LOCUS       NM_011936               3586 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus FTO alpha-ketoglutarate dependent dioxygenase (Fto),
            mRNA.
ACCESSION   NM_011936
VERSION     NM_011936.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3586)
  AUTHORS   Li,Q. and Mu,S.
  TITLE     FTO mediates the diabetic kidney disease progression through
            regulating the m6A modification of NLRP3
  JOURNAL   BMC Nephrol 25 (1), 345 (2024)
   PUBMED   39390397
  REMARK    GeneRIF: FTO mediates the diabetic kidney disease progression
            through regulating the m[6]A modification of NLRP3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3586)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3586)
  AUTHORS   Zhao,Y., Ding,W., Cai,Y., Li,Q., Zhang,W., Bai,Y., Zhang,Y., Xu,Q.
            and Feng,Z.
  TITLE     The m6A eraser FTO suppresses ferroptosis via mediating ACSL4 in
            LPS-induced macrophage inflammation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167354 (2024)
   PUBMED   39004378
  REMARK    GeneRIF: The m[6]A eraser FTO suppresses ferroptosis via mediating
            ACSL4 in LPS-induced macrophage inflammation.
REFERENCE   4  (bases 1 to 3586)
  AUTHORS   Huang,T., Zhang,C., Ren,J., Shuai,Q., Li,X., Li,X., Xie,J. and
            Xu,J.
  TITLE     FTO-mediated m 6A demethylation of ULK1 mRNA promotes autophagy and
            activation of hepatic stellate cells in liver fibrosis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (10), 1509-1520 (2024)
   PUBMED   39175431
  REMARK    GeneRIF: FTO-mediated m [6]A demethylation of ULK1 mRNA promotes
            autophagy and activation of hepatic stellate cells in liver
            fibrosis.
REFERENCE   5  (bases 1 to 3586)
  AUTHORS   Wang,D.X., Bao,S.Y., Song,N.N., Chen,W.Z., Ding,X.Q., Walker,R.J.
            and Fang,Y.
  TITLE     FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by
            targeting RUNX1 and further enhancing PI3K/AKT pathway
  JOURNAL   FASEB J 38 (5), e23436 (2024)
   PUBMED   38430461
  REMARK    GeneRIF: FTO-mediated m6A mRNA demethylation aggravates renal
            fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.
REFERENCE   6  (bases 1 to 3586)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 3586)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3586)
  AUTHORS   Peters,T., Ausmeier,K., Dildrop,R. and Ruther,U.
  TITLE     The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb
            deletion including the entire Iroquois B gene cluster
  JOURNAL   Mamm Genome 13 (4), 186-188 (2002)
   PUBMED   11956760
REFERENCE   9  (bases 1 to 3586)
  AUTHORS   Peters,T., Ausmeier,K. and Ruther,U.
  TITLE     Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft)
            mouse mutation
  JOURNAL   Mamm Genome 10 (10), 983-986 (1999)
   PUBMED   10501967
REFERENCE   10 (bases 1 to 3586)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290198.1, BC057008.1 and CA321822.1.
            
            On Feb 5, 2008 this sequence version replaced NM_011936.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057008.1, AJ237917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BY290198.1         2-35
            35-3007             BC057008.1         1-2973
            3008-3217           CA321822.1         502-711
            3218-3586           BC057008.1         3184-3552
FEATURES             Location/Qualifiers
     source          1..3586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.34 cM"
     gene            1..3586
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /note="FTO alpha-ketoglutarate dependent dioxygenase"
                     /db_xref="GeneID:26383"
                     /db_xref="MGI:MGI:1347093"
     exon            1..96
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /inference="alignment:Splign:2.1.0"
     exon            97..174
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /inference="alignment:Splign:2.1.0"
     exon            175..793
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /inference="alignment:Splign:2.1.0"
     exon            794..937
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1017
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1161
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1281
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1406
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..3558
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3536..3541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /note="hexamer: AATAAA"
     polyA_site      3558
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /note="major polyA site"
ORIGIN      
        1 agggcgaggg ggaacacggc ccacggtggc gaaggcggct ttagtagcag catgaagcgc
       61 gtccagaccg cggaggaacg agagcgggaa gctaagaaac tgaggctcct tgaggagctt
      121 gaagacactt ggcttcctta cctgaccccc aaagatgatg agttctatca gcagtggcag
      181 ctgaaatacc ctaaactggt tttccgagag gccggcagca taccagagga gctgcataag
      241 gaggtccccg aggcctttct cacactgcat aagcatggct gcttgtttcg ggacgtggtg
      301 aggatccaag gcaaagatgt gctcacccca gtgtctcgca tcctcatcgg ggacccaggc
      361 tgcacctaca agtacttgaa caccagactc ttcacggtgc cctggcccgt gaagggctgc
      421 acggtcaagt acacagaggc tgagatcgcc gctgcatgtc agaccttcct aaagctcaat
      481 gactacctcc aggtggagac catccaggcc ttggaagaac tggctgtcag agagaaggcc
      541 aatgaagacg ctgtgccact gtgcatggca gagttcccca gggccggcgt ggggccgtcc
      601 tgcgatgatg aagtggacct taagagcaga gcagcctaca acgtgacttt gctaaacttc
      661 atggatcctc agaagatgcc ctacttgaaa gaggagccct atttcggcat ggggaagatg
      721 gcggtgagct ggcatcacga tgagaacctg gtggacaggt cagccgtggc agtgtacagc
      781 tatagctgcg aaggctctga ggatgaaagt gaggacgagt ccagcttcga aggcagagat
      841 cctgatactt ggcatgttgg ttttaagatc tcttgggaca tcgagacacc aggattaaca
      901 atccctcttc accagggaga ctgctatttc atgctggatg acctcaatgc cacccaccag
      961 cactgtgttt tggctggctc acagcctcgg tttagttcca ctcaccgtgt ggcagagtgc
     1021 tcaacaggca ccttggatta tatcttagaa cgctgtcagt tggcgctgca gaatgtcctc
     1081 aatgactcag acgatggcga cgtctcgttg aaatcctttg atcctgcagt tttgaaacaa
     1141 ggagaggaaa tccataatga ggtggagttt gagtggctga ggcagttctg gtttcaaggc
     1201 aatcgataca aactttgcac cgattggtgg tgtgagccca tgactcacct ggaggggctg
     1261 tggaagaaga tggagagcat gacaaatgcg gtgctccgtg aagttaaaag agaggggctc
     1321 ccggtggaac aaaggagtga gattctgtct gccatcctgg tcccgctcac cgtgcgccag
     1381 aacctgagga aggagtggca tgccaggtgc cagtcccgag tcgtccggac tttaccagta
     1441 cagcagaaac cagactgccg gccatattgg gagaaggatg acccttccat gcctctgccc
     1501 tttgacctca cagacgtggt ttccgagctc agaggccagc tgctggaagc aagatcctag
     1561 aggaagcaca agtcttaggt ggagaaggaa aagatatcct tggctttctt cctcaaacct
     1621 tggacaaggg tagtgtagac tcctctcaac ccagtggtta taggacctgg gttccaattc
     1681 aaaacagcta gagaacaaag cccacagatt ctgaagtgtt gaaacgttac tgtgttttag
     1741 tctgacttgg tgttaaatta gagcacccct ccctcccccc aaatattctt cactcaccac
     1801 cccccacaca cacctggagc ccttttgtct cccaaggcag cagtagagat gggctaagcc
     1861 tgtgacaagc ctcacctgct ctcctctttg gctggccacc tcaaagaccc ggaagtaggc
     1921 ctggccatag ggtgacagaa ctagagacat ccatcccagc ttctcaccgt ggcttctagt
     1981 ggttagacca tccaagatgg cagccagtgt ctcaccgcgg ctgcacagat ataaattcag
     2041 ctcagttgtc attaaaactc cattcttcag ttgccctggc gcatgctgat gactgctgat
     2101 ttagacgaca catacagatg tttatgtgtt ccacatctgt gagcgagcct tccttctccc
     2161 agccttctgt agtggctaaa acatggagga aaacagtgaa aggcagtcac cactgtcacc
     2221 tctttcctcc tctgagaggg aaggggccat gagccctgtg cactgcacac aggaagagga
     2281 aggagctaca aggagacagc caaaccctgt ctttgcgggg cttccctgat ccagtgacag
     2341 agaccagccc tgggaccact gttctgtgga gctagtgttt ctcctagaat tccccactca
     2401 tagatactga caggtcgtat gggggcttga agcacccagt tcccaacccc gtgatgtcag
     2461 agcgtcagag agagcatgga ctccgatttc aaagtgccag gagtaagacc caccgcagca
     2521 ctcactccat gacctttgca tgtccttggg tctcagtttt ctcatctgta tgattttggg
     2581 aggtacccaa aatgccaact cctaatgtga aaatgacgtg atatgacaga gctacagatc
     2641 tagagtaatt tctagcatac cgctgaatat ccgatatgtt ccagtgtcgt tacgtgagct
     2701 gacctggaag aggccgtctt cctccccccc ccccccccgg gtctgcagtc ctttgccgtc
     2761 ttgtgtctcg tggcccacat ctttccctag tgacctgagg ccttttggtg gctgaaaggt
     2821 tgacaacagt tagcccatga ttctcttgta ttggccgaga cctgcaattg gaaggacaca
     2881 acatagttgt ggtttttgct gcatccagga ttccagttaa ggtgccttcc tgcctagaat
     2941 ccaccataga agctgcactc caccagcccc aagggcttcc tggtgcaggg acccaaggct
     3001 ctcagacctt gatttgttcc cctttgtctc tgagccagga cttcctcatc agtagagagt
     3061 gaggtacatt ctcacggggt aaaatggaac aacctaagta acggtatagg tggcttcata
     3121 tgtcacaggc tggcccgtct ccccatcccc agccatctgg ctctgtggtt tattaggccc
     3181 cgtgatattt ctttgttcta tttaattggg tgccagaatt aaaaattgag agattccaca
     3241 taaaataaaa atgtctgcat tctctttaga agccagaata cctgtgagcc cctgggtctc
     3301 cataatcgca tggcggtggc ttggcaatgc ctgtgacctt tgtgctctgc tgtgaccctg
     3361 ttgctccctg tcaccatttt gtaaacctgc gtccgtccca gcagcacttt ctagagctgc
     3421 ttgctcgcat ccttggtaga aagcagtagc gttgagtgct cagtccctgc tcctcccatt
     3481 ggtctaagtt catggtctgc ttgtattgct gtgctgtgtg catttgttca tacacaataa
     3541 agaattaaac gatgagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
