LOCUS       NM_010240                986 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ferritin light polypeptide 1 (Ftl1), mRNA.
ACCESSION   NM_010240 XM_001002426
VERSION     NM_010240.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 986)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 986)
  AUTHORS   Bai,X., Wang,B., Cui,Y., Tian,S., Zhang,Y., You,L., Chang,Y.Z. and
            Gao,G.
  TITLE     Hepcidin deficiency impairs hippocampal neurogenesis and mediates
            brain atrophy and memory decline in mice
  JOURNAL   J Neuroinflammation 21 (1), 15 (2024)
   PUBMED   38195497
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 986)
  AUTHORS   Swanson,M.E.V., Mrkela,M., Murray,H.C., Cao,M.C., Turner,C.,
            Curtis,M.A., Faull,R.L.M., Walker,A.K. and Scotter,E.L.
  TITLE     Microglial CD68 and L-ferritin upregulation in response to
            phosphorylated-TDP-43 pathology in the amyotrophic lateral
            sclerosis brain
  JOURNAL   Acta Neuropathol Commun 11 (1), 69 (2023)
   PUBMED   37118836
  REMARK    GeneRIF: Microglial CD68 and L-ferritin upregulation in response to
            phosphorylated-TDP-43 pathology in the amyotrophic lateral
            sclerosis brain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 986)
  AUTHORS   Cao,C. and Fleming,M.D.
  TITLE     Loss of the placental iron exporter ferroportin 1 causes embryonic
            demise in late-gestation mouse pregnancy
  JOURNAL   Development 149 (23) (2022)
   PUBMED   36398730
REFERENCE   5  (bases 1 to 986)
  AUTHORS   Fan,L., Ou,Y.J., Zhu,Y.X., Liang,Y.D., Zhou,Y. and Wang,Y.N.
  TITLE     Lif Deficiency Leads to Iron Transportation Dysfunction in
            Ameloblasts
  JOURNAL   J Dent Res 101 (1), 63-72 (2022)
   PUBMED   34034544
REFERENCE   6  (bases 1 to 986)
  AUTHORS   Fan,H., Villegas,C. and Wright,J.A.
  TITLE     A link between ferritin gene expression and ribonucleotide
            reductase R2 protein, as demonstrated by retroviral vector mediated
            stable expression of R2 cDNA
  JOURNAL   FEBS Lett 382 (1-2), 145-148 (1996)
   PUBMED   8612737
REFERENCE   7  (bases 1 to 986)
  AUTHORS   Dickinson,T.K. and Connor,J.R.
  TITLE     Cellular distribution of iron, transferrin, and ferritin in the
            hypotransferrinemic (Hp) mouse brain
  JOURNAL   J Comp Neurol 355 (1), 67-80 (1995)
   PUBMED   7636015
REFERENCE   8  (bases 1 to 986)
  AUTHORS   Renaudie,F., Boulanger,L., Grandchamp,B. and Beaumont,C.
  TITLE     [Cloning, characterization and expression of mouse ferritin L
            subunit gene]
  JOURNAL   C R Acad Sci III 318 (4), 431-437 (1995)
   PUBMED   7648356
REFERENCE   9  (bases 1 to 986)
  AUTHORS   Yachou,A., Mattei,M.G., Roeckel,N., Grandchamp,B. and Beaumont,C.
  TITLE     Mouse ferritin H sequences map to chromosomes 3, 6, and 19
  JOURNAL   Genomics 9 (1), 204-206 (1991)
   PUBMED   2004762
REFERENCE   10 (bases 1 to 986)
  AUTHORS   Beaumont,C., Dugast,I., Renaudie,F., Souroujon,M. and Grandchamp,B.
  TITLE     Transcriptional regulation of ferritin H and L subunits in adult
            erythroid and liver cells from the mouse. Unambiguous
            identification of mouse ferritin subunits and in vitro formation of
            the ferritin shells
  JOURNAL   J Biol Chem 264 (13), 7498-7504 (1989)
   PUBMED   2708374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY134899.1, AK169159.1 and BC081462.1.
            
            On Sep 14, 2006 this sequence version replaced NM_010240.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020403.1, DV056485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415128, SAMN02415133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BY134899.1         20-66
            48-969              AK169159.1         2-923
            970-986             BC081462.1         890-906
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.32 cM"
     gene            1..986
                     /gene="Ftl1"
                     /gene_synonym="Ftl; Ftl-1; L-ferritin"
                     /note="ferritin light polypeptide 1"
                     /db_xref="GeneID:14325"
                     /db_xref="MGI:MGI:95589"
     exon            1..357
                     /gene="Ftl1"
                     /gene_synonym="Ftl; Ftl-1; L-ferritin"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..807
                     /gene="Ftl1"
                     /gene_synonym="Ftl; Ftl-1; L-ferritin"
                     /note="ferritin L subunit 1"
                     /codon_start=1
                     /product="ferritin light chain 1"
                     /protein_id="NP_034370.2"
                     /db_xref="CCDS:CCDS39952.1"
                     /db_xref="GeneID:14325"
                     /db_xref="MGI:MGI:95589"
                     /translation="MTSQIRQNYSTEVEAAVNRLVNLHLRASYTYLSLGFFFDRDDVA
                     LEGVGHFFRELAEEKREGAERLLEFQNDRGGRALFQDVQKPSQDEWGKTQEAMEAALA
                     MEKNLNQALLDLHALGSARADPHLCDFLESHYLDKEVKLIKKMGNHLTNLRRVAGPQP
                     AQTGAPQGSLGEYLFERLTLKHD"
     exon            358..504
                     /gene="Ftl1"
                     /gene_synonym="Ftl; Ftl-1; L-ferritin"
                     /inference="alignment:Splign:2.1.0"
     exon            505..630
                     /gene="Ftl1"
                     /gene_synonym="Ftl; Ftl-1; L-ferritin"
                     /inference="alignment:Splign:2.1.0"
     exon            631..970
                     /gene="Ftl1"
                     /gene_synonym="Ftl; Ftl-1; L-ferritin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      949..954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ftl1"
                     /gene_synonym="Ftl; Ftl-1; L-ferritin"
                     /note="putative"
     polyA_site      969
                     /gene="Ftl1"
                     /gene_synonym="Ftl; Ftl-1; L-ferritin"
                     /note="putative"
ORIGIN      
        1 ccggagggtc aacatgctat aaaaggagcg ctccttgccc gggacttaga gcagcgcctt
       61 ggaggtcccg tggatctgtg tcttgcttca acagtgtttg aacggaacag acccggggat
      121 tcccactgta ctcgcttcca gccgccttta caagtctctc cagtcgcagc ctccgggacc
      181 atctcctcgc tgccttcagc tcctaggacc agtctgcacc gtctcttcgc ggttagctcc
      241 tactccggat cagccatgac ctctcagatt cgtcagaatt attccaccga ggtggaagct
      301 gccgtgaacc gcctggtcaa cttgcacctg cgggcctcct acacctacct ctctctgggc
      361 ttcttttttg atcgggatga cgtggctctg gagggcgtag gccacttctt ccgcgaattg
      421 gccgaggaga agcgcgaggg cgcggagcgt ctcctcgagt ttcagaacga tcgcgggggc
      481 cgtgcactct tccaggatgt gcagaagcca tctcaagatg aatggggtaa aacccaggag
      541 gccatggaag ctgccttggc catggagaag aacctgaatc aggccctctt ggatctgcat
      601 gccctgggtt ctgcccgcgc ggaccctcat ctctgtgact tcctggaaag ccactatctg
      661 gataaggagg tgaaactcat caagaagatg ggcaaccatc tgaccaacct ccgcagggtg
      721 gcggggccac aaccagcgca gactggcgcg ccccaggggt ctctgggcga gtatctcttt
      781 gagcgcctca ctctcaagca cgactaggag gcctctgtac cttccaaggg gctcccccct
      841 ctgctctgca ccagcccgcc ctgggacctc cacctgaatg aacctctcaa gccactaggc
      901 agctttgtaa ccgccctgga gcctctgtca agtcttggac caagtaaaaa taaagctttt
      961 tgagacagca aaaaaaaaaa aaaaaa
//
