LOCUS       NM_133991               3389 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus FtsJ RNA 2'-O-methyltransferase 1 (Ftsj1), transcript
            variant 1, mRNA.
ACCESSION   NM_133991 XM_905069 XM_919126 XM_919137 XM_919146
VERSION     NM_133991.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Nagayoshi,Y., Chujo,T., Hirata,S., Nakatsuka,H., Chen,C.W.,
            Takakura,M., Miyauchi,K., Ikeuchi,Y., Carlyle,B.C., Kitchen,R.R.,
            Suzuki,T., Katsuoka,F., Yamamoto,M., Goto,Y., Tanaka,M.,
            Natsume,K., Nairn,A.C., Suzuki,T., Tomizawa,K. and Wei,F.Y.
  TITLE     Loss of Ftsj1 perturbs codon-specific translation efficiency in the
            brain and is associated with X-linked intellectual disability
  JOURNAL   Sci Adv 7 (13) (2021)
   PUBMED   33771871
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Jensen,L.R., Garrett,L., Holter,S.M., Rathkolb,B., Racz,I.,
            Adler,T., Prehn,C., Hans,W., Rozman,J., Becker,L.,
            Aguilar-Pimentel,J.A., Puk,O., Moreth,K., Dopatka,M., Walther,D.J.,
            von Bohlen Und Halbach,V., Rath,M., Delatycki,M., Bert,B., Fink,H.,
            Blumlein,K., Ralser,M., Van Dijck,A., Kooy,F., Stark,Z., Muller,S.,
            Scherthan,H., Gecz,J., Wurst,W., Wolf,E., Zimmer,A.,
            Klingenspor,M., Graw,J., Klopstock,T., Busch,D., Adamski,J.,
            Fuchs,H., Gailus-Durner,V., de Angelis,M.H., von Bohlen Und
            Halbach,O., Ropers,H.H. and Kuss,A.W.
  TITLE     A mouse model for intellectual disability caused by mutations in
            the X-linked 2'-O-methyltransferase Ftsj1 gene
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (9), 2083-2093 (2019)
   PUBMED   30557699
  REMARK    GeneRIF: Loss sof Ftsj1 gene is associated with intellectual
            disability.
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   Cox,B.J., Vollmer,M., Tamplin,O., Lu,M., Biechele,S.,
            Gertsenstein,M., van Campenhout,C., Floss,T., Kuhn,R., Wurst,W.,
            Lickert,H. and Rossant,J.
  TITLE     Phenotypic annotation of the mouse X chromosome
  JOURNAL   Genome Res 20 (8), 1154-1164 (2010)
   PUBMED   20548051
REFERENCE   7  (bases 1 to 3389)
  AUTHORS   Means,G.D., Boyd,Y., Willis,C.R. and Derry,J.M.
  TITLE     Transgenic rescue of the tattered phenotype by using a BAC encoding
            Ebp
  JOURNAL   Mamm Genome 12 (4), 323-325 (2001)
   PUBMED   11309666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805902.5.
            
            On Feb 3, 2022 this sequence version replaced NM_133991.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036313.1, SRR5189670.146056.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AL805902.5         43549-43747         c
            200-357             AL805902.5         42257-42414         c
            358-427             AL805902.5         41946-42015         c
            428-518             AL805902.5         41773-41863         c
            519-597             AL805902.5         40356-40434         c
            598-650             AL805902.5         38246-38298         c
            651-704             AL805902.5         38104-38157         c
            705-807             AL805902.5         37909-38011         c
            808-891             AL805902.5         37713-37796         c
            892-995             AL805902.5         36929-37032         c
            996-1184            AL805902.5         36661-36849         c
            1185-1226           AL805902.5         36437-36478         c
            1227-3389           AL805902.5         30045-32207         c
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.73 cM"
     gene            1..3389
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /note="FtsJ RNA 2'-O-methyltransferase 1"
                     /db_xref="GeneID:54632"
                     /db_xref="MGI:MGI:1859648"
     exon            1..199
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            200..357
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1211
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /EC_number="2.1.1.205"
                     /note="isoform 1 is encoded by transcript variant 1; FtsJ
                     RNA methyltransferase homolog 1; protein ftsJ homolog 1;
                     2'-O-ribose RNA methyltransferase TRM7 homolog; putative
                     tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"
                     /codon_start=1
                     /product="tRNA
                     (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
                     isoform 1"
                     /protein_id="NP_598752.2"
                     /db_xref="CCDS:CCDS29994.1"
                     /db_xref="GeneID:54632"
                     /db_xref="MGI:MGI:1859648"
                     /translation="MGRTSKDKRDVYYRLAKENGWRARSAFKLLQLDEEFQLFKGVKR
                     AVDLCAAPGSWSQVLSQKVGGQGSGQVVAVDLQAMAPLPGVIQIQGDITQLSTAKEII
                     QHFEGCPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKLGGCFVAKIFRG
                     RDVTLLYSQLRIFFSSVLCAKPKSSRNSSIEAFAVCQGYDPPEGFIPDLTRPLLNHSY
                     DTDFNQLDGPTRVIVPFVACGDLSAYDSDRTYSLDLDGGSEYKYTPPTQPPIAPPYQE
                     ACRLKKNGQLAKELLPQECSINSVDKLPQPLAIHTLLDPKVEDNEIHC"
     exon            358..427
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            428..518
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            519..597
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            598..650
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            651..704
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            705..807
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            808..891
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            892..995
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1184
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1226
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..3389
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1612..1617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /note="hexamer: AATAAA"
     polyA_site      1637
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /note="major polyA site"
     regulatory      1879..1884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
                     /note="hexamer: ATTACA"
     polyA_site      1904
                     /gene="Ftsj1"
                     /gene_synonym="Ftsj; Ftsjl; Sfc12"
ORIGIN      
        1 gtcatacgtt gtgctccggt ctggatctcc gtggaactga actgttttac aaagcaaact
       61 ttaccgcgtg gcgacaacct ctaggcgtgt acgacaggcc ttcgggtcca ctccgaacac
      121 caactggagt ctgtaatttt cagtttgcaa actgttctcg aggctggtga acagccacgc
      181 tctgtatcca agagctgagg acagcatcag cacacactgt ctgccagcag actgagatgg
      241 gacggacatc taaggataaa cgggatgtct actaccgcct ggccaaggag aatggctggc
      301 gggcccgaag cgctttcaag ctcctgcaac tggatgagga attccaactc ttcaaaggtg
      361 tgaagcgagc ggttgacttg tgtgcagccc caggcagctg gagccaggtg ctgagccaga
      421 aggttggggg ccagggttct ggtcaggtgg tggccgtgga cttacaggct atggctccac
      481 tgccaggtgt gatacagata cagggcgaca tcactcagct ttccactgcc aaggagatca
      541 tccagcactt tgaaggctgc cctgctgacc tagtagtgtg tgacggggct cctgatgtca
      601 ctggtctcca tgatgtggat gagtacatgc aggcccagct tctgctagct gctctcaaca
      661 tcgctactca tgtcttgaag ctagggggct gcttcgtggc caagatattc cgaggccggg
      721 atgtgaccct gctctacagc caactacgta tcttcttctc cagtgtgctc tgcgctaagc
      781 ccaagagcag ccggaactct agcattgagg cctttgctgt gtgtcagggt tatgaccctc
      841 ctgagggctt cattccagac ctgaccagac ccctgctgaa ccactcatat gatacagatt
      901 tcaaccagtt ggatggtccc acccgtgtta ttgtgccctt tgtggcctgt ggggacctca
      961 gcgcctacga ttcggaccgc acttactctc tggatctaga cggtggctct gagtacaaat
     1021 atactccacc cacacagccc cccatcgcac ccccatacca agaggcctgc aggttgaaga
     1081 agaatggaca gctggccaag gaactcctcc cccaagaatg ctccatcaac agtgtggaca
     1141 agttgcccca gcctctggct atccataccc tgctagaccc caaggtggaa gacaatgaaa
     1201 ttcattgttg accttaacac attaagagtt tgcaggaaaa atcaaactaa tacagcccaa
     1261 aagctgctgc ctgccaagac aactagaagc tggcttgatg agtttgtttg cagatgtcat
     1321 ctatggggac tgaacagacc gacctagagt gagaatctat aacacctcca tcatgacaaa
     1381 gaaatggtga agaagtcctc agaactgcag gaaggatttg ttgagactgt gagcacattc
     1441 ctcttctcca aacctctcct ggaatgtcct agaaggccca ggaattcccc caaagcactg
     1501 gttcttccta tggtcaaacg tcagcaacct ccaccaaaca tgatggagga aagcgtgaat
     1561 gttgtcacta tgacggaagt tcagctttag tcccagttaa caaatattgg caataaatca
     1621 aaacaggaaa aaccctacat atgcacgttg cttacttttt tatatgacag ttcacagaca
     1681 tctgaaatac tgctcatatt tctcaccact ttgaatgata gttgatttta taaattaatc
     1741 ctataattag acatctcatc tattaccgca tcccaattgg gtgattggct gggcaggtat
     1801 ttgtaagaca tcctcccata taggctacac cgcccttaaa actcaaaatc ctcctgtgtc
     1861 agttccctga gtgctgagat tacaggcctg tgccaccaaa cctagctact gtcttccagt
     1921 tttattcaaa tgtaaggtga taactgtatt tcagcatagt ctgctttcct catcattcag
     1981 acgtgtttgt gtgcatatgc aggtgtgcct tcaaagacgt cctgtgatgg gctgaggatg
     2041 cggatgcggt aggtaggtcc ttgcctcgta tgcataaggc cctgggttcc aatttcacta
     2101 gcacacacac aaagcctgat agttggatgt agtactacca ccacctatag tcctagctac
     2161 ttgggtgcct aaaatgaaaa ccctcaagcc tagaactgca aggccaatgt ggacagtata
     2221 gctaggccct tttcaaaaac aaaacaaagc aaaacaaaag gtgaagccaa atgtagtagt
     2281 actataatcc cagatttcca aaggatttct caaacaattt ttgctctagt tttgctttat
     2341 tttgttgaga aagggtctca tgtagccaag gctggcctca aactcactgt atacccaaga
     2401 atgacattga aatacagatc caagctgagc gtggtggcgc acgcctttaa tcccagtact
     2461 cggcaggcag atttctgagt ttgaggccag cctggtctac aaagtgagtt ccaggacagc
     2521 cagggctaca cagagaaacc ctgtctcaaa aaacaaaaaa acaaaacaaa aaaaaaacaa
     2581 aaaaaaaaaa acaaagaaac agagattctc cctcccatcc gtacctccca agtccacatt
     2641 aaaggcatgt ttcgcgatgc ctgattttac cagaccaaag ttttttaggt tgacagtctt
     2701 ttcttcacgc ttagctaaca tgtacaagtc cttgaattgt atgcccagca ctaccagtat
     2761 aagcgggtgt gggagggaga cttgttttct agtctcccta gagcccgaca ggcagcagct
     2821 gacatgcacg ccctaagcta cagggtgccg tcttctgtgg cctaatccaa tgtctttaca
     2881 aaccctcgta ttcctgtgcg cctgcacttt ggtctctgac cacgcctctc tctgtgatgc
     2941 ccggaatgtc tgcaccccac tctgtctaga ggtgttcaca ctacaatggt ttaatccaag
     3001 atgatgattt tcattccaat caatgtgacc acaggaatgt ccacagccca ggctatctga
     3061 cctcaggaat gcatgtctgg agggtccaca ggaagggcat tcaatcacag atgcttctac
     3121 gcccacaccc attgccacag caactccgca gtgcccggga aagagctcca caagtgtccc
     3181 tgttctgggc tttgactctt aggagttgta tcggtggggc aagtgatcca ggcaaaggaa
     3241 ggggaaacct tgtgcttgcc ctattccatg agcagcacgc agagatgagg gatggagctg
     3301 gaacagtcaa cctgaggacc agtggtgcga catgagatca gagagggcct ataggaggag
     3361 caagaaatgc ctgaatggaa cccaatagc
//
