LOCUS       NM_024243               2523 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus fucosidase, alpha-L- 1, tissue (Fuca1), mRNA.
ACCESSION   NM_024243
VERSION     NM_024243.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2523)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2523)
  AUTHORS   Baudot,A.D., Wang,V.M., Leach,J.D., O'Prey,J., Long,J.S.,
            Paulus-Hock,V., Lilla,S., Thomson,D.M., Greenhorn,J., Ghaffar,F.,
            Nixon,C., Helfrich,M.H., Strathdee,D., Pratt,J., Marchesi,F.,
            Zanivan,S. and Ryan,K.M.
  TITLE     Glycan degradation promotes macroautophagy
  JOURNAL   Proc Natl Acad Sci U S A 119 (26), e2111506119 (2022)
   PUBMED   35737835
REFERENCE   3  (bases 1 to 2523)
  AUTHORS   Stroobants,S., Wolf,H., Callaerts-Vegh,Z., Dierks,T., Lubke,T. and
            D'Hooge,R.
  TITLE     Sensorimotor and Neurocognitive Dysfunctions Parallel Early
            Telencephalic Neuropathology in Fucosidosis Mice
  JOURNAL   Front Behav Neurosci 12, 69 (2018)
   PUBMED   29706874
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2523)
  AUTHORS   Wolf,H., Damme,M., Stroobants,S., D'Hooge,R., Beck,H.C.,
            Hermans-Borgmeyer,I., Lullmann-Rauch,R., Dierks,T. and Lubke,T.
  TITLE     A mouse model for fucosidosis recapitulates storage pathology and
            neurological features of the milder form of the human disease
  JOURNAL   Dis Model Mech 9 (9), 1015-1028 (2016)
   PUBMED   27491075
REFERENCE   5  (bases 1 to 2523)
  AUTHORS   Phopin,K., Nimlamool,W., Lowe-Krentz,L.J., Douglass,E.W.,
            Taroni,J.N. and Bean,B.S.
  TITLE     Roles of mouse sperm-associated alpha-L-fucosidases in
            fertilization
  JOURNAL   Mol Reprod Dev 80 (4), 273-285 (2013)
   PUBMED   23426913
REFERENCE   6  (bases 1 to 2523)
  AUTHORS   Bahary,N., Pachter,J.E., Felman,R., Leibel,R.L., Albright,K.,
            Cram,S. and Friedman,J.M.
  TITLE     Molecular mapping of mouse chromosomes 4 and 6: use of a
            flow-sorted Robertsonian chromosome
  JOURNAL   Genomics 13 (3), 761-769 (1992)
   PUBMED   1639403
REFERENCE   7  (bases 1 to 2523)
  AUTHORS   Bahary,N., Zorich,G., Pachter,J.E., Leibel,R.L. and Friedman,J.M.
  TITLE     Molecular genetic linkage maps of mouse chromosomes 4 and 6
  JOURNAL   Genomics 11 (1), 33-47 (1991)
   PUBMED   1684952
REFERENCE   8  (bases 1 to 2523)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   9  (bases 1 to 2523)
  AUTHORS   Johnson,W.G. and Hong,J.L.
  TITLE     Variation in alpha-L-fucosidase properties among 28 inbred mouse
            strains: six strains have high enzyme activity and heat-stabile
            enzyme with a variant pH-activity curve; twenty-two strains have
            low activity and heat-labile enzyme
  JOURNAL   Biochem Genet 24 (5-6), 469-483 (1986)
   PUBMED   3741369
REFERENCE   10 (bases 1 to 2523)
  AUTHORS   Self,S.J., Winchester,B.G. and Archer,J.R.
  TITLE     Strain variation in spermatozoal glycosidases in inbred mice
  JOURNAL   Genet Res 32 (2), 183-193 (1978)
   PUBMED   744483
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY158254.1, AK151361.1, AK089958.1 and AL672076.10.
            
            On Mar 13, 2008 this sequence version replaced NM_024243.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089958.1, AK150890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY158254.1         2-12
            12-1511             AK151361.1         1-1500
            1512-1855           AK089958.1         1482-1825
            1856-2523           AL672076.10        118744-119411
FEATURES             Location/Qualifiers
     source          1..2523
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.01 cM"
     gene            1..2523
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /note="fucosidase, alpha-L- 1, tissue"
                     /db_xref="GeneID:71665"
                     /db_xref="MGI:MGI:95593"
     exon            1..425
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1437
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /EC_number="3.2.1.51"
                     /note="tissue alpha-L-fucosidase; alpha-L-fucosidase 1;
                     alpha-L-fucosidase I; alpha-L-fucoside fucohydrolase 1"
                     /codon_start=1
                     /product="tissue alpha-L-fucosidase precursor"
                     /protein_id="NP_077205.3"
                     /db_xref="CCDS:CCDS18794.1"
                     /db_xref="GeneID:71665"
                     /db_xref="MGI:MGI:95593"
                     /translation="MLLLLLLLLVAAAQAVALAPRRFTPDWQSLDSRPLPSWFDEAKF
                     GVFVHWGVFSVPAWGSEWFWWHWQGDRMPAYQRFMTENYPPGFSYADFAPQFTARFFH
                     PDQWAELFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGAAVRK
                     RNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVRAKTMPELYDLVNSYKPDLIWSDGE
                     WECPDTYWNSTSFLAWLYNDSPVKDEVIVNDRWGQNCSCHHGGYYNCQDKYKPQSLPD
                     HKWEMCTSMDRASWGYRKDMTMSTIAKENEIIEELVQTVSLGGNYLLNIGPTKDGLIV
                     PIFQERLLAVGKWLQINGEAIYASKPWRVQSEKNKTVVWYTTKNATVYATFLYWPENG
                     IVNLKSPKTTSATKITMLGLEGDLSWTQDPLEGVLISLPQLPPTVLPVEFAWTLKLTK
                     VN"
     exon            426..560
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            561..698
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            699..804
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1005
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1196
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1296
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..2523
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1488..1493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /note="hexamer: AATAAA"
     polyA_site      1512
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /note="major polyA site"
     polyA_site      1954
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
     regulatory      2443..2448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
                     /note="hexamer: AGTAAA"
     polyA_site      2476
                     /gene="Fuca1"
                     /gene_synonym="0610006A03Rik; 9530055J05Rik; Afuc; Fuca"
ORIGIN      
        1 gtgttaagag gggggcggtg cgggcccgga agcaaggatg taggagctga acttgagtgg
       61 tgggctgtgg actctgggat gctgctgctg ctgctgctgc tgctagtggc tgcggcccag
      121 gcagtggccc tggctccgcg ccgcttcact ccggactggc agagcttgga ctcgcggcca
      181 ctgccgagct ggttcgatga ggccaagttc ggggtgttcg tgcactgggg ggtgttctcg
      241 gtgcccgcct ggggcagtga atggttctgg tggcactggc agggcgatcg gatgccggcc
      301 taccagcgct tcatgacaga aaactacccg cccggcttca gctacgccga cttcgcaccg
      361 cagttcacag cgcgcttctt ccacccggat cagtgggccg aactctttca ggctgccggg
      421 gccaagtacg tcgtcctgac cacaaagcat catgaaggct tcacaaactg gccaagccct
      481 gtgtcttgga actggaactc gaaggacgtg gggccccacc gtgatttggt cggtgagttg
      541 ggagcagctg tgcggaagag gaacatacgc tacggcctct accactcgct cttggaatgg
      601 ttccatccac tctacctact tgataagaaa aatggcttca aaactcagca tttcgtcagg
      661 gcaaaaacaa tgccagagct gtatgacctt gttaacagct acaagcctga cctgatctgg
      721 tccgacgggg agtgggagtg tcctgacacg tactggaact ccaccagctt ccttgcttgg
      781 ctctacaacg atagccctgt caaggatgag gtgatagtga atgaccggtg gggccagaac
      841 tgctcctgtc atcatggagg gtactacaac tgtcaagaca aatacaagcc acagagcttg
      901 ccagaccaca agtgggagat gtgcaccagc atggacagag catcctgggg ctatcgaaaa
      961 gacatgacca tgtcgaccat cgccaaggaa aatgaaatca tcgaggaatt ggttcagacg
     1021 gtaagtttgg gaggcaacta tcttctcaac attggaccaa ctaaagatgg tctgatcgtc
     1081 cccatcttcc aagaaaggct tcttgctgtc ggcaagtggc tgcagatcaa cggggaggcc
     1141 atctatgcct ccaaaccctg gagggtgcag tcggaaaaga acaagacggt tgtgtggtac
     1201 actactaaaa acgcaactgt ttacgccact ttcctgtact ggccagaaaa tgggatcgtg
     1261 aacctcaaat cccccaaaac gacctcggcc acaaagataa caatgctagg actagaagga
     1321 gacctgagct ggacccagga tccactggag ggcgtcctca tctctctgcc acagttgcca
     1381 cctaccgttc tgccggtgga gtttgcgtgg actctgaagc tgacaaaggt gaactgatca
     1441 aaggagctca aggacagact gcctggggcg ctgcttacca tccctgcaat aaagtagctt
     1501 cccttccttc cacccagtgg tcaatctccc aagccgttct aatggatggg cgagccattg
     1561 ctagcatttc tggtgggcag agagacctgg ccagctcagc tgagtcaccc atgcctccac
     1621 tagggtggaa cttccctctc ttctctgatg acctacctga taatgagcca agtcatcctc
     1681 ttgcctgtgg gagcaggtca gagaggtctg gcgagctcaa ccccctctgc cttattggtt
     1741 ggtaccagtc ccgcagagat ggaccaggtc ctgccctccg ggcttgccag gctgtcatgc
     1801 caagcaagcc aaacgctctg ccactgagca cgtcttcaga gatatcccgt ccctcgggat
     1861 tcagttattc gtgggtgcca gggggaccgc agacctgtaa ggatatggga ttggaagaga
     1921 aaagagaagc agatgaccaa gtagattgta cctatcaagg tctccattta ttatgctgag
     1981 gtgccttgtt ttatagcata cattgcaggg aatggggagg ggtcgagggg gaattttaac
     2041 aaagaacaaa aaagtgggca tctgctcaca tgaggtccga agtcaggctc caggcggcgg
     2101 gcactctgca tcttatagat ctatgcggaa catagatcct ccttgacagc cttggggtgt
     2161 caggccgggc tcaggcgtaa ctcatgtcct tggatggctt gggagtcagg aagagacagg
     2221 gaagagggga ctataattta gcttttacag cctcaggtgc caggaaggga atagggagga
     2281 gggagtgata accagctcct agcatgaggc catttggcct gtcagggaga ttgtgaaggg
     2341 ctcgctttct cacgggatgg tctctgacac agagatacca atgaaagaag gcgatgctgc
     2401 cttgccttaa aaaaaaaaaa aaaaaaaaaa aaaaaagatg gaagtaaatt tgtatgccaa
     2461 attatttcta ccacaagcat gtgataggtt tctttcccta acttaggtta cagctttata
     2521 ctc
//
