LOCUS       NM_080845               2710 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus formiminotransferase cyclodeaminase (Ftcd), mRNA.
ACCESSION   NM_080845
VERSION     NM_080845.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2710)
  AUTHORS   Liu,Y., Tang,Y., Jiang,H., Zhang,X., Chen,X., Guo,J., Jin,C. and
            Wu,M.
  TITLE     Exosome-Related FTCD Facilitates M1 Macrophage Polarization and
            Impacts the Prognosis of Hepatocellular Carcinoma
  JOURNAL   Biomolecules 14 (1), 41 (2023)
   PUBMED   38254641
  REMARK    GeneRIF: Exosome-Related FTCD Facilitates M1 Macrophage
            Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2710)
  AUTHORS   Yamamoto,S., Yamazaki,T., Komazaki,S., Yamashita,T., Osaki,M.,
            Matsubayashi,M., Kidoya,H., Takakura,N., Yamazaki,D. and
            Kakizawa,S.
  TITLE     Contribution of calumin to embryogenesis through participation in
            the endoplasmic reticulum-associated degradation activity
  JOURNAL   Dev Biol 393 (1), 33-43 (2014)
   PUBMED   25009997
REFERENCE   3  (bases 1 to 2710)
  AUTHORS   Kirchhof,P., Kahr,P.C., Kaese,S., Piccini,I., Vokshi,I.,
            Scheld,H.H., Rotering,H., Fortmueller,L., Laakmann,S., Verheule,S.,
            Schotten,U., Fabritz,L. and Brown,N.A.
  TITLE     PITX2c is expressed in the adult left atrium, and reducing Pitx2c
            expression promotes atrial fibrillation inducibility and complex
            changes in gene expression
  JOURNAL   Circ Cardiovasc Genet 4 (2), 123-133 (2011)
   PUBMED   21282332
REFERENCE   4  (bases 1 to 2710)
  AUTHORS   Yabuta,Y., Ohta,H., Abe,T., Kurimoto,K., Chuma,S. and Saitou,M.
  TITLE     TDRD5 is required for retrotransposon silencing, chromatoid body
            assembly, and spermiogenesis in mice
  JOURNAL   J Cell Biol 192 (5), 781-795 (2011)
   PUBMED   21383078
REFERENCE   5  (bases 1 to 2710)
  AUTHORS   Lapierre,P., Beland,K., Martin,C., Alvarez,F. Jr. and Alvarez,F.
  TITLE     Forkhead box p3+ regulatory T cell underlies male resistance to
            experimental type 2 autoimmune hepatitis
  JOURNAL   Hepatology 51 (5), 1789-1798 (2010)
   PUBMED   20232291
  REMARK    GeneRIF: Autoreactive B cell response against
            formiminotransferase-cyclodeaminase correlated with disease
            activity, possibly linking B-cell autoreactivity and AIH
            pathogenesis
REFERENCE   6  (bases 1 to 2710)
  AUTHORS   Liu,S.P., Li,Y.S., Chen,Y.J., Chiang,E.P., Li,A.F., Lee,Y.H.,
            Tsai,T.F., Hsiao,M., Huang,S.F. and Chen,Y.M.
  TITLE     Glycine N-methyltransferase-/- mice develop chronic hepatitis and
            glycogen storage disease in the liver
  JOURNAL   Hepatology 46 (5), 1413-1425 (2007)
   PUBMED   17937387
  REMARK    Erratum:[Hepatology. 2008 Feb;47(2):769. Hwang, Shiu-Feng
            [corrected to Huang, Shiu-Feng]]
REFERENCE   7  (bases 1 to 2710)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2710)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   9  (bases 1 to 2710)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (bases 1 to 2710)
  AUTHORS   Solans,A., Estivill,X. and de la Luna,S.
  TITLE     Cloning and characterization of human FTCD on 21q22.3, a candidate
            gene for glutamate formiminotransferase deficiency
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 43-49 (2000)
   PUBMED   10773664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB610765.1, CD297973.1, AK165414.1 and CB949427.1.
            
            On Dec 29, 2007 this sequence version replaced NM_080845.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010813.1, SRR5189682.69877.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               BB610765.1         2-297
            297-637             CD297973.1         300-640
            638-964             AK165414.1         547-873
            965-1362            CB949427.1         103-500
            1363-2710           AK165414.1         1570-2917
FEATURES             Location/Qualifiers
     source          1..2710
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.25 cM"
     gene            1..2710
                     /gene="Ftcd"
                     /note="formiminotransferase cyclodeaminase"
                     /db_xref="GeneID:14317"
                     /db_xref="MGI:MGI:1339962"
     exon            1..112
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1684
                     /gene="Ftcd"
                     /EC_number="2.1.2.5"
                     /EC_number="4.3.1.4"
                     /note="glutamate formiminotransferase"
                     /codon_start=1
                     /product="formimidoyltransferase-cyclodeaminase"
                     /protein_id="NP_543121.1"
                     /db_xref="CCDS:CCDS23950.1"
                     /db_xref="GeneID:14317"
                     /db_xref="MGI:MGI:1339962"
                     /translation="MSQLVECVPNFSEGNNQEVIDAISRAISQTPGCVLLDVDAGPST
                     NRTVYTFVGQPECVVEGALHAARTASQLIDMSKHKGEHPRMGALDVCPFIPVRGVSME
                     ECVLCAKAFGQRLAEELNVPVYLYGEAAQTPSRQTLPAIRAGEYEALPEKLKQAEWVP
                     DFGPSSFVPSWGATVTGARKFLIAFNINLLSTKEQAHRIALNLREQGRGKDQPGRLKK
                     VQGIGWYLEEKNLAQVSTNLLDFEVTALHTVFEEARREAQELNLPVVGSQLVGLVPLK
                     ALLDAAAFYCDKEKLFVLEEEHRIRLVVNRLGLDSLAPFDPKERIIEYLVPDSGPEQS
                     LLDTSLRGFVREVGARSAAPGGGSVAAAVAALGAALASMVGQMTYGRRQFDHLDSTMR
                     RLIPPFHAASAQLTSLVDADARAFAACLEAIKLPKNTPEERDRRACALQEGLRQAVAV
                     PLKLAETVSQLWPALQELAHCGNLSCLSDLQVAAKALETGVFGAYFNVLINLKDMTDD
                     VFKEKTHHRISSLLQEAKTQAALVLGSLEARKE"
     exon            113..296
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            297..425
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            426..514
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            515..694
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            695..832
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            833..964
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1026
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1156
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1318
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1362
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1501
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1597
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..2710
                     /gene="Ftcd"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1933
                     /gene="Ftcd"
                     /note="major polyA site"
ORIGIN      
        1 gtcactctgt gtccctctac agcctcttga gaggaacctc tggactcagg tgctggccat
       61 gtctcagttg gtggaatgtg tccccaactt ctcagagggg aacaaccagg aggtgattga
      121 tgccatctct cgagccatct cccagacccc aggctgtgtg ctgttggacg tcgatgccgg
      181 accctccacc aaccgcactg tctacacttt cgtggggcag ccagagtgtg tcgtagaggg
      241 ggccctccat gctgcgcgta cggcctcaca gctcatcgac atgagcaagc acaagggtga
      301 gcaccctcga atgggcgctc tggatgtgtg tcccttcatc ccggtgaggg gcgtcagcat
      361 ggaagagtgt gtgctctgtg ccaaggcatt tgggcagcgg ctggcagagg aacttaatgt
      421 accagtgtat ctctatggtg aggcagctca gacgcccagt cgtcagaccc tgccagccat
      481 ccgggctgga gagtatgagg ccctgcctga gaagctcaaa caggccgagt gggtgccaga
      541 ctttggccct agctcctttg tccccagttg gggtgctact gtcacgggtg cacggaagtt
      601 cctcattgca ttcaatatca acctgctaag caccaaggag caggcccacc gtattgctct
      661 taacctgcgg gagcagggcc gagggaaaga ccagcctgga cgtctgaaaa aggtccaggg
      721 catcggttgg tacctggaag agaagaacct ggctcaggtg tccacaaacc tcctggactt
      781 tgaggtcaca gctctgcaca cagtgtttga ggaggcccgc agagaggctc aggagctgaa
      841 tctcccagtg gtgggctcgc agctggtggg cctggtgcct ctgaaggcct tactggatgc
      901 cgcagccttc tactgtgaca aggagaagct gtttgttctg gaggaggagc atcggatacg
      961 gctggtggtg aaccggctgg gcctggattc gctggcaccc ttcgacccaa aggaacggat
     1021 catcgagtac ctagtccccg atagtggacc agaacagagc ctgttggaca cctcactgcg
     1081 cggttttgtt cgggaggtgg gagcccgctc tgctgcccca ggaggaggtt ctgtagcagc
     1141 agcggtagca gctctgggtg cagccctggc ttctatggtg ggccagatga cctatggccg
     1201 gcgccagttt gatcacttgg attccacaat gcgacgcctg atcccaccct tccacgcagc
     1261 ctctgcccag ctgacttcat tggtggatgc tgatgcccgg gcgtttgctg cctgtttgga
     1321 ggcaataaag ctgcccaaga acacgcctga agagagagac aggcgtgcat gcgctctgca
     1381 ggaggggctg agacaggcag tcgctgtgcc actgaaactg gccgagactg tgtcccagct
     1441 atggccagcg ctgcaggagc tggcccactg tgggaacctg tcctgcttgt ctgacctgca
     1501 ggtggcagcc aaagccttgg agacaggtgt gtttggtgcg tacttcaacg tgctcatcaa
     1561 cctgaaggac atgacggatg atgtatttaa agagaagaca caccatcgaa tctccagcct
     1621 tctgcaggaa gccaagactc aggctgcgct ggtgctgggt agcctagaag cccgaaagga
     1681 gtgaagagac cgctccagtg aatggtccaa cttccagtat tccttaccta tcttaagtgg
     1741 cccaagcctt gcttgggggg gaagagtcag ccatgacacc atcagggcca ggttggggct
     1801 caatgcacag ctgtctatgc aggatcagaa gatgcaacgg agggggtttg gggtagggta
     1861 tggtagggcc tgattggtgg tggtatcctg ataccctctg ttatccatgg tttctggtaa
     1921 attctgaaca caagtttttc tggtgtgctt gggtttgggg cccatagtca aggactgaga
     1981 ctgcaattgg gaggatggcc agggaacctg ttgatctgtg agcaatgaat tagaagcccc
     2041 agccccagag atcccagatg taggatttat gggggatgca tccagcactg gtatactctg
     2101 agcactggat tctgagttag gattaccatt actgtgatgc aacaccatga gcaaaaaagc
     2161 aagttgagga ggaaagggct tatttgcctt acgcttccac attgctgttc atcattaaag
     2221 gaagtcagga cagaaactca aacagggcag gaacctggag gcaggagctg atacatgggc
     2281 tatggaggga tactgcttgc tgccttgctc ttcatagctt gctcagcctg ctttcttata
     2341 aaaatccagg accaccagcc taggggtagc cccacccaca aagggctggg ccctgcccca
     2401 tcaatcactg attaagacaa tgccttacag ccagatctta tggaggcatc ttctcaattg
     2461 aggttccctc ctttccgatg actctagttt gtgtgtcaag ttgacataca attcaccagc
     2521 acagccatgt agcaaggaac agagatgtct ggtttctaag gactgtgagg gcattctctt
     2581 ccttcaccag acagtctacg tctaccttcc atgccacctt taagggggct caccccatcc
     2641 tccatcctca gaggtcgtgt tcgtcacttc ctttctctct agtccctatt actaataaac
     2701 catcccaatg
//
