LOCUS       NM_028058               2964 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus FUN14 domain containing 1 (Fundc1), transcript variant
            1, mRNA.
ACCESSION   NM_028058
VERSION     NM_028058.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2964)
  AUTHORS   Tang,T., Hu,L.B., Ding,C., Zhang,Z., Wang,N., Wang,T., Zhou,H.,
            Xia,S., Fan,L., Fu,X.J., Yan,F., Zhang,X., Chen,G. and Li,J.
  TITLE     Src inhibition rescues FUNDC1-mediated neuronal mitophagy in
            ischaemic stroke
  JOURNAL   Stroke Vasc Neurol 9 (4), 367-379 (2024)
   PUBMED   37793899
  REMARK    GeneRIF: Src inhibition rescues FUNDC1-mediated neuronal mitophagy
            in ischaemic stroke.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2964)
  AUTHORS   Wang,J., Zhuang,H., Jia,L., He,X., Zheng,S., Ji,K., Xie,K.,
            Ying,T., Zhang,Y., Li,C. and Chang,X.
  TITLE     Nuclear receptor subfamily 4 group A member 1 promotes myocardial
            ischemia/reperfusion injury through inducing mitochondrial fission
            factor-mediated mitochondrial fragmentation and inhibiting FUN14
            domain containing 1-depedent mitophagy
  JOURNAL   Int J Biol Sci 20 (11), 4458-4475 (2024)
   PUBMED   39247823
  REMARK    GeneRIF: Nuclear receptor subfamily 4 group A member 1 promotes
            myocardial ischemia/reperfusion injury through inducing
            mitochondrial fission factor-mediated mitochondrial fragmentation
            and inhibiting FUN14 domain containing 1-depedent mitophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2964)
  AUTHORS   Guo,X., Zhang,Z., Gu,J., Ke,P., Liu,J., Meng,Y., Zheng,W., Que,W.,
            Fan,R., Luo,J. and Xiao,F.
  TITLE     FUDNC1-dependent mitophagy ameliorate motor neuron death in an
            amyotrophic lateral sclerosis mouse model
  JOURNAL   Neurobiol Dis 197, 106534 (2024)
   PUBMED   38759931
  REMARK    GeneRIF: FUDNC1-dependent mitophagy ameliorate motor neuron death
            in an amyotrophic lateral sclerosis mouse model.
REFERENCE   4  (bases 1 to 2964)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2964)
  AUTHORS   Wu,Q., Yu,S. and Peng,K.
  TITLE     Silencing of FUN14 Domain Containing 1 Inhibits Platelet Activation
            in Diabetes Mellitus through Blocking Mitophagy
  JOURNAL   Crit Rev Immunol 44 (2), 25-33 (2024)
   PUBMED   38305334
  REMARK    GeneRIF: Silencing of FUN14 Domain Containing 1 Inhibits Platelet
            Activation in Diabetes Mellitus through Blocking Mitophagy.
REFERENCE   6  (bases 1 to 2964)
  AUTHORS   Tian,W., Li,W., Chen,Y., Yan,Z., Huang,X., Zhuang,H., Zhong,W.,
            Chen,Y., Wu,W., Lin,C., Chen,H., Hou,X., Zhang,L., Sui,S., Zhao,B.,
            Hu,Z., Li,L. and Feng,D.
  TITLE     Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to
            mitochondria and mitophagy
  JOURNAL   FEBS Lett 589 (15), 1847-1854 (2015)
   PUBMED   25980607
REFERENCE   7  (bases 1 to 2964)
  AUTHORS   Wu,W., Tian,W., Hu,Z., Chen,G., Huang,L., Li,W., Zhang,X., Xue,P.,
            Zhou,C., Liu,L., Zhu,Y., Zhang,X., Li,L., Zhang,L., Sui,S., Zhao,B.
            and Feng,D.
  TITLE     ULK1 translocates to mitochondria and phosphorylates FUNDC1 to
            regulate mitophagy
  JOURNAL   EMBO Rep 15 (5), 566-575 (2014)
   PUBMED   24671035
REFERENCE   8  (bases 1 to 2964)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   9  (bases 1 to 2964)
  AUTHORS   Li,W., Zhang,X., Zhuang,H., Chen,H.G., Chen,Y., Tian,W., Wu,W.,
            Li,Y., Wang,S., Zhang,L., Chen,Y., Li,L., Zhao,B., Sui,S., Hu,Z.
            and Feng,D.
  TITLE     MicroRNA-137 is a novel hypoxia-responsive microRNA that inhibits
            mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX
  JOURNAL   J Biol Chem 289 (15), 10691-10701 (2014)
   PUBMED   24573672
  REMARK    GeneRIF: MicroRNA-137 has a role in inhibiting mitophagy via
            regulation of two mitophagy receptors FUNDC1 and NIX
REFERENCE   10 (bases 1 to 2964)
  AUTHORS   Liu,L., Feng,D., Chen,G., Chen,M., Zheng,Q., Song,P., Ma,Q.,
            Zhu,C., Wang,R., Qi,W., Huang,L., Xue,P., Li,B., Wang,X., Jin,H.,
            Wang,J., Yang,F., Liu,P., Zhu,Y., Sui,S. and Chen,Q.
  TITLE     Mitochondrial outer-membrane protein FUNDC1 mediates
            hypoxia-induced mitophagy in mammalian cells
  JOURNAL   Nat Cell Biol 14 (2), 177-185 (2012)
   PUBMED   22267086
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005345.12, AK005163.1 and BM934468.1.
            
            On Sep 1, 2015 this sequence version replaced NM_028058.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005163.1, AK168868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BX005345.12        194729-194756       c
            29-1747             AK005163.1         2-1720
            1748-2299           BX005345.12        178679-179230       c
            2300-2964           BM934468.1         11-675              c
FEATURES             Location/Qualifiers
     source          1..2964
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 12.8 cM"
     gene            1..2964
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
                     /note="FUN14 domain containing 1"
                     /db_xref="GeneID:72018"
                     /db_xref="MGI:MGI:1919268"
     exon            1..173
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..613
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
                     /note="isoform 1 is encoded by transcript variant 1; FUN14
                     domain-containing protein 1"
                     /codon_start=1
                     /product="FUN14 domain-containing protein 1 isoform 1"
                     /protein_id="NP_082334.1"
                     /db_xref="CCDS:CCDS30035.1"
                     /db_xref="GeneID:72018"
                     /db_xref="MGI:MGI:1919268"
                     /translation="MASRNPPPQDYESDDESYEVLDLTEYARRHHWWNRVFGHSSGPM
                     VEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQVASHSGYVQIDWKRV
                     EKDVNKAKRQIKKRANKAAPEINNIIEEATDFIKQNIVISSGFVGGFLLGLAS"
     exon            174..330
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            331..406
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            407..535
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            536..2947
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1958..1963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1983
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
                     /note="major polyA site"
     regulatory      2927..2932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      2947
                     /gene="Fundc1"
                     /gene_synonym="1500005J14Rik; 1810033P05Rik"
ORIGIN      
        1 ggcggtgacg cgactgtgtg ggcggggcga ggaggaggct gaggaaaaaa gagagaccat
       61 agacttccaa ctcggcctag agcgtccttt aaagtggtgg ggagaggcgg gcagggacca
      121 cccccaactg gccgctggcg gtatcatggc atcccggaac ccccctcccc aagactatga
      181 aagcgatgac gaatcatacg aagtgttgga tttaactgaa tatgcaagaa gacaccactg
      241 gtggaatcga gtatttggcc acagttccgg acctatggta gaaaaatact cagtagctac
      301 tcagattgta atgggtggcg tgactggctg gtgtgcagga tttttattcc agaaggttgg
      361 aaaacttgct gcaactgcag taggtggtgg tttccttctt cttcaggttg ccagtcacag
      421 tggctatgta cagatcgact ggaagagagt tgaaaaagat gtaaacaaag caaagagaca
      481 gataaagaag cgagcaaata aagcagcacc tgaaatcaac aatataattg aagaagcaac
      541 agactttatc aagcagaaca ttgtgatatc cagcggcttc gtgggaggct ttttgctagg
      601 cctggcatct taaggacttg aaggctctat ggtagtggat ccaacaatga gaggaagact
      661 gtggcagcag ggttatctct taatggcaca tgctaccagt ctccaaagta aggaacagcc
      721 ggctggacga ttgcaaatga agcagcttag cattttgccg cctgaagctt accaagctag
      781 tatctcctgt aagacaacct atgtgctgtg tacacaatag tattcttgag caaccatgga
      841 ttttgcaaat ttttaaattt aacatttgtt tagaaactag cctatgatta tcatcactgg
      901 atatagtgga gacagaaaaa gctgttacat gtactgtcca atgaaatatt accctatcta
      961 cttttcaaag ttttttgtgc tttactgtct agtgctaata attaaatatt gtcttatagc
     1021 ttcaatgtta tggctgattt tttttaaaga tgtgtttgca ataaactgaa gaattgtttt
     1081 acccctttgt ggaaggcaac aatagaatta ttaagatatt aaactcttct gatatgtcaa
     1141 tctttagtta ggtttttccc ccttctcttt cttactttgc ttatgtgtaa tatttacatt
     1201 aaaggaggat tttgtaatga aatactacgc gactaaaaca ctttcccttt ctctaatgtc
     1261 tgcagttttt gaaacgtctc cttgtacgtt ctaatttttc aagtttgttt gctttaacag
     1321 aactaatttg ggagtatgtc attagttggt cattgatatg ctttattaat ttcaaatgca
     1381 tctcattttt tatttctaaa aatcctaatt atttttttgt ctcttcacca aaaggtacag
     1441 attgctttaa aatacttaat agtataatat gaacttattg tctgaagaac tgtgattttc
     1501 tgtgtagtcc taaaattata gcttaaatat aattgcttcc ttgattatat gatgtaagca
     1561 ctagggctct caggcattgc tagcgttcca tttcttgaac attaggccag tttacttgtt
     1621 tctctgggcc agcctcacac ttgttccgag catctcttgt ccaagaacag ctttcaatat
     1681 tgttattctt gttcatagaa ttcttggctg tccctgggga aaacagcaga acagtatagg
     1741 ttagagtctt cagactggaa atattgcagc tattcagact atcttcctgt gataggacac
     1801 tcccattgta tactctgtgt cttgtaaatg tgtcatttca tatttttgat attggttaca
     1861 agctgtgtgc ttgtactgtc ttgaaattct ttaaattcaa atgtacaatt gaattttagt
     1921 ttcttttatt ctcattagtg cctcatatag aatgctaaat aaaactcagt tccttaatat
     1981 gaagtgattg tgcttatata tccttgttat tcttttttga gcttttctcc attttctctg
     2041 gctaaacctt tcattgttat aaaactaaaa ggaacatata tcttgattgt gttcaggtca
     2101 tgtcagtaga accatgagaa cctggccctg cttctgagta ccatacctgg gtgttactgt
     2161 gcagcaaggc aggctacttc aaggaactcc agtcttttta ttttgaagat ggttatagtg
     2221 tctgttcttt gggggatatg ttagaagagc agggaaaaca caatatatca gctctcaagc
     2281 tttcaattag aggcattaca atattccagt actgaagaat tcatattgta atatgggagc
     2341 tattcaaata cggtgttgag tggagagaat ttcctttaag agtccaaata tacaaacgaa
     2401 aacaagagtt ggaaatggtg atatcctgca ataattccag catacagaaa gctggtgcag
     2461 gaggatcaga gtggctggag gctataatgg gtatgtagta agctcctgtc tcacacaaca
     2521 aaggctgagt gtgatggtgt tcacctttaa tcccaagcac ctgggaggca gaggcaggca
     2581 ggcctctgaa ttcacagcca acttggtcta catattgaat tctgggctag ctaggtatac
     2641 gtaatagacc ctatctctaa aacccaaacc taacaaaaca acagcagcaa caacaacaac
     2701 aaaaagcagg taacaaaaga taacactttt attgtacact tctaagtctc ttgaaatttt
     2761 gaaatgtttt gtatgtaaat gtaagttgtt tccagtactc tgtcatacct tcccctctct
     2821 cagtcttctt gtttcccctc ctggctatgt tgtttcttcc tctaggttga gcattacctg
     2881 aaacgatgtg ttactcaatc tcttaacttg tatgacatac gcactgacta aatgtccctt
     2941 atctgaaaaa aaaaaaaaaa aaaa
//
