LOCUS       NM_025310               3153 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus FtsJ RNA 2'-O-methyltransferase 3 (Ftsj3), mRNA.
ACCESSION   NM_025310
VERSION     NM_025310.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3153)
  AUTHORS   Zhuang,Q., Dai,Z., Xu,X., Bai,S., Zhang,Y., Zheng,Y., Xing,X.,
            Hu,E., Wang,Y., Guo,W., Zhao,B., Zeng,Y. and Liu,X.
  TITLE     RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway
            to Promote Hepatocellular Carcinoma Immune Evasion
  JOURNAL   Cancer Res 84 (3), 405-418 (2024)
   PUBMED   37963197
  REMARK    GeneRIF: RNA Methyltransferase FTSJ3 Regulates the Type I
            Interferon Pathway to Promote Hepatocellular Carcinoma Immune
            Evasion.
REFERENCE   2  (bases 1 to 3153)
  AUTHORS   Hemberger,M., Himmelbauer,H., Ruschmann,J., Zeitz,C. and Fundele,R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
REFERENCE   3  (bases 1 to 3153)
  AUTHORS   Kerr,S.M., Taggart,M.H., Lee,M. and Cooke,H.J.
  TITLE     Ott, a mouse X-linked multigene family expressed specifically
            during meiosis
  JOURNAL   Hum Mol Genet 5 (8), 1139-1148 (1996)
   PUBMED   8842733
REFERENCE   4  (bases 1 to 3153)
  AUTHORS   Kerr,S.M., Vambrie,S., McKay,S.J. and Cooke,H.J.
  TITLE     Analysis of cDNA sequences from mouse testis
  JOURNAL   Mamm Genome 5 (9), 557-565 (1994)
   PUBMED   8000140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL604045.7.
            
            On Mar 1, 2018 this sequence version replaced NM_025310.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004996.2, AK145490.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AL604045.7         37810-38133         c
            325-417             AL604045.7         37634-37726         c
            418-523             AL604045.7         37369-37474         c
            524-570             AL604045.7         36835-36881         c
            571-650             AL604045.7         36656-36735         c
            651-750             AL604045.7         35811-35910         c
            751-945             AL604045.7         35531-35725         c
            946-1061            AL604045.7         35338-35453         c
            1062-1166           AL604045.7         35130-35234         c
            1167-1267           AL604045.7         34949-35049         c
            1268-1348           AL604045.7         34715-34795         c
            1349-1498           AL604045.7         34477-34626         c
            1499-1634           AL604045.7         34252-34387         c
            1635-1816           AL604045.7         33203-33384         c
            1817-1934           AL604045.7         32955-33072         c
            1935-2209           AL604045.7         32611-32885         c
            2210-2295           AL604045.7         32397-32482         c
            2296-2395           AL604045.7         32204-32303         c
            2396-2579           AL604045.7         31922-32105         c
            2580-2674           AL604045.7         31753-31847         c
            2675-3153           AL604045.7         31187-31665         c
FEATURES             Location/Qualifiers
     source          1..3153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.89 cM"
     gene            1..3153
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /note="FtsJ RNA 2'-O-methyltransferase 3"
                     /db_xref="GeneID:56095"
                     /db_xref="MGI:MGI:1860295"
     exon            1..324
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            325..417
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..2867
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /EC_number="2.1.1.-"
                     /note="ectoplacental cone, invasive trophoblast giant
                     cells, extraembryonic ectoderm and chorion sequence 3;
                     putative rRNA methyltransferase 3; rRNA
                     (uridine-2'-O-)-methyltransferase 3; protein ftsJ homolog
                     3; FtsJ homolog 3; 2'-O-ribose RNA methyltransferase SPB1
                     homolog; pre-rRNA processing protein FTSJ3; FtsJ RNA
                     methyltransferase homolog 3"
                     /codon_start=1
                     /product="pre-rRNA 2'-O-ribose RNA methyltransferase
                     FTSJ3"
                     /protein_id="NP_079586.1"
                     /db_xref="CCDS:CCDS25552.1"
                     /db_xref="GeneID:56095"
                     /db_xref="MGI:MGI:1860295"
                     /translation="MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQK
                     ARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQEDITTERCRQAL
                     RKELKTWKVDVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARGGCFITKVFR
                     SRDYQPLLWIFQQLFHRVQATKPQASRHESAEIFVVCQGFLAPDKVDAKFFDPKFAFK
                     EVEVQAKTVTELVTKKKPKAEGYAEGDLTLYHRTSVTDFLRAANPVDFLSKASEISID
                     DEELAQHPATTEDIRVCCQDIKVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISL
                     SSEEEEEGDEEEAVAETKQAPEEEEEREEEQLNRTLAEMKAQEVAELKRKKKKLLREQ
                     RKQRERVELKMDLPGVSIADEGETGMFSLRTIRGQQLLEEVTQGDMNAADTFLSDLPR
                     DDIYVSDAEDDDDTSLESDLDPEELAGVRTHSDLKEQKYLRFTQVDDNKEEEGENPLL
                     VPLEEKAVLQEEQASLWFSKDGFSGIEDDADEALEISQAQLLYKSRQKEQQPTDPPPP
                     PTNLKTEKKSPQGQNEVPKETEAILGTEAVTDPGGEERGNSSDSDSSSSEDEDSWKVS
                     RGVKRGRGSKADEDGFEVVPIQDPVKYRILDPEGLALGAVIASSKKAKRDLIDNSFNR
                     YAFNEEEGELPEWFAQEEKQHRIRQLPVDKKEVEHYRKRWREINARPIKKVAEAKARK
                     KRRVLKKLEQTKKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRQVTYVVAKKGV
                     GRKVRRPAGVKGHFKVVDSRMKKDQRAQQRKEQKKKHKRK"
     exon            418..523
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..570
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            571..650
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            651..750
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            751..945
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1061
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1166
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1267
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1348
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1498
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1634
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1816
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1934
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2209
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2295
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2395
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2579
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2674
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..3153
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3132..3137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /note="hexamer: AATAAA"
     polyA_site      3150
                     /gene="Ftsj3"
                     /gene_synonym="D11Ertd400e; Epcs3"
                     /note="major polyA site"
ORIGIN      
        1 tgggcggggt gtgtggcgat acaaacacag tggctgtatt agtagaggct ctactggagg
       61 tcactagttt tgtgaagaga tatagaactt ctggttgatg cttcctagcg tttaggatac
      121 gagttattgc actctacttc ctagcctcta cttttaactt gtaaggcctg ctgacaaaaa
      181 aattttggcc acactcaaaa tggcggaaat catgacgcca ggaatgtagg aaacgcgcgc
      241 agaagcggaa gtacgattac tgcctacatg tgctgcttcc taagagttga aaacctgcgg
      301 agttaagggc tatctaacgt ctggagtgag tgatactccc ccatcccgcc atgggcaaga
      361 aaggcaaagt aggcaagagc cggcgggaca agttctatca cttggccaag gagactggtt
      421 atcgttcgcg ctctgccttc aaactgatcc agctcaatcg ccgctttcag ttcctgcaga
      481 aagcccgggc cttgttggac ctgtgtgctg cgcctggcgg atggctgcag gtggctgcca
      541 agtttatgcc tgtatccagt cttattgtag gagtggacct cgttccaatc aagcctctcc
      601 ccaatgtggt gactctccag gaggatatca caacagaacg ctgtaggcag gccctgagga
      661 aggagctgaa gacctggaaa gttgatgttg tgctcaatga tggggctccc aatgtggggg
      721 ctagttgggt ccatgacgct tactcccaag ctcacctaac tctgatggct ctgcgtttgg
      781 cttgtgattt tttggcccgt ggtggttgtt tcatcacaaa agtctttcgt tcccgagact
      841 atcagccctt gctgtggatc ttccagcagc tgttccaccg tgtccaggcc acgaagcccc
      901 aagcctctcg ccatgaatct gcagaaatct ttgtagtctg tcaaggattc ctggctccgg
      961 acaaggttga tgctaaattc tttgatccca agtttgcctt taaggaggtt gaagttcagg
     1021 ctaaaactgt tactgagttg gtgacaaaga agaagccaaa ggctgaaggc tatgccgaag
     1081 gtgaccttac tctttatcac cgaacctcag ttacggactt cttgcgagct gccaatcctg
     1141 ttgacttcct ctccaaggcc agcgaaatct caatagatga tgaagagttg gcacagcatc
     1201 cagctacaac tgaagacatt agagtatgct gtcaggacat caaagtgctg gggcgaaagg
     1261 aacttaggtc tcttctgaat tggagaacaa agcttcggcg atatgtggct aagaagctga
     1321 aagagcaagc aaaggcattg gacatcagcc tcagctcaga agaagaagaa gaaggtgatg
     1381 aagaagaggc agtagctgag acaaagcagg cgccagagga agaagaagag agagaggaag
     1441 aacagcttaa tcggactctg gcagagatga aagcccaaga agtggcagaa ctcaagagga
     1501 agaagaagaa gttgcttcgt gagcagagga agcagcggga gcgtgtcgag ctgaagatgg
     1561 atctgcctgg ggtttctatt gcagatgagg gggagacagg catgttctcc ctgcgaacca
     1621 tccgtggcca gcagttatta gaggaagtaa cacaaggaga catgaacgct gcagacacct
     1681 ttctgtctga tctgccaagg gatgacatct atgtgtcaga tgctgaggac gatgatgata
     1741 cttctctgga aagtgacctg gatccagaag agctggcagg agtcaggaca cactcggatc
     1801 tgaaggagca gaagtacttg cggtttactc aagtagatga caataaagag gaagaaggag
     1861 aaaatccatt gctggtacca ctggaagaaa aggcagtact gcaggaagag caagctagcc
     1921 tgtggttctc caaggacggc ttcagtggga tagaggatga tgctgacgaa gccctggaga
     1981 tcagtcaggc acagctgctg tacaagagcc gtcagaagga gcagcagcca acagatccac
     2041 ctccaccacc tactaacttg aagactgaga agaaatctcc ccagggccag aatgaggtcc
     2101 ctaaggagac agaagccatc ttggggacag aggctgtcac tgaccctgga ggggaggaaa
     2161 gaggcaacag ctcagatagt gacagcagca gtagtgagga tgaagatagc tggaaagtgt
     2221 cccgtggtgt gaagcgaggc cgtggctcta aggcagatga ggatgggttt gaggtggtgc
     2281 ctattcagga cccagtgaaa taccgaattc tggaccctga aggccttgct ctaggtgctg
     2341 ttattgcctc ttcaaaaaag gcaaagagag acctcataga taactcgttc aaccggtatg
     2401 cttttaatga agaggaggga gaacttcctg agtggtttgc acaggaagaa aagcagcatc
     2461 ggatacgcca gctgcctgtt gataagaagg aggtggaaca ttaccgaaaa cgctggcggg
     2521 aaatcaatgc acggcccatc aagaaagtag ctgaggccaa ggccagaaag aaacggaggg
     2581 tgctgaagaa gctggaacag accaaaaaga aggcagaagc tgtggtgaat acagtggaca
     2641 tctcagaacg ggaaaaggtg gcacagctgc gaagtctcta caagaaagct ggacttggca
     2701 aggagaaacg ccaggtcact tatgttgtag ccaaaaaggg tgtaggccgt aaggtccgga
     2761 ggccagctgg agtcaaaggt catttcaagg tagtggactc tcggatgaag aaggatcaga
     2821 gagcacaaca acggaaggaa cagaagaaaa aacacaagcg caagtgagca gaattgtctg
     2881 gaaagactga aggacagaga gggaggtgta cagttctctc tggaggcttt gtgggattgg
     2941 gagagctgct acagaggagt accatgaaag cactgaggaa acatttcttc atcgtgttac
     3001 actgacaacc cacatcttgg cttgtgatgg atcaaatctt ttatgaagcc ttcaggggga
     3061 ctcagtattg ctggcctttg ttgtagcctg tggttccttc ggagtcctct cccacccttt
     3121 tccagtattt gaataaaaag ataaaagaga taa
//
