LOCUS       NM_011046               4336 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus furin, paired basic amino acid cleaving enzyme
            (Furin), transcript variant 1, mRNA.
ACCESSION   NM_011046 XM_908988 XM_921102 XM_921108 XM_921116 XM_921122
VERSION     NM_011046.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4336)
  AUTHORS   Veler,H., Lun,C.M., Waheed,A.A. and Freed,E.O.
  TITLE     Guanylate-binding protein 5 antagonizes viral glycoproteins
            independently of furin processing
  JOURNAL   mBio 15 (10), e0208624 (2024)
   PUBMED   39212413
  REMARK    GeneRIF: Guanylate-binding protein 5 antagonizes viral
            glycoproteins independently of furin processing.
REFERENCE   2  (bases 1 to 4336)
  AUTHORS   Kubo,Y., Hans,M.B., Nakamura,T. and Hayashi,H.
  TITLE     The Furin Protease Dependence and Antiviral GBP2 Sensitivity of
            Murine Leukemia Virus Infection Are Determined by the Amino Acid
            Sequence at the Envelope Glycoprotein Cleavage Site
  JOURNAL   Int J Mol Sci 25 (18), 9987 (2024)
   PUBMED   39337476
  REMARK    GeneRIF: The Furin Protease Dependence and Antiviral GBP2
            Sensitivity of Murine Leukemia Virus Infection Are Determined by
            the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4336)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4336)
  AUTHORS   Kato,S., Iwata,O., Kato,H., Fukaya,S., Imai,Y. and Saitoh,S.
  TITLE     Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse
            Model of Hyperoxic Lung Injury
  JOURNAL   Biomolecules 13 (11), 1656 (2023)
   PUBMED   38002338
  REMARK    GeneRIF: Furin Regulates the Alveolarization of Neonatal Lungs in a
            Mouse Model of Hyperoxic Lung Injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4336)
  AUTHORS   Xie,S., Xie,X., Tang,J., Luo,B., Chen,J., Wen,Q., Zhou,J. and
            Chen,G.
  TITLE     Cerebral furin deficiency causes hydrocephalus in mice
  JOURNAL   Genes Dis 11 (3), 101009 (2023)
   PUBMED   38292192
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4336)
  AUTHORS   Takahashi,S., Nakagawa,T., Banno,T., Watanabe,T., Murakami,K. and
            Nakayama,K.
  TITLE     Localization of furin to the trans-Golgi network and recycling from
            the cell surface involves Ser and Tyr residues within the
            cytoplasmic domain
  JOURNAL   J Biol Chem 270 (47), 28397-28401 (1995)
   PUBMED   7499343
REFERENCE   7  (bases 1 to 4336)
  AUTHORS   Steiner,D.F., Smeekens,S.P., Ohagi,S. and Chan,S.J.
  TITLE     The new enzymology of precursor processing endoproteases
  JOURNAL   J Biol Chem 267 (33), 23435-23438 (1992)
   PUBMED   1429684
  REMARK    Review article
REFERENCE   8  (bases 1 to 4336)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   9  (bases 1 to 4336)
  AUTHORS   Seidah,N.G., Mattei,M.G., Gaspar,L., Benjannet,S., Mbikay,M. and
            Chretien,M.
  TITLE     Chromosomal assignments of the genes for neuroendocrine convertase
            PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2)
            to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region)
  JOURNAL   Genomics 11 (1), 103-107 (1991)
   PUBMED   1765368
REFERENCE   10 (bases 1 to 4336)
  AUTHORS   Hatsuzawa,K., Hosaka,M., Nakagawa,T., Nagase,M., Shoda,A.,
            Murakami,K. and Nakayama,K.
  TITLE     Structure and expression of mouse furin, a yeast Kex2-related
            protease. Lack of processing of coexpressed prorenin in GH4C1 cells
  JOURNAL   J Biol Chem 265 (36), 22075-22078 (1990)
   PUBMED   2266110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC136740.10.
            
            On Jul 8, 2015 this sequence version replaced NM_011046.2.
            
            Summary: This gene encodes a calcium-dependent serine endoprotease
            that proteolytically activates different proprotein substrates
            traversing the secretory pathway. The encoded protein undergoes
            proteolytic autoactivation during which an N-terminal propeptide is
            cleaved to generate the mature protein. Mice lacking the encoded
            protein die at an embryonic stage and display hemodynamic
            insufficiency, cardiac ventral closure defect, axial rotation
            defect and abnormal yolk sac vasculature. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L26489.1, SRR13422601.860969.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AC136740.10        177561-177843       c
            284-618             AC136740.10        173625-173959       c
            619-717             AC136740.10        173126-173224       c
            718-813             AC136740.10        172929-173024       c
            814-942             AC136740.10        172153-172281       c
            943-1019            AC136740.10        171960-172036       c
            1020-1108           AC136740.10        170991-171079       c
            1109-1281           AC136740.10        170366-170538       c
            1282-1494           AC136740.10        168440-168652       c
            1495-1595           AC136740.10        167915-168015       c
            1596-1699           AC136740.10        167705-167808       c
            1700-1817           AC136740.10        167501-167618       c
            1818-1997           AC136740.10        167218-167397       c
            1998-2122           AC136740.10        166759-166883       c
            2123-2233           AC136740.10        166539-166649       c
            2234-4336           AC136740.10        164225-166327       c
FEATURES             Location/Qualifiers
     source          1..4336
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.65 cM"
     gene            1..4336
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /note="furin, paired basic amino acid cleaving enzyme"
                     /db_xref="GeneID:18550"
                     /db_xref="MGI:MGI:97513"
     exon            1..283
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..618
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..717
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..813
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..942
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1019
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1108
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1281
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1494
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1595
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1699
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1817
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1997
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2122
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2233
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..4336
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4310..4315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /note="hexamer: ATTAAA"
     polyA_site      4336
                     /gene="Furin"
                     /gene_synonym="9130404I01Rik; Fur; PACE; Pcsk3; SPC1"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgccg ccgctgtgac agcggcccga gtaaacaagc cgcgccgccg cggccgggcc
       61 gctgcccccc gcccgcgccc gagcccaggc cgagccttgc cctggtcgcc ggccgggccg
      121 aggccgcgcc gccgcgcctc cccgcctgcg cgccgtgacg ccgctgccgg gcgcggggac
      181 cgccggagcc aggcccccgc cgccgggctc cgtgctcggc cgaggggtac ccgagcggcc
      241 gcggcgctcg tccggaaaag tttccccgcc cgggctcccc aggatctggc ccttaccctg
      301 tcctccagcc ctgcccatct cggccccatg cccccaccag tcagccccgg gaccctggca
      361 ctgagcaggc acgtggcagc caaggccctg tgaccaggcc agggagacag gcgctctggg
      421 gttccagtca cctgcccccc catggagctg agatcctggt tgctatgggt ggtcgcagca
      481 gcaggagccg tggtcctgct ggcagctgat gctcaaggcc agaagatctt caccaacacc
      541 tgggccgtgc acattcctgg aggcccagct gtggctgata gggtggcgca gaagcatggc
      601 ttccacaacc tgggccagat cttcggtgac tattaccact tctggcacag agcagtgaca
      661 aagcggtccc tgtcgcctca ccgcccgcgg cacagccggc tacagaggga gcctcaagta
      721 aagtggctgg agcagcaggt agccaagcga agagccaaga gggacgtgta tcaggagccc
      781 acggacccca agttccccca gcagtggtac ctgtctggtg tcactcagcg agacctgaat
      841 gtgaaggagg cctgggccca gggcttcaca ggccatggca ttgtggtctc catcctggat
      901 gacggcattg agaagaatca tcccgaccta gcaggcaatt atgaccctgg agccagtttt
      961 gacgtgaatg accaggaccc cgacccacag cctcggtaca cacagatgaa tgacaacagg
     1021 catggcactc gctgtgccgg ggaagtggca gcagtggcca acaatggtgt ctgtggcgta
     1081 ggtgtagctt acaatgcccg aattggaggg gtgcggatgt tggatggcga ggtgactgat
     1141 gcagtagagg cacgttcgct gggcctgaat cccaaccaca tccacatcta cagcgccagc
     1201 tggggccctg aggacgacgg caagaccgtg gatggaccag cccggctcgc tgaggaggcc
     1261 ttctttcggg gagttagcca gggccgagga gggctgggct ccatctttgt ctgggcctca
     1321 gggaatgggg gccgggaaca tgacagctgc aactgtgacg gctacaccaa cagcatctat
     1381 acactgtcca tcagcagcgc cacacagttc ggcaatgtgc cctggtacag tgaggcctgc
     1441 tcctccacac tggccaccac ctacagcagc ggcaaccaga atgagaagca gatcgtgaca
     1501 actgacctga ggcagaagtg cacagaatct cacacaggca cctcggcttc tgcccccttg
     1561 gcagctggta tcattgctct caccctggag gccaacaaga acctcacctg gcgggacatg
     1621 cagcacctgg tagtgcagac ctcaaagcca gcccacctca acgctgatga ttgggctacc
     1681 aacggcgtgg gccggaaagt gagccattcg tatggctacg ggctgttgga tgcaggtgcc
     1741 atggtggctc tggcccagaa ctggacaaca gtggcccccc agcggaagtg cattgttgaa
     1801 atcctggtgg aacccaagga catcggcaaa cggctagagg tgcgcaaggc ggtgacagca
     1861 tgcctgggtg agcccaacca catcaccagg ctggaacacg ttcaggcccg gctcaccctg
     1921 tcttacaatc gccgcggtga cctggctatc cacctcatca gccccatggg cacccgctcc
     1981 accctgttag ctgccagacc acatgactac tctgctgatg ggtttaatga ttgggctttc
     2041 atgacaaccc attcctggga tgaggatccg gctggcgaat gggtcctaga gattgaaaat
     2101 accagtgaag ccaacaacta tgggacgctg accaagttca ctctcgttct gtatggcaca
     2161 gcccccgagg ggctctctac acctccagaa agcagcggct gcaagaccct cacatccagc
     2221 caggcctgcg tggtgtgtga ggaaggttac tctctgcacc agaaaagctg tgtccagcac
     2281 tgcccaccag gcttcatccc ccaagtcctt gatacacact acagcactga gaatgatgtg
     2341 gagatcatcc gtgccagcgt ctgtaccccc tgccacgcct catgtgccac ttgccagggc
     2401 ccggccccca cagactgcct cagctgcccc agccatgcct ccctggaccc agtggagcag
     2461 acctgctccc ggcaaagcca gagcagccgg gagtctcggc ctcagcagca gcctcctgca
     2521 ctgcgccctg aggtggagat ggagccccgg ctgcaggctg ggttggcctc tcacctgccc
     2581 gaggtcctgg ccggcctcag ctgccttatc atcgtgctca tctttggcat cgtcttcctg
     2641 ttcctgcatc ggtgttcggg cttcagcttc cggggagtga aagtgtacac catggaccgc
     2701 ggcctcatct cctacaaggg gctgccccct gaagcctggc aggaggagtg cccatcggac
     2761 tcagaggagg acgagggccg gggcgagagg accgccttca tcaaagacca gagcgccctt
     2821 tgaaaagccc actgcccacc ctatcaaatc gatcccttcc tcgggcactt tttaattcac
     2881 caaagtattt ttttatcttg cgactggatt tggaccctag ctgggaggcg agaggggcag
     2941 agactgcttc ttaccccacc cttgggccta cctgtttgcc tgaggtggga tcccaggagc
     3001 ctcaccccta ccacccctcc atgtggagga aagaggaaat ctttagggca gcttccttgg
     3061 cccagctgga cttcccgcag agtgaagagg ggcggcctct ctctgagtcc ctgaccaggc
     3121 tgcagccctg ccccttccct tccctgcccc tcagaaagca ataatggttc ccatccaggc
     3181 aacagggagg ctggccagga ggtacttgaa gaaggcagcc acctctccaa gggcttttgc
     3241 atcccctgac cctctctggc tcacaggtga gcctccgaag aagctgcagt cttaggaagg
     3301 gaccaaagca aagcaggccc ctcccagtgt gcctgtactt tcttgctctc agcctgcctc
     3361 tgcactccag gcctccacct ccgtggaagc caggctgagc taggccagca cgggccggcc
     3421 gagctaaagc tctgggggcc ttgctggtgt ctgaccatcc tttatggcac cctcccccct
     3481 tgccagggcc ctgttttctg agcccggggc tgcctgggct gttggcagtt acagtacagg
     3541 agcccctggg tgggtggtgg ggaggcacgg tggcccagcc ttctcctccc gcctcccacc
     3601 cgatgctgct ttcccctgtg gggatctcag gagctgtttg aggatatatt ttcactttgt
     3661 gattattcac tttagatgct gattcttttt tttttttttt tttgtatttt taatgggggt
     3721 agcagctgga cccttgacct tctcatgccc acacccaccc tgcccttccc atggctgccc
     3781 agccctgggg tatagggaat aactaagccc catgtcctga agaggcaggc cagcccggtg
     3841 ggctctaaga aagggggttg tggtgggagg ggtaggctga catcatctgt ttcaaatggg
     3901 gttgtgccaa gggcttatgg gtcgctggct ctccaagtgc caggggtggg caggtggcac
     3961 caccaagccc tttctaacac tgtgccctgg tggagaaagc attggcctat gatgcccccc
     4021 aaaccccctc ttctgatgtg ccttttgcac ccttcccatt aggacaatca gtcccctccc
     4081 acttgggctc cccccccccc attttctttt ccttagccct tctcagtacc cagcctacct
     4141 gtccaggggt gccccttgct ctcctgccca cccctcacgg ccatccaggc tggttttgta
     4201 agatgctggg ttggtgcaca gtgatttttt ttttccttgt aatttaaaca ggcctggcat
     4261 tgttggttct atttaatgga cacgagataa tgttagaggt tttaaagtga ttaaacgtgc
     4321 agactatgca aaccaa
//
