LOCUS       NM_026126               3261 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus FUN14 domain containing 2 (Fundc2), mRNA.
ACCESSION   NM_026126
VERSION     NM_026126.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3261)
  AUTHORS   Yin,L., Cao,R., Liu,Z., Luo,G., Li,Y., Zhou,X., Chen,X., Wu,Y.,
            He,J., Zu,X. and Shen,Y.
  TITLE     FUNDC2, a mitochondrial outer membrane protein, mediates
            triple-negative breast cancer progression via the AKT/GSK3beta/GLI1
            pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (11), 1770-1783 (2023)
   PUBMED   37700593
  REMARK    GeneRIF: FUNDC2, a mitochondrial outer membrane protein, mediates
            triple-negative breast cancer progression via the AKT/GSK3beta/GLI1
            pathway.
REFERENCE   2  (bases 1 to 3261)
  AUTHORS   Ta,N., Qu,C., Wu,H., Zhang,D., Sun,T., Li,Y., Wang,J., Wang,X.,
            Tang,T., Chen,Q. and Liu,L.
  TITLE     Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis
            and contributes to doxorubicin-induced cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 119 (36), e2117396119 (2022)
   PUBMED   36037337
  REMARK    GeneRIF: Mitochondrial outer membrane protein FUNDC2 promotes
            ferroptosis and contributes to doxorubicin-induced cardiomyopathy.
REFERENCE   3  (bases 1 to 3261)
  AUTHORS   Li,S., Han,S., Zhang,Q., Zhu,Y., Zhang,H., Wang,J., Zhao,Y.,
            Zhao,J., Su,L., Li,L., Zhou,D., Ye,C., Feng,X.H., Liang,T. and
            Zhao,B.
  TITLE     FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated
            mitochondrial fusion
  JOURNAL   Nat Commun 13 (1), 3486 (2022)
   PUBMED   35710796
  REMARK    GeneRIF: FUNDC2 promotes liver tumorigenesis by inhibiting
            MFN1-mediated mitochondrial fusion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3261)
  AUTHORS   Lu,H., Yuan,X., Zhang,Y., Han,M., Liu,S., Han,K., Liang,P. and
            Cheng,J.
  TITLE     HCBP6 deficiency exacerbates glucose and lipid metabolism disorders
            in non-alcoholic fatty liver mice
  JOURNAL   Biomed Pharmacother 129, 110347 (2020)
   PUBMED   32535386
  REMARK    GeneRIF: HCBP6 deficiency exacerbates glucose and lipid metabolism
            disorders in non-alcoholic fatty liver mice.
REFERENCE   5  (bases 1 to 3261)
  AUTHORS   Ma,Q., Zhang,W., Zhu,C., Liu,J. and Chen,Q.
  TITLE     FUNDC2 regulates platelet activation through AKT/GSK-3beta/cGMP
            axis
  JOURNAL   Cardiovasc Res 115 (11), 1672-1679 (2019)
   PUBMED   30576423
  REMARK    GeneRIF: FUNDC2 positively regulates platelet functions via
            AKT/GSK-3beta/cGMP signalling pathways.
REFERENCE   6  (bases 1 to 3261)
  AUTHORS   Ma,Q., Zhu,C., Zhang,W., Ta,N., Zhang,R., Liu,L., Feng,D.,
            Cheng,H., Liu,J. and Chen,Q.
  TITLE     Mitochondrial PIP3-binding protein FUNDC2 supports platelet
            survival via AKT signaling pathway
  JOURNAL   Cell Death Differ 26 (2), 321-331 (2019)
   PUBMED   29786068
  REMARK    GeneRIF: FUNDC2 knockout mice carrying excessively apoptotic
            platelets exhibit thrombocytopenia in response to hypoxia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY124891.1, BC061464.1 and AL731844.18.
            
            On Oct 24, 2009 this sequence version replaced NM_026126.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031214.1, SRR9219382.85084.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY124891.1         1-30
            31-857              BC061464.1         1-827
            858-3261            AL731844.18        170994-173397
FEATURES             Location/Qualifiers
     source          1..3261
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.22 cM"
     gene            1..3261
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
                     /note="FUN14 domain containing 2"
                     /db_xref="GeneID:67391"
                     /db_xref="MGI:MGI:1914641"
     exon            1..53
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..490
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
                     /note="hepatitis C virus core-binding protein 6"
                     /codon_start=1
                     /product="FUN14 domain-containing protein 2"
                     /protein_id="NP_080402.3"
                     /db_xref="CCDS:CCDS30239.1"
                     /db_xref="GeneID:67391"
                     /db_xref="MGI:MGI:1914641"
                     /translation="MAANSQGNFDGKFEALDLAELTKKQPWWRKLFGQESGPSAEKYS
                     VATQLVIGGVTGWCTGFVFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMK
                     KAKEQLKIRKNKQIPTEVKSKAEEVVSFVKKNVLVTGGFFGGFLLGMAS"
     exon            54..204
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            205..280
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            281..412
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            413..3261
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      830..835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
                     /note="hexamer: AATACA"
     polyA_site      857
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
                     /note="major polyA site"
     regulatory      2537..2542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
                     /note="hexamer: AATAAA"
     polyA_site      2562
                     /gene="Fundc2"
                     /gene_synonym="4833415N24Rik; DC44; HCBP6"
ORIGIN      
        1 atactagggt cccccccccc cccgcgcccc cgaaatggcc gctaacagtc aaggaaactt
       61 tgatggaaaa tttgaagcac tggatcttgc agaattaact aaaaaacaac catggtggcg
      121 taagctgttt gggcaggaat ctgggccatc agctgaaaaa tatagtgtag caacccagct
      181 ggtaattggg ggtgttactg gatggtgcac tggtttcgta ttccagaagg ttggaaaatt
      241 ggctgcaaca gctgtaggag gtggattctt tctccttcag ctggcaaacc atactggata
      301 catcaaagtt gactggcaaa gagtagaaaa agacatgaag aaagccaaag agcagttgaa
      361 aattcgtaag aataagcaaa taccaactga ggtcaagagc aaagctgagg aggttgtatc
      421 atttgtaaag aagaatgttc tagtgactgg aggatttttt ggaggctttc tgcttggcat
      481 ggcatcctaa gaacttcact tcattgttct atttttatag ttgtttgttt cttgccagca
      541 gcttctacac tccaacatag gacaatcggc actcctcttc ctcatcttct cctgtgcctt
      601 cctccctgtt gtagcaaatc tgaatggctt taataggctt ctcctggtgc aaggtcttct
      661 caggccttct caatttaaca cgttggaaga gacagtaggt gttaactctt ccagtaccct
      721 ccttacttgg ttggtgtgta gcttaacaag aatgttcctt ttcccctatg taagatcctt
      781 ttccaaactc aatttgttac cttattacat gttacatgaa aaggaaccaa atacatttgc
      841 ctttaagcat gaaaaaattt tggtatcttg gtgtatgctt tctttttaaa ttggttttag
      901 gctatagaaa gagaggtatt tatacttact ataattatgt tgccaaaatg gcagtgtaag
      961 taccaacact aaaaatatta aatgaacttc tgcaaacaat gcatgaagta atataagtat
     1021 tatatatggt aggtgggtct ttatggaaac cagctgtaag aacttcatga aatacaacat
     1081 ttaagcaaga atttgaaatg tatttctttt acatacgagt actctatctg catgttcaac
     1141 tctgtgccaa atcccattac agatggttgt aagccaccat gtggttgctg ggaattggac
     1201 ttaggaccac ttgaagagca accagtgctc ttaactgctg agcatctctc cagtccctta
     1261 agcaaaaatt ttaaagagat gttccaggca ttcagaataa gaatagcata tgtgtaataa
     1321 attattttca tcaaatgcaa tctccatcag aaatattgct taatataaaa atccatgtat
     1381 actttacatt attccataat agctattacc atgagctcaa ctccaactac aaaagcatct
     1441 tccagaagtt aagtcttcta tcatcttcat tatacccaca gggcttactg cttaatagat
     1501 ttcaaatatt tttgaatata ttaattgtat aaagaaagct tcccgttaaa ggttaggttt
     1561 acctcaaatg aattcttaga tatgtagatg atcctttgtg caatagtata tttttaaggt
     1621 catacattaa gcataattac ttttttgaca taccttaaca ttgacatact tttgaaaatt
     1681 gaaactacca gtggatgtgt aaaactaatt aggattcacc tatttgcatt tcctcactac
     1741 gttttgattt tatttgagcc aatataagtt attctacttg taatacatat taatcatctt
     1801 tccttacatg gtagtataac cagccttggt atatattttt ctcaaaaatt tgaagatgat
     1861 ttttcactat ttactgtgga aacataaaga gagtacagtg atttccccaa gtatccattg
     1921 cttgcctata gcaatcatgt aattgtattt tttatcaatt attataatat acctgccatt
     1981 ttattgtttg ccatatgtat tcaatactaa aaatctaaat atttttttgt tttaaaactt
     2041 taaaaaaggg ctggagagat ggcttagcca ttaaaggcta ggctcacaac caaaagtata
     2101 aaacttttaa aaaaatcata ataccttttt attacagaaa aattaataat ggttaatgtc
     2161 aaaaccatgc agtatttaaa atcctctttg tatgtacaat atatttattg acacctgtgt
     2221 gctatcatct gttttatagt tctttgtatt cttcttgggg ttgtgccatt tatggtgatt
     2281 cttgatgtag ccatgttgtt ctccctgtgt cttaagtatc attggcatgg tgagagcaaa
     2341 agctactgca atgccccttt gggtatgtgg tgaggagtgg tcatctagta tctctctagt
     2401 gggttggtag ctgacttctg atccatctgc tttctttctg attaataggg gttacaacta
     2461 atagactagt ggactggagt tccttcaaaa ggttataata ggtaatggtc tagactcaca
     2521 ttctaccctg gtctgaaata aaatctataa ttctatcctc aagttggtca gactccactt
     2581 gtgtttgtgt agaggtggtg cagagggtta ttagtcacaa ttagcacact tcaagctcca
     2641 gtttaggtca gtggttagtg aagtagcctc aagcagtttg gggaacctct attgagggct
     2701 cattgagtca gcatctttgc ttcatcttaa atgggagatt actggggatg tagctcagtg
     2761 gtaaagcatt tacctagtgt ttgtgagggc ctgggttcaa tcaccaacat tgtgagaaca
     2821 gaatagccaa gcaggcttga gtttaaatgg gagattacat tttctgaaaa aagcaggtag
     2881 ctgtctttcc atgcacaacc taaatgttac cagggtgagg cagttacact attgaataca
     2941 tttggttttg attagtgtta atgttttcaa tgaaaatgac ccccatagtc tcatagggaa
     3001 tgacactaat aggaggtgtg tccttgttga aagtaggtgt accttattgg aggaagtttg
     3061 tcactgggag tgggattgag gtttcagaag atcaagcaag gcctagtggt tcattctctt
     3121 gcctactgat ccagatgtaa agctcagtcc tttctctaac actgtgtctg cctgcctaga
     3181 tgatagatgc ttcccaccat aatgataatg gactaaacct ctgaactgta agccaacccc
     3241 aattaaatgt tttcgtttat a
//
