LOCUS       NM_139149               1845 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus fused in sarcoma (Fus), transcript variant 1, mRNA.
ACCESSION   NM_139149 XM_986259
VERSION     NM_139149.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Vazquez-Sanchez,S., Tilkin,B., Gasset-Rosa,F., Zhang,S., Piol,D.,
            McAlonis-Downes,M., Artates,J., Govea-Perez,N., Verresen,Y.,
            Guo,L., Cleveland,D.W., Shorter,J. and Da Cruz,S.
  TITLE     Frontotemporal dementia-like disease progression elicited by seeded
            aggregation and spread of FUS
  JOURNAL   Mol Neurodegener 19 (1), 46 (2024)
   PUBMED   38862967
  REMARK    GeneRIF: Frontotemporal dementia-like disease progression elicited
            by seeded aggregation and spread of FUS.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Jia,J., Fan,H., Wan,X., Fang,Y., Li,Z., Tang,Y., Zhang,Y., Huang,J.
            and Fang,D.
  TITLE     FUS reads histone H3K36me3 to regulate alternative polyadenylation
  JOURNAL   Nucleic Acids Res 52 (10), 5549-5571 (2024)
   PUBMED   38499486
  REMARK    GeneRIF: FUS reads histone H3K36me3 to regulate alternative
            polyadenylation.
REFERENCE   3  (bases 1 to 1845)
  AUTHORS   Zhong,C., Wang,H., Yuan,X., He,Y., Cong,J., Yang,R., Ma,W., Gao,L.,
            Gao,C., Cui,Y., Wu,J., Tan,R. and Pu,D.
  TITLE     The crucial role of HFM1 in regulating FUS ubiquitination and
            localization for oocyte meiosis prophase I progression in mice
  JOURNAL   Biol Res 57 (1), 36 (2024)
   PUBMED   38822414
  REMARK    GeneRIF: The crucial role of HFM1 in regulating FUS ubiquitination
            and localization for oocyte meiosis prophase I progression in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1845)
  AUTHORS   Chiusa,M., Lee,Y.A., Zhang,M.Z., Harris,R.C., Sherrill,T.,
            Lindner,V., Brooks,C.R., Yu,G., Fogo,A.B., Flynn,C.R.,
            Zienkiewicz,J., Hawiger,J., Zent,R. and Pozzi,A.
  TITLE     Cytoplasmic retention of the DNA/RNA-binding protein FUS
            ameliorates organ fibrosis in mice
  JOURNAL   J Clin Invest 134 (6), e175158 (2024)
   PUBMED   38488009
  REMARK    GeneRIF: Cytoplasmic retention of the DNA/RNA-binding protein FUS
            ameliorates organ fibrosis in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1845)
  AUTHORS   Kodavati,M., Wang,H., Guo,W., Mitra,J., Hegde,P.M., Provasek,V.,
            Rao,V.H.M., Vedula,I., Zhang,A., Mitra,S., Tomkinson,A.E.,
            Hamilton,D.J., Van Den Bosch,L. and Hegde,M.L.
  TITLE     FUS unveiled in mitochondrial DNA repair and targeted ligase-1
            expression rescues repair-defects in FUS-linked motor neuron
            disease
  JOURNAL   Nat Commun 15 (1), 2156 (2024)
   PUBMED   38461154
  REMARK    GeneRIF: FUS unveiled in mitochondrial DNA repair and targeted
            ligase-1 expression rescues repair-defects in FUS-linked motor
            neuron disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1845)
  AUTHORS   Kuroda,M., Sok,J., Webb,L., Baechtold,H., Urano,F., Yin,Y.,
            Chung,P., de Rooij,D.G., Akhmedov,A., Ashley,T. and Ron,D.
  TITLE     Male sterility and enhanced radiation sensitivity in TLS(-/-) mice
  JOURNAL   EMBO J 19 (3), 453-462 (2000)
   PUBMED   10654943
REFERENCE   7  (bases 1 to 1845)
  AUTHORS   Hicks,G.G., Singh,N., Nashabi,A., Mai,S., Bozek,G., Klewes,L.,
            Arapovic,D., White,E.K., Koury,M.J., Oltz,E.M., Van Kaer,L. and
            Ruley,H.E.
  TITLE     Fus deficiency in mice results in defective B-lymphocyte
            development and activation, high levels of chromosomal instability
            and perinatal death
  JOURNAL   Nat Genet 24 (2), 175-179 (2000)
   PUBMED   10655065
REFERENCE   8  (bases 1 to 1845)
  AUTHORS   Kuroda,M., Wang,X., Sok,J., Yin,Y., Chung,P., Giannotti,J.W.,
            Jacobs,K.A., Fitz,L.J., Murtha-Riel,P., Turner,K.J. and Ron,D.
  TITLE     Induction of a secreted protein by the myxoid liposarcoma oncogene
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 5025-5030 (1999)
   PUBMED   10220412
REFERENCE   9  (bases 1 to 1845)
  AUTHORS   Mencinger,M. and Aman,P.
  TITLE     Characterization of TFG in mus musculus and Caenorhabditis elegans
  JOURNAL   Biochem Biophys Res Commun 257 (1), 67-73 (1999)
   PUBMED   10092511
REFERENCE   10 (bases 1 to 1845)
  AUTHORS   Yang,L., Embree,L.J., Tsai,S. and Hickstein,D.D.
  TITLE     Oncoprotein TLS interacts with serine-arginine proteins involved in
            RNA splicing
  JOURNAL   J Biol Chem 273 (43), 27761-27764 (1998)
   PUBMED   9774382
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY269119.1, AK145582.1 and AK139960.1.
            
            On Aug 18, 2006 this sequence version replaced NM_139149.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139960.1, AK146198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY269119.1         24-34
            12-1842             AK145582.1         2-1832
            1843-1845           AK139960.1         1842-1844
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.87 cM"
     gene            1..1845
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /note="fused in sarcoma"
                     /db_xref="GeneID:233908"
                     /db_xref="MGI:MGI:1353633"
     exon            1..99
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            100..124
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            125..279
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            280..424
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            425..612
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            613..829
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            830..864
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            865..897
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1001
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1131
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1233
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1357
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1458
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1603
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1845
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1821..1826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /note="hexamer: ATTAAA"
     polyA_site      1845
                     /gene="Fus"
                     /gene_synonym="D430004D17Rik; D930039C12Rik; Fus1; Tls"
                     /note="major polyA site"
ORIGIN      
        1 gcggggccgc tcagtcctcg cggcatcgct tcgcggtcgt ctggaacttt gttgcttggc
       61 ggcctgcgct gcgcgcgtgc gcggacatgg cttcaaacga ctatacccaa caagcaactc
      121 aaagctacgg ggcctatcct acccagcctg ggcagggcta ctcccaacag agcagtcagc
      181 cctatggcca acagagttac agtggttatg gccagtcagc tgacacttca ggatacggcc
      241 agagcagcta tggttcttct tatggacaga cccaaaacac aggctatgga actcagtcag
      301 ctccccaggg atatggttcc actggaggct atggcagcag ccaaagttca caatcttctt
      361 atgggcagca gtcctcctac cctggctatg gccaacagcc agctcctagc agcacctcag
      421 gaagttatgg tggcagttct cagagcagca gctatgggca accccagagt ggaggttatg
      481 gtcaacagtc tggctatggt ggacagcaac aaagctacgg acaacaacaa agctcctata
      541 acccacctca gggttatgga caacagaacc agtacaacag tagcagtgga ggtggtggag
      601 ggggtggtgg aggcaactat ggccaagatc agtcctctat gagtggtggc ggtggcggtg
      661 gtggttatgg caatcaggac cagagtggtg gcggcggcgg cggctacggg ggaggccaac
      721 aggatcgtgg gggccgaggc aggggcggtg gaggtggtta caaccgaagc agtggtggct
      781 atgaacccag aggccgtgga ggtggccgag gaggcagagg cggcatgggc ggaagtgacc
      841 gcggtggctt caataaattt ggtggtcctc gggatcaagg atctcgtcat gattctgaac
      901 aggataattc agacaacaat accatcttcg tgcaaggcct aggcgagaat gttacaattg
      961 aatctgtggc tgattacttc aagcagattg gaattattaa gacaaacaag aaaactggac
     1021 agcctatgat taatttgtac acagacaggg aaactggcaa gttgaagggt gaggcaacag
     1081 tttcatttga tgacccacct tctgctaaag cagctatcga ctggtttgat ggtaaagaat
     1141 tctctgggaa tcctattaaa gtttcatttg ctacccgccg agctgacttc aatcggggtg
     1201 gtggaaatgg tcgcggaggc cgagggcgag gaggacccat gggccgtgga ggctatggag
     1261 gaggtggcag tggtggtggt ggccggggag gattccccag tggaggtggt ggaggtggag
     1321 gacagcaacg agctggagac tggaagtgtc ctaatcctac atgtgagaac atgaacttct
     1381 cttggagaaa tgaatgcaac cagtgtaagg cacctaagcc agatggccca ggagggggac
     1441 caggaggctc tcatatgggg ggaaactatg gagatgatcg acgtggcaga ggaggatatg
     1501 accggggcgg ctaccggggc cgaggagggg accgtggggg cttcagaggg ggccggggtg
     1561 gtggggacag aggcggtttt ggccctggca agatggactc caggggcgag cacagacagg
     1621 atcgcaggga gaggccatat tagcctggct cctgaagttc tggaactctt cctgtaccca
     1681 gtgttaccct tgttattttg taaacttaca attcaggatc gctcatggat attttttttt
     1741 ggggggggtg gggcggttgt gtgtgtatgt gtgtgtgtgt gtgtcagact accctaattg
     1801 taaccatatc tctggttccc attaaaaaac atcattttag ttaaa
//
