LOCUS       NP_476513                642 aa            linear   ROD 02-MAY-2024
DEFINITION  far upstream element-binding protein 1 isoform 8 [Mus musculus].
ACCESSION   NP_476513
VERSION     NP_476513.2
DBSOURCE    REFSEQ: accession NM_057172.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 642)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 642)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 642)
  AUTHORS   Zheng,Y., Dubois,W., Benham,C., Batchelor,E. and Levens,D.
  TITLE     FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC
            expression in primary single murine cells
  JOURNAL   Commun Biol 3 (1), 545 (2020)
   PUBMED   33005010
  REMARK    GeneRIF: FUBP1 and FUBP2 enforce distinct epigenetic setpoints for
            MYC expression in primary single murine cells.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 642)
  AUTHORS   Zhang,X.X., Chen,H., Li,H.Y., Chen,R., He,L., Yang,J.L., Xiao,L.L.
            and Chen,J.L.
  TITLE     Long non-coding RNA small nucleolar RNA host gene 6 aggravates
            pancreatic cancer through upregulation of far upstream element
            binding protein 1 by sponging microRNA-26a-5p
  JOURNAL   Chin Med J (Engl) 133 (10), 1211-1220 (2020)
   PUBMED   32433053
  REMARK    GeneRIF: Long non-coding RNA small nucleolar RNA host gene 6
            aggravates pancreatic cancer through upregulation of far upstream
            element binding protein 1 by sponging microRNA-26a-5p.
REFERENCE   5  (residues 1 to 642)
  AUTHORS   Kang,M., Lee,S.M., Kim,W., Lee,K.H. and Kim,D.Y.
  TITLE     Fubp1 supports the lactate-Akt-mTOR axis through the upregulation
            of Hk1 and Hk2
  JOURNAL   Biochem Biophys Res Commun 512 (1), 93-99 (2019)
   PUBMED   30871777
  REMARK    GeneRIF: Fubp1 upregulates the mRNA levels of two hexokinase genes,
            Hk1 and Hk2. We suggest that Fubp1 contributes to cell survival
            through supporting lactate-Akt-mTOR axis.
REFERENCE   6  (residues 1 to 642)
  AUTHORS   Contos,J.J. and Chun,J.
  TITLE     The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic
            structure, chromosomal localization, and expression pattern
  JOURNAL   Gene 267 (2), 243-253 (2001)
   PUBMED   11313151
  REMARK    Erratum:[Gene 2001 Jul 11;272(1-2):345]
REFERENCE   7  (residues 1 to 642)
  AUTHORS   Ring,H.Z., Vameghi-Meyers,V., Min,H., Nikolic,J.M., Black,D.L. and
            Francke,U.
  TITLE     The mouse Fubp gene maps near the distal end of chromosome 3
  JOURNAL   Genomics 56 (3), 357-358 (1999)
   PUBMED   10087207
REFERENCE   8  (residues 1 to 642)
  AUTHORS   Wang,X., Avigan,M. and Norgren,R.B. Jr.
  TITLE     FUSE-binding protein is developmentally regulated and is highly
            expressed in mouse and chicken embryonic brain
  JOURNAL   Neurosci Lett 252 (3), 191-194 (1998)
   PUBMED   9739993
REFERENCE   9  (residues 1 to 642)
  AUTHORS   Craig,J.C., Eberwine,J.H., Calvin,J.A., Wlodarczyk,B., Bennett,G.D.
            and Finnell,R.H.
  TITLE     Developmental expression of morphoregulatory genes in the mouse
            embryo: an analytical approach using a novel technology
  JOURNAL   Biochem Mol Med 60 (2), 81-91 (1997)
   PUBMED   9169087
REFERENCE   10 (residues 1 to 642)
  AUTHORS   Davis-Smyth,T., Duncan,R.C., Zheng,T., Michelotti,G. and Levens,D.
  TITLE     The far upstream element-binding proteins comprise an ancient
            family of single-strand DNA-binding transactivators
  JOURNAL   J Biol Chem 271 (49), 31679-31687 (1996)
   PUBMED   8940189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123075.5.
            
            On Jan 10, 2006 this sequence version replaced NP_476513.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.261337.1,
                                           SRR17253012.3651104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..642
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 77.05 cM"
     Protein         1..642
                     /product="far upstream element-binding protein 1 isoform
                     8"
                     /note="far upstream element (FUSE) binding protein 4; far
                     upstream element-binding protein 1; FUSE-binding protein
                     1"
                     /calculated_mol_wt=67313
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q96AE4; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Region          40..92
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Site            48
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96AE4; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Site            51
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96AE4; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Region          93..167
                     /region_name="KH-I_FUBP1_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in far upstream element-binding protein 1 (FUBP1)
                     and similar proteins; cd22478"
                     /db_xref="CDD:411906"
     Site            order(94..95,97,99,107..109,111..113,130..136,141..144,
                     146)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:411906"
     Site            order(105,107..109,111..115,118..119,122..123,128..131)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411906"
     Site            135
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96AE4; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Site            148
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Region          181..250
                     /region_name="KH-I_FUBP1_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in far upstream element-binding protein 1 (FUBP1)
                     and similar proteins; cd22481"
                     /db_xref="CDD:411909"
     Site            order(190,192..194,196..200,203..204,207..208,213..216)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411909"
     Region          271..338
                     /region_name="KH-I_FUBP1_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in far upstream element-binding protein 1 (FUBP1)
                     and similar proteins; cd22484"
                     /db_xref="CDD:411912"
     Site            order(279..284,286..290,293..294,303,305..306,316)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411912"
     Site            316
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Site            354
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Site            356
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Site            358
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Region          371..442
                     /region_name="KH-I_FUBP1_rpt4"
                     /note="fourth type I K homology (KH) RNA-binding domain
                     found in far upstream element-binding protein 1 (FUBP1)
                     and similar proteins; cd22487"
                     /db_xref="CDD:411915"
     Site            order(380..381,383..385,387..388,390..391,394..395,399,
                     404,406..407,409,420)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411915"
     Site            410
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Site            427
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96AE4; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Region          442..527
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91WJ8.1)"
     Region          606..>620
                     /region_name="DUF1897"
                     /note="Domain of unknown function (DUF1897); pfam09005"
                     /db_xref="CDD:462653"
     Site            628
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96AE4; propagated from
                     UniProtKB/Swiss-Prot (Q91WJ8.1)"
     CDS             1..642
                     /gene="Fubp1"
                     /gene_synonym="9530027K12Rik; D3Ertd330e; FBP; Fubp;
                     Fubp4"
                     /coded_by="NM_057172.5:114..2042"
                     /note="isoform 8 is encoded by transcript variant 8"
                     /db_xref="CCDS:CCDS38672.1"
                     /db_xref="GeneID:51886"
                     /db_xref="MGI:MGI:1196294"
ORIGIN      
        1 madystvppp ssgsaggggg gvvndafkda lqrarqiaak iggdagtsln sndygyggqk
       61 rpledgdqpd akkvppqnds fgaqlppmhq qqrsvmteey kvpdgmvgfi igrggeqisr
      121 iqqesgckiq iapdsgglpe rscmltgtpe svqsakrlld qivekgrpap gfhhgdgpgn
      181 avqeimipas kaglvigkgg etikqlqera gvkmvmiqdg pqntgadkpl ritgdpykvq
      241 qakemvleli rdqggfrevr neygsriggn egidvpiprf avgivigrng emikkiqnda
      301 gvriqfkpdd gttpdriaqi tgppdrcqha aeiitdllrs vqagnpggpg pggrgrgrgq
      361 gnwnmgppgg lqefnfivpt gktgliigkg getiksisqq sgarielqrs pppnadpnmk
      421 lftirgtpqq idyarqliee kiggpvnplg ppvphgphgv pgphgppgpp gpgtpmgpyn
      481 papynpgppg paphgppapy apqgwgnayp hwqqqappdp akagadpnsa awaayyahyy
      541 qqqaqpppaa pagapattqt ngqgnygdqq apapagqvdy tkaweeyykk mgqavpapag
      601 appggqpdys aawaeyyrqq aayyaqtspq gmpqhppapq gq
//
