LOCUS       NM_026928               2309 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus fucose mutarotase (Fuom), transcript variant 1, mRNA.
ACCESSION   NM_026928
VERSION     NM_026928.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2309)
  AUTHORS   Park,D., Choi,D., Lee,J., Lim,D.S. and Park,C.
  TITLE     Male-like sexual behavior of female mouse lacking fucose mutarotase
  JOURNAL   BMC Genet 11, 62 (2010)
   PUBMED   20609214
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2309)
  AUTHORS   Lee,K.H., Ryu,K.S., Kim,M.S., Suh,H.Y., Ku,B., Song,Y.L., Ko,S.,
            Lee,W. and Oh,B.H.
  TITLE     Crystal structures and enzyme mechanisms of a dual fucose
            mutarotase/ribose pyranase
  JOURNAL   J Mol Biol 391 (1), 178-191 (2009)
   PUBMED   19524593
  REMARK    GeneRIF: The mouse FucU assembles into four different oligomeric
            forms, among which the smallest homodimeric form is most abundant
            and would be the predominant species under physiological
            conditions.
REFERENCE   3  (bases 1 to 2309)
  AUTHORS   Park,D., Ryu,K.S., Choi,D., Kwak,J. and Park,C.
  TITLE     Characterization and role of fucose mutarotase in mammalian cells
  JOURNAL   Glycobiology 17 (9), 955-962 (2007)
   PUBMED   17602138
REFERENCE   4  (bases 1 to 2309)
  AUTHORS   Nakashima,N. and Tamura,T.
  TITLE     A novel system for expressing recombinant proteins over a wide
            temperature range from 4 to 35 degrees C
  JOURNAL   Biotechnol Bioeng 86 (2), 136-148 (2004)
   PUBMED   15052633
REFERENCE   5  (bases 1 to 2309)
  AUTHORS   Kim,M.S., Shin,J., Lee,W., Lee,H.S. and Oh,B.H.
  TITLE     Crystal structures of RbsD leading to the identification of
            cytoplasmic sugar-binding proteins with a novel folding
            architecture
  JOURNAL   J Biol Chem 278 (30), 28173-28180 (2003)
   PUBMED   12738765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109205.12.
            
            On Jun 17, 2019 this sequence version replaced NM_026928.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU524476.1, BX514782.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC109205.12        112497-112596       c
            101-169             AC109205.12        111791-111859       c
            170-240             AC109205.12        111522-111592       c
            241-339             AC109205.12        111280-111378       c
            340-413             AC109205.12        110069-110142       c
            414-2309            AC109205.12        108001-109896       c
FEATURES             Location/Qualifiers
     source          1..2309
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 85.11 cM"
     gene            1..2309
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
                     /note="fucose mutarotase"
                     /db_xref="GeneID:69064"
                     /db_xref="MGI:MGI:1916314"
     exon            1..100
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..477
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
                     /EC_number="5.1.3.29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein fucU homolog"
                     /codon_start=1
                     /product="fucose mutarotase isoform 1"
                     /protein_id="NP_081204.2"
                     /db_xref="CCDS:CCDS40173.1"
                     /db_xref="GeneID:69064"
                     /db_xref="MGI:MGI:1916314"
                     /translation="MVALKGIPKVLSPELLFALARMGHGDEIVLADANFPTSSICQCG
                     PVEIRADGLDIPQLLEAVLRLLPLDTYVESPAAVMDLVPSDKEKGLQTPIWKRYESLL
                     LEADCKKTLMKLERFEFYERAKKAFAVVATGEMALYGNIILKKGTLDLGPS"
     exon            101..169
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
                     /inference="alignment:Splign:2.1.0"
     exon            170..240
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
                     /inference="alignment:Splign:2.1.0"
     exon            241..339
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
                     /inference="alignment:Splign:2.1.0"
     exon            340..413
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
                     /inference="alignment:Splign:2.1.0"
     exon            414..2309
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      650
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
                     /note="major polyA site"
     regulatory      1589..1594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
                     /note="hexamer: AATAAA"
     polyA_site      1616
                     /gene="Fuom"
                     /gene_synonym="Fucu; Le51"
ORIGIN      
        1 accaatcctg cggccatggt tgcgctcaag ggcatcccga aggtgctgtc tcctgagctg
       61 ttgttcgcgc ttgcgcggat ggggcatgga gacgaaattg tccttgctga tgcgaacttc
      121 cctacctcct ccatctgcca gtgcggacct gtggagatcc gagcagacgg cctggacatc
      181 ccacagcttc tggaggctgt gctgaggctc ctgcccctgg acacctacgt ggaaagcccg
      241 gctgctgtca tggacctggt gcccagtgac aaggagaagg gcctgcagac cccgatatgg
      301 aagcgttatg aatcccttct tctcgaagct gactgtaaaa aaaccctgat gaagctagag
      361 agatttgaat tttatgaacg tgcaaaaaag gcatttgctg tggttgcaac cggggagatg
      421 gcactctatg gaaacatcat cctcaagaag ggaactcttg acctcggacc ctcatagaga
      481 ccaccttccc ttggcagcaa ccagacctgg acatcagcct cgggctcaag aagatggcag
      541 atcttgagag actctgctga ccctgacaaa ttcccccttc catgacttgt gagattgatc
      601 ggggagggag tcattgtcaa gctttaatct aaaggttttg tagtcatgaa cttgtcttgt
      661 ggtgagttcc atggatgcca tcagctccca aggaagcatc ccctacgtgc ccgtgacgaa
      721 tcctcagtta ggaaatccac atggaaagaa gcatggtgat ttgagggctg ggagctgagc
      781 aggagctagg cctgggtagg aacctgggag ctggacaggg tctgtggctg tggcctgggc
      841 ctaggcccag tggttgatgt tgagtaagat gcacagcagg gggctggagc tggttgcact
      901 aggcttgtat ggggtagggg cttctgtatt agccacttgg attgcaatat acagtgattc
      961 ttgagtaggc ccaatctctg agctcggagc cagagggcaa gtgacagccg ggccgggcat
     1021 cttagataga aggcctctga cactcagaga tgactgctca gctgctagta atggtaaact
     1081 gtcctctctg gttcaaggtc agagaggtct gggtgtgggc tggatcccat gcagatgttt
     1141 ggtaggttga gcaccccact acctatgcat gagcagctat gttaggccca ggaactcaga
     1201 tgcaatgtgg ctgctcccag ctttgaatcc tcagttgtcc caggaggtaa aggatcagct
     1261 gaggctcagt atagccagag atgaggggaa gaacccaggc agacaagaaa ctgtttccct
     1321 actgagtgct tggactggat ctccagcact tgtctacaga caactggtga atgttcgtag
     1381 cagctttgtc tatacttgcc aaaaggggca aaccaactga gttcagtagg tgactagaca
     1441 gtccctttga tagagcaagt gctcttatct ctccagcccc agttacatcc tttaggagga
     1501 aatggcccca gaggttcctg gctcaggcaa aactagaatg aaacctggtc acagtcaccc
     1561 tcctgggcca gtagatgctt ttggtcccaa taaaacacca ggcacttgga acaccagcat
     1621 ctgcaggtcc tctacttaga ttcagggagt ggggaggtga gacagctcaa attttgatca
     1681 tggatccaac ctcacgggca ctagacagag tgtttcacaa ggcactgttt tcagaccacc
     1741 tgggcctggg ttattctcat ggtctctggc catctctaac ttgacggagg agtgacaaga
     1801 agaggtttga tcacaatctg catggtcagt tctgctcgat tgagaattgc ctggaaatgc
     1861 tagcaaagca tctccgagtc gatctggagg tgctcagagg attacctatg caggggaaga
     1921 cctgccctca gcgtttccag gactaggctg gaggtcacga gtgctaatac gagaaaggag
     1981 agcagctgcg gtgccctctg ggatctggtg ctacctgaga cctgagcagg atgctggcgc
     2041 ctctgcagag gctgctctac cgagggtggg ccacggacag attcatttag gtccttagcg
     2101 ggatgacagg tgggactact ctgtgatgaa ggctagacct tgaggtcact gtcagagcct
     2161 ggcagttcat cttcaggacc ctggacttgt ctgtaagatg gaatgttggg ctgtaatgtg
     2221 ggggtactaa gtttttctgt aatgcggact catctgcagc gtgggagcaa tgggatcaaa
     2281 tagtttgaag accccagatt caactatga
//
