LOCUS       NM_026286               1461 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ferritin mitochondrial (Ftmt), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_026286
VERSION     NM_026286.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1461)
  AUTHORS   Kusminski,C.M., Ghaben,A.L., Morley,T.S., Samms,R.J., Adams,A.C.,
            An,Y., Johnson,J.A., Joffin,N., Onodera,T., Crewe,C., Holland,W.L.,
            Gordillo,R. and Scherer,P.E.
  TITLE     A Novel Model of Diabetic Complications: Adipocyte Mitochondrial
            Dysfunction Triggers Massive beta-Cell Hyperplasia
  JOURNAL   Diabetes 69 (3), 313-330 (2020)
   PUBMED   31882562
  REMARK    GeneRIF: In a model of FtMT overexpression, during dietary
            challenge, mice are leaner but exhibit glucose intolerance, low
            adiponectin levels, increased reactive oxygen species damage, and
            elevated GDF15 and FGF21 levels, indicating metabolically
            dysfunctional fat. Despite harboring highly dysfunctional fat, mice
            display massive beta-cell hyperplasia, reflecting a beneficial
            mitochondria-induced fat-to-pancreas interorgan signa...
REFERENCE   2  (bases 1 to 1461)
  AUTHORS   Wang,L., Wang,L., Dai,Z., Wu,P., Shi,H. and Zhao,S.
  TITLE     Lack of mitochondrial ferritin aggravated neurological deficits via
            enhancing oxidative stress in a traumatic brain injury murine model
  JOURNAL   Biosci Rep 37 (6) (2017)
   PUBMED   28963372
  REMARK    GeneRIF: Lack of mitochondrial ferritin aggravated neurological
            deficits via enhancing oxidative stress in a traumatic brain injury
            murine model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1461)
  AUTHORS   Wang,P., Wu,Q., Wu,W., Li,H., Guo,Y., Yu,P., Gao,G., Shi,Z.,
            Zhao,B. and Chang,Y.Z.
  TITLE     Mitochondrial Ferritin Deletion Exacerbates beta-Amyloid-Induced
            Neurotoxicity in Mice
  JOURNAL   Oxid Med Cell Longev 2017, 1020357 (2017)
   PUBMED   28191272
REFERENCE   4  (bases 1 to 1461)
  AUTHORS   Wang,X., Yang,H., Yanagisawa,D., Bellier,J.P., Morino,K., Zhao,S.,
            Liu,P., Vigers,P. and Tooyama,I.
  TITLE     Mitochondrial ferritin affects mitochondria by stabilizing
            HIF-1alpha in retinal pigment epithelium: implications for the
            pathophysiology of age-related macular degeneration
  JOURNAL   Neurobiol Aging 47, 168-179 (2016)
   PUBMED   27599360
  REMARK    GeneRIF: Age-related increase is found in FtMt and
            hypoxia-inducible factor-1a (HIF-1a) in murine retinal pigment
            epithelium (RPE).HIF-1alpha stabilization reduced the protein level
            of the mature, functional form of mitochondrial ferritin.
REFERENCE   5  (bases 1 to 1461)
  AUTHORS   Bartnikas,T.B., Campagna,D.R., Antiochos,B., Mulhern,H.,
            Pondarre,C. and Fleming,M.D.
  TITLE     Characterization of mitochondrial ferritin-deficient mice
  JOURNAL   Am J Hematol 85 (12), 958-960 (2010)
   PUBMED   20960432
REFERENCE   6  (bases 1 to 1461)
  AUTHORS   Nie,G., Sheftel,A.D., Kim,S.F. and Ponka,P.
  TITLE     Overexpression of mitochondrial ferritin causes cytosolic iron
            depletion and changes cellular iron homeostasis
  JOURNAL   Blood 105 (5), 2161-2167 (2005)
   PUBMED   15522954
  REMARK    GeneRIF: overexpression of MtFt causes a dramatic change in
            intracellular iron homeostasis and shunting iron to MtFt likely
            limits its availability for active iron proteins
REFERENCE   7  (bases 1 to 1461)
  AUTHORS   Langlois d'Estaintot,B., Santambrogio,P., Granier,T., Gallois,B.,
            Chevalier,J.M., Precigoux,G., Levi,S. and Arosio,P.
  TITLE     Crystal structure and biochemical properties of the human
            mitochondrial ferritin and its mutant Ser144Ala
  JOURNAL   J Mol Biol 340 (2), 277-293 (2004)
   PUBMED   15201052
REFERENCE   8  (bases 1 to 1461)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1461)
  AUTHORS   Drysdale,J., Arosio,P., Invernizzi,R., Cazzola,M., Volz,A.,
            Corsi,B., Biasiotto,G. and Levi,S.
  TITLE     Mitochondrial ferritin: a new player in iron metabolism
  JOURNAL   Blood Cells Mol Dis 29 (3), 376-383 (2002)
   PUBMED   12547228
  REMARK    Review article
REFERENCE   10 (bases 1 to 1461)
  AUTHORS   Levi,S., Corsi,B., Bosisio,M., Invernizzi,R., Volz,A., Sanford,D.,
            Arosio,P. and Drysdale,J.
  TITLE     A human mitochondrial ferritin encoded by an intronless gene
  JOURNAL   J Biol Chem 276 (27), 24437-24440 (2001)
   PUBMED   11323407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK015400.1 and AK133009.1.
            
            On Jul 2, 2009 this sequence version replaced NM_026286.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK133009.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK015400.1         2-14
            14-1461             AK133009.1         2-1449
FEATURES             Location/Qualifiers
     source          1..1461
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 28.19 cM"
     gene            1..1461
                     /gene="Ftmt"
                     /gene_synonym="4930447C24Rik; FerH; Fth3; MtF"
                     /note="ferritin mitochondrial"
                     /db_xref="GeneID:67634"
                     /db_xref="MGI:MGI:1914884"
     exon            1..1461
                     /gene="Ftmt"
                     /gene_synonym="4930447C24Rik; FerH; Fth3; MtF"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..792
                     /gene="Ftmt"
                     /gene_synonym="4930447C24Rik; FerH; Fth3; MtF"
                     /EC_number="1.16.3.1"
                     /note="ferritin heavy chain 3; ferritin H"
                     /codon_start=1
                     /product="ferritin, mitochondrial precursor"
                     /protein_id="NP_080562.2"
                     /db_xref="CCDS:CCDS29246.1"
                     /db_xref="GeneID:67634"
                     /db_xref="MGI:MGI:1914884"
                     /translation="MLSCFWFFSKHISSALMSLPRVLHRFTAPQCLASRYPLGPLLAS
                     PRRLLASVASSQDSTRPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDV
                     ALYNFSKYFLRQSLEEREHAEKLMKLQNQRGGRICLQDIKKPDKDDWECGLRAMECAL
                     LLEKNVNQSLLDLHTLASEKGDPHLCDFLETHYLHEQVKSIKELGDHVHNLVTMGAPA
                     AGLAEYLFDKHTLGSESKH"
     regulatory      1438..1443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ftmt"
                     /gene_synonym="4930447C24Rik; FerH; Fth3; MtF"
                     /note="hexamer: ATTAAA"
     polyA_site      1459
                     /gene="Ftmt"
                     /gene_synonym="4930447C24Rik; FerH; Fth3; MtF"
                     /note="major polyA site"
ORIGIN      
        1 atttagaccc gacgctcagc agcagacctt gtgctgagct tgcctgacct cagtttcccc
       61 tcctttcaaa caggagtcat gctgtcctgc ttttggttct tctccaagca catcagctct
      121 gcactgatgt ccctgccccg tgtgttacac agattcactg ccccacagtg cttggcctcc
      181 aggtatcctt taggtcccct actggcctcc cctcgacgcc tcctggcctc ggtggcttcc
      241 tctcaggact ccactagacc ttccagggtc cgccagaact ttcacccgga ctcggaggct
      301 gctatcaacc gccaaatcaa cctggagctt tacgcatcct acgtgtacct gtccatggct
      361 tactacttct ccagggatga tgtggccttg tataacttct ccaagtattt ccttcgccag
      421 tccctggaag agagggaaca tgcagagaag ctaatgaaac tgcagaacca gcgaggaggc
      481 cggatctgcc tccaggacat caagaagcca gataaagatg actgggaatg cggactgcgg
      541 gccatggaat gtgccctgct cctggaaaag aatgtaaacc agtcgctgct ggacttacat
      601 actctggcct cagaaaaagg agatcctcat ttgtgtgact ttctggaaac tcactacctg
      661 catgagcaag tgaagtctat caaagaatta ggtgaccacg tgcacaactt agtcaccatg
      721 ggggctccag ccgcgggctt agcggaatat cttttcgaca agcacacgct tggaagcgag
      781 agcaagcact aagacaagag gctgcctatc tgatacccca gtgggtccca agacctggat
      841 ggagttaacg atctcctgtt tcttgccctt aaaacttgac accgtctttc cattctcctc
      901 cttctttgaa ctgttttgct agtgttttgt agagaaaata tgctaagccc tgtgctcact
      961 acggctttct accaacacca aaataccaat tatttcccca gcctgaaaga tagcccagaa
     1021 tactatggta tgacagggat gggagacaaa acacttaaat tagatacaag agtatgttct
     1081 ttgaatatta ttaagtgctg ttcctatcca taaacctgaa ctgaaattcc atgacttcca
     1141 attcaaccat ctgtactgcc ttaaaaatca tatacaaaat ggtcggtgag agaaatatat
     1201 aatgtataaa taattgtaag acagagaaga tatagagtac ttcaaaaatc acacatgcaa
     1261 aattttgaca attattctat tttcccagtg tgttccaaga aatggcagtg tatggagaca
     1321 acctaggtat tgttttaaag gattcatgtc aaacttggta agagccacat cgggtatcag
     1381 tggtggtgtt gagcagctca gtaggctcac attttaaggg ctcagagaag actcttaatt
     1441 aaaaccacag gaaaaaatat c
//
