LOCUS       NM_010239                942 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus ferritin heavy polypeptide 1 (Fth1), transcript
            variant 1, mRNA.
ACCESSION   NM_010239
VERSION     NM_010239.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 942)
  AUTHORS   Yuan,Z., Yang,L., Li,Y., Li,X., Peng,C., Pan,J. and Cai,D.
  TITLE     FTH1 protects against osteoarthritis by MAPK pathway inhibition of
            extracellular matrix degradation
  JOURNAL   BMC Musculoskelet Disord 25 (1), 282 (2024)
   PUBMED   38609896
  REMARK    GeneRIF: FTH1 protects against osteoarthritis by MAPK pathway
            inhibition of extracellular matrix degradation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 942)
  AUTHORS   Wu,Q., Carlos,A.R., Braza,F., Bergman,M.L., Kitoko,J.Z.,
            Bastos-Amador,P., Cuadrado,E., Martins,R., Oliveira,B.S.,
            Martins,V.C., Scicluna,B.P., Landry,J.J., Jung,F.E., Ademolue,T.W.,
            Peitzsch,M., Almeida-Santos,J., Thompson,J., Cardoso,S.,
            Ventura,P., Slot,M., Rontogianni,S., Ribeiro,V., Domingues,V.D.S.,
            Cabral,I.A., Weis,S., Groth,M., Ameneiro,C., Fidalgo,M., Wang,F.,
            Demengeot,J., Amsen,D. and Soares,M.P.
  TITLE     Ferritin heavy chain supports stability and function of the
            regulatory T cell lineage
  JOURNAL   EMBO J 43 (8), 1445-1483 (2024)
   PUBMED   38499786
REFERENCE   3  (bases 1 to 942)
  AUTHORS   Kao,Y.R., Chen,J., Kumari,R., Ng,A., Zintiridou,A., Tatiparthy,M.,
            Ma,Y., Aivalioti,M.M., Moulik,D., Sundaravel,S., Sun,D.,
            Reisz,J.A., Grimm,J., Martinez-Lopez,N., Stransky,S., Sidoli,S.,
            Steidl,U., Singh,R., D'Alessandro,A. and Will,B.
  TITLE     An iron rheostat controls hematopoietic stem cell fate
  JOURNAL   Cell Stem Cell 31 (3), 378-397 (2024)
   PUBMED   38402617
REFERENCE   4  (bases 1 to 942)
  AUTHORS   Beaumont,C., Seyhan,A., Yachou,A.K., Grandchamp,B. and Jones,R.
  TITLE     Mouse ferritin H subunit gene. Functional analysis of the promoter
            and identification of an upstream regulatory element active in
            erythroid cells
  JOURNAL   J Biol Chem 269 (32), 20281-20288 (1994)
   PUBMED   8051121
REFERENCE   5  (bases 1 to 942)
  AUTHORS   Yachou,A.K., Renaudie,F., Guenet,J.L., Simon-Chazottes,D.,
            Jones,R., Grandchamp,B. and Beaumont,C.
  TITLE     Mouse ferritin H multigene family is polymorphic and contains a
            single multiallelic functional gene located on chromosome 19
  JOURNAL   Genomics 10 (3), 531-538 (1991)
   PUBMED   1679743
REFERENCE   6  (bases 1 to 942)
  AUTHORS   Yachou,A., Mattei,M.G., Roeckel,N., Grandchamp,B. and Beaumont,C.
  TITLE     Mouse ferritin H sequences map to chromosomes 3, 6, and 19
  JOURNAL   Genomics 9 (1), 204-206 (1991)
   PUBMED   2004762
REFERENCE   7  (bases 1 to 942)
  AUTHORS   Kwak,E.L., Torti,S.V. and Torti,F.M.
  TITLE     Murine ferritin heavy chain: isolation and characterization of a
            functional gene
  JOURNAL   Gene 94 (2), 255-261 (1990)
   PUBMED   2258056
REFERENCE   8  (bases 1 to 942)
  AUTHORS   Yachou,A.K., Renaudie,F., Grandchamp,B. and Beaumont,C.
  TITLE     Nucleotide sequence of the mouse ferritin H chain gene
  JOURNAL   Nucleic Acids Res 17 (19), 8005 (1989)
   PUBMED   2798146
REFERENCE   9  (bases 1 to 942)
  AUTHORS   Beaumont,C., Dugast,I., Renaudie,F., Souroujon,M. and Grandchamp,B.
  TITLE     Transcriptional regulation of ferritin H and L subunits in adult
            erythroid and liver cells from the mouse. Unambiguous
            identification of mouse ferritin subunits and in vitro formation of
            the ferritin shells
  JOURNAL   J Biol Chem 264 (13), 7498-7504 (1989)
   PUBMED   2708374
REFERENCE   10 (bases 1 to 942)
  AUTHORS   Torti,S.V., Kwak,E.L., Miller,S.C., Miller,L.L., Ringold,G.M.,
            Myambo,K.B., Young,A.P. and Torti,F.M.
  TITLE     The molecular cloning and characterization of murine ferritin heavy
            chain, a tumor necrosis factor-inducible gene
  JOURNAL   J Biol Chem 263 (25), 12638-12644 (1988)
   PUBMED   3410854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134437.3 and AK147082.1.
            
            On Sep 27, 2012 this sequence version replaced NM_010239.1.
            
            Transcript Variant: This variant (1) encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012314.1, AK150679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC134437.3         92140-92194
            56-923              AK147082.1         2-869
            924-942             AC134437.3         94587-94605
FEATURES             Location/Qualifiers
     source          1..942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.23 cM"
     gene            1..942
                     /gene="Fth1"
                     /gene_synonym="FHC; Fth; HFt; MFH"
                     /note="ferritin heavy polypeptide 1"
                     /db_xref="GeneID:14319"
                     /db_xref="MGI:MGI:95588"
     exon            1..338
                     /gene="Fth1"
                     /gene_synonym="FHC; Fth; HFt; MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            339..485
                     /gene="Fth1"
                     /gene_synonym="FHC; Fth; HFt; MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            486..611
                     /gene="Fth1"
                     /gene_synonym="FHC; Fth; HFt; MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            612..942
                     /gene="Fth1"
                     /gene_synonym="FHC; Fth; HFt; MFH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      904..909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fth1"
                     /gene_synonym="FHC; Fth; HFt; MFH"
                     /note="hexamer: AATAAA"
     polyA_site      924
                     /gene="Fth1"
                     /gene_synonym="FHC; Fth; HFt; MFH"
                     /note="major polyA site"
ORIGIN      
        1 agcgctcgcc tgacgcagga tcccgctata agtgcggccc gctgtcccct cctgcgccag
       61 acgttctcgc ccagagtcgc cgcggtttcc tgcttcaaca gtgcttgaac ggaacccggt
      121 gctcgacccc tccgaccccc gccggccgct tcgagcctga gccctttgca acttcgtcgt
      181 tccgccgctc cagcgtcgcc accgcgcctc gccccgccgc caccatgacc accgcgtctc
      241 cctcgcaagt gcgccagaac taccaccagg acgcggaggc tgccatcaac cgccagatca
      301 acctggagtt gtatgcctcc tacgtctatc tgtctatgtc ttgttatttt gaccgagatg
      361 atgtggctct gaagaacttt gccaaatact ttctccacca atctcatgag gagagggagc
      421 atgccgagaa actgatgaag ctgcagaacc agcgaggtgg ccgaatcttc ctgcaggata
      481 taaagaaacc agaccgtgat gactgggaga gcgggctgaa tgcaatggag tgtgcactgc
      541 acttggaaaa gagtgtgaat cagtcactac tggaactgca caaactggct actgacaaga
      601 atgatcccca cttatgtgac ttcattgaga cgtattatct gagtgaacag gtgaaatcca
      661 ttaaagaact gggtgaccac gtgaccaact tacgcaagat gggtgcccct gaagctggca
      721 tggcagaata tctctttgac aagcacaccc tgggacacgg tgatgagagc taagctgact
      781 tccccaaagc cacgtgactt tactggtcac tgaggcagtg catgcatgtc aggctgcctt
      841 catcttttct ataagttgca ccaaaacatc tgcttaagtt ctttaatttg taccatttct
      901 tcaaataaag aattttggta cccagcttct tttctttgtg at
//
