301 ccagtggcca tggtatgcct acctcatcca ttgcagacat ctaatggctc cccttcctgt
      361 cctgagcagt cctcctcact ctctgggact tggacaatca ccccaggagg caggtttggt
      421 aaccagatgg ggcagtatgc tacattgctg gccctagccc agctcaatgg tcgccaagcc
      481 ttcatccaac ctgagatgca tgccgccctg gcccccgtgt tccgaatctc cctgccagtg
      541 ctggaccctg aggtggacag cctcacacct tggcagcact tagtcctaca tgactggatg
      601 tcagaggagt actcccatct ggaggaccca tttctcaagc tgtctggttt cccctgctct
      661 tggacctttt tccatcatct tcgggaacag attcgtaggg aattcactct gcataaccat
      721 ctacgggaag gtgcccagta cctgttgagc gggctccgta taggcccggc gggcatccgc
      781 cctcatacct ttgtgggtgt ccatgtgcgt cgtggagact atctggaggt gatgcccaat
      841 cgctggaagg gtgtggtggg tgaccgagct tacctccagc aagccatgga ctggttccgg
      901 gcccgacaca aagaccccat ctttgtggtc accagcaatg gcatgaaatg gtgtttggag
      961 aacattgaca catcccatgg tgatgtggtc ttcgctggca atggacagga gggtacaccg
     1021 gggaaggact ttgcacttct cacacagtgt aaccacacca tcatgactat tggcaccttt
     1081 ggcttctggg ctgcctactt agctggtgga gacacggtct accttgcaaa cttcaccctg
     1141 ccagattcgg agtttctgaa gatcttcagg cctgaggctg ccttcctgcc tgagtgggtg
     1201 ggcatcaatg cagacttgtc cccgctgcag gctcaatttg acccctggaa gccagacagt
     1261 ctttttagat tggtctgact catcagaagt cagccatcca tgtctctatg ctttggtgta
     1321 tgtctgtggt agccctggag ctgtgggtac tcatttccag acttgcacat caacttgctg
     1381 gaaatgctgg aatgctttgc agacacttca acaggatatc attttctgat tgcaggggaa
     1441 gcccaagtca gcactgtaag ccacagtctc ttccgactct tctggctcgt cttcttagaa
     1501 cctctgggca gctgtttctg ggttagggag gctgaagaaa atccagactt accaactggt
     1561 ctcctggatt tctggggtta ttctaggctg tttctgagaa cctggtccag tccctttgca
     1621 acactctgca gggccctctc aacactccag acagtgaaga atttaatgaa ggtagatgca
     1681 aaagctcagt acttcctcac tgctggaggc acggagtgat gctagaggca cagagtgatg
     1741 ctgctggagg cacggagtga tgctggaggc acggagtgat gctggaagca cggagtgatg
     1801 ctgctggagg cacggagtga tgctggaagc acggagtgat gctggaggca cggagtgatt
     1861 cgagcctttc tggagccagt ctcttgttag agagatgaga acaattggag gacatatgaa
     1921 ttctgtccaa ctccttggcc ccagagaaac ctgaaagact tttatttagg atgggaagag
     1981 caaatggcta taagtgggct ggaggagaga gccgctgttg agacacatct gtctcgaggc
     2041 acggggtctc ctaaaagatc taggaacttt acaagagaga gagagagaga gagagagaga
     2101 gagagagaga gagctcaaaa gttaaagaac aacacagatt aatcttggat ttaggatcaa
     2161 ggaggtttct tcttctgaag atgctattag gggatctggg atctgttttc tagaggtaac
     2221 caggcctaca gaaaagaagg gcatacccct gggcccacaa agtccccaaa tctggctctg
     2281 agaagatcca gggtaaaggg tctgaaggtg ttccagaacc tagaacccag aaccccgaac
     2341 ccagcctatg cccctacaga agcccgggct tgaaacaagg atgggacgtt tggctgagat
     2401 tgggtatgtg tgatgccttt tcaagaatgg aggaaggttc ctcagatagc atttaatcta
     2461 actgtattta ttcccttcca agagcaactt ctattcttct cagggagttt ccgggcactt
     2521 tttcccaagt tggcctgtac aggctggaga gggagctgtg aattaaaggg ccacatcgcc
//
